{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T20:10:34Z","timestamp":1791663034883,"version":"4.3.4"},"reference-count":41,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T00:00:00Z","timestamp":1681257600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: White spot lesions (WSLs) denote regions of subsurface demineralization on the enamel that manifest as opaque and milky-white regions. Treatment for WSLs is essential for both clinical and aesthetic reasons. Resin infiltration has been identified as the most efficacious solution for alleviating WSLs, but studies with long-term monitoring are scarce. The aim of this clinical study is to assess the color change stability of the lesion after four years of implementing the resin infiltration technique. Materials and Methods: Forty non-cavity and unrestored white spot lesions (WSLs) were treated with the resin infiltration technique. The color of the WSLs and adjacent healthy enamel (SAE) was assessed using a spectrophotometer at T0 (baseline), T1 (after treatment), T2 (1 year after) and T3 (4 years after). The Wilcoxon test was utilized to determine the significance of the variation of color (\u0394E) between WSLs and SAE over the observed time periods. Results: When comparing the color difference \u0394E (WSLs-SAE) at T0-T1, the Wilcoxon test demonstarated a statistically significant difference (p &lt; 0.05). For \u0394E (WSLs-SAE) at T1-T2 and T1-T3, the color variation was not statistically significant (p = 0.305 and p = 0.337). Conclusions: The study\u2019s findings indicate that the resin infiltration technique is an effective solution for resolving the appearance of WSLs, and the results have demonstrated stability for a minimum of four years.<\/jats:p>","DOI":"10.3390\/medicina59040749","type":"journal-article","created":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T02:57:08Z","timestamp":1681268228000},"page":"749","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Long-Term Chromatic Durability of White Spot Lesions through Employment of Infiltration Resin Treatment"],"prefix":"10.3390","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2819-7266","authenticated-orcid":false,"given":"Francesco","family":"Puleio","sequence":"first","affiliation":[{"name":"Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Messina University, 98100 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5458-6559","authenticated-orcid":false,"given":"Federica","family":"Di Spirito","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry \u201cSchola Medica Salernitana\u201d, University of Salerno, 84084 Baronissi, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5100-2426","authenticated-orcid":false,"given":"Giuseppe","family":"Lo Giudice","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Messina University, 98100 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Pantaleo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry \u201cSchola Medica Salernitana\u201d, University of Salerno, 84084 Baronissi, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Independent Researcher, 98124 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3529-709X","authenticated-orcid":false,"given":"Roberto","family":"Lo Giudice","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Messina University, 98100 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"bcr2018225639","DOI":"10.1136\/bcr-2018-225639","article-title":"Efcacy of 4-year treatment of icon infltration resin on postorthodontic white spot lesions","volume":"2018","author":"Cazzolla","year":"2018","journal-title":"BMJ Case Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0002-9416(82)90032-X","article-title":"Incidence of white spot formation after bonding and banding","volume":"81","author":"Gorelick","year":"1982","journal-title":"Am. 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