{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:55:13Z","timestamp":1787028913850,"version":"build-2736575974"},"reference-count":50,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,4,30]],"date-time":"2023-04-30T00:00:00Z","timestamp":1682812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Total knee arthroplasties (TKAs) are the most effective surgical treatment for end-stage knee osteoarthritis. The tourniquet is used to reduce intraoperative blood loss, improving surgical field visualization. There is much controversy regarding the effectiveness and safety of using a tourniquet during total knee arthroplasties. The purpose of this prospective study is to determine the effect of tourniquet usage during TKAs on early functional outcomes and pain in our center. Materials and Methods: We conducted a randomized controlled trial of patients following a primary total knee replacement between October 2020 and August 2021. We recorded presurgical data, which included age, sex and knee range of motion. Intraoperatively, we measured the amount of blood aspiration and the surgical room time. After the surgery, we measured the amount of blood aspirated through the drains and the hemoglobin. We measured flexion, extension, Visual Analogue Scale (VAS) scores, and Western Ontario and McMaster Universities Arthritis Index (WOMAC score) scores for the functional evaluation. Results: We included 96 patients in the T group and 94 in the NT group, respectively, who remained until the last follow-up. Regarding blood loss, the NT group demonstrated significantly lower levels: 245 \u00b1 97.8 mL intraoperative and 324.8 \u00b1 151.65 mL postoperative, compared to the T group, where we recorded 276 \u00b1 109.2 mL during the surgical procedures and 353.44 \u00b1 101.55 mL after the surgery, (p &lt; 0.05). We also recorded significantly shorter operative room time for the NT group, (p &lt; 0.05). During the follow-up, we noticed postoperative improvements but without significant differences between the groups. Conclusions: We found a significant decrease in bleeding after no tourniquet usage during total knee replacements and shorter operative times. On the other hand, the knee function demonstrated no significant differences between the groups. Further studies may be required in order to assess complications.<\/jats:p>","DOI":"10.3390\/medicina59050870","type":"journal-article","created":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T13:54:46Z","timestamp":1682949286000},"page":"870","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The Impact of Tourniquet Usage on TKA Outcome: A Single-Center Prospective Trial"],"prefix":"10.3390","volume":"59","author":[{"given":"Serban","family":"Dragosloveanu","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, \u201cFoisor\u201d Orthopaedics Hospital, 030167 Bucharest, Romania"},{"name":"\u201cCarol Davila\u201d Faculty of Medicine, University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiana","family":"Dragosloveanu","sequence":"additional","affiliation":[{"name":"\u201cCarol Davila\u201d Faculty of Medicine, University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Clinical Hospital for Ophthalmological Emergencies, 030167 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihnea","family":"Petre","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, \u201cFoisor\u201d Orthopaedics Hospital, 030167 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2269-511X","authenticated-orcid":false,"given":"Mihai E.","family":"Gherghe","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, \u201cFoisor\u201d Orthopaedics Hospital, 030167 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragos C.","family":"Cotor","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, \u201cFoisor\u201d Orthopaedics Hospital, 030167 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1016\/S0140-6736(18)32344-4","article-title":"Knee replacement","volume":"392","author":"Price","year":"2018","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.3899\/jrheum.170990","article-title":"Rates of Total Joint Replacement in the United States: Future Projections to 2020\u20132040 Using the National Inpatient Sample","volume":"46","author":"Singh","year":"2019","journal-title":"J. Rheumatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1159\/000127950","article-title":"Early biochemical and hemodynamic changes after operation in a bloodless field","volume":"9","author":"Larsson","year":"1977","journal-title":"Eur. Surg. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1055\/s-0039-1681035","article-title":"Tourniquet Use in Total Knee Arthroplasty","volume":"32","author":"Arthur","year":"2019","journal-title":"J. Knee Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/s00776-014-0664-6","article-title":"Use of a tourniquet in total knee arthroplasty: A systematic review and meta-analysis of randomized controlled trials","volume":"20","author":"Jiang","year":"2015","journal-title":"J. Orthop. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1097\/CORR.0000000000000572","article-title":"Does Tourniquet Use in TKA Increase Postoperative Pain? A Systematic Review and Meta-analysis","volume":"477","author":"Hu","year":"2019","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"731","DOI":"10.3892\/etm.2021.10163","article-title":"Preclinical study analysis of massive magnesium alloy graft for calcaneal fractures","volume":"22","author":"Dragosloveanu","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s00264-013-2177-x","article-title":"The influence of a half-course tourniquet strategy on peri-operative blood loss and early functional recovery in primary total knee arthroplasty","volume":"38","author":"Chen","year":"2014","journal-title":"Int. Orthop."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1749-799X-9-13","article-title":"The effects of a tourniquet used in total knee arthroplasty: A meta-analysis","volume":"9","author":"Zhang","year":"2014","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s11999-015-4393-8","article-title":"Does tourniquet use in TKA affect recovery of lower extremity strength and function? A randomized trial","volume":"474","author":"Dennis","year":"2016","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1213\/01.ane.0000194875.05587.7e","article-title":"Anesthetic, patient, and surgical risk factors for neurologic complications after prolonged total tourniquet time during total knee arthroplasty","volume":"102","author":"Horlocker","year":"2006","journal-title":"Anesth. Analg."},{"key":"ref_12","unstructured":"Cristea, S., Predescu, V., Dragosloveanu, S., Cuculici, S., and Marandici, N. (2016). Arthroplasty\u2014A Comprehensive Review [Internet], InTechOpen."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s00167-014-3341-6","article-title":"Influence of the tourniquet on tibial cement mantle thickness in primary total knee arthroplasty","volume":"24","author":"Pfitzner","year":"2016","journal-title":"Knee Surg. Sports Traumatol. Arthrosc."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1016\/j.arth.2021.02.068","article-title":"Does the Use of a Tourniquet Influence Outcomes in Total Knee Arthroplasty: A Randomized Controlled Trial","volume":"36","author":"Zak","year":"2021","journal-title":"J. Arthroplast."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.arth.2011.04.046","article-title":"A comparison of outcomes with and without a tourniquet in total knee arthroplasty: A systematic review and meta-analysis of randomized controlled trials","volume":"27","author":"Alcelik","year":"2012","journal-title":"J. Arthroplast."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.knee.2009.06.007","article-title":"Is a tourniquet beneficial in total knee replacement surgery? A meta-analysis and systematic review","volume":"17","author":"Smith","year":"2010","journal-title":"Knee"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1007\/s00590-013-1278-y","article-title":"The effect of tourniquet use in total knee arthroplasty: Grading the evidence through an updated meta-analysis of randomized, controlled trials","volume":"24","author":"Li","year":"2014","journal-title":"Eur. J. Orthop. Surg. Traumatol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.2106\/JBJS.19.00146","article-title":"Tourniquet Use Does Not Affect Functional Outcomes or Pain After Total Knee Arthroplasty: A Prospective, Double-Blinded, Randomized Controlled Trial","volume":"101","author":"Goel","year":"2019","journal-title":"J. Bone Joint. Surg. Am."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1007\/s00167-015-3859-2","article-title":"Tourniquet-induced ischaemia during total knee arthroplasty results in higher proteolytic activities within vastus medialis cells: A randomized clinical trial","volume":"24","author":"Jawhar","year":"2016","journal-title":"Knee Surg. Sports Traumatol. Arthrosc."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/s00068-015-0600-2","article-title":"Effect of limited ischemia time on the amount and function of mitochondria within human skeletal muscle cells","volume":"42","author":"Jawhar","year":"2016","journal-title":"Eur. J. Trauma Emerg. Surg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/j.1399-6576.2005.00621.x","article-title":"Changes in coagulation-fibrinolysis marker and neutrophil elastase following the use of tourniquet during total knee arthroplasty and the influence of neutrophil elastase on thromboembolism","volume":"49","author":"Katsumata","year":"2005","journal-title":"Acta Anaesthesiol. Scand."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1007\/s00402-002-0404-9","article-title":"Comparative study between thromboembolism and total knee arthroplasty with or without tourniquet in rheumatoid arthritis patients","volume":"122","author":"Wauke","year":"2002","journal-title":"Arch. Orthop. Trauma Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.artd.2018.02.014","article-title":"What are the incidence and risk factors of in-hospital mortality after venous thromboembolism events in total hip and knee arthroplasty patients?","volume":"4","author":"Shahi","year":"2018","journal-title":"Arthroplast. Today"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.knee.2010.03.006","article-title":"The prevalence of cognitive dysfunction after conventional and computer-assisted total knee replacement","volume":"18","author":"Deo","year":"2011","journal-title":"Knee"},{"key":"ref_25","first-page":"416","article-title":"Tourniquet-induced rhabdomyolysis after total knee replacement","volume":"76","author":"Palmer","year":"1994","journal-title":"Ann. R. Coll. Surg. Engl."},{"key":"ref_26","first-page":"211","article-title":"Vascular injuries in total knee arthroplasty. A review of the problem with special reference to the possible effects of the tourniquet","volume":"13","author":"Kumar","year":"1998","journal-title":"J. Arthroplast."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"W11","DOI":"10.1308\/147870805X60761","article-title":"Subcutaneous thigh fat necrosis as a result of tourniquet control during total knee arthroplasty","volume":"87","author":"Tamvakopoulos","year":"2005","journal-title":"Ann. R. Coll. Surg. Engl."},{"key":"ref_28","unstructured":"(2022, November 01). WOMAC Osteoarthritis Index. Available online: https:\/\/www.physiopedia.com\/WOMAC_Osteoarthritis_Index."},{"key":"ref_29","first-page":"461","article-title":"Painful knee prosthesis: CT scan to assess patellar angle and implant malrotation","volume":"4","author":"Spinarelli","year":"2016","journal-title":"Muscles Ligaments Tendons J."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Stoica, C.I., Nedelea, G., Cotor, D.C., Gherghe, M., Georgescu, D.E., Dragosloveanu, C., and Dragosloveanu, S. (2022). The Outcome of Total Knee Arthroplasty for Patients with Psychiatric Disorders: A Single Center Retrospective Study. Medicina, 58.","DOI":"10.3390\/medicina58091277"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1007\/s00167-015-3872-5","article-title":"Comparison of quadriceps muscle volume after unilateral total knee arthroplasty with and without tourniquet use","volume":"24","author":"Guler","year":"2016","journal-title":"Knee Surg. Sports Traumatol. Arthrosc."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1007\/s00167-019-05646-5","article-title":"No effect of tourniquet in primary total knee arthroplasty on muscle strength, functional outcome, patient satisfaction and health status: A randomized clinical trial","volume":"28","author":"Jawhar","year":"2020","journal-title":"Knee Surg. Sports Traumatol. Arthrosc."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"422","DOI":"10.3109\/17453674.2014.931197","article-title":"Faster recovery without the use of a tourniquet in total knee arthroplasty","volume":"85","author":"Ejaz","year":"2014","journal-title":"Acta Orthop."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"302","DOI":"10.47102\/annals-acadmedsg.V44N8p302","article-title":"Does limited tourniquet usage in primary total knee arthroplasty result in better functional outcomes?","volume":"44","author":"Singh","year":"2015","journal-title":"Ann. Acad. Med. Singapore"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.2106\/JBJS.16.01525","article-title":"Intravenous and topical tranexamic acid alone are superior to tourniquet use for primary total knee arthroplasty: A prospective, randomized controlled trial","volume":"99","author":"Huang","year":"2017","journal-title":"J. Bone Joint. Surg. Am."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.2106\/JBJS.K.00813","article-title":"Effects of tourniquet use on blood loss and soft-tissue damage in total knee arthroplasty: A randomized controlled trial","volume":"94","author":"Tai","year":"2012","journal-title":"J. Bone Joint. Surg. Am."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.artd.2022.08.010","article-title":"Efficacy of Tourniquet Use in Total Knee Arthroplasty: A Retrospective Cohort Review","volume":"17","author":"Riggle","year":"2022","journal-title":"Arthroplast Today"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"216","DOI":"10.3892\/etm.2020.9346","article-title":"A new perspective towards failure of gamma nail systems","volume":"20","author":"Dragosloveanu","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.2106\/JBJS.16.00750","article-title":"Use of a tourniquet in total knee arthroplasty causes a paradoxical increase in total blood loss","volume":"99","author":"Schnettler","year":"2017","journal-title":"J. Bone Joint. Surg. Am."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1186\/s13018-019-1422-4","article-title":"The effects of tourniquet use on blood loss in primary total knee arthroplasty for patients with osteoarthritis: A meta-analysis","volume":"14","author":"Cai","year":"2019","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1007\/s00167-019-05617-w","article-title":"More pain and slower functional recovery when a tourniquet is used during total knee arthroplasty","volume":"28","author":"Liu","year":"2020","journal-title":"Knee Surg. Sports Traumatol. Arthrosc."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1302\/0301-620X.103B.BJJ-2020-1926.R1","article-title":"Time to reconsider the routine use of tourniquets in total knee arthroplasty surgery","volume":"103","author":"Ahmed","year":"2021","journal-title":"Bone Joint. J."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"25e34","DOI":"10.1177\/074880680502200104","article-title":"A study of time-dependent operating room fees and how to save $100 000 by using time-saving products","volume":"22","author":"Shippert","year":"2005","journal-title":"Am. J. Cosmet. Surg."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e176233","DOI":"10.1001\/jamasurg.2017.6233","article-title":"Understanding costs of care in the operating room","volume":"153","author":"Childers","year":"2018","journal-title":"JAMA Surg."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"u219831","DOI":"10.1136\/bmjquality.u219831.w8131","article-title":"Improving theatre turnaround time","volume":"6","author":"Fletcher","year":"2017","journal-title":"BMJ Qual. Improv. Rep."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e642","DOI":"10.3928\/01477447-20160606-03","article-title":"Effects of tourniquet release on total knee arthroplasty","volume":"39","author":"Tie","year":"2016","journal-title":"Orthopedics"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.arth.2016.10.019","article-title":"Patient and perioperative variables affecting 30-day readmission for surgical complications after hip and knee arthroplasties: A matched cohort study","volume":"32","author":"Ricciardi","year":"2017","journal-title":"J. Arthroplast."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3547","DOI":"10.1007\/s10792-020-01544-9","article-title":"Comparison of 360 degrees circumferential trabeculotomy and conventional trabeculotomy in primary pediatric glaucoma surgery: Complications, reinterventions and preoperative predictive risk factors","volume":"40","author":"Dragosloveanu","year":"2020","journal-title":"Int. Ophtalmol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1016\/j.arth.2020.12.049","article-title":"Effect of Different Tourniquet Pressure on Postoperative Pain and Complications After Total Knee Arthroplasty: A Prospective, Randomized Controlled Trial","volume":"36","author":"Pinsornsak","year":"2021","journal-title":"J. Arthroplast."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/S0883-5403(97)90153-4","article-title":"Thigh pain following tourniquet application in simultaneous bilateral total knee replacement arthroplasty","volume":"12","author":"Worland","year":"1997","journal-title":"J. Arthroplast."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/5\/870\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:27:04Z","timestamp":1760124424000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/5\/870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,30]]},"references-count":50,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["medicina59050870"],"URL":"https:\/\/doi.org\/10.3390\/medicina59050870","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,30]]}}}