{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T14:15:35Z","timestamp":1793196935241,"version":"4.5.0"},"reference-count":47,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T00:00:00Z","timestamp":1673827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>This review seeks to establish, through the recent available literature, the prevalence of therapeutic intensification delay and its sequences in poorly controlled Type 2 Diabetes Mellitus (T2DM) patients. The strategy identified studies exploring the clinical inertia and its associated factors in the treatment of patients with T2DM. A total of 25 studies meeting the pre-established quality criteria were included in this review. These studies were conducted between 2004 and 2021 and represented 575,067 patients diagnosed with T2DM. Trusted electronic bibliographic databases, including Medline, Embase, and the Cochrane Central Register of Controlled Trials, were used to collect studies by utilizing a comprehensive set of search terms to identify Medical Subject Headings (MeSH) terms. Most o the studies included in this review showed clinical inertia rates over 50% of T2DM patients. In the USA, clinical inertia ranged from 35.4% to 85.8%. In the UK, clinical inertia ranged from 22.1% to 69.1%. In Spain, clinical inertia ranged from 18.1% to 60%. In Canada, Brazil, and Thailand, clinical inertia was reported as 65.8%, 68%, and 68.4%, respectively. The highest clinical inertia was reported in the USA (85.8%). A significant number of patients with T2DM suffered from poor glycemic control for quite a long time before treatment intensification with oral antidiabetic drugs (OADs) or insulin. Barriers to treatment intensification exist at the provider, patient, and system levels. There are deficiencies pointed out by this review at specialized centers in terms of clinical inertia in the management of T2DM including in developed countries. This review shows that the earlier intensification in the T2DM treatment is appropriate to address issues around therapeutic inertia.<\/jats:p>","DOI":"10.3390\/medicina59010182","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T04:57:19Z","timestamp":1673845039000},"page":"182","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Clinical Inertia in the Management of Type 2 Diabetes Mellitus: A Systematic Review"],"prefix":"10.3390","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8029-3071","authenticated-orcid":false,"given":"Turky H.","family":"Almigbal","sequence":"first","affiliation":[{"name":"Department of Family and Community Medicine, College of Medicine, King Saud University, Riyadh 12372, Saudi Arabia"},{"name":"Department of Family Medicine, King Saud University Medical City, King Saud University, Riyadh 12372, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A.","family":"Alzarah","sequence":"additional","affiliation":[{"name":"Vision College of Medicine, Vision Colleges, Riyadh 13226, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flwah A.","family":"Aljanoubi","sequence":"additional","affiliation":[{"name":"Vision College of Medicine, Vision Colleges, Riyadh 13226, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nouryah A.","family":"Alhafez","sequence":"additional","affiliation":[{"name":"Vision College of Medicine, Vision Colleges, Riyadh 13226, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munirah R.","family":"Aldawsari","sequence":"additional","affiliation":[{"name":"Vision College of Medicine, Vision Colleges, Riyadh 13226, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahraa Y.","family":"Alghadeer","sequence":"additional","affiliation":[{"name":"Vision College of Medicine, Vision Colleges, Riyadh 13226, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah A.","family":"Alrasheed","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine, College of Medicine, King Saud University, Riyadh 12372, Saudi Arabia"},{"name":"Department of Family Medicine, King Saud University Medical City, King Saud University, Riyadh 12372, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,16]]},"reference":[{"key":"ref_1","unstructured":"Suvi, K., and Joao da Rocha Fernandes, B.M. (2017). IDF Diabetes Atlas, 2017, International Diabetes Fedration. [8th ed.]. Available online: http:\/\/www.diabetesatlas.org\/."},{"key":"ref_2","unstructured":"World Health Organization (2022, February 25). Diabetes. Available online: https:\/\/www.who.int\/health-topics\/diabetes#tab=tab_1."},{"key":"ref_3","unstructured":"(2020, December 30). Global Report on Diabetes 2016. Available online: https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/204871\/9789241565257_eng.pdf;sequence=1."},{"key":"ref_4","unstructured":"(2020, December 30). The top 10 Causes of Death. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/the-top-10-causes-of-death."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Bellou, V., Belbasis, L., Tzoulaki, I., and Evangelou, E. (2018). Risk factors for type 2 diabetes mellitus: An exposure-wide umbrella review of meta-analyses. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0194127"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Galicia-Garcia, U., Benito-Vicente, A., Jebari, S., Larrea-Sebal, A., Siddiqi, H., Uribe, K., Ostolaza, H., and Mart\u00edn, C. (2020). Pathophysiology of Type 2 Diabetes Mellitus. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21176275"},{"key":"ref_7","unstructured":"Goyal, R., and Jialal, I. (2018). Diabetes Mellitus, Type 2, StatPearls."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Wan, K.S., Moy, F.M., Yusof, K.M., Mustapha, F.I., Ali, Z.M., and Hairi, N.N. (2020). Clinical inertia in type 2 diabetes management in a middle-income country: A retrospective cohort study. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0240531"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"551","DOI":"10.15446\/revfacmed.v66n4.58933","article-title":"Clinical inertia in insulin prescription for patients with type 2 diabetes mellitus at a primary health care institution of Cartagena, Colombia","volume":"66","year":"2018","journal-title":"Rev. Fac. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13098-020-00559-7","article-title":"Clinical inertia is the enemy of therapeutic success in the management of diabetes and its complications: A narrative literature review","volume":"12","author":"Andreozzi","year":"2020","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1007\/s12325-018-0819-5","article-title":"Addressing Clinical Inertia in Type 2 Diabetes Mellitus: A Review","volume":"35","author":"Okemah","year":"2018","journal-title":"Adv. Ther."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e11121","DOI":"10.1097\/MD.0000000000011121","article-title":"Clinical inertia in the pharmacological management of hypertension: A systematic review and meta-analysis","volume":"97","author":"Milman","year":"2018","journal-title":"Medicine"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2042018819844694","DOI":"10.1177\/2042018819844694","article-title":"Therapeutic inertia in type 2 diabetes: Prevalence, causes, consequences and methods to overcome inertia","volume":"10","author":"Khunti","year":"2019","journal-title":"Ther. Adv. Endocrinol. Metab."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1185\/03007995.2013.833089","article-title":"Clinical inertia in the treatment of hyperglycemia in type 2 diabetes patients in primary care","volume":"29","author":"Saez","year":"2013","journal-title":"Curr. Med. Res. Opin."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/jdi.13352","article-title":"Clinical inertia in patients with type 2 diabetes treated with oral antidiabetic drugs: Results from a Japanese cohort study (JDDM53)","volume":"12","author":"Maegawa","year":"2021","journal-title":"J. Diabetes Investig."},{"key":"ref_16","first-page":"3","article-title":"An observational study of clinical inertia among patients with type 2 diabetes mellitus in a tertiary care hospital","volume":"16","author":"Kaewbut","year":"2020","journal-title":"Arch. Med. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/jep.13429","article-title":"Assessment of clinical inertia in people with diabetes within primary care","volume":"27","author":"Meredith","year":"2021","journal-title":"J. Eval. Clin. Pract."},{"key":"ref_18","unstructured":"Statement, P. (2021, March 29). PRISMA Statement. Available online: https:\/\/www.prisma-statement.org\/Default.aspx."},{"key":"ref_19","unstructured":"Wells, G.A., Shea, B., O\u2019Connell, D., Peterson, J., Welch, V., Losos, M., and Tugwell, P. (2000). The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-Analyses, University of Ottawa."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e114","DOI":"10.2337\/dc14-0165","article-title":"Clinical Inertia in People with Type 2 Diabetes: A Retrospective Cohort Study of More Than 80,000 People","volume":"37","author":"Khunti","year":"2014","journal-title":"Diabetes Care"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"403","DOI":"10.12659\/MSM.892248","article-title":"Family physician clinical inertia in glycaemic control among patients with type 2 diabetes","volume":"21","author":"Lang","year":"2015","journal-title":"Med. Sci. Monit."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.ando.2016.03.001","article-title":"Reasons for non-intensification of treatment in people with type 2 diabetes receiving oral monotherapy: Outcomes from the prospective DIAttitude study","volume":"77","author":"Balkau","year":"2016","journal-title":"Ann. d\u2019Endocrinol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e12954","DOI":"10.1111\/ijcp.12954","article-title":"Effectiveness and clinical inertia in patients with antidi-abetic therapy","volume":"71","year":"2017","journal-title":"Int. J. Clin. Pract."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.diabres.2018.10.011","article-title":"Clinical inertia among patients with type 2 diabetes mellitus treated with DPP-4i and\/or SGLT-2i","volume":"146","author":"Lanzinger","year":"2018","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s13300-019-00745-5","article-title":"Clinical Inertia in Poorly Controlled Type 2 Diabetes Mellitus Patients with Obesity: An Observational Retrospective Study","volume":"11","author":"Romera","year":"2019","journal-title":"Diabetes Ther."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.diabres.2014.05.005","article-title":"Time to do more: Addressing clinical inertia in the man-agement of type 2 diabetes mellitus","volume":"105","author":"Strain","year":"2014","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/dme.12592","article-title":"Acknowledging and allocating responsibility for clinical inertia in the man-agement of type 2 diabetes in primary care: A qualitative study","volume":"32","author":"Zafar","year":"2015","journal-title":"Diabet. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1177\/0300060516663095","article-title":"Therapeutic inertia and intensified treatment in diabetes mellitus prescription patterns: A nationwide population-based study in Taiwan","volume":"44","author":"Huang","year":"2016","journal-title":"J. Int. Med. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/1753-0407.12410","article-title":"Clinical inertia causing new or progression of diabetic retinopathy in type 2 diabetes: A retrospective cohort study","volume":"9","author":"Osataphan","year":"2016","journal-title":"J. Diabetes"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s13098-018-0382-x","article-title":"Clinical inertia on insulin treatment intensification in type 2 diabetes mellitus patients of a tertiary public diabetes center with limited pharmacologic armamentarium from an up-per-middle income country","volume":"10","author":"Alvarenga","year":"2018","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/dom.12626","article-title":"Clinical inertia with regard to intensifying therapy in people with type 2 diabetes treated with basal insulin","volume":"18","author":"Khunti","year":"2016","journal-title":"Diabetes Obes. Metab."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.pcd.2017.09.001","article-title":"Therapeutic inertia amongst general practitioners with interest in diabetes","volume":"12","author":"Seidu","year":"2018","journal-title":"Prim. Care Diabetes"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e00019","DOI":"10.1002\/edm2.19","article-title":"Glycaemic impact of treatment intensification in patients with type 2 diabetes uncontrolled with oral antidiabetes drugs or basal insulin","volume":"1","author":"Buysman","year":"2018","journal-title":"Endocrinol. Diabetes Metab."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"151","DOI":"10.4158\/EP15868.OR","article-title":"Does Clinical Inertia Vary by Personalized A1C Goal? A Study of Predictors and Prevalence of Clinical Inertia In A U.S. Managed-Care Setting","volume":"22","author":"Lin","year":"2016","journal-title":"Endocr. Pract."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/dom.13045","article-title":"Therapeutic inertia in patients treated with two or more antidiabetics in primary care: F actors predicting intensification of treatment","volume":"20","author":"Real","year":"2018","journal-title":"Diabetes Obes. Metab."},{"key":"ref_36","first-page":"e418","article-title":"Clinical inertia in patients with T2DM requiring insulin in family practice","volume":"56","author":"Harris","year":"2010","journal-title":"Can. Fam. Physician"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1016\/S1262-3636(12)71534-3","article-title":"Therapeutic inertia in type 2 diabetes: Insights from the PANORAMA study in France","volume":"38","author":"Simon","year":"2012","journal-title":"Diabetes Metab."},{"key":"ref_38","first-page":"203","article-title":"Clinical inertia in type 2 diabetes: A retrospective analysis of pharmacist-managed diabetes care vs. usual medical care","volume":"11","author":"Yam","year":"2013","journal-title":"Pharm. Pract."},{"key":"ref_39","first-page":"304","article-title":"Factors Associated with Diabetes-Related Clinical Inertia in a Managed Care Population and Its Effect on Hemoglobin A1c Goal Attainment: A Claims-Based Analysis","volume":"25","author":"Wander","year":"2019","journal-title":"J. Manag. Care Sp\u00e9c. Pharm."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s13300-020-00993-w","article-title":"A Retrospective Analysis of Therapeutic Inertia in Type 2 Diabetes Management Across a Diverse Population of Health Care Organizations in the USA","volume":"12","author":"Rattelman","year":"2021","journal-title":"Diabetes Ther."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1111\/dom.14482","article-title":"Author response for \u201cEthnic, social and multimorbidity disparities in therapeutic inertia: A UK primary care observational study in patients newly diagnosed with type 2 diabetes\u201d","volume":"23","author":"Chudasama","year":"2021","journal-title":"Diabetes Obes. Metab."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/j.1464-5491.2004.01095.x","article-title":"Clinical inertia in the management of Type 2 diabetes metabolic risk factors","volume":"21","author":"Grant","year":"2004","journal-title":"Diabet. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1177\/0145721705279050","article-title":"Clinical Inertia Contributes to Poor Diabetes Control in a Primary Care Setting","volume":"31","author":"Ziemer","year":"2005","journal-title":"Diabetes Educ."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.healthpol.2020.12.006","article-title":"Impact of interprofessional collaboration on chronic disease management: Findings from a systematic review of clinical trial and meta-analysis","volume":"125","author":"Pascucci","year":"2020","journal-title":"Health Policy"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1097\/CM9.0000000000002073","article-title":"Visit-to-visit glycated hemoglobin A1c variability in adults with type 2 diabetes: A systematic review and meta-analysis","volume":"135","author":"Qu","year":"2022","journal-title":"Chin. Med. J."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1370\/afm.421","article-title":"Quality of Preventive Care for Diabetes: Effects of Visit Frequency and Competing Demands","volume":"4","author":"Fenton","year":"2006","journal-title":"Ann. Fam. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/dme.12366","article-title":"Improving quality of care in people with Type 2 diabetes through the Associazione Medici Diabetologi-annals initiative: A long-term cost-effectiveness analysis","volume":"31","author":"Giorda","year":"2013","journal-title":"Diabet. Med."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/1\/182\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:07:20Z","timestamp":1760119640000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/1\/182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,16]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["medicina59010182"],"URL":"https:\/\/doi.org\/10.3390\/medicina59010182","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,16]]}}}