{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T01:29:20Z","timestamp":1775784560367,"version":"3.50.1"},"reference-count":91,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T00:00:00Z","timestamp":1678752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Liver transplantation (LT) is the best strategy for curing several primary and secondary hepatic malignancies. In recent years, growing interest has been observed in the enlargement of the transplant oncology indications. This paper aims to review the most recent developments in the setting of LT oncology, with particular attention to LT for unresectable colorectal liver metastases (CRLM) and cholangiocellular carcinoma (CCA). Materials and Methods: A review of the recently published literature was conducted. Results: Growing evidence exists on the efficacy of LT in curing CRLM and peri-hilar and intrahepatic CCA in well-selected patients when integrating this strategy with (neo)-adjuvant chemotherapy, radiotherapy, or locoregional treatments. Conclusion: For unresectable CCA and CRLM management, several prospective protocols are forthcoming to elucidate LT\u2019s impact relative to alternative therapies. Advances in diagnosis, treatment protocols, and donor-to-recipient matching are needed to better define the oncological indications for transplantation. Prospective, multicenter trials studying these advances and their impact on outcomes are still required.<\/jats:p>","DOI":"10.3390\/medicina59030568","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T05:53:44Z","timestamp":1678859624000},"page":"568","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["New Insights in the Setting of Transplant Oncology"],"prefix":"10.3390","volume":"59","author":[{"given":"Silvia","family":"Quaresima","sequence":"first","affiliation":[{"name":"General Surgery and Organ Transplantation Unit, AOU Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Melandro","sequence":"additional","affiliation":[{"name":"General Surgery and Organ Transplantation Unit, AOU Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Giovanardi","sequence":"additional","affiliation":[{"name":"General Surgery and Organ Transplantation Unit, AOU Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kejal","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology, James Cancer Center, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1603-0787","authenticated-orcid":false,"given":"Valerio","family":"De Peppo","sequence":"additional","affiliation":[{"name":"General Surgery and Organ Transplantation Unit, AOU Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Mennini","sequence":"additional","affiliation":[{"name":"General Surgery and Organ Transplantation Unit, AOU Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7933-8941","authenticated-orcid":false,"given":"Davide","family":"Ghinolfi","sequence":"additional","affiliation":[{"name":"Hepatobiliary Surgery and Liver Transplantation, University of Pisa Medical School Hospital, 56124 Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley","family":"Limkemann","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology, James Cancer Center, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7994-9870","authenticated-orcid":false,"given":"Timothy M.","family":"Pawlik","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology, James Cancer Center, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1487-3235","authenticated-orcid":false,"given":"Quirino","family":"Lai","sequence":"additional","affiliation":[{"name":"General Surgery and Organ Transplantation Unit, AOU Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1111\/tri.13358","article-title":"2018 Annual Report of the European Liver Transplant Registry (ELTR)\u201450-year evolution of liver transplantation","volume":"31","author":"Adam","year":"2018","journal-title":"Transpl. Int."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1007\/s13304-021-01078-4","article-title":"Hepatocellular cancer selection systems and liver transplantation: From the tower of babel to an ideal comprehensive score","volume":"73","author":"Lerut","year":"2021","journal-title":"Updates Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1111\/j.1432-2277.2010.01076.x","article-title":"Liver transplantation for unresectable hepatocellular carcinoma in patients without liver cirrhosis","volume":"23","author":"Mergental","year":"2010","journal-title":"Transpl. Int."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"60","DOI":"10.21037\/tgh.2018.08.03","article-title":"Resection for intrahepatic cholangiocellular cancer: New advances","volume":"3","author":"Waisberg","year":"2018","journal-title":"Transl. Gastroenterol. Hepatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/j.jhep.2020.08.015","article-title":"Liver transplantation for secondary liver tumours: The difficult balance between survival and recurrence","volume":"73","author":"Line","year":"2020","journal-title":"J. Hepatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"241","DOI":"10.4161\/org.29245","article-title":"Current status of the organ replacement approach for malignancies and an overture for organ bioengineering and regenerative medicine","volume":"10","author":"Hibi","year":"2014","journal-title":"Organogenesis"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"v28","DOI":"10.1093\/annonc\/mdw324","article-title":"Biliary cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"27","author":"Valle","year":"2016","journal-title":"Ann. Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1177\/000313481107701246","article-title":"Klatskin tumors and the accuracy of the Bismuth-Corlette classification","volume":"77","author":"Paul","year":"2011","journal-title":"Am. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1245\/s10434-018-7075-4","article-title":"Actual 5-Year Survivors After Surgical Resection of Hilar Cholangiocarcinoma","volume":"26","author":"Tran","year":"2019","journal-title":"Ann. Surg. Oncol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.amjsurg.2008.11.022","article-title":"Partial or complete mesohepatectomy combined with resection of the hilar bifurcation in cases of Klatskin tumors: A reasonable strategy?","volume":"198","author":"Sotiropoulos","year":"2009","journal-title":"Am. J. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1097\/01.sla.0000179678.13285.fa","article-title":"Liver transplantation with neoadjuvant chemoradiation is more effective than resection for hilar cholangiocarcinoma","volume":"242","author":"Rea","year":"2005","journal-title":"Ann. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1097\/00000658-198804000-00002","article-title":"Liver transplantation for malignant disease. Results in 93 consecutive patients","volume":"207","author":"Polson","year":"1988","journal-title":"Ann. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1634\/theoncologist.2-3-164","article-title":"Indications and Role of Liver Transplantation for Malignant Tumors","volume":"2","author":"Pichlmayr","year":"1997","journal-title":"Oncologist"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1097\/00007890-200004270-00019","article-title":"Liver transplantation for cholangiocarcinoma: Results in 207 patients","volume":"69","author":"Meyer","year":"2000","journal-title":"Transplantation"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1002\/lt.21887","article-title":"Extended bile duct resection and [corrected] liver and transplantation in patients with hilar cholangiocarcinoma: Long-term results","volume":"15","author":"Seehofer","year":"2009","journal-title":"Liver Transpl."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1097\/00000658-198909000-00013","article-title":"Abdominal organ cluster transplantation for the treatment of upper abdominal malignancies","volume":"210","author":"Starzl","year":"1989","journal-title":"Ann. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/BF00195875","article-title":"Extended bile duct resection\u2014A new oncological approach to the treatment of central bile duct carcinomas? Description of method and early results","volume":"379","author":"Neuhaus","year":"1994","journal-title":"Langenbecks Arch. Chir."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1097\/00000658-198901000-00013","article-title":"The role of liver transplantation in hepatobiliary malignancy. A retrospective analysis of 95 patients with particular regard to tumor stage and recurrence","volume":"209","author":"Ringe","year":"1989","journal-title":"Ann. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1053\/jlts.2001.29419","article-title":"Liver transplantation for cholangiocellular carcinoma: Analysis of a single\u2013center experience and review of the literature","volume":"7","author":"Shimoda","year":"2001","journal-title":"Liver Transpl."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S1072-7515(98)00207-5","article-title":"Treatment of hilar cholangiocarcinoma (Klatskin tumors) with hepatic resection or transplantation","volume":"187","author":"Iwatsuki","year":"1998","journal-title":"J. Am. Coll. Surg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1034\/j.1600-6143.2002.20812.x","article-title":"Radiochemotherapy and transplantation allow long\u2013term survival for nonresectable hilar cholangiocarcinoma","volume":"2","author":"Sudan","year":"2002","journal-title":"Am. J. Transpl."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1055\/s-2004-828896","article-title":"Liver transplantation for unresectable perihilar cholangiocarcinoma","volume":"24","author":"Heimbach","year":"2004","journal-title":"Semin. Liver Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1016\/j.transproceed.2007.06.060","article-title":"Liver transplantation for Klatskin\u2019s tumor: Contraindicated, palliative, or indicated?","volume":"39","author":"Robles","year":"2007","journal-title":"Transplant. Proc."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3191","DOI":"10.1016\/j.transproceed.2008.08.039","article-title":"Liver transplantation for hilar cholangiocarcinoma: A German survey","volume":"40","author":"Kaiser","year":"2008","journal-title":"Transplant. Proc."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jamcollsurg.2012.03.014","article-title":"Neoadjuvant therapy and liver transplantation for hilar cholangiocarcinoma: Is pretreatment pathological confirma\u2013 tion of diagnosis necessary?","volume":"215","author":"Rosen","year":"2012","journal-title":"Am. Coll. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1053\/j.gastro.2012.04.008","article-title":"Efficacy of neoadjuvant chemoradiation, followed by liver transplantation, for perihilar cholangiocarcinoma at 12 US centers","volume":"143","author":"Kim","year":"2012","journal-title":"Gastroenterology"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Mantel, H.T., Westerkamp, A.C., Adam, R., Bennet, W.F., Seehofer, D., Settmacher, U., S\u00e1nchez-Bueno, F., Fabregat Prous, J., Boleslawski, E., and Friman, S. (2016). Strict Selection Alone of Patients Undergoing Liver Transplantation for Hilar Cholangiocarcinoma Is Associated with Improved Survival. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0156127"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"363","DOI":"10.6002\/ect.2018.0024","article-title":"Liver transplant for perihilar cholangiocarcinoma (Klatskin Tumor): The essential role of patient selection","volume":"17","author":"Dondorf","year":"2019","journal-title":"Exp. Clin. Transplant."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1097\/SLA.0000000000002574","article-title":"Transplantation Versus Resection for Hilar Cholangiocarcinoma: An Argument for Shifting Treatment Paradigms for Resectable Disease","volume":"267","author":"Ethun","year":"2018","journal-title":"Ann. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1097\/TP.0000000000003114","article-title":"Neoadjuvant Chemoradiotherapy and Liver Transplantation for Unresectable Hilar Cholangiocarcinoma: The Irish Experience of the Mayo Protocol","volume":"104","author":"Zaborowski","year":"2020","journal-title":"Transplantation"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jamcollsurg.2019.12.037","article-title":"Living Donor Liver Transplantation for Perihilar Cholangiocarcinoma: Outcomes and Complications","volume":"231","author":"Tan","year":"2020","journal-title":"J. Am. Coll. Surg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1080\/13651820801992542","article-title":"Surgery for cholangiocarcinoma: The role of liver transplantation","volume":"10","author":"Rosen","year":"2008","journal-title":"HPB"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"370","DOI":"10.3109\/00365521.2010.533384","article-title":"Liver transplantation for cholangiocarcinoma: Selection is essential for acceptable results","volume":"46","author":"Friman","year":"2011","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1097\/SLA.0000000000002716","article-title":"Transplantation Versus Resection for Hilar Cholangiocarcinoma: An Argument for Shifting Paradigms for Resectable Disease in Annals of Surgery 2018","volume":"267","author":"Rosen","year":"2018","journal-title":"Ann. Surg."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1007\/s11605-020-04721-4","article-title":"Liver Transplantation for Peri\u2013hilar Cholangiocarcinoma","volume":"24","author":"Tan","year":"2020","journal-title":"J. Gastrointest. Surg."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/cld.848","article-title":"Liver\u2013Intestine\/Multivisceral Perspective: Indications, Patient Selection, and Allocation Policy","volume":"14","author":"Mangus","year":"2019","journal-title":"Clin. Liver Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.jamcollsurg.2005.07.011","article-title":"Clinical and pathologic features of proximal biliary strictures masquerading as hilar cholangiocarcinoma","volume":"201","author":"Corvera","year":"2005","journal-title":"J. Am. Coll. Surg."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1097\/SLA.0000000000003801","article-title":"Meta-analysis and Meta-regression of Survival After Liver Transplantation for Unresectable Perihilar Cholangiocarcinoma","volume":"273","author":"Cambridge","year":"2021","journal-title":"Ann. Surg."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1097\/PAS.0000000000000588","article-title":"Prognostic Significance of the Histologic Response of Perihilar Cholangiocarcinoma to Preoperative Neoadjuvant Chemoradiation in Liver Explants","volume":"40","author":"Lehrke","year":"2016","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Moris, D., Kostakis, I.D., Machairas, N., Prodromidou, A., Tsilimigras, D.I., Ravindra, K.V., Sudan, D.L., Knechtle, S.J., and Barbas, A.S. (2019). Comparison between liver transplantation and resection for hilar cholangiocarcinoma: A systematic review and meta-analysis. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0220527"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1111\/ajt.13408","article-title":"A Multistep, Consensus\u2013Based Approach to Organ Allocation in Liver Transplantation: Toward a \u201cBlended Principle Model\u201d","volume":"15","author":"Cillo","year":"2015","journal-title":"Am. J. Transpl."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"409","DOI":"10.2217\/hep.15.30","article-title":"Liver transplantation in the management of perihilar cholangiocarcinoma","volume":"2","author":"Gulamhusein","year":"2015","journal-title":"Hepat. Oncol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jamcollsurg.2015.01.064","article-title":"Is Liver Transplantation Appropriate for Patients with Potentially Resectable De Novo Hilar Cholangiocarcinoma?","volume":"221","author":"Croome","year":"2015","journal-title":"J. Am. Coll. Surg."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.ejso.2007.10.005","article-title":"Surgery for hilar cholangiocarcinoma: The Leeds experience","volume":"34","author":"Hidalgo","year":"2008","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_45","first-page":"1337","article-title":"Surgical treatment of Klatskin tumor: Liver resection versus transplantation","volume":"57","author":"Kaiser","year":"2010","journal-title":"Hepatogastroenterology"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/SLA.0b013e3182708b57","article-title":"Evolution of surgical treatment for perihilar cholangiocarcinoma: A single\u2013center 34\u2013year review of 574 consecutive resections","volume":"258","author":"Nagino","year":"2013","journal-title":"Ann. Surg."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1002\/bjs.10556","article-title":"Surgical resection for Bismuth type IV perihilar cholangiocarcinoma","volume":"105","author":"Ebata","year":"2018","journal-title":"Br. J. Surg."},{"key":"ref_48","first-page":"272","article-title":"Cholangiocarcinoma: Increasing burden of classifications","volume":"2","author":"Cardinale","year":"2013","journal-title":"Hepatobiliary Surg. Nutr."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1007\/BF00299775","article-title":"Role of liver transplantation in the treatment of unresectable liver cancer","volume":"19","author":"Pichlmayr","year":"1995","journal-title":"World J. Surg."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/S0002-9610(05)80696-8","article-title":"Is liver transplantation indicated for cholangiocarcinoma?","volume":"166","author":"Goldstein","year":"1993","journal-title":"Am. J. Surg."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.jamcollsurg.2010.12.005","article-title":"Predictive index for tumor recurrence after liver transplantation for locally advanced intrahepatic and hilar cholangiocarcinoma","volume":"212","author":"Hong","year":"2011","journal-title":"J. Am. Coll. Surg."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1097\/TP.0000000000000286","article-title":"Tumors with intrahepatic bile duct differentiation in cirrhosis: Implications on outcomes after liver transplantation","volume":"99","author":"Facciuto","year":"2015","journal-title":"Transplantation"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1097\/SLA.0000000000000494","article-title":"Intrahepatic cholangiocarcinoma or mixed hepatocellular\u2013cholangiocarcinoma in patients undergoing liver transplantation: A Spanish matched cohort multicenter study","volume":"259","author":"Sapisochin","year":"2014","journal-title":"Ann. Surg."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1002\/hep.28744","article-title":"Liver transplantation for \u201cvery early\u201d intrahepatic cholangiocarcinoma: International retrospective study supporting a prospective assessment","volume":"64","author":"Sapisochin","year":"2016","journal-title":"Hepatology"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/lt.25737","article-title":"Analysis of Liver Resection Versus Liver Transplantation on Outcome of Small Intrahepatic Cholangiocarcinoma and Combined Hepatocellular\u2013Cholangiocarcinoma in the Setting of Cirrhosis","volume":"26","author":"Rayar","year":"2020","journal-title":"Liver Transpl."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1002\/lt.25052","article-title":"Liver transplantation for intrahepatic cholangiocarcinoma","volume":"24","author":"Lee","year":"2018","journal-title":"Liver Transpl."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1007\/s13304-021-01064-w","article-title":"Liver transplantation for unresectable intrahepatic cholangiocarcinoma: An Italian experience","volume":"73","author":"Gruttadauria","year":"2021","journal-title":"Updates Surg."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.surg.2021.09.034","article-title":"Intrahepatic cholangiocarcinoma: Is there a role for liver transplantation?","volume":"171","author":"Kim","year":"2022","journal-title":"Surgery"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1001\/archsurg.2011.116","article-title":"Comparative analysis of resection and liver transplantation for intrahepatic and hilar cholangiocarcinoma: A 24-year experience in a single center","volume":"146","author":"Hong","year":"2011","journal-title":"Arch. Surg."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S2468-1253(18)30045-1","article-title":"Liver transplantation for locally advanced intrahepatic cholangiocarcinoma treated with neoadjuvant therapy: A prospective case-series","volume":"3","author":"Lunsford","year":"2018","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1002\/jso.26370","article-title":"A comparison of surgical resection and liver transplantation in the treatment of intrahepatic cholangiocarcinoma in the era of modern chemotherapy: An analysis of the National Cancer Database","volume":"123","author":"Hue","year":"2021","journal-title":"J. Surg. Oncol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"908687","DOI":"10.3389\/fonc.2022.908687","article-title":"Gemcitabine Plus Cisplatin Versus Non-Gemcitabine and Cisplatin Regimens as Neoadjuvant Treatment for Cholangiocarcinoma Patients Prior to Liver Transplantation: An Institution Experience","volume":"12","author":"Abdelrahim","year":"2022","journal-title":"Front. Oncol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1111\/ajt.16906","article-title":"Survival following liver transplantation for locally advanced, unresectable intrahepatic cholangiocarcinoma","volume":"22","author":"McMillan","year":"2022","journal-title":"Am. J. Transpl."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/lt.26285","article-title":"A 3-Decade, Single-Center Experience of Liver Transplantation for Cholangiocarcinoma: Impact of Era, Tumor Size, Location, and Neoadjuvant Therapy","volume":"28","author":"Ito","year":"2022","journal-title":"Liver Transpl."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.21037\/jgo-20-209","article-title":"A model for predicting post-liver transplantation recurrence in intrahepatic cholangiocarcinoma recipients","volume":"11","author":"Ren","year":"2020","journal-title":"J. Gastrointest Oncol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/jso.24671","article-title":"Liver transplantation for unresectable colorectal liver metastases: A systematic review","volume":"116","author":"Moris","year":"2017","journal-title":"J. Surg. Oncol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1111\/j.1432-2277.2010.01097.x","article-title":"Liver transplantation for colorectal liver metastases: Revisiting the concept","volume":"23","author":"Foss","year":"2010","journal-title":"Transpl. Int."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"8198","DOI":"10.1245\/s10434-021-10220-w","article-title":"Liver-First Approach for Synchronous Colorectal Metastases: Analysis of 7360 Patients from the LiverMetSurvey Registry","volume":"28","author":"Giuliante","year":"2021","journal-title":"Ann. Surg. Oncol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1200\/JCO.2011.38.0915","article-title":"Phase III trial of cetuximab with continuous or intermittent fluorouracil, leucovorin, and oxaliplatin (Nordic FLOX) versus FLOX alone in first-line treatment of metastatic colorectal cancer: The NORDIC\u2013VII study","volume":"30","author":"Tveit","year":"2012","journal-title":"J. Clin. Oncol."},{"key":"ref_70","first-page":"56","article-title":"Treatment of colorectal liver metastases: A review","volume":"1","author":"Hendlisz","year":"2009","journal-title":"Rev. Recent. Clin. Trials."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"74","DOI":"10.21037\/tgh.2018.08.04","article-title":"Transplantation for colorectal metastases: On the edge of a revolution","volume":"3","author":"Andres","year":"2018","journal-title":"Transl. Gastroenterol. Hepatol."},{"key":"ref_72","first-page":"1567","article-title":"Is orthotopic liver transplantation a feasible treatment for secondary cancer of the liver?","volume":"23","author":"Huk","year":"1991","journal-title":"Transpl. Proc."},{"key":"ref_73","first-page":"726","article-title":"Hepatic transplantation for primary and metastatic cancers of the liver","volume":"110","author":"Penn","year":"1991","journal-title":"Surgery"},{"key":"ref_74","unstructured":"Belle, S.H., Beringer, K.C., and Detre, K.M. (1995). An update on liver transplantation in the United States: Recipient characteristics and outcome. Clin. Transpl., 19\u201333."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1097\/SLA.0b013e3182823957","article-title":"Liver transplantation for nonresectable liver metastases from colorectal cancer","volume":"257","author":"Hagness","year":"2013","journal-title":"Ann. Surg."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1097\/SLA.0000000000003404","article-title":"Survival Following Liver Transplantation for Patients With Nonresectable Liver\u2013only Colorectal Metastases","volume":"271","author":"Dueland","year":"2020","journal-title":"Ann. Surg."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1002\/lt.24791","article-title":"Liver transplantation for colorectal liver metastasis: Survival without recurrence can be achieved","volume":"23","author":"Toso","year":"2017","journal-title":"Liver Transpl."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/bjs5.50278","article-title":"Liver transplantation for unresectable colorectal liver metastases in patients and donors with extended criteria (SECA\u2013II arm D study)","volume":"4","author":"Smedman","year":"2020","journal-title":"BJS Open"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1001\/jamasurg.2021.0267","article-title":"Survival Outcomes After Portal Vein Embolization and Liver Resection Compared With Liver Transplant for Patients With Extensive Colorectal Cancer Liver Metastases","volume":"156","author":"Dueland","year":"2021","journal-title":"JAMA Surg."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1111\/tri.13981","article-title":"Liver transplantation versus liver resection for colorectal liver metastasis: A survival benefit analysis in patients stratified according to tumor burden score","volume":"34","author":"Lanari","year":"2021","journal-title":"Transpl. Int."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1097\/SLA.0000000000000786","article-title":"Chemotherapy or liver transplantation for nonresectable liver metastases from colorectal cancer?","volume":"261","author":"Dueland","year":"2015","journal-title":"Ann. Surg."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1111\/tri.13471","article-title":"Transplant oncology: Assessment of response and tolerance to systemic chemotherapy for metastatic colorectal cancer after liver transplantation\u2014A retrospective study","volume":"32","author":"Smedman","year":"2019","journal-title":"Transpl. Int."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1001\/jamasurg.2022.0300","article-title":"Recipient and Donor Outcomes After Living\u2013Donor Liver Transplant for Unresectable Colorectal Liver Metastases","volume":"157","author":"Ruffolo","year":"2022","journal-title":"JAMA Surg."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1097\/SLA.0000000000001165","article-title":"A Novel Concept for Partial Liver Transplantation in Nonresectable Colorectal Liver Metastases: The RAPID Concept","volume":"262","author":"Line","year":"2015","journal-title":"Ann. Surg."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1097\/SLA.0000000000002861","article-title":"Paradigm Shift in the Management of Irresectable Colorectal Liver Metastases: Living Donor Auxiliary Partial Orthotopic Liver Transplantation in Combination With Two\u2013stage Hepatectomy (LD\u2013RAPID)","volume":"270","author":"Templin","year":"2019","journal-title":"Ann. Surg."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"476","DOI":"10.21037\/hbsn.2020.03.10","article-title":"The potential use of extended criteria donors and eligible recipients in liver transplantation for unresectable colorectal liver metastases in Central Sweden","volume":"10","author":"Villard","year":"2021","journal-title":"Hepatobiliary Surg. Nutr."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"75","DOI":"10.21037\/tgh.2017.09.04","article-title":"Selection of patients with hepatocellular cancer: A difficult balancing between equity, utility, and benefit","volume":"2","author":"Vitale","year":"2017","journal-title":"Transl. Gastroenterol. Hepatol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1002\/hep.29342","article-title":"Intention-to-treat survival benefit of liver transplantation in patients with hepatocellular cancer","volume":"66","author":"Lai","year":"2017","journal-title":"Hepatology"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1097\/SLA.0000000000002943","article-title":"Tacrolimus and Single Intraoperative High-dose of Anti-T-lymphocyte Globulins Versus Tacrolimus Monotherapy in Adult Liver Transplantation: One-year Results of an Investigator-driven Randomized Controlled Trial","volume":"268","author":"Iesari","year":"2018","journal-title":"Ann. Surg."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.hbpd.2019.05.006","article-title":"Hepatocellular carcinoma recurrence after acute liver allograft rejection treatment: A multicenter European experience","volume":"18","author":"Lai","year":"2019","journal-title":"Hepatobiliary Pancreat Dis. Int."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"100309","DOI":"10.1016\/j.aohep.2021.100309","article-title":"Cumulative incidence of solid and hematological De novo malignancy after liver transplantation in a multicentre cohort","volume":"24","author":"Lucidi","year":"2021","journal-title":"Ann. Hepatol."}],"updated-by":[{"DOI":"10.3390\/medicina61122242","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T00:00:00Z","timestamp":1678752000000}}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/3\/568\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T14:18:31Z","timestamp":1766067511000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/3\/568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,14]]},"references-count":91,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["medicina59030568"],"URL":"https:\/\/doi.org\/10.3390\/medicina59030568","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,14]]}}}