{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:01:32Z","timestamp":1760148092965,"version":"build-2065373602"},"reference-count":29,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T00:00:00Z","timestamp":1680048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Introduction: This study aimed to evaluate the long-term adverse effects on the physical appearance and overall well-being of breast cancer patients who receive hypofractionated radiotherapy as whole breast and simultaneous integrated boost (SIB) treatment, utilizing intensive modulated radiotherapy (IMRT), volumetric modulated arc therapy (VMAT), or a hybrid therapy approach. Material\/Methods: This investigation involved administering hypofractionated SIB-VMAT therapy to individuals diagnosed with early-stage breast cancer. Treatment was carried out over a three-week period in which a total dose of 48.06 Gy was given to the entire breast and 54 Gy was given to the tumor bed. Data on skin toxicity and cosmetic outcomes were analyzed both during the acute phase and during the three-month and five-year follow-up periods after treatment. Results: A total of 125 patients treated between December 2014 and December 2016 were included in the study. The data of these patients with at least 5 years of follow-up were analyzed. Conclusions: Considering these long-term results, hypofractionated SIB-VMAT can be considered a viable treatment choice, even for patients with unfavorable conditions.<\/jats:p>","DOI":"10.3390\/medicina59040675","type":"journal-article","created":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T02:03:53Z","timestamp":1680055433000},"page":"675","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Hypofractionated Radiotherapy Schedule with a Simultaneous Integrated Boost for Breast Cancer: Outcomes including Late Toxicity and Health Quality"],"prefix":"10.3390","volume":"59","author":[{"given":"Zuleyha","family":"Akgun","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Memorial Sisli Hospital, Kaptan Pa\u015fa, Kaptan Pa\u015fa Mahallesi, Piyale Pa\u015fa Bulvari, Istanbul 34384, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aydin","family":"Cakir","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Memorial Sisli Hospital, Kaptan Pa\u015fa, Kaptan Pa\u015fa Mahallesi, Piyale Pa\u015fa Bulvari, Istanbul 34384, Turkey"},{"name":"Vocational School, Department of Radiology, Istanbul Bilgi University, Sisli, Istanbul 34387, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esra","family":"Sa\u011flam","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Memorial Sisli Hospital, Kaptan Pa\u015fa, Kaptan Pa\u015fa Mahallesi, Piyale Pa\u015fa Bulvari, Istanbul 34384, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sertac","family":"Demirel","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Memorial Sisli Hospital, Kaptan Pa\u015fa, Kaptan Pa\u015fa Mahallesi, Piyale Pa\u015fa Bulvari, Istanbul 34384, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah","family":"Igci","sequence":"additional","affiliation":[{"name":"School of Medicine, Department of General Surgery, Istanbul University, Istanbul 34452, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serkan","family":"Keskin","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Memorial Sisli Hospital, Kaptan Pa\u015fa, Kaptan Pa\u015fa Mahallesi, Piyale Pa\u015fa Bulvari, Istanbul 34384, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Early Breast Cancer Trialists\u2019 Collaborative Group (EBCTCG) (2005). 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