{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:49:49Z","timestamp":1762080589589,"version":"build-2065373602"},"reference-count":44,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T00:00:00Z","timestamp":1670544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>The ideal surgical treatment of femoral neck fractures remains controversial. When treating these fractures with internal fixation, many fixation constructs exist. The primary aim of this study was to evaluate the incidence and specific risk factors associated with complication and re-operation following fixation of intracapsular proximal femoral fractures using the Targon-FN system (B.Braun Melsungen AG). A secondary aim was to identify if lateral prominence of the implant relative to the lateral border of the vastus ridge was a specific risk factor for elective plate removal. Methodically, a retrospective case series was conducted of all consecutive adult patients treated at a single level 1 trauma center in Switzerland for an intracapsular proximal femoral fracture with the Targon-FN. Demographic data were collected. Patients with a follow-up of less than three months were excluded. Complications as well as plate position were recorded. Statistical analysis to identify specific risk factors for re-operation and complications was performed. In result, a total of 72 cases with intracapsular femoral neck fractures were treated with the Targon-FN locking plate system between 2010 and 2017. Thirty-four patients (47.2%) experienced one or more complications. The most common complication was mechanical irritation of the iliotibial band (ITB) (23.6%, n = 17). Complications included intraarticular screw perforation (6.9%, n = 5), avascular necrosis (5.6%, n = 4), non-union (5.6%, n = 4) among others. In total, 46 re-operations were required. Younger age, fracture displacement and time to postoperative weight bearing were identified as risk factors for re-operation. In conclusion, intracapsular femoral neck fractures treated with the Targon-FN system resulted in a high rate of post-operative complication and re-operation. Statistical analysis revealed patient age, fracture displacement, time to postoperative full weight bearing were risk factors for re-operation. The main limitation is the limited number of cases and a short follow-up of less than 12 months in a subgroup of our patients.<\/jats:p>","DOI":"10.3390\/medicina58121812","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T04:46:46Z","timestamp":1670561206000},"page":"1812","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["High Percentage of Complications and Re-Operations Following Dynamic Locking Plate Fixation with the Targon\u00ae FN for Intracapsular Proximal Femoral Fractures: An Analysis of Risk Factors"],"prefix":"10.3390","volume":"58","author":[{"given":"Emanuel","family":"Kuner","sequence":"first","affiliation":[{"name":"Department of Orthopedic and Trauma Surgery, Lucerne Cantonal Hospital, 6000 Lucerne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"G\u00fctler","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Zug Cantonal Hospital, 6340 Baar, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitri E.","family":"Delagrammaticas","sequence":"additional","affiliation":[{"name":"Central Coast Orthopedic Medical Group, 862 Meinecke Avenue, Suite 100, San Luis Obispo, CA 93405, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan J. M.","family":"van de Wall","sequence":"additional","affiliation":[{"name":"Department of Orthopedic and Trauma Surgery, Lucerne Cantonal Hospital, 6000 Lucerne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9166-0965","authenticated-orcid":false,"given":"Matthias","family":"Knobe","sequence":"additional","affiliation":[{"name":"Department of Orthopedic and Trauma Surgery, Lucerne Cantonal Hospital, 6000 Lucerne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank J. P.","family":"Beeres","sequence":"additional","affiliation":[{"name":"Department of Orthopedic and Trauma Surgery, Lucerne Cantonal Hospital, 6000 Lucerne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reto","family":"Babst","sequence":"additional","affiliation":[{"name":"Department of Orthopedic and Trauma Surgery, Lucerne Cantonal Hospital, 6000 Lucerne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3289-6935","authenticated-orcid":false,"given":"Bj\u00f6rn-Christian","family":"Link","sequence":"additional","affiliation":[{"name":"Department of Orthopedic and Trauma Surgery, Lucerne Cantonal Hospital, 6000 Lucerne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1302\/0301-620X.102B1.BJJ-2019-1041.R1","article-title":"Cemented or uncemented hemiarthroplasty for displaced intracapsular fractures of the hip: A randomized trial of 400 patients","volume":"102-B","author":"Parker","year":"2019","journal-title":"Bone Jt. J."},{"key":"ref_2","first-page":"3426","article-title":"Der Oberschenkelhalsbruch","volume":"102","author":"Lucke","year":"2005","journal-title":"Dtsch. Arztebl."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/s00132-014-2265-7","article-title":"H\u00fcftgelenknahe Frakturen im hohen Lebensalter","volume":"43","author":"Knobe","year":"2014","journal-title":"Orthop\u00e4de"},{"key":"ref_4","first-page":"1680","article-title":"Comparison of Internal Fixation with Total Hip Replacement for Displaced Femoral Neck Fractures: Randomized, Controlled Trial Performed at Four Years","volume":"87","author":"Blomfeldt","year":"2005","journal-title":"JBJS"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3109\/17453679308994564","article-title":"Factors predicting healing complications in femoral neck fractures: 138 patients followed for 2 years","volume":"64","author":"Nilsson","year":"1993","journal-title":"Acta Orthop. Scand."},{"key":"ref_6","first-page":"639","article-title":"Prediction of disturbed healing in femoral neck fracture","volume":"63","author":"Alho","year":"1992","journal-title":"Acta Orthop. Scand."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"136","DOI":"10.2106\/JBJS.18.00316","article-title":"Screw Fixation Versus Hemiarthroplasty for Nondisplaced Femoral Neck Fractures in Elderly Patients: A Multicenter Randomized Controlled Trial","volume":"101","author":"Dolatowski","year":"2019","journal-title":"J. Bone Joint Surg. Am."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Maffulli, N., and Aicale, R. (2022). Proximal Femoral Fractures in the Elderly: A Few Things to Know, and Some to Forget. Medicina Mex, 58.","DOI":"10.3390\/medicina58101314"},{"key":"ref_9","first-page":"2254","article-title":"Treatment of femoral neck fractures in young adults","volume":"90","author":"Ly","year":"2008","journal-title":"J. Bone Jt. Surg. Am."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/BLO.0b013e3180325a42","article-title":"Incidence of fracture-healing complications after femoral neck fractures","volume":"458","author":"Parker","year":"2007","journal-title":"Clin. Orthop."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2106\/00004623-199401000-00003","article-title":"Outcomes after displaced fractures of the femoral neck. A meta-analysis of one hundred and six published reports","volume":"76","author":"Keller","year":"1994","journal-title":"J. Bone Jt. Surg.\u2014Ser. A"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s00264-017-3587-y","article-title":"Screw-blade fixation systems in Pauwels three femoral neck fractures: A biomechanical evaluation","volume":"42","author":"Knobe","year":"2018","journal-title":"Int. Orthop."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1007\/s00264-009-0866-2","article-title":"Risk factors in cutout of sliding hip screw in intertrochanteric fractures: An evaluation of 937 patients","volume":"34","author":"Hsueh","year":"2010","journal-title":"Int. Orthop."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1016\/j.injury.2016.10.022","article-title":"Risk factors of avascular necrosis of the femoral head and fixation failure in patients with valgus angulated femoral neck fractures over the age of 50 years","volume":"47","author":"Song","year":"2016","journal-title":"Injury"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.injury.2010.11.053","article-title":"The Pauwels classification for intracapsular hip fractures: Is it reliable?","volume":"42","author":"Roukema","year":"2011","journal-title":"Injury"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/00003086-200206000-00004","article-title":"Classification and diagnosis of intracapsular fractures of the proximal femur","volume":"399","author":"Caviglia","year":"2002","journal-title":"Clin. Orthop."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.injury.2014.12.008","article-title":"Fixed angle devices versus multiple cancellous screws: What does the evidence tell us?","volume":"46","author":"Hoshino","year":"2015","journal-title":"Injury"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0020-1383(86)90322-0","article-title":"Avascular femoral head necrosis following fracture fixation","volume":"17","author":"Linde","year":"1986","journal-title":"Injury"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1016\/S0140-6736(17)30066-1","article-title":"Fracture fixation in the operative management of hip fractures (FAITH): An international, multicentre, randomised controlled trial","volume":"389","author":"Nauth","year":"2017","journal-title":"Lancet"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1097\/BOT.0b013e3182a225fa","article-title":"Osteosynthesis of unstable intracapsular femoral neck fracture by dynamic locking plate or screw fixation: Early results","volume":"28","author":"Thein","year":"2014","journal-title":"J. Orthop. Trauma"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1302\/0301-620X.95B10.31511","article-title":"Internal fixation of intracapsular fractures of the hip using a dynamic locking plate: Two-year follow-up of 320 patients","volume":"95","author":"Parker","year":"2013","journal-title":"Bone Jt. J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1016\/j.injury.2013.05.002","article-title":"Clinical experience, primary results and pitfalls in the treatment of intracapsular hip fractures with the Targon\u00ae FN locking plate","volume":"44","author":"Wieland","year":"2013","journal-title":"Injury"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"S44","DOI":"10.1016\/S0020-1383(16)30854-3","article-title":"Clinical results of surgical treatment for femoral neck fractures with the Targon\u00ae FN","volume":"47","author":"Takigawa","year":"2016","journal-title":"Injury"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"22","DOI":"10.4055\/cios.2015.7.1.22","article-title":"The targon FN system for the management of intracapsular neck of femur fractures: Minimum 2-year experience and outcome in an independent hospital","volume":"7","author":"Osarumwense","year":"2015","journal-title":"CiOS Clin. Orthop. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1016\/j.injury.2017.08.063","article-title":"The outcome of intracapsular hip fracture fixation using the Targon Femoral Neck (TFN) locking plate system or cannulated cancellous screws: A comparative study involving 2004 patients","volume":"48","author":"Alshameeri","year":"2017","journal-title":"Injury"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Hou, X., Shi, G., Zhang, Y., Xing, B., and Xu, D. (2022). Comparison between Three Cannulated Screws and Targon Locking Plate for Displaced Intracapsular Hip Fracture: A Retrospective Stud. Res. Sq., preprint.","DOI":"10.21203\/rs.3.rs-1528403\/v1"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.injury.2009.10.003","article-title":"Hemiarthroplasty versus internal fixation for displaced intracapsular hip fractures: A long-term follow-up of a randomised trial","volume":"41","author":"Parker","year":"2010","journal-title":"Injury"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1302\/0301-620X.96B5.33391","article-title":"The Targon Femoral Neck hip screw versus cannulated screws for internal fixation of intracapsular fractures of the hip","volume":"96-B","author":"Griffin","year":"2014","journal-title":"Bone. Jt. J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/j.ijsu.2014.07.013","article-title":"The strengthening the reporting of observational studies in epidemiology (STROBE) statement: Guidelines for reporting observational studies","volume":"12","author":"Altman","year":"2014","journal-title":"Int. J. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.injury.2009.09.004","article-title":"Internal fixation of intracapsular hip fractures with a dynamic locking plate: Initial experience and results for 83 patients treated with a new implant","volume":"41","author":"Parker","year":"2010","journal-title":"Injury"},{"key":"ref_31","first-page":"647","article-title":"Low-Angle Fixation in Fractures of the Femoral Neck","volume":"43-B","author":"Garden","year":"1961","journal-title":"Bone Jt. J."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"M\u00fcller, M.E., Koch, P., Nazarian, S., and Schatzker, J. (1990). The Comprehensive Classification of Fractures of Long Bones, Springer.","DOI":"10.1007\/978-3-642-61261-9"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1259\/bjr\/29690721","article-title":"To what degree is digital imaging reliable? Validation of femoral neck shaft angle measurement in the era of picture archiving and communication systems","volume":"84","author":"Wilson","year":"2011","journal-title":"Br. J. Radiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1177\/230949901402200123","article-title":"The Dorr type and cortical thickness index of the proximal femur for predicting peri-operative complications during hemiarthroplasty","volume":"22","author":"Nash","year":"2014","journal-title":"J. Orthop. Surg."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.2106\/00004623-199507000-00012","article-title":"The value of the tip-apex distance in predicting failure of fixation of peritrochanteric fractures of the hip","volume":"77","author":"Baumgaertner","year":"1995","journal-title":"J. Bone Jt. Surg."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"18404","DOI":"10.1038\/s41598-021-97951-8","article-title":"The radiographic relationship between the cortical overlap view (COV) and the tip of the greater trochanter","volume":"11","author":"Link","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1086\/646436","article-title":"CDC Definitions of Nosocomial Surgical Site Infections, 1992, A Modification of CDC Definitions of Surgical Wound Infections","volume":"13","author":"Horan","year":"1992","journal-title":"Infect. Control Hosp. Epidemiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1302\/0301-620X.77B1.7822393","article-title":"A quantitative system for staging avascular necrosis","volume":"77","author":"Steinberg","year":"1995","journal-title":"J. Bone Jt. Surg. Br."},{"key":"ref_39","first-page":"1465","article-title":"Internal fixation implants for intracapsular hip fractures in adults","volume":"4","year":"2011","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.injury.2008.11.003","article-title":"Avascular necrosis after internal fixation of intracapsular hip fractures; a study of the outcome for 1023 patients","volume":"40","author":"Loizou","year":"2009","journal-title":"Injury"},{"key":"ref_41","first-page":"131","article-title":"Complications after intracapsular hip fractures in young adults: A meta-analysis of 18 published studies involving 564 fractures","volume":"36","author":"Damany","year":"2005","journal-title":"Injury"},{"key":"ref_42","first-page":"291","article-title":"Joint-preserving treatment of medial femoral neck fractures with an angular stable implant","volume":"28","author":"Mittlmeier","year":"2016","journal-title":"Oper. Orthop. Traumatol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1302\/0301-620X.97B7.35524","article-title":"Hemiarthroplasty versus internal fixation for displaced intracapsular fractures of the hip in elderly men","volume":"97-B","author":"Parker","year":"2015","journal-title":"Bone Jt. J."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.injury.2021.02.046","article-title":"Comparison of time to healing and major complications after surgical fixation of nondisplaced femoral neck stress fractures: A systematic review","volume":"52","author":"Kolaczko","year":"2021","journal-title":"Injury"}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/58\/12\/1812\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:37:05Z","timestamp":1760146625000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/58\/12\/1812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,9]]},"references-count":44,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["medicina58121812"],"URL":"https:\/\/doi.org\/10.3390\/medicina58121812","relation":{},"ISSN":["1648-9144"],"issn-type":[{"type":"electronic","value":"1648-9144"}],"subject":[],"published":{"date-parts":[[2022,12,9]]}}}