{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T20:50:39Z","timestamp":1783630239171,"version":"3.55.0"},"reference-count":39,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,8]],"date-time":"2023-01-08T00:00:00Z","timestamp":1673136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Padova, Italy","award":["DOR2215418\/22"],"award-info":[{"award-number":["DOR2215418\/22"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Introduction: Chronic otitis media (COM) and chronic rhinosinusitis (CRS) are two of the most common otolaryngological disorders. CRS and COM share pathophysiological mechanisms such as bacterial infection, biofilm, and the persistence of the obstruction state of ventilation routes. The purpose of this systematic review was to evaluate all available information on the association between COM and CRS. Methods: The protocol of this investigation was registered on PROSPERO in November 2022. Pubmed, Scopus, Web of Science, and Cochrane databases were systematically searched according to the PRISMA statement. Results: After the application of inclusion-exclusion criteria, four manuscripts with adequate relevance to this topic were included in the review. The study population consisted of 20,867 patients with a diagnosis of CRS, of whom 991 were also diagnosed with COM (4.75%). Conclusions: The included studies have shown that CRS has become significantly associated with COMas: a global inflammatory process that involves the epithelium in both the middle ear and upper airway. The identification of a relationship between CRS and COM may contribute to preventing chronic inflammatory conditions through the early management of the associated disease. Further, carefully designed studies are necessary to demonstrate the relationship between COM and CRS.<\/jats:p>","DOI":"10.3390\/medicina59010123","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T02:09:39Z","timestamp":1673230179000},"page":"123","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Chronic Otitis Media in Patients with Chronic Rhinosinusitis: A Systematic Review"],"prefix":"10.3390","volume":"59","author":[{"given":"Giuseppe","family":"Brescia","sequence":"first","affiliation":[{"name":"Department of Neuroscience DNS, Otolaryngology Section, University of Padova, 35100 Padova, Italy"},{"name":"ENT Unit, Surgical Department, Ospedali Riuniti Padova Sud, 35043 Monselice-Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1347-4013","authenticated-orcid":false,"given":"Andrea","family":"Frosolini","sequence":"additional","affiliation":[{"name":"Audiology Unit, Department of Neuroscience DNS, University of Padova, 31100 Treviso, Italy"},{"name":"Maxillofacial Surgery Unit, Department of Medical Biotechnologies, University of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2306-4088","authenticated-orcid":false,"given":"Leonardo","family":"Franz","sequence":"additional","affiliation":[{"name":"Department of Neuroscience DNS, Otolaryngology Section, University of Padova, 35100 Padova, Italy"},{"name":"Audiology Unit, Department of Neuroscience DNS, University of Padova, 31100 Treviso, Italy"},{"name":"Guided Therapeutics (GTx) International Scholarship Program, Techna Institute, University Health Network (UHN), Toronto, ON M5G2C4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3687-8814","authenticated-orcid":false,"given":"Antonio","family":"Daloiso","sequence":"additional","affiliation":[{"name":"Department of Neuroscience DNS, Otolaryngology Section, University of Padova, 35100 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Fantin","sequence":"additional","affiliation":[{"name":"Audiology Unit, Department of Neuroscience DNS, University of Padova, 31100 Treviso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Lovato","sequence":"additional","affiliation":[{"name":"Otolaryngology Unit, Vicenza Hospital, 36100 Vicenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosimo de","family":"Filippis","sequence":"additional","affiliation":[{"name":"Audiology Unit, Department of Neuroscience DNS, University of Padova, 31100 Treviso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8751-0588","authenticated-orcid":false,"given":"Gino","family":"Marioni","sequence":"additional","affiliation":[{"name":"Department of Neuroscience DNS, Otolaryngology Section, University of Padova, 35100 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.amjoto.2018.03.020","article-title":"Nasal polyposis pathophysiology: Endotype and phenotype open issues","volume":"39","author":"Brescia","year":"2018","journal-title":"Am. 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