{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:37:30Z","timestamp":1785433050978,"version":"3.56.0"},"reference-count":22,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,2,5]],"date-time":"2023-02-05T00:00:00Z","timestamp":1675555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Acute appendicitis is the most common abdominal emergency requiring surgery and it has an estimated lifetime risk of 6.7 to 8.6%. The COVID-19 pandemic has transformed medical care worldwide, influencing diagnostic tactics, treatment modalities and outcomes. Our study aims to compare and analyze management of acute appendicitis before and during the first and second waves of the pandemic. Materials and Methods: Patients suffering acute appendicitis were enrolled retrospectively in a single-center study for a 10-month period before the pandemic (pre-COVID-19 period: 1 March to 31 December 2019) and during the pandemic (COVID-19 period: 1 March to 31 December 2020). The total number of patients, disease severity, diagnostic methods, complications, length of hospitalization and outcomes were analyzed. Results: A total number of 863 patients were included, 454 patients in the pre-COVID-19 period and 409 patients in the COVID-19 period. Compared to the pre-COVID-19 period, the number of complicated appendicitis increased in the COVID-19 period (24.4% to 37.2%; p &lt; 0.001). The proportion of laparoscopic appendectomies increased during the COVID-19 period but did not show statistically significant differences between periods. In both time periods, we found that open technique was the chosen surgical approach more frequently in elderly patients (p &lt; 0.001). Generalized peritonitis was significantly more common during the COVID-19 period (3.5% vs. 6.1%, p &lt; 0.001). The postoperative course of patients was similar in the pre-COVID-19 period and during the COVID-19 period, with no significant differences in ICU admissions, overall hospital stay or morbidity. Conclusions: The COVID-19 pandemic has led to a significant increase in complicated forms of acute appendicitis; however, no significant impact was observed in terms of diagnostic or treatment approach.<\/jats:p>","DOI":"10.3390\/medicina59020295","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T02:57:32Z","timestamp":1675652252000},"page":"295","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Course and Surgical Treatment of Acute Appendicitis during the First and Second Wave of the COVID-19 Pandemic: A Retrospective Analysis in University Affiliated Hospital in Latvia"],"prefix":"10.3390","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7561-4259","authenticated-orcid":false,"given":"Anna Marija","family":"Lescinska","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Latvia, LV-1004 Riga, Latvia"},{"name":"Faculty of Medicine, Riga Stradins University, LV-1007 Riga, Latvia"},{"name":"Department of General and Emergency Surgery, Riga East Clinical University Hospital, LV-1038 Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4818-860X","authenticated-orcid":false,"given":"Elza","family":"Sondore","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Riga Stradins University, LV-1007 Riga, Latvia"},{"name":"Department of General and Emergency Surgery, Riga East Clinical University Hospital, LV-1038 Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6939-8115","authenticated-orcid":false,"given":"Margarita","family":"Ptasnuka","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Riga Stradins University, LV-1007 Riga, Latvia"},{"name":"Department of General and Emergency Surgery, Riga East Clinical University Hospital, LV-1038 Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8899-0453","authenticated-orcid":false,"given":"Maksims","family":"Mukans","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Riga Stradins University, LV-1007 Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3951-5437","authenticated-orcid":false,"given":"Haralds","family":"Plaudis","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Riga Stradins University, LV-1007 Riga, Latvia"},{"name":"Department of General and Emergency Surgery, Riga East Clinical University Hospital, LV-1038 Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1056\/NEJMoa2001316","article-title":"Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia","volume":"382","author":"Li","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_2","unstructured":"Wuhan City Health Committee (WCHC) (2021, April 07). Wuhan Municipal Health and Health Commission\u2019s Briefing on the Current Pneumonia Epidemic Situation in Our City 2019, Available online: https:\/\/wjw.wuhan.gov.cn\/front\/web\/showDetail\/2019123108989."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"61","DOI":"10.46234\/ccdcw2020.017","article-title":"A Novel Coronavirus Genome Identified in a Cluster of Pneumonia Cases\u2014Wuhan, China 2019\u22122020","volume":"2","author":"Tan","year":"2020","journal-title":"China CDC Wkly."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1056\/NEJMoa2001017","article-title":"A Novel Coronavirus from Patients with Pneumonia in China, 2019","volume":"382","author":"Zhu","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_5","unstructured":"WHO (2021, April 07). WHO Director-General\u2019s Remarks at the Media Briefing on 2019-nCoV on 11 February 2020. Available online: https:\/\/www.who.int\/director-general\/speeches\/detail\/who-director-general-s-remarks-at-the-media-briefing-on-2019-ncov-on-11-february-2020."},{"key":"ref_6","unstructured":"EU Fundamental Rights Agency (2021, April 07). Coronavirus COVID-19 Outbreak in the EU Fundamental Rights Implications. Available online: https:\/\/fra.europa.eu\/sites\/default\/files\/fra_uploads\/latvia-report-covid-19-april-2020_en.pdf."},{"key":"ref_7","unstructured":"(2023, January 23). COVID-19 Statistics in Latvia, Available online: https:\/\/www.spkc.gov.lv\/lv\/covid-19-statistika."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1136\/bmj.38940.664363.AE","article-title":"Acute Appendicitis","volume":"333","author":"Humes","year":"2006","journal-title":"BMJ"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1177\/000313481307900930","article-title":"Risk Factors for Conversion from Laparoscopic to Open Surgery: Analysis of 2138 Converted Operations in the American College of Surgeons National Surgical Quality Improvement Program","volume":"79","author":"Papandria","year":"2013","journal-title":"Am. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1056\/NEJMcp1215006","article-title":"Acute Appendicitis\u2014Appendectomy or the \u201cAntibiotics First\u201d Strategy","volume":"372","author":"Flum","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ijsu.2020.05.061","article-title":"International guidelines and recommendations for surgery during COVID-19 pandemic: A Systematic Review","volume":"79","author":"Moletta","year":"2020","journal-title":"Int. J. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1016\/j.jviscsurg.2020.04.014","article-title":"Antibiotics alone as an alternative to appendectomy for uncomplicated acute appendicitis in adults: Changes in treatment modalities related to the COVID-19 health crisis","volume":"157","author":"Collard","year":"2020","journal-title":"J. Visc. Surg."},{"key":"ref_13","unstructured":"Macrotrends (2022, August 24). Riga, Latvia Metro Area Population 1950\u20132022. Available online: http:\/\/www.macrotrends.net\/cities\/21778\/riga\/population."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13017-015-0053-2","article-title":"Acute appendicitis: Proposal of a new comprehensive grading system based on clinical, imaging and laparoscopic findings","volume":"10","author":"Gomes","year":"2015","journal-title":"World J. Emerg. Surg."},{"key":"ref_15","unstructured":"(2021, April 07). STROBE\u2014Strengthening the Reporting of Observational Studies in Epidemiology. Available online: www.strobe-statement.org."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1097\/TA.0000000000002923","article-title":"Dramatic decrease of surgical emergencies during COVID-19 outbreak","volume":"89","author":"Rausei","year":"2020","journal-title":"J. Trauma: Inj. Infect. Crit. Care"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00423-020-02041-4","article-title":"Influence of COVID-19 Confinement Measures on Appendectomies in Germany\u2014A Claims Data Analysis of 9797 Patients","volume":"406","author":"Maneck","year":"2020","journal-title":"Langenbeck\u2019s Arch. Surg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s00423-021-02081-4","article-title":"Impact of the COVID-19 Pandemic on Appendicitis Treatment in Germany\u2014A Population-Based Analysis","volume":"406","author":"Acar","year":"2021","journal-title":"Langenbeck\u2019s Arch. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1001\/jama.2020.15191","article-title":"Surgery and COVID-19","volume":"324","author":"Kibbe","year":"2020","journal-title":"JAMA"},{"key":"ref_20","first-page":"1","article-title":"Urgent care center wait times increase for COVID-19 results in August 2020, with rapid testing availability limited. BMC Heal","volume":"21","author":"Yousman","year":"2021","journal-title":"Serv. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.amjsurg.2020.09.026","article-title":"Increasing incidence of complicated appendicitis during COVID-19 pandemic","volume":"221","author":"Orthopoulos","year":"2021","journal-title":"Am. J. Surg."},{"key":"ref_22","first-page":"353","article-title":"Emergency Surgery during COVID-19 Pandemia","volume":"73","author":"Rivas","year":"2020","journal-title":"Arch. Esp. Urol."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/2\/295\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:25:02Z","timestamp":1760120702000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/2\/295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,5]]},"references-count":22,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["medicina59020295"],"URL":"https:\/\/doi.org\/10.3390\/medicina59020295","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,5]]}}}