{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T01:55:03Z","timestamp":1769738103841,"version":"3.49.0"},"reference-count":39,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T00:00:00Z","timestamp":1683849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"R\u012bga Stradi\u0146\u0161 University (RSU)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Parkinson\u2019s disease (PD) is a chronic, progressive illness with a profound impact on health-related quality of life, and it is crucial to know what factors influence the quality of life throughout the course of the disease. This study aimed to evaluate PD patients\u2019 motor and non-motor symptoms to compare symptom severity between PD clinical phenotypes and to assess the impact of disease symptoms on quality of life in a cohort of Latvian patients. Materials and Methods: We evaluated 43 patients with Parkinson\u2019s disease. Fourteen patients had tremor dominant (TD) PD, twenty-five patients had postural instability\/gait difficulty (PIGD), and four patients had a mixed phenotype. Results: The patients\u2019 mean age was 65.21 years, and the disease\u2019s mean duration was 7 years. The most common non-motor symptoms were fatigue (95.3%), sleep disturbance (83.7%), daytime sleepiness (83.7%), and pain and other sensations (81.4%). PIGD patients had a higher prevalence of depressed mood, daytime sleepiness, constipation, lightheadedness on standing, cognitive impairment, and severe gastrointestinal and urinary disturbances (as assessed using the SCOPA-AUT domains) compared with TD patients. A high prevalence of fatigue was assessed in both disease subtypes. Health-related quality of life significantly statistically correlated with MDS-UPDRS parts III and IV (r = 0.704), the Hoehn and Yahr scale (r = 0.723), as well as the SCOPA-AUT scale\u2019s gastrointestinal (r = 0.639), cardiovascular (r = 0.586), thermoregulatory (r = 0.566) and pupillomotor domains (r = 0.597). Conclusions: The severity of motor symptoms, as well as non-motor symptoms, such as fatigue, apathy, sleep problems and daytime sleepiness, pain, and disturbances in gastrointestinal and cardiovascular function, negatively affect PD patients\u2019 health-related quality of life. Thermoregulatory and pupillomotor symptoms also significantly affect PD patients\u2019 well-being.<\/jats:p>","DOI":"10.3390\/medicina59050935","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T10:49:51Z","timestamp":1683888591000},"page":"935","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical Symptoms Influencing Parkinson\u2019s Patients\u2019 Quality of Life in Latvia: A Single-Center Cohort Study"],"prefix":"10.3390","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6074-0129","authenticated-orcid":false,"given":"Olga","family":"Minibajeva","sequence":"first","affiliation":[{"name":"Department of Doctoral Studies, R\u012bga Stradi\u0146\u0161 University, LV-1007 R\u012bga, Latvia"},{"name":"Department of Neurology and Neurosurgery, Riga East University Hospital, LV-1079 R\u012bga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estere","family":"Zelti\u0146a","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, R\u012bga Stradi\u0146\u0161 University, LV-1007 R\u012bga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9586-2775","authenticated-orcid":false,"given":"Guntis","family":"Karelis","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, Riga East University Hospital, LV-1079 R\u012bga, Latvia"},{"name":"Department of Infectology, R\u012bga Stradi\u0146\u0161 University, LV-1006 R\u012bga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nata\u013cja","family":"Kurj\u0101ne","sequence":"additional","affiliation":[{"name":"Department of Biology and Microbiology, R\u012bga Stradi\u0146\u0161 University, LV-1007 R\u012bga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktorija","family":"\u0136\u0113ni\u0146a","sequence":"additional","affiliation":[{"name":"Department of Biology and Microbiology, R\u012bga Stradi\u0146\u0161 University, LV-1007 R\u012bga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cger.2019.08.002","article-title":"Parkinson Disease Epidemiology, Pathology, Genetics, and Pathophysiology","volume":"36","author":"Simon","year":"2020","journal-title":"Clin. 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