{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:50:00Z","timestamp":1785423000220,"version":"3.56.0"},"reference-count":110,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,2,19]],"date-time":"2023-02-19T00:00:00Z","timestamp":1676764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Electrical storm is a medical emergency characterized by ventricular arrythmia recurrence that can lead to hemodynamic instability. The incidence of this clinical condition is rising, mainly in implantable cardioverter defibrillator patients, and its prognosis is often poor. Early acknowledgment, management and treatment have a key role in reducing mortality in the acute phase and improving the quality of life of these patients. In an emergency setting, several measures can be employed. Anti-arrhythmic drugs, based on the underlying disease, are often the first step to control the arrhythmic burden; besides that, new therapeutic strategies have been developed with high efficacy, such as deep sedation, early catheter ablation, neuraxial modulation and mechanical hemodynamic support. The aim of this review is to provide practical indications for the management of electrical storm in acute settings.<\/jats:p>","DOI":"10.3390\/medicina59020405","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T03:56:07Z","timestamp":1676865367000},"page":"405","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Emergency Management of Electrical Storm: A Practical Overview"],"prefix":"10.3390","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3473-1058","authenticated-orcid":false,"given":"Fabrizio","family":"Guarracini","sequence":"first","affiliation":[{"name":"Department of Cardiology, S. Chiara Hospital, 38122 Trento, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Bonvicini","sequence":"additional","affiliation":[{"name":"Department of Cardiology, S. Chiara Hospital, 38122 Trento, Italy"},{"name":"Department of Cardiology, University of Verona, 37126 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Zanon","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Verona, 37126 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, S. Chiara Hospital, 38122 Trento, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Casagranda","sequence":"additional","affiliation":[{"name":"Department of Radiology, Santa Chiara Hospital, 38122 Trento, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4651-466X","authenticated-orcid":false,"given":"Marianna","family":"Mochen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Santa Chiara Hospital, 38122 Trento, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Coser","sequence":"additional","affiliation":[{"name":"Department of Cardiology, S. Chiara Hospital, 38122 Trento, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Quintarelli","sequence":"additional","affiliation":[{"name":"Department of Cardiology, S. Chiara Hospital, 38122 Trento, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Branzoli","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Unit, Santa Chiara Hospital, 38122 Trento, Italy"},{"name":"Department of Cardiac Surgery, Universitair Ziekenhuis Brussel-Vrije Universiteit Brussel, 1090 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizio","family":"Mazzone","sequence":"additional","affiliation":[{"name":"Cardiothoracovascular Department, Electrophysiology Unit, Niguarda Hospital, 20162 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Bonmassari","sequence":"additional","affiliation":[{"name":"Department of Cardiology, S. Chiara Hospital, 38122 Trento, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9388-3292","authenticated-orcid":false,"given":"Massimiliano","family":"Marini","sequence":"additional","affiliation":[{"name":"Department of Cardiology, S. 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Heart J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1097\/HCO.0b013e32835b59db","article-title":"Electrical storm: Definitions, clinical importance, and treatment","volume":"28","author":"Gao","year":"2013","journal-title":"Curr. Opin. Cardiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1093\/eurheartj\/ehl276","article-title":"Electrical storm in patients with an implantable defibrillator: Incidence, features, and preventive therapy: Insights from a randomized trial","volume":"27","author":"Hohnloser","year":"2006","journal-title":"Eur. Heart J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.pcad.2008.07.003","article-title":"Recurrent Ventricular Arrhythmia Storms in the Age of Implantable Cardioverter Defibrillator Therapy: A Comprehensive Review","volume":"51","author":"Huang","year":"2008","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1152\/physrev.00014.2006","article-title":"Arrhythmogenic ion-channel remodeling in the heart: Heart failure, myocardial infarction, and atrial fibrillation","volume":"87","author":"Nattel","year":"2007","journal-title":"Physiol. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/europace\/eut304","article-title":"Role of electrical storm as a mortality and morbidity risk factor and its clinical predictors: A meta-analysis","volume":"16","author":"Guerra","year":"2014","journal-title":"Europace"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1111\/j.1540-8159.2005.00153.x","article-title":"Characteristics and relevance of clustering ventricular arrhythmias in defibrillator recipients","volume":"28","author":"Stuber","year":"2005","journal-title":"Pacing Clin. Electrophysiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1542-474X.2007.00187.x","article-title":"Electrical storm in patients with an implanted defibrillator: A matter of definition","volume":"12","author":"Israel","year":"2007","journal-title":"Ann. Noninvasive Electrocardiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1093\/eurheartj\/ehs453","article-title":"Venturing into ventricular arrhythmia storm: A systematic review and meta-analysis","volume":"34","author":"Nayyar","year":"2013","journal-title":"Eur. Heart J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.pcad.2021.06.007","article-title":"Electrical storm: Prognosis and management","volume":"66","author":"Elsokkari","year":"2021","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1161\/CIRCEP.112.971101","article-title":"Heist EKPredictors of sustained ventricular arrhythmias in cardiac resynchronization therapy","volume":"5","author":"Friedman","year":"2012","journal-title":"Circ. Arrhythmia Electrophysiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1016\/S0735-1097(98)00495-1","article-title":"Electrical storm in patients with transvenous implantable cardioverter- defibrillators: Incidence, management and prognostic implications","volume":"32","author":"Credner","year":"1998","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1161\/01.CIR.103.16.2066","article-title":"Electrical storm presages nonsudden death: The antiarrhythmics versus implantable defibrillators (AVID) trial","volume":"103","author":"Exner","year":"2001","journal-title":"Circulation"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1093\/eurheartj\/ehi726","article-title":"Clinical predictors and prognostic significance of electrical storm in patients with implantable cardioverter defibrillators","volume":"27","author":"Brigadeau","year":"2006","journal-title":"Eur. Heart J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1093\/eurjhf\/hfs105","article-title":"ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012","volume":"14","author":"McMurray","year":"2012","journal-title":"Eur. J. Heart Fail."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/0735-1097(88)90370-1","article-title":"Prognosis of patients with ventricular tachycardia and ventricular fibrillation: Role of the underlying etiology","volume":"12","author":"Trappe","year":"1988","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S0735-1097(98)00519-1","article-title":"Sudden death in implantable cardioverter-defibrillator recipients: Clinical context, arrhythmic events and device responses","volume":"33","author":"Pires","year":"1999","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/S0735-1097(00)00726-9","article-title":"Clusters of ventricular tachycardias signify impaired survival in patients with idiopathic dilated cardiomyopathy and implantable cardioverter defibrillators","volume":"36","author":"Brunn","year":"2000","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.hrthm.2009.11.027","article-title":"Differences in effects of electrical therapy type for ventricular arrhythmias on mortality in implantable cardioverter-defibrillator patients","volume":"7","author":"Sweeney","year":"2010","journal-title":"Heart Rhythm"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1093\/oxfordjournals.eurheartj.a015093","article-title":"Left ventricular function after repeated episodes of ventricular fibrillation and defibrillation assessed by transoesophageal echocardiography","volume":"18","author":"Bergfeldt","year":"1997","journal-title":"Eur. Heart J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jacep.2019.11.012","article-title":"Mortality Risk Increases With Clustered Ventricular Arrhythmias in Patients With Implantable Cardioverter-Defibrillators","volume":"6","author":"lsokkari","year":"2020","journal-title":"JACC Clin. Electrophysiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/j.hrthm.2007.07.013","article-title":"Huang DTVentricular arrhythmia storms in postinfarction patients with implantable defibrillators for primary prevention indications: A MADIT-II substudy","volume":"4","author":"Sesselberg","year":"2007","journal-title":"Heart Rhythm"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1161\/CIRCULATIONAHA.106.686534","article-title":"Catheter ablation for the treatment of electrical storm in patients with implantable cardioverter-defibrillators: Short-and long-term outcomes in a prospective single-center study","volume":"117","author":"Carbucicchio","year":"2008","journal-title":"Circulation"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.amjcard.2011.03.030","article-title":"Catheter ablation of electrical storm in a collaborative hospital network","volume":"108","author":"Deneke","year":"2011","journal-title":"Am. J. Cardiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1161\/CIRCULATIONAHA.118.037997","article-title":"Catheter Ablation of Refractory Ventricular Fibrillation Storm after Myocardial Infarction: A Multicenter Study","volume":"139","author":"Komatsu","year":"2019","journal-title":"Circulation"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e007505","DOI":"10.1161\/CIRCHEARTFAILURE.120.007505","article-title":"Remodeling of the Purkinje Network in Congestive Heart Failure in the Rabbit","volume":"14","author":"Logantha","year":"2021","journal-title":"Circ. Heart Fail."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.jaccas.2021.04.023","article-title":"Successful Substrate Ablation for Ventricular Fibrillation in a Patient With Nonischemic Cardiomyopathy","volume":"3","author":"Yamaguchi","year":"2021","journal-title":"JACC Case Rep."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.amjcard.2005.08.058","article-title":"Sadr-Ameli MAPrevalence and predictors of electrical storm in patients with implantable cardioverter-defibrillator","volume":"97","author":"Arya","year":"2006","journal-title":"Am. J. Cardiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e004875","DOI":"10.1161\/CIRCEP.116.004875","article-title":"Cardiac resynchronization therapy reduces ventricular arrhythmias in primary but not secondary prophylactic implantable cardioverter defibrillator patients: Insight from the resynchronization in ambulatory heart failure trial","volume":"10","author":"Sapp","year":"2017","journal-title":"Circ. Arrhythmia Electrophysiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1093\/cvr\/cvy182","article-title":"Cardiac resynchronization is pro-arrhythmic in the absence of reverse ventricular remodelling: A systematic review and meta-analysis","volume":"114","author":"Deif","year":"2018","journal-title":"Cardiovasc. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.cjca.2021.12.015","article-title":"Recent Insights Into Mechanisms and Clinical Approaches to Electrical Storm","volume":"38","author":"Elsokkari","year":"2022","journal-title":"Can. J. Cardiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1093\/ehjacc\/zuac044","article-title":"Incidence and predictors of mortality after an electrical storm in the ICU","volume":"11","author":"Ninni","year":"2022","journal-title":"Eur. Heart J. Acute Cardiovasc. Care."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/j.amjcard.2019.02.021","article-title":"Characteristics and Outcomes in Patients with Electrical Storm","volume":"123","author":"Tajstra","year":"2019","journal-title":"Am. J. Cardiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jjcc.2022.02.016","article-title":"Predictors of cardiovascular mortality after an electrical storm in patients with structural heart disease","volume":"80","author":"Koizumi","year":"2022","journal-title":"J. Cardiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.hlc.2018.10.005","article-title":"Contemporary Management of Electrical Storm","volume":"28","author":"Geraghty","year":"2019","journal-title":"Heart Lung Circ."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1093\/eurheartj\/ehz467","article-title":"2019 ESC Guidelines for the management of patients with supraventricular tachycardiaThe Task Force for the management of patients with supraventricular tachycardia of the European Society of Cardiology (ESC)","volume":"41","author":"Brugada","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e001255","DOI":"10.1161\/JAHA.114.001255","article-title":"Implantable cardioverter-defibrillator therapy in patients with ventricular fibrillation out of hospital cardiac arrest secondary to acute coronary syndrome","volume":"4","author":"Madhavan","year":"2015","journal-title":"J. Am. Heart Assoc."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1016\/S0735-1097(01)01597-2","article-title":"AVID Investigators Life-threatening ventricular arrhythmias due to transient or correctable causes: High risk for death in follow-up","volume":"38","author":"Wyse","year":"2001","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1001\/jama.2011.1967","article-title":"Serum potassium levels and mortality in acute myocardial infarction","volume":"307","author":"Goyal","year":"2012","journal-title":"JAMA"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s10557-018-6783-0","article-title":"Association of Abnormal Serum Potassium Levels with Arrhythmias and Cardiovascular Mortality: A Systematic Review and Meta-Analysis of Observational Studies","volume":"32","author":"Hoppe","year":"2018","journal-title":"Cardiovasc. Drugs Ther."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e014160","DOI":"10.1161\/JAHA.119.014160","article-title":"Potassium Disturbances and Risk of Ventricular Fibrillation Among Patients with ST-Segment\u2013Elevation Myocardial Infarction","volume":"9","author":"Jabbari","year":"2020","journal-title":"J. Am. Heart Assoc."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Shao, H., Shi, D., and Dai, Y. (2022). Linezolid and the risk of QT interval prolongation: A pharmacovigilance study of the Food and Drug Administration Adverse Event Reporting System. Br. J. Clin. Pharmacol.","DOI":"10.1111\/bcp.15587"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"f99","DOI":"10.1093\/europace\/eux286","article-title":"Hysing JPredictors of mortality in high-risk patients with QT prolongation in a community hospital","volume":"20","author":"Gibbs","year":"2018","journal-title":"Europace"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1001\/jamainternmed.2020.0148","article-title":"Association of QT-Prolonging Medications with Risk of Autopsy-Defined Causes of Sudden Death","volume":"180","author":"Simpson","year":"2020","journal-title":"JAMA Intern. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1007\/s00395-013-0336-2","article-title":"Electrical storm: Recent pathophysiological insights and therapeutic consequences","volume":"108","author":"Tsuji","year":"2013","journal-title":"Basic Res. Cardiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1161\/CIRCULATIONAHA.110.950147","article-title":"Who are the long-QT syndrome patients who receive an implantable cardioverter-defibrillator and what happens to them?: Data from the European Long-QT syndrome implantable cardioverter-defibrillator (LQTS ICD) registry","volume":"122","author":"Schwartz","year":"2010","journal-title":"Circulation"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1093\/europace\/eur277","article-title":"Therapeutic approach for patients with catecholaminergic polymorphic ventricular tachycardia: State of the art and future developments","volume":"14","author":"Zwinderman","year":"2012","journal-title":"Europace"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e929507","DOI":"10.12659\/AJCR.929507","article-title":"Electrical storm in a case of bilateral pheochromocytomas","volume":"22","author":"Gauvin","year":"2021","journal-title":"Am. J. Case Rep."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e004634","DOI":"10.1161\/CIRCEP.116.004634","article-title":"Temporal trends and temperature-related incidence of electrical storm: The TEMPEST Study (Temperature-related incidence of electrical storm)","volume":"10","author":"Guerra","year":"2017","journal-title":"Circ. Arrhythmia Electrophysiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1080\/10903127.2019.1708518","article-title":"Seasonal Variation in Out-of-Hospital Cardiac Arrest in Victoria 2008\u20132017: Winter Peak","volume":"24","author":"Muller","year":"2020","journal-title":"Prehospital Emerg. Care"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1093\/eurheartj\/ehab275","article-title":"Short-coupled ventricular fibrillation represents a distinct phenotype among latent causes of unexplained cardiac arrest: A report from the CASPER registry","volume":"42","author":"Steinberg","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.jacc.2013.05.030","article-title":"Electrical storm in idiopathic ventricular fibrillation is associated with early repolarization","volume":"62","author":"Aizawa","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1111\/j.1540-8167.2012.02295.x","article-title":"Electrical storm in short-QT syndrome successfully treated with isoproterenol","volume":"23","author":"Bun","year":"2012","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1097\/00000441-200104000-00007","article-title":"Cardiovascular complications of weight reduction diets","volume":"321","author":"Ahmed","year":"2001","journal-title":"Am. J. Med. Sci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1161\/01.CIR.0000143159.30585.90","article-title":"Efficacy of Quinidine in High-Risk Patients with Brugada Syndrome","volume":"110","author":"Belhassen","year":"2004","journal-title":"Circulation"},{"key":"ref_56","first-page":"665","article-title":"J-Wave Syndromes Expert Consensus Conference Report: Emerging Concepts and Gaps in Knowledge","volume":"19","author":"Antzelevitch","year":"2017","journal-title":"Eur. Eur. Pacing Arrhythm. Card. Electrophysiol. J. Work. Groups Card. Pacing Arrhythm. Card. Cell. Electrophysiol. Eur. Soc. Cardiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"669","DOI":"10.2459\/JCM.0000000000001107","article-title":"Clinical Management of Electrical Storm: A Current Overview","volume":"22","author":"Guarracini","year":"2021","journal-title":"J. Cardiovasc. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.jacep.2021.03.024","article-title":"Quinidine in the Management of Recurrent Ventricular Arrhythmias: A Reappraisal","volume":"7","author":"Li","year":"2021","journal-title":"JACC Clin. Electrophysiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1161\/CIRCULATIONAHA.118.038036","article-title":"Quinidine-Responsive Polymorphic Ventricular Tachycardia in Patients with Coronary Heart Disease","volume":"139","author":"Viskin","year":"2019","journal-title":"Circulation"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/0002-9149(94)90544-4","article-title":"Evaluation of Intravenous Lidocaine for the Termination of Sustained Monomorphic Ventricular Tachycardia in Patients with Coronary Artery Disease with or without Healed Myocardial Infarction","volume":"74","author":"Nasir","year":"1994","journal-title":"Am. J. Cardiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/FJC.0b013e31829651fe","article-title":"Mexiletine as an Adjunctive Therapy to Amiodarone Reduces the Frequency of Ventricular Tachyarrhythmia Events in Patients With an Implantable Defibrillator","volume":"62","author":"Gao","year":"2013","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.5603\/KP.2017.0189","article-title":"Efficacy and Tolerability of Mexiletine Treatment in Patients with Recurrent Ventricular Tachyarrhythmias and Implantable Cardioverter-Defibrillator Shocks","volume":"75","author":"Sobiech","year":"2017","journal-title":"Kardiol. Pol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.jelectrocard.2018.08.035","article-title":"The Role of Mexiletine in the Management of Long QT Syndrome","volume":"51","author":"Li","year":"2018","journal-title":"J. Electrocardiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0735-1097(92)90060-Z","article-title":"Dissociation of Termination and Prevention of Inducibility of Sustained Ventricular Tachycardia with Infusion of Procainamide: Evidence for Distinct Mechanisms","volume":"19","author":"Callans","year":"1992","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0002-9149(96)00224-X","article-title":"Comparison of Procainamide and Lidocaine in Terminating Sustained Monomorphic Ventricular Tachycardia","volume":"78","author":"Gorgels","year":"1996","journal-title":"Am. J. Cardiol."},{"key":"ref_66","first-page":"1329","article-title":"Randomized Comparison of Intravenous Procainamide vs. Intravenous Amiodarone for the Acute Treatment of Tolerated Wide QRS Tachycardia: The PROCAMIO Study","volume":"38","author":"Ortiz","year":"2017","journal-title":"Eur. Heart J."},{"key":"ref_67","first-page":"419","article-title":"The Antiarrhythmic Mechanisms of Flecainide in Catecholaminergic Polymorphic Ventricular Tachycardia","volume":"13","author":"Li","year":"2022","journal-title":"Front. Physiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.pcad.2008.01.003","article-title":"The Role of the Autonomic Nervous System in Sudden Cardiac Death","volume":"50","author":"Vaseghi","year":"2008","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1136\/heart.86.1.45","article-title":"Grace AABeta(2) Adrenergic Receptors Mediate Important Electrophysiological Effects in Human Ventricular Myocardium","volume":"86","author":"Lowe","year":"2001","journal-title":"Heart (Br. Card. Soc.)"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.ijcard.2003.11.033","article-title":"Suppression by Propranolol and Amiodarone of an Electrical Storm Refractory to Metoprolol and Amiodarone","volume":"99","author":"Tsagalou","year":"2005","journal-title":"Int. J. Cardiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1016\/j.jacc.2018.02.056","article-title":"Propranolol Versus Metoprolol for Treatment of Electrical Storm in Patients with Implantable Cardioverter-Defibrillator","volume":"71","author":"Chatzidou","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3892\/etm.2016.3281","article-title":"Successful Treatment of Cardiac Electrical Storm in Dilated Cardiomyopathy Using Esmolol: A Case Report","volume":"12","author":"Li","year":"2016","journal-title":"Exp. Ther. Med."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s40265-018-0883-9","article-title":"Landiolol: A Review in Tachyarrhythmias","volume":"78","author":"Syed","year":"2018","journal-title":"Drugs"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1253\/circrep.CR-20-0017","article-title":"Efficacy and Safety of Landiolol in Patients with Ventricular Tachyarrhythmias with or Without Renal Impairment- Subanalysis of the J-Land II Study","volume":"2","author":"Shiga","year":"2020","journal-title":"Circ. Rep."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1161\/01.CIR.64.2.273","article-title":"Long-Term Management of Sustained, Recurrent, Symptomatic Ventricular Tachycardia with Amiodarone","volume":"64","author":"Kaski","year":"1981","journal-title":"Circulation"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1161\/01.CIR.92.11.3255","article-title":"Randomized, Double-Blind Comparison of Intravenous Amiodarone and Bretylium in the Treatment of Patients with Recurrent, Hemodynamically Destabilizing Ventricular Tachycardia or Fibrillation","volume":"92","author":"Kowey","year":"1995","journal-title":"Circulation"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/0002-9149(92)90354-2","article-title":"Effects of Chronic Amiodarone Therapy on Defibrillation Threshold","volume":"70","author":"Jung","year":"1992","journal-title":"Am. J. Cardiol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/0033-0620(89)90016-9","article-title":"A General Overview of Amiodarone Toxicity: Its Prevention, Detection, and Management","volume":"31","author":"Vrobel","year":"1989","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1111\/j.1540-8159.2007.00825.x","article-title":"Effect of Dl-Sotalol on Mortality and Recurrence of Ventricular, Tachyarrhythmias:Ischemic Compared to Nonischemic Cardiomyopathy","volume":"30","author":"Furushima","year":"2007","journal-title":"Pacing Clin. Electrophysiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1056\/NEJM199906173402402","article-title":"Prevention of Implantable-Defibrillator Shocks by Treatment with Sotalol. d,l-Sotalol Implantable Cardioverter-Defibrillator Study Group","volume":"340","author":"Pacifico","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0008-6363(97)00067-9","article-title":"Role of Interventricular Dispersion of Repolarization in Acquired Torsade-de-Pointes Arrhythmias: Reversal by Magnesium","volume":"34","author":"Verduyn","year":"1997","journal-title":"Cardiovasc. Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1001\/jama.295.2.165","article-title":"Optimal Pharmacological Therapy in Cardioverter Defibrillator Patients (OPTIC) Investigators. Comparison of beta-blockers, amiodarone plus beta-blockers, or sotalol for prevention of shocks from implantable cardioverter defibrillators: The OPTIC study: A randomized trial","volume":"295","author":"Connolly","year":"2006","journal-title":"JAMA"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.jccase.2021.12.002","article-title":"Multifocal Purkinje-related premature contractions and electrical storm suppressed by quinidine and verapamil in a case with short-coupled ventricular fibrillation","volume":"25","author":"Kataoka","year":"2021","journal-title":"J. Cardiol. Cases"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.4067\/S0034-98872013001000016","article-title":"Electrical storm in Brugada syndrome successfully treated with isoproterenol. Report of a case","volume":"141","author":"Vega","year":"2013","journal-title":"Rev. Med. De Chile"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"e226","DOI":"10.1111\/j.1540-8159.2011.03066.x","article-title":"Characteristics of J Wave-Associated Idiopathic Ventricular Fibrillation: Role of Drugs","volume":"35","author":"Chinushi","year":"2012","journal-title":"Pacing Clin. Electrophysiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s10840-008-9348-5","article-title":"Electrical storm reversible by isoproterenol infusion in a striking case of early repolarization","volume":"25","author":"Bernard","year":"2009","journal-title":"J. Interv. Card. Electrophysiol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1161\/01.CIR.77.2.392","article-title":"Treatment of torsade de pointes with magnesium sulfate","volume":"77","author":"Tzivoni","year":"1988","journal-title":"Circulation"},{"key":"ref_88","first-page":"121","article-title":"The value of magnesium in intensive care medicine","volume":"83","author":"Manz","year":"1994","journal-title":"Z. Fur Kardiol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/BF03042655","article-title":"Effect of magnesium on sustained ventricular tachycardia","volume":"22","author":"Manz","year":"1997","journal-title":"Herz"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.hrthm.2017.08.022","article-title":"Successful Ventricular Tachycardia Ablation in Patients with Electrical Storm Reduces Recurrences and Improves Survival","volume":"15","author":"Vergara","year":"2018","journal-title":"Heart Rhythm."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.jacep.2017.01.020","article-title":"Long-Term Outcomes of Catheter Ablation of Electrical Storm in Nonischemic Dilated Cardiomyopathy Compared with Ischemic Cardiomyopathy","volume":"3","author":"Muser","year":"2017","journal-title":"JACC. Clin. Electrophysiol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.hrthm.2019.01.032","article-title":"Stevenson WGCatheter Ablation of Polymorphic Ventricular Tachycardia\/Fibrillation in Patients with and without Structural Heart Disease","volume":"16","author":"Nakamura","year":"2019","journal-title":"Heart Rhythm."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.jacep.2018.01.016","article-title":"Impact of Number of Oral Antiarrhythmic Drug Failures Before Referral on Outcomes Following Catheter Ablation of Ventricular Tachycardia","volume":"4","author":"Romero","year":"2018","journal-title":"JACC. Clin. Electrophysiol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1111\/j.1540-8167.2011.02081.x","article-title":"Ventricular Tachycardia Ablation Remains Treatment of Last Resort in Structural Heart Disease: Argument for Earlier Intervention","volume":"22","author":"Frankel","year":"2011","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1161\/CIRCULATIONAHA.122.059598","article-title":"Does Timing of Ventricular Tachycardia Ablation Affect Prognosis in Patients with an Implantable Cardioverter Defibrillator? Results From the Multicenter Randomized PARTITA Trial","volume":"145","author":"Baratto","year":"2022","journal-title":"Circulation"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.hrthm.2016.09.019","article-title":"Simultaneous Noninvasive Recording of Skin Sympathetic Nerve Activity and Electrocardiogram","volume":"14","author":"Doytchinova","year":"2017","journal-title":"Heart Rhythm."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"377.e1","DOI":"10.1016\/j.ajem.2021.04.028","article-title":"Ventricular Tachycardia Converts to Sinus Rhythm after Administration of Propofol","volume":"48","author":"Shannon","year":"2021","journal-title":"Am. J. Emerg. Med."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1177\/2048872620903453","article-title":"Deep Sedation as Temporary Bridge to Definitive Treatment of Ventricular Arrhythmia Storm","volume":"9","author":"Bundgaard","year":"2020","journal-title":"Eur. Heart Journal. Acute Cardiovasc. Care"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1161\/CIRCULATIONAHA.120.047468","article-title":"Effectiveness of Deep Sedation for Patients with Intractable Electrical Storm Refractory to Antiarrhythmic Drugs","volume":"142","author":"Martins","year":"2020","journal-title":"Circulation"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1161\/CIRCULATIONAHA.109.929703","article-title":"Neuraxial Modulation for Refractory Ventricular Arrhythmias: Value of Thoracic Epidural Anesthesia and Surgical Left Cardiac Sympathetic Denervation","volume":"121","author":"Bourke","year":"2010","journal-title":"Circulation"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"e007080","DOI":"10.1161\/JAHA.117.007080","article-title":"Thoracic Epidural Anesthesia Can Be Effective for the Short-Term Management of Ventricular Tachycardia Storm","volume":"6","author":"Do","year":"2017","journal-title":"J. Am. Heart Assoc. Cardiovasc. Cerebrovasc. Dis."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.jacep.2019.12.017","article-title":"Stellate Ganglion Blockade for the Treatment of Refractory Ventricular Arrhythmias","volume":"6","author":"Fudim","year":"2020","journal-title":"JACC. Clin. Electrophysiol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1007\/s12630-021-02068-1","article-title":"Stellate Ganglion Blockade for Treating Refractory Electrical Storm: A Historical Cohort Study","volume":"68","author":"Reinertsen","year":"2021","journal-title":"Can. J. Anaesth. = J. Can. D\u2019anesthesie"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"3070","DOI":"10.1016\/j.jacc.2017.04.035","article-title":"Cardiac Sympathetic Denervation for Refractory Ventricular Arrhythmias","volume":"69","author":"Vaseghi","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1111\/jce.15004","article-title":"Renal Denervation for the Treatment of Ventricular Arrhythmias: A Systematic Review and Meta-Analysis","volume":"32","author":"Prado","year":"2021","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1007\/s00392-016-1012-y","article-title":"Renal Denervation for Treatment of Ventricular Arrhythmias: Data from an International Multicenter Registry","volume":"105","author":"Ukena","year":"2016","journal-title":"Clin. Res. Cardiol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1097\/01.CCM.0000269030.57298.AF","article-title":"Extracorporeal Life Support to Terminate Refractory Ventricular Tachycardia","volume":"35","author":"Tsai","year":"2007","journal-title":"Crit. Care Med."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ccep.2016.10.011","article-title":"Hemodynamic Support for Ventricular Tachycardia Ablation","volume":"9","author":"Palaniswamy","year":"2017","journal-title":"Cardiac Electrophysiology Clinics"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/j.ajem.2020.04.017","article-title":"Electrical Storm: A Focused Review for the Emergency Physician","volume":"38","author":"Dyer","year":"2020","journal-title":"Am. J. Emerg. Med."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"e010955","DOI":"10.1161\/CIRCEP.122.010955","article-title":"Stereotactic Radioablation for Ventricular Tachycardia in the Setting of Electrical Storm","volume":"15","author":"Ninni","year":"2022","journal-title":"Circ. Arrhythmia Electrophysiol."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/2\/405\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:36:29Z","timestamp":1760121389000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/2\/405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,19]]},"references-count":110,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["medicina59020405"],"URL":"https:\/\/doi.org\/10.3390\/medicina59020405","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,19]]}}}