{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:14:48Z","timestamp":1791972888274,"version":"4.3.4"},"reference-count":13,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,12,17]],"date-time":"2022-12-17T00:00:00Z","timestamp":1671235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Primary squamous cell carcinoma (SCC) of the liver is a rare disease that is difficult to diagnose until the pathology is confirmed. The age of the patients generally ranges from 18 to 83 years. The pathogenesis of primary SCC of the liver remains unclear and therapeutic guidelines have not yet been established. The overall survival rate may be less than 1 year. The prognosis for patients without surgery is worse than that for patients who undergo surgery. Herein, we report a case of primary SCC of the liver that responded well to intravenous carboplatin and 5-flurouracil (5-FU) with the aim of providing an alternative therapeutic option. A 61-year-old woman with no history of alcohol use disorder, cirrhosis, exposure to hepatotoxic chemicals, or a remarkable family history presented to our hospital with a complaint of epigastric pain, poor appetite, and fatigue, which had occurred 3 days before presentation. Blood tests revealed levels of alpha-fetoprotein of &lt;2.0 ng\/mL, carcinoembryonic antigen of 4.39 ng\/mL, carbohydrate antigen (CA) 19-9 of 1306.15 U\/mL, CA 125 of 66.3 U\/mL, CA 153 of 19.7 U\/mL, and SCC antigen of 8.5 ng\/mL. Computed tomography scans of the abdomen showed a 5.8-cm lobulated soft-tissue mass with central necrosis in segment 6 of the liver, which caused compression of the common hepatic duct. Pathological examination of the masses revealed squamous cell carcinoma with focal glandular differentiation. The patient underwent palliative chemotherapy with intravenous carboplatin 150 mg (day 1) and 5-FU 1000 mg (days 1\u20134) instead of surgery. After two cycles of chemotherapy, jaundice and liver function improved. The patient was discharged in stable condition and was followed up in our outpatient department. Although the patient refused to undergo surgery, no tumor recurrence or distant metastasis was found during the 8-month follow-up period. This report highlights that neoadjuvant chemotherapy with carboplatin and 5-FU can be considered for primary SCC of the liver before a liver resection.<\/jats:p>","DOI":"10.3390\/medicina58121864","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T05:55:43Z","timestamp":1671429343000},"page":"1864","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Primary Squamous Cell Carcinoma of the Liver with Good Response to Carboplatin and 5-Flurouracil: A Case Report"],"prefix":"10.3390","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1338-945X","authenticated-orcid":false,"given":"Hsu-Lin","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Hematology and Oncology, Department of Internal Medicine, Taichung Armed Forces General Hospital, Taichung 411, Taiwan"},{"name":"Division of Hematology and Oncology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Kai","family":"Fu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Taichung Armed Forces General Hospital, Taichung 411, Taiwan"},{"name":"Division of Gastroenterology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang-Yu","family":"Chien","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacy, Tri-Service General Hospital Songshan Branch, National Defense Medical Center, Taipei 114, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Mien","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Internal Medicine, Taichung Armed Forces General Hospital, Taichung 411, Taiwan"},{"name":"Division of Hematology and Oncology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e868","DOI":"10.1097\/MD.0000000000000868","article-title":"Primary Squamous Cell Carcinoma of Liver: Case Series and Review of Literatures","volume":"94","author":"Zhang","year":"2015","journal-title":"Medicine"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"5830","DOI":"10.3748\/wjg.v18.i40.5830","article-title":"Primary squamous cell carcinoma of the liver associated with hepatolithiasis: A case report","volume":"18","author":"Zhu","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"829","DOI":"10.2147\/CMAR.S290523","article-title":"Primary Squamous Cell Carcinoma of the Liver is Rare but Hostile: Case Series and Comprehensive Review of the Literature","volume":"13","author":"Xiao","year":"2021","journal-title":"Cancer Manag. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"275","DOI":"10.5009\/gnl.2012.6.2.275","article-title":"Primary squamous cell carcinoma of the liver initially presenting with pseudoachalasia","volume":"6","author":"Choi","year":"2012","journal-title":"Gut Liver"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2739\/kurumemedj.50.71","article-title":"A case report of primary hepatic squamous cell carcinoma that remarkably responded to low dose arterial injection of anti-cancer drugs","volume":"50","author":"Kaji","year":"2003","journal-title":"Kurume Med. 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Gastroenterol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1002\/hep.31737","article-title":"Primary Hepatic Squamous Cell Carcinoma With High Microsatellite Instability Shows Good Response to Programmed Cell Death 1 Inhibitor as Adjuvant Therapy","volume":"74","author":"Wang","year":"2021","journal-title":"Hepatology"}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/58\/12\/1864\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:43:11Z","timestamp":1760146991000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/58\/12\/1864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,17]]},"references-count":13,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["medicina58121864"],"URL":"https:\/\/doi.org\/10.3390\/medicina58121864","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,17]]}}}