{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:53:35Z","timestamp":1760205215732,"version":"build-2065373602"},"reference-count":38,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T00:00:00Z","timestamp":1674864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Central Giant Cell Granuloma constitutes approximately 7% of benign tumors of the jaws. The aggressive form of CGCG clinically behaves like a classic semi-malignant neoplasm. In the literature, the suggested method of treatment of aggressive forms of CGCG is curettage or resection with the margin of 0.5 cm. Surgical treatment, especially in the developmental age, entails disturbances in the growth and differentiation of tissues and deforms and disturbs the functioning of the stomatognathic system. Alternative treatment methods of the CGCG presented in this article lead to the patient avoiding a mutilating procedure and improve their quality of life. The aim was to present alternative method of treatment of aggressive forms of Central Giant Cell Lesion of the jaws\u2014injections of dexamethasone into the tumor mass through drilled bony canals. Here, we present the three cases of aggressive forms of CGCG of jaws treated with dexamethasone injections into the tumor mass. Two cases resulted in regression of the tumor, which was confirmed in histologic evaluation after remodeling surgery. Those two patients were uneventful and showed no signs of tumor recurrence at 8 and 9 years of thorough follow-up, respectively. The third patient was qualified for the mandible resection due to the enlargement of the lesion and destruction of the cortical bone. According to our observations, if the proper patient discipline, and thorough, careful clinical and radiological examinations are provided, the dexamethasone injections could be a recommended method of treatment of intraosseous giant cell granuloma. The indication is restricted to the cases with preserved bony borders despite deformation. Additionally, leaving vital teeth in the lesion is also possible.<\/jats:p>","DOI":"10.3390\/medicina59020250","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T04:58:25Z","timestamp":1675054705000},"page":"250","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Bony Canal Method of Dexamethasone Injections in Aggressive Form of Central Giant Cell Granuloma\u2014Case Series"],"prefix":"10.3390","volume":"59","author":[{"given":"Iwona","family":"Niedzielska","sequence":"first","affiliation":[{"name":"Department of Cranio-Maxillo-Facial Surgery, Medical University of Silesia in Katowice, ul. Francuska 20-24, 40-027 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mateusz","family":"Bielecki","sequence":"additional","affiliation":[{"name":"Department of Cranio-Maxillo-Facial Surgery, Medical University of Silesia in Katowice, ul. Francuska 20-24, 40-027 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0919-6746","authenticated-orcid":false,"given":"Micha\u0142","family":"B\u0105k","sequence":"additional","affiliation":[{"name":"Department of Cranio-Maxillo-Facial Surgery, Medical University of Silesia in Katowice, ul. Francuska 20-24, 40-027 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Dziuk","sequence":"additional","affiliation":[{"name":"Department of Cranio-Maxillo-Facial Surgery, Medical University of Silesia in Katowice, ul. Francuska 20-24, 40-027 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damian","family":"Niedzielski","sequence":"additional","affiliation":[{"name":"Department of Cranio-Maxillo-Facial Surgery, Medical University of Silesia in Katowice, ul. Francuska 20-24, 40-027 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1111\/his.14265","article-title":"Updates from the 2020 World Health Organization Classification of Soft Tissue and Bone Tumours","volume":"78","author":"Anderson","year":"2021","journal-title":"Histopathology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s12105-021-01404-7","article-title":"Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Odontogenic and Maxillofacial Bone Tumours","volume":"16","author":"Vered","year":"2022","journal-title":"Head Neck Pathol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1177\/019459988709700514","article-title":"Giant cell reparative granuloma of the ethmoid sinus","volume":"97","author":"Wiatrak","year":"1987","journal-title":"Otolaryngol. 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