{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:54:30Z","timestamp":1788386070737,"version":"build-2803163510"},"reference-count":28,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:00:00Z","timestamp":1682467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background: A current popular aesthetic problem, especially among younger women, is striae distensae (SD), also referred to as \u201cstretch marks.\u201d. Aim: The potential use of the 675 nm laser has been investigated in the treatment of SD. Methods: Patients underwent three sessions of the 675 nm laser with a 1-month interval between sessions. A total of three sessions were performed. The Manchester Scar Scale was used to assess stretch mark changes, and the mean scores related to each parameter at baseline and 6M FU after the last treatment session were measured. A clinical photographic evaluation was performed to show the aesthetic improvement of SD. Results: The patients\u2019 treated areas were the abdomen, thighs, buttocks, and breasts. Mean scores related to each Manchester Scar Scale parameter, with their relative percentage change, at baseline and 6M FU after the last treatment session were significantly improved. The total mean Manchester Scar Scale score significantly diminished from 14.16 (\u00b11.30) to 10.06 (\u00b11.32) at 6M FU (p &lt; 0.01). The clinical photographs showed promising aesthetic SD improvement. Conclusions: 675 nm laser therapy demonstrated a good tolerance for the treatment of stretch marks applied to various body areas preventing any discomfort for the patient and with a significant improvement in skin texture.<\/jats:p>","DOI":"10.3390\/medicina59050841","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T02:50:00Z","timestamp":1682563800000},"page":"841","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Striae Distensae: Clinical Results and Evidence-Based Evaluation of a Novel 675 nm Laser Wavelength"],"prefix":"10.3390","volume":"59","author":[{"given":"Alice","family":"Verdelli","sequence":"first","affiliation":[{"name":"Laser Cutaneous Cosmetic and Plastic Surgery Unit, Villa Donatello Clinic, 50121 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Bonan","sequence":"additional","affiliation":[{"name":"Laser Cutaneous Cosmetic and Plastic Surgery Unit, Villa Donatello Clinic, 50121 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7264-8808","authenticated-orcid":false,"given":"Irene","family":"Fusco","sequence":"additional","affiliation":[{"name":"El.En. Group, 50041 Calenzano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Madeddu","sequence":"additional","affiliation":[{"name":"El.En. Group, 50041 Calenzano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1983-0592","authenticated-orcid":false,"given":"Domenico","family":"Piccolo","sequence":"additional","affiliation":[{"name":"Skin Centers, 67051 Avezzano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/PRS.0000000000008065","article-title":"Striae Distensae: Scars without Wounds","volume":"148","author":"Borrelli","year":"2021","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"380","DOI":"10.4103\/idoj.IDOJ_336_18","article-title":"Striae Distensae Treatment Review and Update","volume":"10","author":"Lokhande","year":"2019","journal-title":"Indian Derm. Online J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1111\/jocd.13916","article-title":"Resurfacing with a new 675-nm laser device: A case series","volume":"20","author":"Piccolo","year":"2021","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1089\/photob.2020.4908","article-title":"A New 675\u2009nm Laser Device in the Treatment of Facial Aging: A Prospective Observational Study","volume":"39","author":"Cannarozzo","year":"2021","journal-title":"Photobiomodul. Photomed. Laser Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1089\/photob.2020.4927","article-title":"Histological Skin Changes After Treatment with 675\u2009nm Laser","volume":"39","author":"Cannarozzo","year":"2021","journal-title":"Photobiomodul. Photomed. Laser Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s10103-020-03063-6","article-title":"A new 675-nm laser device in the treatment of acne scars: An observational study","volume":"36","author":"Cannarozzo","year":"2021","journal-title":"Lasers Med. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1089\/photob.2020.4850","article-title":"A New 675\u2009nm Laser Device in the Treatment of Melasma: Results of a Prospective Observational Study","volume":"38","author":"Tolone","year":"2020","journal-title":"Photobiomodul. Photomed. Laser Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1089\/photob.2021.0076","article-title":"Could 675-nm Laser Treatment Be Effective for Facial Melasma Even in Darker Phototype?","volume":"39","author":"Bonan","year":"2021","journal-title":"Photobiomodul. Photomed. Laser Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"4070","DOI":"10.1111\/jocd.14529","article-title":"Facial rejuvenation: A safe and effective treatment with a fractional non-ablative 675 nm laser in Asian population","volume":"20","author":"Bonan","year":"2021","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1097\/00006534-199811000-00022","article-title":"A new quantitative scale for clinical scar assessment","volume":"102","author":"Beausang","year":"1998","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/j.1524-4725.2009.01094.x","article-title":"Striae distensae (stretch marks) and different modalities of therapy: An update","volume":"35","author":"Elsaie","year":"2009","journal-title":"Dermatol. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1080\/14764170701313767","article-title":"Prospective clinical and histological study to evaluate the efficacy and safety of a targeted high-intensity narrow band UVB\/UVA1 therapy for striae alba","volume":"9","author":"Sadick","year":"2007","journal-title":"J. Cosmet. Laser Ther."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1080\/14764172.2017.1418515","article-title":"Treatment of striae distensae: An evidence-based approach","volume":"21","author":"Forbat","year":"2019","journal-title":"J. Cosmet. Laser Ther."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"165S","DOI":"10.1097\/PRS.0000000000002647","article-title":"Evidence-Based Scar Management: How to Improve Results with Technique and Technol-ogy","volume":"138","author":"Khansa","year":"2016","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e22256","DOI":"10.1097\/MD.0000000000022256","article-title":"Comparative effectiveness of different therapies for treating striae dis-tensae: A systematic review and network meta-analysis","volume":"99","author":"Lu","year":"2020","journal-title":"Medicine"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/jdv.13223","article-title":"Topical management of striae distensae (stretch marks): Prevention and therapy of striae rubrae and albae","volume":"30","author":"McGeorge","year":"2016","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/bjd.12681","article-title":"Striae distensae: A comprehensive review and evidence-based evaluation of prophylaxis and treatment","volume":"170","author":"Gilmore","year":"2014","journal-title":"Br. J. Dermatol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1097\/DSS.0000000000001079","article-title":"Striae Distensae: Preventative and Therapeutic Modalities to Improve Aesthetic Appearance","volume":"43","author":"Ross","year":"2017","journal-title":"Dermatol. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/phpp.12636","article-title":"Synergistic effect of platelet-rich plasma in combination with fractional carbon dioxide laser versus its combination with pulsed dye laser in striae distensae: A comparative study","volume":"37","author":"Neinaa","year":"2021","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_20","first-page":"632","article-title":"Efficacy of pulsed dye laser versus intense pulsed light in the treatment of striae distensae","volume":"40","author":"Shokeir","year":"2014","journal-title":"Comp. Study Dermatol. Surg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"184","DOI":"10.4103\/2277-9175.140090","article-title":"Comparison of the fractional CO2 laser and the combined use of a pulsed dye laser with fractional CO2 laser in striae alba treatment","volume":"3","author":"Nikyar","year":"2014","journal-title":"Adv. Biomed. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3109\/14764172.2013.854621","article-title":"Treatment of striae distensae using an ablative Erbium: YAG fractional laser versus a 585-nm pulsed-dye laser","volume":"16","author":"Gauglitz","year":"2014","journal-title":"Case Rep. J. Cosmet. Laser Ther."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s40257-016-0182-8","article-title":"Laser and Light Treatments for Striae Distensae: A Comprehensive Review of the Literature","volume":"17","author":"Aldahan","year":"2016","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/jocd.13510","article-title":"Combined microwaves and fractional microablative CO2 laser treatment for postpartum abdominal laxity","volume":"20","author":"Bonan","year":"2021","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/phpp.12180","article-title":"Ex vivo evaluation of the effect of photodynamic therapy on skin scars and striae distensae","volume":"31","year":"2015","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/(SICI)1096-9101(1997)20:1<56::AID-LSM9>3.0.CO;2-Y","article-title":"Effects of photostimulation on wound healing in diabetic mice","volume":"20","author":"Yu","year":"1997","journal-title":"Laser Surg. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1159\/000018140","article-title":"Diabetic neuropathic foot ulcer: Successful treatment by low-intensity laser therapy","volume":"198","author":"Schindl","year":"1999","journal-title":"Dermatology"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1089\/pho.2005.23.485","article-title":"Polarized light (400\u20132000 nm) and non-ablative laser (685 nm): A description of the wound healing process using immunohistochemical analysis","volume":"23","author":"Pinheiro","year":"2005","journal-title":"Photomed. Laser Surg."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/5\/841\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:23:38Z","timestamp":1760124218000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/5\/841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,26]]},"references-count":28,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["medicina59050841"],"URL":"https:\/\/doi.org\/10.3390\/medicina59050841","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,26]]}}}