{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T15:34:41Z","timestamp":1772638481495,"version":"3.50.1"},"reference-count":38,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T00:00:00Z","timestamp":1683763200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Dong-A University research fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives. Swallowing and coughing reflexes are both closely associated with airway protection. Peak cough flow (PCF) is associated with dysphagia in several neurogenic diseases. In this study, we aimed to analyze the relationship between PCF and aspiration in Parkinson\u2019s disease (PD) and determine the cut-off value of PCF. Materials and Methods. We retrospectively analyzed the records of patients with PD who underwent a videofluoroscopic swallowing study and checked for PCF. A total of 219 patients were divided into an aspiration group (n = 125) and a non-aspiration group (n = 94). Results. Significantly lower PCF values were observed in the aspiration group compared to the non-aspiration group (132.63 \u00b1 83.62 vs. 181.38 \u00b1 103.92 L\/min, p &lt; 0.001). Receiver operating characteristic curve analysis revealed that a PCF cut-off value of 153 L\/min (area under the receiver operating characteristic curve, 0.648; sensitivity, 73.06%; specificity, 51.06%) was associated with aspiration in PD. Additionally, a univariate analysis showed that the male sex, lower body mass indexes, higher Hoehn and Yahr scales, and PCF values of \u2264153 L\/min indicated an increased risk of aspiration. Conclusions. Through a multivariate analysis, we demonstrated that a PCF value \u2264153 L\/min was associated with an increased risk of aspiration (odds ratio 3.648; 1.797\u20137.407), highlighting that a low PCF is a risk factor for aspiration in patients with PD.<\/jats:p>","DOI":"10.3390\/medicina59050921","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T04:29:01Z","timestamp":1683779341000},"page":"921","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Cut-Off Value of Voluntary Peak Cough Flow in Patients with Parkinson\u2019s Disease and Its Association with Severe Dysphagia: A Retrospective Pilot Study"],"prefix":"10.3390","volume":"59","author":[{"given":"Kyeong-Woo","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, College of Medicine, Dong-A University, Busan 49201, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang-Beom","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, College of Medicine, Dong-A University, Busan 49201, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong-Hwa","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, College of Medicine, Dong-A University, Busan 49201, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong-Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, College of Medicine, Dong-A University, Busan 49201, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1002\/mds.21330","article-title":"Pattern of subclinical pulmonary dysfunctions in Parkinson\u2019s disease and the effect of levodopa","volume":"22","author":"Pal","year":"2007","journal-title":"Mov. Disord."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s00408-014-9584-7","article-title":"Sequential voluntary cough and aspiration or aspiration risk in Parkinson\u2019s disease","volume":"192","author":"Hegland","year":"2014","journal-title":"Lung"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1378\/chest.124.3.1009","article-title":"Impaired efficacy of cough in patients with Parkinson disease","volume":"124","author":"Ebihara","year":"2003","journal-title":"Chest"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.otc.2013.09.013","article-title":"Central neural circuits for coordination of swallowing, breathing, and coughing: Predictions from computational modeling and simulation","volume":"46","author":"Bolser","year":"2013","journal-title":"Otolaryngol. Clin. N. Am."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1590\/1678-775720140132","article-title":"A framework for understanding shared substrates of airway protection","volume":"22","author":"Troche","year":"2014","journal-title":"J. Appl. Oral Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1590\/S0004-28032010000100008","article-title":"Coordination of respiration and swallowing: Functional pattern and relevance of vocal folds closure","volume":"47","author":"Costa","year":"2010","journal-title":"Arq. Gastroenterol."},{"key":"ref_7","unstructured":"Eccles, R. (2009). Pharmacology and Therapeutics of Cough. Handbook of Experimental Pharmacology, Springer."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1152\/japplphysiol.01299.2011","article-title":"Volitional control of reflex cough","volume":"113","author":"Hegland","year":"2012","journal-title":"J. Appl. Physiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s00408-022-00533-2","article-title":"Abnormal Pulmonary Function in Early Parkinson\u2019s Disease: A Preliminary Prospective Observational Study","volume":"200","author":"Zhang","year":"2022","journal-title":"Lung"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"48S","DOI":"10.1378\/chest.129.1_suppl.48S","article-title":"Global physiology and pathophysiology of cough: ACCP evidence-based clinical practice guidelines","volume":"129","author":"McCool","year":"2006","journal-title":"Chest"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.resp.2006.02.016","article-title":"Cough motor mechanisms","volume":"152","author":"Fontana","year":"2006","journal-title":"Respir. Physiol. Neurobiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1007\/s00455-020-10097-z","article-title":"Handheld cough testing: A novel tool for cough assessment and dysphagia screening","volume":"35","author":"Curtis","year":"2020","journal-title":"Dysphagia"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1378\/chest.08-1389","article-title":"Impact of expiratory muscle strength training on voluntary cough and swallow function in Parkinson disease","volume":"135","author":"Pitts","year":"2009","journal-title":"Chest"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.apmr.2015.10.098","article-title":"Measurement of voluntary cough production and airway protection in Parkinson disease","volume":"97","author":"Silverman","year":"2016","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s00455-016-9734-6","article-title":"Reflex cough and disease duration as predictors of swallowing dysfunction in Parkinson\u2019s disease","volume":"31","author":"Troche","year":"2016","journal-title":"Dysphagia"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s00455-010-9317-x","article-title":"Self-reported dysphagia and its correlates within a prevalent population of people with Parkinson\u2019s disease","volume":"26","author":"Walker","year":"2011","journal-title":"Dysphagia"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1053\/gast.1996.v110.pm8566584","article-title":"Mechanisms of oral-pharyngeal dysphagia in patients with Parkinson\u2019s disease","volume":"110","author":"Ali","year":"1996","journal-title":"Gastroenterology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1080\/003655000750045677","article-title":"Effect of swallowing training on swallowing disorders in Parkinson\u2019s disease","volume":"32","author":"Nagaya","year":"2000","journal-title":"Scand. J. Rehabil. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1136\/jnnp.2007.131045","article-title":"Parkinson\u2019s disease: Clinical features and diagnosis","volume":"79","author":"Jankovic","year":"2008","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/PL00009512","article-title":"Pharyngo-esophageal dysphagia in Parkinson\u2019s disease","volume":"12","author":"Leopold","year":"1997","journal-title":"Dysphagia"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.parkreldis.2017.05.024","article-title":"Non-invasive assessment determine the swallowing and respiration dysfunction in early Parkinson\u2019s disease","volume":"42","author":"Wang","year":"2017","journal-title":"Park. Relat. Disord."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00408-013-9540-y","article-title":"Airway protective mechanisms","volume":"192","author":"Pitts","year":"2014","journal-title":"Lung"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"106740","DOI":"10.1016\/j.rmed.2022.106740","article-title":"The use of cough peak flow in the assessment of respiratory function in clinical practice\u2014A narrative literature review","volume":"193","author":"Brennan","year":"2022","journal-title":"Respir. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1378\/chest.10-0342","article-title":"Using voluntary cough to detect penetration and aspiration during oropharyngeal swallowing in patients with Parkinson disease","volume":"138","author":"Pitts","year":"2010","journal-title":"Chest"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1097\/00020840-199812000-00008","article-title":"The evaluation and treatment of swallowing disorders","volume":"6","author":"Logemann","year":"1998","journal-title":"Curr. Opin. Otolaryngol. Head Neck Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/BF00417897","article-title":"A penetration-aspiration scale","volume":"11","author":"Rosenbek","year":"1996","journal-title":"Dysphagia"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1378\/chest.13-0596","article-title":"Concordance and discriminatory power of cough measurement devices for individuals with Parkinson disease","volume":"145","author":"Silverman","year":"2014","journal-title":"Chest"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s00455-009-9245-9","article-title":"The Impact of Dysphagia on Quality of Life in Ageing and Parkinson\u2019s Disease as Measured by the Swallowing Quality of Life (SWAL-QOL) Questionnaire","volume":"25","author":"Leow","year":"2010","journal-title":"Dysphagia"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/mds.23301","article-title":"Silent Saliva Aspiration in Parkinson\u2019s Disease","volume":"26","author":"Rodrigues","year":"2011","journal-title":"Mov. Disord."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s00455-015-9671-9","article-title":"Dysphagia in Parkinson\u2019s disease","volume":"31","author":"Suttrup","year":"2016","journal-title":"Dysphagia"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1378\/chest.110.6.1566","article-title":"Criteria for extubation and tracheostomy tube removal for patients with ventilatory failure: A different approach to weaning","volume":"110","author":"Bach","year":"1996","journal-title":"Chest"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Han, Y.J., Lee, J., Sohn, D.G., Park, G.-Y., Kim, Y., Park, H.-Y., Jung, S.-A., and Im, S. (2020). Cut-off Values of the Respiratory Muscle Power and Peak Cough Flow in Post-Stroke Dysphagia. Medicina, 56.","DOI":"10.3390\/medicina56120635"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"9","DOI":"10.7888\/juoeh.35.9","article-title":"Differences in the peak cough flow among stroke patients with and without dysphagia","volume":"35","author":"Kimura","year":"2013","journal-title":"J. UOEH"},{"key":"ref_34","unstructured":"Mann, G. (2002). MASA: The Mann Assessment of Swallowing Ability, Singular\/Thomson Learning."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1016\/j.parkreldis.2014.09.031","article-title":"Swallowing disturbances in Parkinson\u2019s disease: A multivariate analysis of contributing factors","volume":"20","author":"Cereda","year":"2014","journal-title":"Park. Relat. Disord."},{"key":"ref_36","first-page":"1727","article-title":"Predictors of Pharyngeal Dysphagia in Patients with Parkinson\u2019s Disease","volume":"10","author":"Claus","year":"2020","journal-title":"J. Park. Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"130","DOI":"10.14802\/jmd.15031","article-title":"Gender differences in age-related striatal dopamine depletion in Parkinson\u2019s disease","volume":"8","author":"Lee","year":"2015","journal-title":"J. Mov. Disord."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1136\/jnnp.2006.103788","article-title":"Gender differences in Parkinson\u2019s disease","volume":"78","author":"Haaxma","year":"2007","journal-title":"J. Neurol. Neurosurg. Psychiatry"}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/5\/921\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:32:45Z","timestamp":1760124765000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/5\/921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,11]]},"references-count":38,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["medicina59050921"],"URL":"https:\/\/doi.org\/10.3390\/medicina59050921","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,11]]}}}