{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T13:21:13Z","timestamp":1780406473226,"version":"3.54.1"},"reference-count":20,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T00:00:00Z","timestamp":1674777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: To answer the research question: \u201cIs prophylactic central neck lymph node dissection (pCNLD) beneficial among differentiated thyroid carcinoma (DTC) patients?\u201d Materials and Methods: This was a retrospective cohort study enrolling DTC patients treated at the University Hospital Kaspela, Bulgaria, from 30 January 2019 to October 2021. The predictor variable was presence of pCNLD (total thyroidectomy with vs. without pCNLD). The main outcome variables were postoperative complications (i.e., vocal cord paralysis, hypoparathyroidism, postoperative bleeding, and adjacent organ injury) and recurrence parameters. Appropriate statistics were computed with the significant level at p \u2264 0.05. Results: During the study period, 300 DTC patients (59.7% with pCNLD; 79.3% females) with an average age of 52 \u00b1 2.8 years were treated. The mean follow-up period of the entire cohort was 45.8 \u00b1 19.1 months. On bivariate analyses, TT with pCNLD, when compared to TT alone, required longer surgical time (mean difference: 9.4 min), caused nearly similar complications (except transient hypothyroidism: p = 0.04; relative risk, 1.32; 95% confidence interval, 1.0 to 1.73), and no significantly different recurrence events, time to recurrence, and recurrent sites. The benefit\u2013risk analyses using the number needed to treat and to harm (NNT; NNH) also confirmed that TT plus pCNLD was not very beneficial in DTC management. Conclusion: The results of this study refute the benefit of pCNLD in DTC patient care with TT. Further well-designed studies in a larger cohort with a longer follow-up period are required to confirm this conclusion.<\/jats:p>","DOI":"10.3390\/medicina59020239","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T03:56:27Z","timestamp":1675050987000},"page":"239","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prophylactic Central Neck Lymph Node Dissection Adds No Short-Term Benefit to Total Thyroidectomy for Differentiated Thyroid Cancer"],"prefix":"10.3390","volume":"59","author":[{"given":"Rosen","family":"Dimov","sequence":"first","affiliation":[{"name":"Department of Special Surgery, Medical Faculty, Medical University of Plovdiv, 4001 Plovdiv, Bulgaria"},{"name":"Department of Surgery, University Hospital \u201cKaspela\u201d, 4001 Plovdiv, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5137-6903","authenticated-orcid":false,"given":"Gancho","family":"Kostov","sequence":"additional","affiliation":[{"name":"Department of Special Surgery, Medical Faculty, Medical University of Plovdiv, 4001 Plovdiv, Bulgaria"},{"name":"Department of Surgery, University Hospital \u201cKaspela\u201d, 4001 Plovdiv, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7029-8397","authenticated-orcid":false,"given":"Mladen","family":"Doykov","sequence":"additional","affiliation":[{"name":"Department of Urology and General Medicine, Medical Faculty, Medical University of Plovdiv, 4001 Plodiv, Bulgaria"},{"name":"Department of Urology, University Hospital \u201cKaspela\u201d, 4001 Plovdiv, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luboslav","family":"Dimov","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Medical Faculty, Medical University of Plovdiv, 4001 Plovdiv, Bulgaria"},{"name":"Department of Endocrinology, University Hospital \u201cKaspela\u201d, 4001 Plovdiv, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyan","family":"Nonchev","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Medical Faculty, Medical University of Plovdiv, 4001 Plovdiv, Bulgaria"},{"name":"Department of Endocrinology, University Hospital \u201cKaspela\u201d, 4001 Plovdiv, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0197-5195","authenticated-orcid":false,"given":"Rositsa","family":"Dimova","sequence":"additional","affiliation":[{"name":"Department of Health Management and Health Economics, Faculty of Public Health, Medical University of Plovdiv, 4001 Plovdiv, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2943-1766","authenticated-orcid":false,"given":"Bozhidar","family":"Hristov","sequence":"additional","affiliation":[{"name":"Second Department of Internal Diseases, Section of Gastroenterology, Medical Faculty, Medical University of Plovdiv, 4001 Plovdiv, Bulgaria"},{"name":"Department of Gastroenterology, University Hospital \u201cKaspela\u201d, 4001 Plovdiv, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,27]]},"reference":[{"key":"ref_1","unstructured":"Sentieri Working Group (2023, January 19). 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