{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T20:06:10Z","timestamp":1760731570253,"version":"build-2065373602"},"reference-count":44,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T00:00:00Z","timestamp":1670284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Patients infected with SARS-CoV-2 can have persistent symptoms after acute illness, which affects their quality of life (QoL). Research and data about this topic in Latin American ambulatory patients are scarce. Materials and Methods: We conducted an observational, prospective, transversal, and analytical study. To measure QoL, we used a validated Spanish version of the MOS\/RAND 36-Item Short Form Health Survey (SF-36). Results: We included 206 outpatients in the study. A total of 73.3% patients had persistence of one or more symptoms. The most frequent persistent symptoms were fatigue (36.9%), anxiety (26.2%), and headache (24.8%). No statistically significant difference in the SF-36 QoL scores and the frequency of persistent COVID-19 symptoms was found when comparing the \u22645 and &gt;5 months groups, except for myalgia, which was less frequently observed in the &gt;5 months group after COVID-19 (26.2% vs. 14.1%, p &lt; 0.038). Female gender was associated with an increased risk of persistence of symptoms (OR = 2.95, 95% CI 1.56\u20135.57). Having comorbidities\/sequelae attributed to COVID-19 and persistence of COVID-19 symptoms were associated risk factors for poor physical component summary (PCS); on the other hand, female gender, anxiety, and depression were associated with poor mental component summary (MCS). Conclusion: Most outpatients had persistent COVID-19 symptoms after infection. Persistence of symptoms was associated with poor MCS and PCS. It is important to follow-up not only patients discharged from the hospital after SARS-CoV-2 infection, but also those under ambulatory management to provide them with rehabilitation and psychological therapy to improve their QoL.<\/jats:p>","DOI":"10.3390\/medicina58121795","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T02:18:48Z","timestamp":1670379528000},"page":"1795","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Quality of Life and Persistence of Symptoms in Outpatients after Recovery from COVID-19"],"prefix":"10.3390","volume":"58","author":[{"given":"Lizeth Guadalupe","family":"Guti\u00e9rrez-Canales","sequence":"first","affiliation":[{"name":"Fellow of the General Directorate of Quality and Health Education, Ministry of Health, Le\u00f3n 11410, Mexico"},{"name":"Department of Medicine and Nutrition, University of Guanajuato, San Carlos La Roncha, Le\u00f3n 37660, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2359-0846","authenticated-orcid":false,"given":"Carolina","family":"Mu\u00f1oz-Corona","sequence":"additional","affiliation":[{"name":"Department of Medicine and Nutrition, University of Guanajuato, San Carlos La Roncha, Le\u00f3n 37660, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaac","family":"Barrera-Ch\u00e1vez","sequence":"additional","affiliation":[{"name":"Department of Medicine and Nutrition, University of Guanajuato, San Carlos La Roncha, Le\u00f3n 37660, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Viloria-\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Department of Medicine and Nutrition, University of Guanajuato, San Carlos La Roncha, Le\u00f3n 37660, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro E.","family":"Mac\u00edas","sequence":"additional","affiliation":[{"name":"Department of Medicine and Nutrition, University of Guanajuato, San Carlos La Roncha, Le\u00f3n 37660, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6494-5511","authenticated-orcid":false,"given":"Eduardo","family":"Guan\u00ed-Guerra","sequence":"additional","affiliation":[{"name":"Department of Medicine and Nutrition, University of Guanajuato, San Carlos La Roncha, Le\u00f3n 37660, Mexico"},{"name":"Department of Research, Hospital Regional de Alta Especialidad del Baj\u00edo (HRAEB), San Carlos La Roncha, Le\u00f3n 37660, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/eurpub\/ckab153","article-title":"The COVID-19 disaster and mental health-assessing, responding and recovering","volume":"31","author":"Lindert","year":"2021","journal-title":"Eur. 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