{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T02:35:58Z","timestamp":1781577358747,"version":"3.54.5"},"reference-count":27,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T00:00:00Z","timestamp":1672358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Appendiceal carcinoids are rare neuroendocrine tumors and mainly found incidentally during histopathological examination following appendectomy. This observational cohort study was performed to determine the prevalence, treatment modalities and outcomes in children diagnosed with an appendiceal carcinoid tumor. Materials and Methods: Data from the largest German statutory health insurance \u201cTechniker Krankenkasse\u201d were analyzed within an 8-year period: January 2010 to December 2012 and January 2016 to December 2020. Patient characteristics, surgical technique, type of surgical department, diagnostic management, and postoperative morbidity were analyzed. Results: Out of 40.499 patients following appendectomy, appendiceal carcinoids were found in 44 children, resulting in a prevalence of 0.11%. Mean age at appendectomy was 14.7 (\u00b12.6) years. Laparoscopic approach was performed in 40 (91%) cases. Right-sided hemicolectomy was performed in 8 (18%) patients. Additional diagnostic work-up (CT and MRI) was recorded in 5 (11%) children. Conclusions: This large nationwide pediatric study shows that 1 in 1000 patients was found to have a neuroendocrine tumor of the appendix (prevalence 0.11%), emphasizing its low prevalence in the pediatric age group. The majority of patients were treated with appendectomy only. However, treatment modalities are still variable. Longer follow-up analyses are needed to evaluate published guidelines and recommendations to aim for a limited surgical approach.<\/jats:p>","DOI":"10.3390\/medicina59010080","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T03:31:17Z","timestamp":1672371077000},"page":"80","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Appendiceal Carcinoids in Children\u2013Prevalence, Treatment and Outcome in a Large Nationwide Pediatric Cohort"],"prefix":"10.3390","volume":"59","author":[{"given":"Johannes Wolfgang","family":"Duess","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, University of Leipzig, 04103 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansgar","family":"Lange","sequence":"additional","affiliation":[{"name":"Center for Health Economics Research Hannover (CHERH), Leibniz University Hannover, 30159 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0104-2267","authenticated-orcid":false,"given":"Jan","family":"Zeidler","sequence":"additional","affiliation":[{"name":"Center for Health Economics Research Hannover (CHERH), Leibniz University Hannover, 30159 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Blaser","sequence":"additional","affiliation":[{"name":"Techniker Health Insurance, Representative Officer of Lower Saxony, 30159 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Dingemann","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Medical School Hannover, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benno M.","family":"Ure","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Medical School Hannover, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Lacher","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, University of Leipzig, 04103 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Hendrik","family":"Gosemann","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, University of Leipzig, 04103 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro Daniel","family":"Hofmann","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Medical School Hannover, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1055\/s-0038-1667032","article-title":"A National Long-Term Study of Neuroendocrine Tumors of the Appendix in Children: Are We Too Aggressive?","volume":"29","author":"Sommer","year":"2019","journal-title":"Eur. 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