{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:05:33Z","timestamp":1760148333886,"version":"build-2065373602"},"reference-count":43,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T00:00:00Z","timestamp":1681948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Korean Society of Geriatric Anesthesia and Pain","award":["KSGAP-2020-001"],"award-info":[{"award-number":["KSGAP-2020-001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and objectives: Herpes zoster (HZ) is caused by the reactivation of a pre-existing latent varicella zoster virus, which is one of the viruses that causes hearing loss, and hearing loss may occur due to a systemic immune response even if it does not invade the auditory nerve. This study aimed to determine the correlation between sudden sensorineural hearing loss (SSNHL) in older adult patients who received HZ treatment. Materials and Methods: We used the cohort data of patients aged 60 years and above (n = 624,646) between 2002 and 2015 provided by the National Health Insurance Service. The patients were divided into two groups: those who were diagnosed with HZ between 2003 and 2008 (group H, n = 36,121) and those who had not been diagnosed with HZ between 2002 and 2015 (group C, n = 584,329). Results: In the main model (adjusted HR = 0.890, 95% CI = 0.839\u20130.944, p &lt; 0.001) adjusted for sex, age, and income, and the full model (adjusted HR = 0.894, 95% CI = 0.843\u20130.949, p &lt; 0.001) adjusted for all comorbidities, group H had a lower risk of SSNHL than group C. Conclusions: This study showed that patients who received HZ treatment had a lower incidence of SSNHL within five years after diagnosis.<\/jats:p>","DOI":"10.3390\/medicina59040808","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T03:01:48Z","timestamp":1682046108000},"page":"808","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Herpes Zoster Treatment and Sudden Sensorineural Hearing Loss Using National Health Insurance Claims Data of South Korea"],"prefix":"10.3390","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7710-7605","authenticated-orcid":false,"given":"Hyo Jung","family":"Son","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, National Police Hospital, Seoul 05715, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3731-0785","authenticated-orcid":false,"given":"Eun-Ji","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesia and Pain Medicine, Dental Research Institute, School of Dentistry, Pusan National University, Yangsan 50612, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ukjin","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, National Police Hospital, Seoul 05715, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3031-357X","authenticated-orcid":false,"given":"Yoon Ji","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Ansan 15355, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1080\/00325481.2017.1335574","article-title":"Herpes zoster\u2014Typical and atypical presentations","volume":"129","author":"Dayan","year":"2017","journal-title":"Postgrad. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"622","DOI":"10.4097\/kjae.2015.68.6.622","article-title":"Recurrence of herpes zoster in a young woman with IgG3 deficiency","volume":"68","author":"Yang","year":"2015","journal-title":"Korean J. Anesthesiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"486","DOI":"10.5021\/ad.2019.31.4.486","article-title":"Population-Based Epidemiologic Study on Herpes Zoster in Korea: Seven-Year Nationwide Analysis from 2010 to 2016","volume":"31","author":"Kwon","year":"2019","journal-title":"Ann. Dermatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"S143","DOI":"10.4097\/kjae.2013.65.6S.S143","article-title":"Abdominal distention and constipation followed by herpes zoster infection","volume":"65","author":"Kim","year":"2013","journal-title":"Korean J. Anesthesiol."},{"key":"ref_5","first-page":"18","article-title":"Viral causes of hearing loss: A review for hearing health professionals","volume":"29","author":"Cohen","year":"2014","journal-title":"Trends Hear."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1055\/s-0036-1586162","article-title":"Sudden Sensorioneural Hearing Loss and Autoimmune Systemic Diseases","volume":"21","author":"Rossini","year":"2017","journal-title":"Int. Arch. Otorhinolaryngol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e5438","DOI":"10.1097\/MD.0000000000005438","article-title":"Characteristics of hearing loss in patients with herpes zoster oticus","volume":"95","author":"Kim","year":"2016","journal-title":"Medicine"},{"key":"ref_8","first-page":"230","article-title":"Viral infections in sudden hearing loss. Do we have enough evidence?","volume":"3","author":"Mishra","year":"2005","journal-title":"Kathmandu Univ. Med. J. KUMJ"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3109\/00016489.2011.633227","article-title":"No increased risk of sudden sensorineural hearing loss following recent herpes zoster: A nationwide population-based study","volume":"132","author":"Sheu","year":"2012","journal-title":"Acta Oto-Laryngol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1056\/NEJMp058091","article-title":"Aging, immunity, and the varicella-zoster virus","volume":"352","author":"Arvin","year":"2005","journal-title":"N. Engl J. Med."},{"key":"ref_11","first-page":"1","article-title":"Prevention of herpes zoster: Recommendations of the Advisory Committee on Immunization Practices (ACIP)","volume":"57","author":"Harpaz","year":"2008","journal-title":"MMWR Recomm. Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.ophtha.2007.10.009","article-title":"Herpes zoster ophthalmicus natural history, risk factors, clinical presentation, and morbidity","volume":"115","author":"Liesegang","year":"2008","journal-title":"Ophthalmology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.4065\/82.11.1341","article-title":"A population-based study of the incidence and complication rates of herpes zoster before zoster vaccine introduction","volume":"82","author":"Yawn","year":"2007","journal-title":"Mayo Clin. Proc."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e004833","DOI":"10.1136\/bmjopen-2014-004833","article-title":"Systematic review of incidence and complications of herpes zoster: Towards a global perspective","volume":"4","author":"Kawai","year":"2014","journal-title":"BMJ Open"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1056\/NEJMoa042271","article-title":"Decline in mortality due to varicella after implementation of varicella vaccination in the United States","volume":"352","author":"Nguyen","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1542\/peds.2004-0012","article-title":"Decline in varicella-related hospitalizations and expenditures for children and adults after introduction of varicella vaccine in the United States","volume":"114","author":"Davis","year":"2004","journal-title":"Pediatrics"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"15016","DOI":"10.1038\/nrdp.2015.16","article-title":"Varicella zoster virus infection","volume":"1","author":"Gershon","year":"2015","journal-title":"Nat. Rev. Dis. Primers."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1056\/NEJMcp0802129","article-title":"Clinical practice. Idiopathic sudden sensorineural hearing loss","volume":"359","author":"Rauch","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"5153","DOI":"10.1016\/j.vaccine.2019.07.086","article-title":"The changing epidemiology of herpes zoster over a decade in South Korea, 2006\u20132015","volume":"37","author":"Choi","year":"2019","journal-title":"Vaccine"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"462","DOI":"10.4097\/kjae.2013.65.5.462","article-title":"Epidural catheterization with a subcutaneous injection port for the long-term administration of opioids and local anesthetics to treat zoster-associated pain -a report of two cases","volume":"65","author":"Min","year":"2013","journal-title":"Korean J. Anesthesiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"311","DOI":"10.4097\/kjae.2010.58.3.311","article-title":"The effect of Gunn\u2019s intramuscular stimulation for postherpetic neuralgia -A report of 4 cases","volume":"58","author":"Jung","year":"2010","journal-title":"Korean J. Anesthesiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1177\/1084713811408349","article-title":"Sudden sensorineural hearing loss: A review of diagnosis, treatment, and prognosis","volume":"15","author":"Kuhn","year":"2011","journal-title":"Trends Amplif."},{"key":"ref_23","first-page":"216592","article-title":"Acute-phase inflammatory response in idiopathic sudden deafness: Pathogenic implications","volume":"2012","author":"Abrante","year":"2012","journal-title":"Int. J. Otolaryngol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1002\/lary.20873","article-title":"Systematic review of the evidence for the etiology of adult sudden sensorineural hearing loss","volume":"120","author":"Chau","year":"2010","journal-title":"Laryngoscope"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1177\/0300060519847860","article-title":"Role of viral infection in sudden hearing loss","volume":"47","author":"Chen","year":"2019","journal-title":"J. Int. Med. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.autrev.2011.05.005","article-title":"Sudden sensorineural hearing loss: An autoimmune disease?","volume":"10","author":"Greco","year":"2011","journal-title":"Autoimmun. Rev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1177\/019459988108900129","article-title":"The implication of viruses in idiopathic sudden hearing loss: Primary infection or reactivation of latent viruses?","volume":"89","author":"Veltri","year":"1981","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_28","first-page":"583","article-title":"Acute autoimmune sensorineural hearing loss in pregnant women with Lesniowski-Crohn disease","volume":"60","author":"Kuczkowski","year":"2006","journal-title":"Otolaryngol. Pol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1080\/08916930500499599","article-title":"The autoimmune characteristics of progressive or sudden sensorineural hearing loss","volume":"39","author":"Yehudai","year":"2006","journal-title":"Autoimmunity"},{"key":"ref_30","first-page":"168","article-title":"Autoimmune identification of sudden hearing loss","volume":"123","year":"2003","journal-title":"Acta Oto-Laryngol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.anl.2011.03.007","article-title":"Autoimmune recurrent facial palsy and bilateral sudden sensorineural hearing loss following Ramsay Hunt-like syndrome","volume":"39","author":"Psillas","year":"2012","journal-title":"Auris Nasus Larynx"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1177\/000348940311201113","article-title":"Treatment of idiopathic sudden sensorineural hearing loss with antiviral therapy: A prospective, randomized, double-blind clinical trial","volume":"112","author":"Westerlaken","year":"2003","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1177\/000348940411300605","article-title":"Immune-mediated disorders associated with idiopathic sudden sensorineural hearing loss","volume":"113","author":"Toubi","year":"2004","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_34","first-page":"294","article-title":"Variations in herpes zoster manifestation","volume":"145","author":"Wollina","year":"2017","journal-title":"Indian J. Med. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.clineuro.2016.12.004","article-title":"Clinical characteristics of headache or facial pain prior to the development of acute herpes zoster of the head","volume":"152","author":"Lee","year":"2017","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1007\/s00405-015-3756-9","article-title":"Clinical manifestations in patients with herpes zoster oticus","volume":"273","author":"Shin","year":"2016","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"66","DOI":"10.21053\/ceo.2016.00360","article-title":"Does Herpes Virus Reactivation Affect Prognosis in Idiopathic Sudden Sensorineural Hearing Loss?","volume":"10","author":"Park","year":"2017","journal-title":"Clin. Exp. Otorhinolaryngol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1177\/000348949910800501","article-title":"Therapy of idiopathic sudden sensorineural hearing loss: Antiviral treatment of experimental herpes simplex virus infection of the inner ear","volume":"108","author":"Stokroos","year":"1999","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_39","first-page":"S1","article-title":"Clinical Practice Guideline: Sudden Hearing Loss (Update)","volume":"161","author":"Chandrasekhar","year":"2019","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1159\/000111048","article-title":"Sudden deafness: Is it viral?","volume":"70","author":"Merchant","year":"2008","journal-title":"ORL J. Otorhinolaryngol. Relat. Spec."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.amjoto.2015.02.011","article-title":"Sudden sensorineural hearing loss: Is antiviral treatment really necessary?","volume":"36","author":"Ovet","year":"2015","journal-title":"Am. J. Otolaryngol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"71","DOI":"10.7874\/kja.2012.16.2.71","article-title":"Combination therapy with systemic steroids, an antiviral agent, anticoagulants, and stellate ganglion block for treatment of sudden sensorineural hearing loss","volume":"16","author":"Park","year":"2012","journal-title":"Korean J. Audiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1056\/NEJMoa051016","article-title":"A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults","volume":"352","author":"Oxman","year":"2005","journal-title":"N. Engl. J. Med."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/4\/808\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:20:09Z","timestamp":1760124009000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/4\/808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,20]]},"references-count":43,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["medicina59040808"],"URL":"https:\/\/doi.org\/10.3390\/medicina59040808","relation":{},"ISSN":["1648-9144"],"issn-type":[{"type":"electronic","value":"1648-9144"}],"subject":[],"published":{"date-parts":[[2023,4,20]]}}}