{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T08:04:35Z","timestamp":1761897875314,"version":"build-2065373602"},"reference-count":42,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T00:00:00Z","timestamp":1682553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: With the aging population, the incidence of degenerative lumbar spinal stenosis (LSS) is increasing. Sarcopenia is an age-related muscular decrease. Although epidural balloon neuroplasty is effective in patients with LSS refractory to conventional treatments, its effect has not been assessed in patients with sarcopenia. Therefore, this study evaluated the effect of epidural balloon neuroplasty in patients with LSS and sarcopenia. Materials and Methods: This retrospective study reviewed the following details from the electronic medical records: patient characteristics, including sex, age, body mass index, diabetes, hypertension, stenosis grading, pain duration, location, pain intensity, and medications. Back and leg pain intensity was evaluated before and after the procedure at one, three, and six months during the follow-up period. A generalized estimating equations model was used at six months follow-up. Patients were divided into sarcopenia and non-sarcopenia groups using the cross-sectional area of the psoas muscle at the level of L3 on magnetic resonance imaging. Results: A total of 477 patients were included (sarcopenia group: 314 patients, 65.8%; non-sarcopenia group: 163 patients, 34.2%). Age, sex, body mass index, and medication quantification scale III were statistically different between both groups. The generalized estimating equations analyses\u2014with unadjusted and adjusted estimation\u2014revealed a significantly reduced pain intensity after the procedure compared to the baseline in both groups. The difference in pain intensity between both groups was not statistically different. Conclusions: Percutaneous epidural balloon neuroplasty may be considered for patients with chronic lumbar LSS regardless of accompanying sarcopenia.<\/jats:p>","DOI":"10.3390\/medicina59050847","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T02:27:56Z","timestamp":1682648876000},"page":"847","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of Sarcopenia on Percutaneous Epidural Balloon Neuroplasty in Patients with Lumbar Spinal Stenosis: A Retrospective Analysis"],"prefix":"10.3390","volume":"59","author":[{"given":"Yun-A","family":"Han","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, National Police Hospital, Seoul 05715, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5688-4181","authenticated-orcid":false,"given":"Hyun-Jung","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunhee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min-Gi","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hotaek","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, National Police Hospital, Seoul 05715, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2333-0235","authenticated-orcid":false,"given":"Seong-Soo","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Woo","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3875-0857","authenticated-orcid":false,"given":"Doo-Hwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/ageing\/afq034","article-title":"Sarcopenia: European consensus on definition and diagnosisReport of the European Working Group on Sarcopenia in Older People","volume":"39","author":"Baeyens","year":"2010","journal-title":"Age Ageing"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1152\/japplphysiol.00347.2003","article-title":"Invited review: Aging and sarcopenia","volume":"95","author":"Doherty","year":"2003","journal-title":"J. Appl. Physiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.bja.2019.03.034","article-title":"Frailty assessment: From clinical to radiological tools","volume":"123","author":"Bentov","year":"2019","journal-title":"Br. J. Anaesth."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000448247","article-title":"Oral drugs related with muscle wasting and sarcopenia. A review","volume":"99","author":"Campins","year":"2017","journal-title":"Pharmacology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1080\/00365521.2021.1958368","article-title":"The assessment of sarcopenia using psoas muscle thickness per height is not predictive of post-operative complications in IBD","volume":"56","author":"Alipour","year":"2021","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s00384-020-03799-1","article-title":"Low psoas muscle area is associated with postoperative complications in Crohn\u2019s disease","volume":"36","author":"Zager","year":"2021","journal-title":"Int. J. Colorectal Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1097\/SLA.0000000000002252","article-title":"Assessment of sarcopenia as a predictor of poor outcomes after esophagectomy in elderly patients with esophageal cancer","volume":"267","author":"Nakashima","year":"2018","journal-title":"Annal. Sur."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.athoracsur.2018.10.006","article-title":"Sarcopenia of the psoas muscles is associated with poor outcomes following lung transplantation","volume":"107","author":"Hsu","year":"2019","journal-title":"Annal. Thorac. Sur."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1159\/000524774","article-title":"Presence of Sarcopenia before Kidney Transplantation Is Associated with Poor Outcomes","volume":"53","author":"Druckmann","year":"2022","journal-title":"Am. J. Nephrol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Nakai, Y., Makizako, H., Kiyama, R., Tomioka, K., Taniguchi, Y., Kubozono, T., Takenaka, T., and Ohishi, M. (2019). Association between chronic pain and physical frailty in community-dwelling older adults. Int. J. Environ. Res. Public Health, 16.","DOI":"10.3390\/ijerph16081330"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1093\/pm\/pnz161","article-title":"A review of lumbar spinal stenosis with intermittent neurogenic claudication: Disease and diagnosis","volume":"20","author":"Deer","year":"2019","journal-title":"Pain Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"h6234","DOI":"10.1136\/bmj.h6234","article-title":"Management of lumbar spinal stenosis","volume":"352","author":"Lurie","year":"2016","journal-title":"BMJ"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"S170","DOI":"10.1007\/s00586-003-0612-1","article-title":"Lumbar spinal stenosis in the elderly: An overview","volume":"12","author":"Szpalski","year":"2003","journal-title":"Eur. Spine J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1196\/annals.1395.015","article-title":"Lumbar spinal stenosis in elderly patients","volume":"1100","author":"Kaptan","year":"2007","journal-title":"Annal. N. Y. Acad. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1302\/0301-620X.98B8.37623","article-title":"The prevalence and impact of sarcopenia on degenerative lumbar spinal stenosis","volume":"98","author":"Park","year":"2016","journal-title":"Bone Joint J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.afos.2017.09.001","article-title":"Sarcopenia in elderly patients with chronic low back pain","volume":"3","author":"Sakai","year":"2017","journal-title":"Osteoporos. Sarcopenia"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3344\/kjp.22289","article-title":"Effectiveness of percutaneous epidural neuroplasty using a balloon catheter in patients with chronic spinal stenosis accompanying mild spondylolisthesis: A longitudinal cohort study","volume":"36","author":"Karm","year":"2023","journal-title":"Korean J. Pain"},{"key":"ref_18","first-page":"E841","article-title":"Effectiveness of epidural balloon neuroplasty in patients with chronic spinal stenosis accompanied by redundant nerve roots: A longitudinal cohort study","volume":"25","author":"Karm","year":"2022","journal-title":"Pain Physician"},{"key":"ref_19","first-page":"E1095","article-title":"Comparison of the Effect of Balloon Catheter vs Nucleoplasty vs Balloon Catheter and Nucleoplasty in Patients With Lumbar Spinal Stenosis","volume":"25","author":"Kim","year":"2022","journal-title":"Pain Physician"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Gil, H.Y., Jeong, S., Cho, H., Choi, E., Nahm, F.S., and Lee, P.-B. (2019). Kambin\u2019s triangle approach versus traditional safe triangle approach for percutaneous transforaminal epidural adhesiolysis using an inflatable balloon catheter: A pilot study. J. Clin. Med., 8.","DOI":"10.3390\/jcm8111996"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e1159","DOI":"10.3928\/01477447-20160811-02","article-title":"Effect of sarcopenia on postoperative morbidity and mortality after thoracolumbar spine surgery","volume":"39","author":"Bokshan","year":"2016","journal-title":"Orthopedics"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.spinee.2021.02.001","article-title":"Sarcopenia predicts perioperative adverse events following complex revision surgery for the thoracolumbar spine","volume":"21","author":"Hirase","year":"2021","journal-title":"Spine J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.afos.2018.02.003","article-title":"The impact of sarcopenia on the results of lumbar spinal surgery","volume":"4","author":"Inose","year":"2018","journal-title":"Osteoporos. Sarcopenia"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/papr.13141","article-title":"Influence of cross-sectional area and fat infiltration of paraspinal muscles on analgesic efficacy of epidural steroid injection in elderly patients","volume":"22","author":"Kim","year":"2022","journal-title":"Pain Pract."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1007\/s11605-015-2835-y","article-title":"Impact total psoas volume on short-and long-term outcomes in patients undergoing curative resection for pancreatic adenocarcinoma: A new tool to assess sarcopenia","volume":"19","author":"Amini","year":"2015","journal-title":"J. Gastrointest. Sur."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1533-2500.2007.00163.x","article-title":"Medication Quantification Scale Version III: Internal validation of detriment weights using a chronic pain population","volume":"8","author":"Gallizzi","year":"2008","journal-title":"Pain Pract."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1097\/BRS.0b013e3181d359bd","article-title":"Qualitative grading of severity of lumbar spinal stenosis based on the morphology of the dural sac on magnetic resonance images","volume":"35","author":"Schizas","year":"2010","journal-title":"Spine"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.2214\/AJR.09.2772","article-title":"A practical MRI grading system for lumbar foraminal stenosis","volume":"194","author":"Lee","year":"2010","journal-title":"Am. J. Roentgenol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.exger.2018.05.017","article-title":"Clinical effects of low body mass index on geriatric status in elderly patients","volume":"110","author":"Naruishi","year":"2018","journal-title":"Exp. Gerontol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"990S","DOI":"10.1093\/jn\/127.5.990S","article-title":"Sarcopenia: Origins and clinical relevance","volume":"127","author":"Rosenberg","year":"1997","journal-title":"J. Nutr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1177\/0884533615569888","article-title":"Implications of sarcopenia in major surgery","volume":"30","author":"Friedman","year":"2015","journal-title":"Nutr. Clin. Pract."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Beaudart, C., Zaaria, M., Pasleau, F., Reginster, J.-Y., and Bruy\u00e8re, O. (2017). Health outcomes of sarcopenia: A systematic review and meta-analysis. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0169548"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e164604","DOI":"10.1001\/jamasurg.2016.4604","article-title":"Association of radiologic indicators of frailty with 1-year mortality in older trauma patients: Opportunistic screening for sarcopenia and osteopenia","volume":"152","author":"Kaplan","year":"2017","journal-title":"JAMA Surg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"R206","DOI":"10.1186\/cc12901","article-title":"Skeletal muscle predicts ventilator-free days, ICU-free days, and mortality in elderly ICU patients","volume":"17","author":"Moisey","year":"2013","journal-title":"Crit. Care"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.athoracsur.2018.02.010","article-title":"Psoas muscle size predicts risk-adjusted outcomes after surgical aortic valve replacement","volume":"106","author":"Hawkins","year":"2018","journal-title":"Annal. Thorac. Sur."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1056\/NEJMoa0707136","article-title":"Surgical versus nonsurgical therapy for lumbar spinal stenosis","volume":"358","author":"Weinstein","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1002\/jor.20696","article-title":"Effects of arterial ischemia and venous congestion on the lumbar nerve root in dogs","volume":"26","author":"Kobayashi","year":"2008","journal-title":"J. Orthop. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.clineuro.2015.11.016","article-title":"Post-surgical functional recovery, lumbar lordosis, and range of motion associated with MR-detectable redundant nerve roots in lumbar spinal stenosis","volume":"140","author":"Chen","year":"2016","journal-title":"Clin. Neurol. Neurosur."},{"key":"ref_39","first-page":"E163","article-title":"Assessment of clinical outcomes of cervical epidural neuroplasty using a Racz-catheter and predictive factors of efficacy in patients with cervical spinal pain","volume":"18","author":"Moon","year":"2015","journal-title":"Pain Physician"},{"key":"ref_40","unstructured":"World Health Organization (1995). Physical Status: The Use of and Interpretation of Anthropometry, Report of a WHO Expert Committee."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1136\/bjsm.37.5.436","article-title":"Sex differences in whole body skeletal muscle mass measured by magnetic resonance imaging and its distribution in young Japanese adults","volume":"37","author":"Abe","year":"2003","journal-title":"Br. J. Sports Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13293-018-0189-3","article-title":"Sex differences in body composition and association with cardiometabolic risk","volume":"9","author":"Schorr","year":"2018","journal-title":"Biol. Sex Differ."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/5\/847\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:24:45Z","timestamp":1760124285000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/5\/847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,27]]},"references-count":42,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["medicina59050847"],"URL":"https:\/\/doi.org\/10.3390\/medicina59050847","relation":{},"ISSN":["1648-9144"],"issn-type":[{"type":"electronic","value":"1648-9144"}],"subject":[],"published":{"date-parts":[[2023,4,27]]}}}