{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T00:20:10Z","timestamp":1771028410754,"version":"3.50.1"},"reference-count":39,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T00:00:00Z","timestamp":1669939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Cancer treatments can adversely influence body weight status, body composition, phase angle (PhA), and resting metabolic rate (RMR), which could possibly affect disease course. \u03a4he aim was to assess differences in body composition, PhA, RMR, and related parameters in non-small-cell lung cancer (NSCLC) patients after treatment. Methods: The sample consisted of 82 NSCLC (stage IV) male patients (chemotherapy (C) 15.7%; immunotherapy (I) 13.3%; C + I 25.3%; (C) + radiotherapy (R) 22.9 %; and other 15.5%). Body weight and body composition, PhA, RMR, oxygen consumption (VO2), ventilation rate, and diet were assessed at baseline and at 3 months after initiation of therapy. Results: Reductions in PhA, RMR, VO2, ventilation rate, and intracellular water were observed at follow up. Weight loss was evident for 45% of patients who also had a reduction in lean body mass. In the group under C, lean mass was reduced at follow up (55.3 \u00b1 11.53 vs. 52.4 \u00b1 12.6, p = 0.04) without significant weight changes. In subjects with a low adherence to the Mediterranean diet (MedDietScore &lt; 30), RMR (1940 \u00b1 485 vs. 1730 \u00b1 338 Kcal, p = 0.001), VO2 (277.1 \u00b1 70.2 vs. 247 \u00b1 49.1 mL\/min, p = 0.001), and ventilation rate (10.1 \u00b1 2.28 vs. 9. \u00b1 2 2.2 L\/min, p = 0.03) were significantly reduced. The changes in body weight were positively related to % of change in fat mass (rho = 0.322, p = 0.003) and absolute lean mass change (rho = 0.534, p &lt; 0.001) and negatively associated with % of change in total body water (rho = \u22120.314, p = 0.004) (Spearman correlation coefficients). Conclusions: In conclusion, cancer therapy related to reductions in PhA and RMR, while lean mass reduction may be related to the type of treatment. Our results emphasize the importance of a more holistic nutritional and body composition assessment beyond body weight, to better address patients\u2019 needs in clinical practice.<\/jats:p>","DOI":"10.3390\/medicina58121779","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T02:56:26Z","timestamp":1670208986000},"page":"1779","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Changes in Body Weight, Body Composition, Phase Angle, and Resting Metabolic Rate in Male Patients with Stage IV Non-Small-Cell Lung Cancer Undergoing Therapy"],"prefix":"10.3390","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1723-9192","authenticated-orcid":false,"given":"Paraskevi","family":"Detopoulou","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition, General Hospital Korgialenio Benakio, 57889 Athens, Greece"},{"name":"Department of Nutritional Sciences and Dietetics, University of the Peloponnese, 24150 Kalamata, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodora","family":"Tsiouda","sequence":"additional","affiliation":[{"name":"Pulmonary-Oncology Department, \u2018Theageneio\u2019 Cancer Hospital, 54639 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8519-489X","authenticated-orcid":false,"given":"Maria","family":"Pilikidou","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences and Dietetics, International Hellenic University, 57001 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Foteini","family":"Palyvou","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences and Dietetics, International Hellenic University, 57001 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6535-485X","authenticated-orcid":false,"given":"Eirini","family":"Tsekitsidi","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences and Dietetics, International Hellenic University, 57001 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2535-2841","authenticated-orcid":false,"given":"Maria","family":"Mantzorou","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, University of Aegean, 81100 Lemnos, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Persefoni","family":"Pezirkianidou","sequence":"additional","affiliation":[{"name":"Pulmonary-Oncology Department, \u2018Theageneio\u2019 Cancer Hospital, 54639 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krystallia","family":"Kyrka","sequence":"additional","affiliation":[{"name":"Pulmonary-Oncology Department, \u2018Theageneio\u2019 Cancer Hospital, 54639 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4370-1395","authenticated-orcid":false,"given":"Spyridon","family":"Methenitis","sequence":"additional","affiliation":[{"name":"Sports Performance Laboratory, School of Physical Education and Sports Science, National and Kapodistrian University of Athens, 57668 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gavriela","family":"Voulgaridou","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences and Dietetics, International Hellenic University, 57001 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5119-2207","authenticated-orcid":false,"given":"Pavlos","family":"Zarogoulidis","sequence":"additional","affiliation":[{"name":"Pulmonary Department, General Clinic Euromedica Private Hospital, 54645 Thessaloniki, Greece"},{"name":"3rd Surgery Department, AHEPA University Hospital, Aristotle University of Thessaloniki, 54637 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rena","family":"Oikonomidou","sequence":"additional","affiliation":[{"name":"Health Center of Evosmos, 56224 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitris","family":"Matthaios","sequence":"additional","affiliation":[{"name":"Oncology Department, General Hospital of Rhodes, 86775 Rhodes, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7215-2191","authenticated-orcid":false,"given":"\u039aonstantinos","family":"Porpodis","sequence":"additional","affiliation":[{"name":"Pulmonary Department, \u201cG. Papanikolaou\u201d General Hospital, Aristotle University of Thessaloniki, 57010 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8438-4050","authenticated-orcid":false,"given":"Dimitrios","family":"Giannakidis","sequence":"additional","affiliation":[{"name":"1st Department of Surgery, Attica General Hospital \u201cSismanogleio\u2013Amalia Fleming\u201d, 15126 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sousana K.","family":"Papadopoulou","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences and Dietetics, International Hellenic University, 57001 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21708","article-title":"Cancer Statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"CA Cancer J. 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