{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:10:05Z","timestamp":1792141805675,"version":"4.4.0"},"reference-count":50,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T00:00:00Z","timestamp":1678233600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Macular edema (ME) is a common complication of intermediate uveitis (IU). It is often responsible for a decrease in visual acuity (VA). Three distinct patterns of macular edema have been described in intermediate uveitis, namely, cystoid macular edema (CME), diffuse macular edema (DME), and serous retinal detachment (SRD). The current study aims to describe the characteristics of macular edema in young patients with idiopathic intermediate uveitis and to correlate its features with VA using spectral domain optical coherence tomography (SD-OCT). Materials and Methods: A total of 27 eyes from 18 patients with idiopathic IU complicated by ME were included in this retrospective study. All patients underwent SD-OCT; data were gathered at the onset of ME. Best-corrected VA (BCVA) was correlated with the morphological features of ME. Results: BCVA was negatively correlated with Ellipsoid Zone (EZ) disruption (p = 0.00021), cystoid pattern (p = 0.00021), central subfield thickness (CST) (p &lt; 0.001), and serous retinal detachment (0.037). Conclusions: In ME secondary to idiopathic IU, VA negatively correlates with Ellipsoid Zone disruption and increases in CST. Moreover, vision is influenced by the presence of cysts in the inner nuclear and outer nuclear layers and by the neuroepithelium detachment.<\/jats:p>","DOI":"10.3390\/medicina59030529","type":"journal-article","created":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T02:33:16Z","timestamp":1678329196000},"page":"529","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Correlation between Morphological Characteristics of Macular Edema and Visual Acuity in Young Patients with Idiopathic Intermediate Uveitis"],"prefix":"10.3390","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1790-3532","authenticated-orcid":false,"given":"Ludovico","family":"Iannetti","sequence":"first","affiliation":[{"name":"Ophthalmology Unit, Head and Neck Department, Policlinico Umberto I University Hospital, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5444-4377","authenticated-orcid":false,"given":"Fabio","family":"Scarinci","sequence":"additional","affiliation":[{"name":"IRCCS Fondazione Bietti, 00199 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5366-882X","authenticated-orcid":false,"given":"Ludovico","family":"Alisi","sequence":"additional","affiliation":[{"name":"Department of Sense Organs, Sapienza University of Rome, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Armentano","sequence":"additional","affiliation":[{"name":"Department of Sense Organs, Sapienza University of Rome, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Sampalmieri","sequence":"additional","affiliation":[{"name":"Department of Sense Organs, Sapienza University of Rome, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"La Cava","sequence":"additional","affiliation":[{"name":"Department of Sense Organs, Sapienza University of Rome, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4991-9689","authenticated-orcid":false,"given":"Magda","family":"Gharbiya","sequence":"additional","affiliation":[{"name":"Department of Sense Organs, Sapienza University of Rome, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1080\/08820530500232035","article-title":"Intermediate Uveitis","volume":"20","author":"Bonfioli","year":"2005","journal-title":"Semin. Ophthalmol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"321","DOI":"10.3109\/09273948.2011.603878","article-title":"Intermediate Uveitis in a Pediatric Italian Population","volume":"19","author":"Paroli","year":"2011","journal-title":"Ocul. Immunol. Inflamm."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4103\/0301-4738.58469","article-title":"Intermediate uveitis","volume":"58","author":"Babu","year":"2010","journal-title":"Indian J. Ophthalmol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"657\u2013657","DOI":"10.1136\/bjo.2005.088658","article-title":"HLA typing of a Hong Kong Chinese family with intermediate uveitis","volume":"90","author":"Browning","year":"2006","journal-title":"Br. J. Ophthalmol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0002-9394(14)70994-8","article-title":"The Association of HLA-DR15 and Intermediate Uveitis","volume":"123","author":"Tang","year":"1997","journal-title":"Am. J. Ophthalmol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0896-1549(02)00026-3","article-title":"Intermediate uveitis","volume":"15","author":"Lai","year":"2002","journal-title":"Ophthalmol. Clin. N. Am."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"94","DOI":"10.5301\/ejo.5000336","article-title":"Intermediate Uveitis: Comparison between Childhood-Onset and Adult-Onset Disease","volume":"24","author":"Paroli","year":"2013","journal-title":"Eur. J. Ophthalmol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0002-9394(76)90434-7","article-title":"Complications of Chronic Cyclitis","volume":"82","author":"Smith","year":"1976","journal-title":"Am. J. Ophthalmol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.ophtha.2003.06.014","article-title":"Incidence and prevalence of uveitis in Northern California The Northern California Epidemiology of Uveitis Study","volume":"111","author":"Gritz","year":"2004","journal-title":"Ophthalmology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.ajo.2008.09.014","article-title":"Incidence and Prevalence of Uveitis in Veterans Affairs Medical Centers of the Pacific Northwest","volume":"146","author":"Suhler","year":"2008","journal-title":"Am. J. Ophthalmol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1016\/j.ophtha.2006.03.027","article-title":"Impact of Macular Edema on Visual Acuity in Uveitis","volume":"113","author":"Lardenoye","year":"2006","journal-title":"Ophthalmology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1038\/eye.2016.115","article-title":"Uveitic macular edema","volume":"30","author":"Fardeau","year":"2016","journal-title":"Eye"},{"key":"ref_13","first-page":"2003","article-title":"Intraocular and serum cytokine profiles in patients with intermediate uveitis","volume":"17","author":"Valentincic","year":"2011","journal-title":"Mol. Vis."},{"key":"ref_14","first-page":"477","article-title":"Intermediate uveitis: Long-term course and visual outcome","volume":"93","author":"Kraut","year":"2008","journal-title":"Br. J. Ophthalmol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1136\/bjo.80.4.332","article-title":"Causes and frequency of blindness in patients with intraocular inflammatory disease","volume":"80","author":"Rothova","year":"1996","journal-title":"Br. J. Ophthalmol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1159\/000337234","article-title":"Spectral-Domain Optical Coherence Tomography in Uveitic Macular Edema: Morphological Features and Prognostic Factors","volume":"228","author":"Iannetti","year":"2012","journal-title":"Ophthalmologica"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s10792-013-9822-7","article-title":"Optical coherence tomography imaging in uveitis","volume":"34","author":"Onal","year":"2013","journal-title":"Int. Ophthalmol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"284821","DOI":"10.1155\/2013\/284821","article-title":"Epiretinal Membranes in Patients with Uveitis: Morphological and Functional Analysis with Spectral Domain Optical Coherence Tomography","volume":"2013","author":"Iannetti","year":"2013","journal-title":"BioMed Res. Int."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1080\/09273948.2019.1576910","article-title":"Epidemiology of Macular Edema in Uveitis","volume":"27","author":"Accorinti","year":"2019","journal-title":"Ocul. Immunol. Inflamm."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ajo.2010.01.039","article-title":"The Association Between Percent Disruption of the Photoreceptor Inner Segment\u2013Outer Segment Junction and Visual Acuity in Diabetic Macular Edema","volume":"150","author":"Maheshwary","year":"2010","journal-title":"Am. J. Ophthalmol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/ICU.0b013e3283524162","article-title":"The inner segment\/outer segment junction","volume":"23","author":"Wong","year":"2012","journal-title":"Curr. Opin. Ophthalmol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1080\/09273940802187466","article-title":"Optical Coherence Tomography for Classification and Clinical Evaluation of Macular Edema in Patients with Uveitis","volume":"16","author":"Iannetti","year":"2008","journal-title":"Ocul. Immunol. Inflamm."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.ophtha.2003.08.037","article-title":"Patterns of macular edema in patients with uveitis: Qualitative and quantitative assessment using optical coherence tomography","volume":"111","author":"Markomichelakis","year":"2004","journal-title":"Ophthalmology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1080\/09273940701244509","article-title":"Course of Macular Edema in Uveitis under Medical Treatment","volume":"15","author":"Markomichelakis","year":"2007","journal-title":"Ocul. Immunol. Inflamm."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00347-005-1183-9","article-title":"Zystoides Makula\u00f6dem bei Uveitis","volume":"102","author":"Thurau","year":"2005","journal-title":"Der Ophthalmol."},{"key":"ref_26","unstructured":"R Core Team (2022, April 14). European Environment Agency. Available online: https:\/\/www.eea.europa.eu\/data-and-maps\/indicators\/oxygen-consuming-substances-in-rivers\/r-development-core-team-2006."},{"key":"ref_27","unstructured":"Christensen, R. (2022, January 24). Regression Models for Ordinal Data Introducing R-package Ordinal, Undefined. Available online: https:\/\/www.semanticscholar.org\/paper\/Regression-Models-for-Ordinal-Data-Introducing-Christensen\/a4ddf910eddf0f2abc742a91ac18308cf82ef04e."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/S0002-9394(99)00033-1","article-title":"Patterns of diabetic macular edema with optical coherence tomography","volume":"127","author":"Otani","year":"1999","journal-title":"Am. J. Ophthalmol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0161-6420(99)00087-1","article-title":"Comparison between optical coherence tomography and fundus fluorescein angiography for the detection of cystoid macular edema in patients with uveitis","volume":"107","author":"Antcliff","year":"2000","journal-title":"Ophthalmology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3126\/nepjoph.v10i1.21687","article-title":"Patterns of Macular Edema in Uveitis as Diagnosed by Optical Coherence Tomography in Tertiary Eye Center","volume":"10","author":"Gupta","year":"2018","journal-title":"Nepal. J. Ophthalmol."},{"key":"ref_31","first-page":"391","article-title":"Correlation Between Visual Function and Photoreceptor Integrity in Diabetic Macular Edema: Spectral-Domain Optical Coherence Tomography","volume":"41","author":"Shen","year":"2015","journal-title":"Curr. Eye Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1097\/IAE.0b013e3181c596e3","article-title":"Disruption of the photoreceptor inner segment\/outer segment layer on spectral domain-optical coherence tomography is a predictor of poor visual acuity in patients with epiretinal membranes","volume":"30","author":"Oster","year":"2010","journal-title":"Retina"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.ajo.2011.09.011","article-title":"The Significance of Cone Outer Segment Tips as a Prognostic Factor in Epiretinal Membrane Surgery","volume":"153","author":"Shimozono","year":"2012","journal-title":"Am. J. Ophthalmol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"7302","DOI":"10.1167\/iovs.13-12702","article-title":"Correlation Between Foveal Cone Outer Segment Tips Line and Visual Recovery After Epiretinal Membrane Surgery","volume":"54","author":"Itoh","year":"2013","journal-title":"Investig. Opthalmol. Vis. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1016\/j.ophtha.2012.01.023","article-title":"Correlation between Length of Foveal Cone Outer Segment Tips Line Defect and Visual Acuity after Macular Hole Closure","volume":"119","author":"Itoh","year":"2012","journal-title":"Ophthalmology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1136\/bjophthalmol-2011-301418","article-title":"Association between external limiting membrane status and visual acuity in diabetic macular oedema","volume":"97","author":"Ito","year":"2012","journal-title":"Br. J. Ophthalmol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"853728","DOI":"10.1155\/2015\/853728","article-title":"Correlation between Visual Acuity, Inner Segment\/Outer Segment Junction, and Cone Outer Segment Tips Line Integrity in Uveitic Macular Edema","volume":"2015","author":"Tortorella","year":"2015","journal-title":"BioMed Res. Int."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1007\/s00417-009-1149-8","article-title":"Fundus autofluorescence and spectral domain optical coherence tomography in uveitic macular edema","volume":"247","author":"Roesel","year":"2009","journal-title":"Graefe\u2019s Arch. Clin. Exp. Ophthalmol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1080\/09273940802702587","article-title":"Can We Be More Objective in Determining the Response to Treatment in Uveitis Patients Aside From Recording Anterior Chamber Reaction?","volume":"17","author":"Akduman","year":"2009","journal-title":"Ocul. Immunol. Inflamm."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.ajo.2015.09.017","article-title":"Factors Predicting Visual Acuity Outcome in Intermediate, Posterior, and Panuveitis: The Multicenter Uveitis Steroid Treatment (MUST) Trial","volume":"160","author":"Kempen","year":"2015","journal-title":"Am. J. Ophthalmol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.ophtha.2016.11.013","article-title":"Predictors of Long-Term Visual Outcome in Intermediate Uveitis","volume":"124","author":"Niederer","year":"2017","journal-title":"Ophthalmology"},{"key":"ref_42","first-page":"719","article-title":"Seven-Year Outcomes of Uveitic Macular Edema: The Multicenter Uveitis Steroid Treatment Trial and Follow-up Study Results","volume":"128","author":"Lightman","year":"2020","journal-title":"Ophthalmology"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/j.ophtha.2016.02.040","article-title":"Pharmacotherapies for Retinal Detachment","volume":"123","author":"Wubben","year":"2016","journal-title":"Ophthalmology"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.preteyeres.2013.08.001","article-title":"Photoreceptor cell death and rescue in retinal detachment and degenerations","volume":"37","author":"Murakami","year":"2013","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.ophtha.2008.10.001","article-title":"Foveal Microstructure and Visual Acuity after Retinal Detachment Repair: Imaging Analysis by Fourier-Domain Optical Coherence Tomography","volume":"116","author":"Wakabayashi","year":"2009","journal-title":"Ophthalmology"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"van Rijssen, T.J., Mohabati, D., Dijkman, G., Theelen, T., de Jong, E.K., van Dijk, E.H.C., and Boon, C.J.F. (2018). Correlation between redefined optical coherence tomography parameters and best-corrected visual acuity in non-resolving central serous chorioretinopathy treated with half-dose photodynamic therapy. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0202549"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1007\/s00417-019-04471-3","article-title":"Comparison of clinical outcomes of different components of diabetic macular edema on optical coherence tomography","volume":"257","author":"Hu","year":"2019","journal-title":"Graefe\u2019s Arch. Clin. Exp. Ophthalmol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ajo.2012.06.028","article-title":"Subretinal Fluid in Uveitic Macular Edema: Effect on Vision and Response to Therapy","volume":"155","author":"Lehpamer","year":"2013","journal-title":"Am. J. Ophthalmol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12348-021-00266-y","article-title":"Quantitative effect of subretinal fluid and intraretinal edema on visual acuity in uveitic cystoid macular edema","volume":"11","author":"Weldy","year":"2021","journal-title":"J. Ophthalmic Inflamm. Infect."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1136\/bjo.2007.136846","article-title":"Uveitic macular oedema: Correlation between optical coherence tomography patterns with visual acuity and fluorescein angiography","volume":"92","author":"Tran","year":"2008","journal-title":"Br. J. Ophthalmol."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/3\/529\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:50:53Z","timestamp":1760122253000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/3\/529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,8]]},"references-count":50,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["medicina59030529"],"URL":"https:\/\/doi.org\/10.3390\/medicina59030529","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,8]]}}}