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Foundation","award":["18K08402"],"award-info":[{"award-number":["18K08402"]}]},{"name":"The Nakatomi Foundation","award":["24791018"],"award-info":[{"award-number":["24791018"]}]},{"name":"Takeda Science Foundation","award":["22591090"],"award-info":[{"award-number":["22591090"]}]},{"name":"Takeda Science Foundation","award":["26293123"],"award-info":[{"award-number":["26293123"]}]},{"name":"Takeda Science Foundation","award":["15K09543"],"award-info":[{"award-number":["15K09543"]}]},{"name":"Takeda Science Foundation","award":["18K08402"],"award-info":[{"award-number":["18K08402"]}]},{"name":"Takeda Science Foundation","award":["24791018"],"award-info":[{"award-number":["24791018"]}]},{"name":"Mitsui Sumitomo Insurance Welfare Foundation","award":["22591090"],"award-info":[{"award-number":["22591090"]}]},{"name":"Mitsui Sumitomo Insurance Welfare Foundation","award":["26293123"],"award-info":[{"award-number":["26293123"]}]},{"name":"Mitsui Sumitomo Insurance Welfare Foundation","award":["15K09543"],"award-info":[{"award-number":["15K09543"]}]},{"name":"Mitsui Sumitomo Insurance Welfare Foundation","award":["18K08402"],"award-info":[{"award-number":["18K08402"]}]},{"name":"Mitsui Sumitomo Insurance Welfare Foundation","award":["24791018"],"award-info":[{"award-number":["24791018"]}]},{"name":"Bristol-Myers Squibb Co.","award":["22591090"],"award-info":[{"award-number":["22591090"]}]},{"name":"Bristol-Myers Squibb Co.","award":["26293123"],"award-info":[{"award-number":["26293123"]}]},{"name":"Bristol-Myers Squibb Co.","award":["15K09543"],"award-info":[{"award-number":["15K09543"]}]},{"name":"Bristol-Myers Squibb Co.","award":["18K08402"],"award-info":[{"award-number":["18K08402"]}]},{"name":"Bristol-Myers Squibb Co.","award":["24791018"],"award-info":[{"award-number":["24791018"]}]},{"name":"Abbott Japan Co., Ltd., Astellas Pharma Inc., Chugai Pharmaceutical Co., Ltd., Eisai Co., Ltd., Mitsubishi Tanabe Pharma Corporation, Merck Sharp and Dohme Inc., Pfizer Japan Inc., Takeda Pharmaceutical Company Limited, and Teijin Pharma Limited.","award":["22591090"],"award-info":[{"award-number":["22591090"]}]},{"name":"Abbott Japan Co., Ltd., Astellas Pharma Inc., Chugai Pharmaceutical Co., Ltd., Eisai Co., Ltd., Mitsubishi Tanabe Pharma Corporation, Merck Sharp and Dohme Inc., Pfizer Japan Inc., Takeda Pharmaceutical Company Limited, and Teijin Pharma Limited.","award":["26293123"],"award-info":[{"award-number":["26293123"]}]},{"name":"Abbott Japan Co., Ltd., Astellas Pharma Inc., Chugai Pharmaceutical Co., Ltd., Eisai Co., Ltd., Mitsubishi Tanabe Pharma Corporation, Merck Sharp and Dohme Inc., Pfizer Japan Inc., Takeda Pharmaceutical Company Limited, and Teijin Pharma Limited.","award":["15K09543"],"award-info":[{"award-number":["15K09543"]}]},{"name":"Abbott Japan Co., Ltd., Astellas Pharma Inc., Chugai Pharmaceutical Co., Ltd., Eisai Co., Ltd., Mitsubishi Tanabe Pharma Corporation, Merck Sharp and Dohme Inc., Pfizer Japan Inc., Takeda Pharmaceutical Company Limited, and Teijin Pharma Limited.","award":["18K08402"],"award-info":[{"award-number":["18K08402"]}]},{"name":"Abbott Japan Co., Ltd., Astellas Pharma Inc., Chugai Pharmaceutical Co., Ltd., Eisai Co., Ltd., Mitsubishi Tanabe Pharma Corporation, Merck Sharp and Dohme Inc., Pfizer Japan Inc., Takeda Pharmaceutical Company Limited, and Teijin Pharma Limited.","award":["24791018"],"award-info":[{"award-number":["24791018"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Chronic lung diseases (CLD), including interstitial lung disease (ILD) and airway diseases (ADs), are common complications of rheumatoid arthritis (RA). Rheumatoid factor (RF) and anti-citrullinated peptide antibodies are reported to be associated with CLD in RA patients. The presence of anti-melanoma differentiation-associated gene 5 (MDA5) antibodies (Abs) is associated with clinically amyopathic dermatomyositis developing into rapidly progressive ILD. However, few studies on anti-MDA5 Abs in RA have been published. Here, we analyzed the association of anti-MDA5 Abs with CLD complications in RA. Anti-MDA5 Abs were quantified in sera from RA patients with or without CLD. Anti-MDA5 Ab levels were higher in RA patients with ADs than without (mean \u00b1 SDM, 4.4 \u00b1 2.4 vs. 4.0 \u00b1 4.2, p = 0.0001). AUC values of anti-MDA5 Ab and RF ROC curves were similar in RA patients with or without CLD (0.578, 95%CI 0.530\u20130.627 and 0.579, 95%CI 0.530\u20130.627, respectively, p = 0.9411). Multiple logistic regression analysis of anti-MDA5 Abs and clinical characteristics yielded an MDA5-index with a higher AUC value than anti-MDA5 Ab alone (0.694, 95%CI 0.648\u20130.740, p = 5.08 \u00d7 10\u22125). Anti-MDA5 Abs were associated with ADs in RA patients and could represent a biomarker for CLD, similar to RF. The involvement of anti-MDA5 Abs in the pathogenesis of ADs in RA is proposed.<\/jats:p>","DOI":"10.3390\/medicina59020363","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T02:31:23Z","timestamp":1676428283000},"page":"363","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Antibodies against Serum Anti-Melanoma Differentiation-Associated Gene 5 in Rheumatoid Arthritis Patients with Chronic Lung Diseases"],"prefix":"10.3390","volume":"59","author":[{"given":"Shomi","family":"Oka","sequence":"first","affiliation":[{"name":"Department of Rheumatology, National Hospital Organization Tokyo National Hospital, 3-1-1 Takeoka, Kiyose 204-8585, Japan"},{"name":"Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, Sagamihara 252-0392, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, National Hospital Organization Tokyo National Hospital, 3-1-1 Takeoka, Kiyose 204-8585, Japan"},{"name":"Department of Nephrology, Ushiku Aiwa General Hospital, 896 Shishiko-cho, Ushiku 300-1296, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1353-8056","authenticated-orcid":false,"given":"Hiroshi","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, National Hospital Organization Tokyo National Hospital, 3-1-1 Takeoka, Kiyose 204-8585, Japan"},{"name":"Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, Sagamihara 252-0392, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2860-4266","authenticated-orcid":false,"given":"Kota","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, National Hospital Organization Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, Sagamihara 252-0392, Japan"},{"name":"Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, 2-8-29 Musashi-dai, Fuchu 183-8524, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, National Hospital Organization Himeji Medical Center, 68 Hon-machi, Himeji 670-8520, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, National Hospital Organization Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, Sagamihara 252-0392, Japan"},{"name":"Department of Internal Medicine, Sagami Seikyou Hospital, 6-2-11 Sagamiohno, Minami-ku, Sagamihara 252-0303, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Komiya","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, Sagamihara 252-0392, Japan"},{"name":"Department of Clinical Laboratory, National Hospital Organization Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, Sagamihara 252-0392, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Saisho","sequence":"additional","affiliation":[{"name":"Department of Orthopedics\/Rheumatology, National Hospital Organization Miyakonojo Medical Center, 5033-1 Iwayoshi-cho, Miyakonojo 885-0014, Japan"},{"name":"Tanimura Hospital, 10-2 Kitakoji, Nobeoka 882-0041, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norie","family":"Yoshikawa","sequence":"additional","affiliation":[{"name":"Department of Orthopedics\/Rheumatology, National Hospital Organization Miyakonojo Medical Center, 5033-1 Iwayoshi-cho, Miyakonojo 885-0014, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Katayama","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Hospital Organization Nagoya Medical Center, 4-1-1 Sannomaru, Naka-ku, Nagoya 460-0001, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Matsui","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, Sagamihara 252-0392, Japan"},{"name":"Department of Rheumatology, National Hospital Organization Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, Sagamihara 252-0392, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoshi","family":"Fukui","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, Sagamihara 252-0392, Japan"},{"name":"Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Migita","sequence":"additional","affiliation":[{"name":"Clinical Research Center, National Hospital Organization Nagasaki Medical Center, 2-1001-1 Kubara, Omura 856-8562, Japan"},{"name":"Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeto","family":"Tohma","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, National Hospital Organization Tokyo National Hospital, 3-1-1 Takeoka, Kiyose 204-8585, Japan"},{"name":"Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, Sagamihara 252-0392, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1378\/chest.93.1.114","article-title":"Poor prognosis in patients with rheumatoid arthritis hospitalized for interstitial lung fibrosis","volume":"93","author":"Hakala","year":"1988","journal-title":"Chest"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1080\/03009740310004621","article-title":"Epidemiology of 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Rheumatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1183\/09031936.00092309","article-title":"Usual interstitial pneumonia in rheumatoid arthritis-associated interstitial lung disease","volume":"35","author":"Kim","year":"2010","journal-title":"Eur. Respir. J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1164\/ajrccm.165.3.2107134","article-title":"Comparative study of KL-6, surfactant protein-A, surfactant protein-D, and monocyte chemoattractant protein-1 as serum markers for interstitial lung diseases","volume":"165","author":"Ohnishi","year":"2002","journal-title":"Am. J. Respir. Crit. Care. Med."},{"key":"ref_8","first-page":"1164","article-title":"KL-6 as a novel serum marker for interstitial pneumonia associated with collagen diseases","volume":"27","author":"Nakajima","year":"2000","journal-title":"J. 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BMC Musculoskelet Disord., 23.","DOI":"10.1186\/s12891-021-04985-0"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1002\/art.27584","article-title":"2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology\/European League Against Rheumatism collaborative initiative","volume":"62","author":"Aletaha","year":"2010","journal-title":"Arthritis Rheum"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.rmed.2012.07.006","article-title":"Different risk factors between interstitial lung disease and airway disease in rheumatoid arthritis","volume":"106","author":"Mori","year":"2012","journal-title":"Respir. 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Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1164\/rccm.201411-1950OC","article-title":"Detection of Rheumatoid Arthritis-Interstitial Lung Disease Is Enhanced by Serum Biomarkers","volume":"191","author":"Doyle","year":"2015","journal-title":"Am. J. Respir. Crit. 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Int."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.2169\/internalmedicine.9553-17","article-title":"Successful Treatment of Rapidly Progressive Unclassifiable Idiopathic Interstitial Pneumonia with Anti-melanoma Differentiation-associated Gene-5 Antibody by Intensive Immunosuppressive Therapy","volume":"57","author":"Koga","year":"2018","journal-title":"Intern. 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Rheumatol."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/2\/363\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:35:13Z","timestamp":1760121313000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/2\/363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,14]]},"references-count":29,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["medicina59020363"],"URL":"https:\/\/doi.org\/10.3390\/medicina59020363","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,14]]}}}