{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:31:26Z","timestamp":1789144286280,"version":"build-2803163510"},"reference-count":73,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T00:00:00Z","timestamp":1683849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>The CD34 protein was identified almost four decades ago as a biomarker for hematopoietic stem cell progenitors. CD34 expression of these stem cells has been exploited for therapeutic purposes in various hematological disorders. In the last few decades, studies have revealed the presence of CD34 expression on other types of cells with non-hematopoietic origins, such as interstitial cells, endothelial cells, fibrocytes, and muscle satellite cells. Furthermore, CD34 expression may also be found on a variety of cancer stem cells. Nowadays, the molecular functions of this protein have been involved in a variety of cellular functions, such as enhancing proliferation and blocking cell differentiation, enhanced lymphocyte adhesion, and cell morphogenesis. Although a complete understanding of this transmembrane protein, including its developmental origins, its stem cell connections, and other functions, is yet to be achieved. In this paper, we aimed to carry out a systematic analysis of the structure, functions, and relationship with cancer stem cells of CD34 based on the literature overview.<\/jats:p>","DOI":"10.3390\/medicina59050938","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T10:49:51Z","timestamp":1683888591000},"page":"938","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["CD34\u2014Structure, Functions and Relationship with Cancer Stem Cells"],"prefix":"10.3390","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4006-5397","authenticated-orcid":false,"given":"Petru","family":"Radu","sequence":"first","affiliation":[{"name":"General Surgery Department, Carol Davila Nephrology Hospital Bucharest, 020021 Bucharest, Romania"},{"name":"Tenth Department of Surgery, University of Medicine and Pharmacy \u201cCarol Davila\u201d Bucharest, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2376-521X","authenticated-orcid":false,"given":"Mihai","family":"Zurzu","sequence":"additional","affiliation":[{"name":"General Surgery Department, Carol Davila Nephrology Hospital Bucharest, 020021 Bucharest, Romania"},{"name":"Tenth Department of Surgery, University of Medicine and Pharmacy \u201cCarol Davila\u201d Bucharest, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vlad","family":"Paic","sequence":"additional","affiliation":[{"name":"General Surgery Department, Carol Davila Nephrology Hospital Bucharest, 020021 Bucharest, Romania"},{"name":"Tenth Department of Surgery, University of Medicine and Pharmacy \u201cCarol Davila\u201d Bucharest, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mircea","family":"Bratucu","sequence":"additional","affiliation":[{"name":"General Surgery Department, Carol Davila Nephrology Hospital Bucharest, 020021 Bucharest, Romania"},{"name":"Tenth Department of Surgery, University of Medicine and Pharmacy \u201cCarol Davila\u201d Bucharest, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragos","family":"Garofil","sequence":"additional","affiliation":[{"name":"General Surgery Department, Carol Davila Nephrology Hospital Bucharest, 020021 Bucharest, Romania"},{"name":"Tenth Department of Surgery, University of Medicine and Pharmacy \u201cCarol Davila\u201d Bucharest, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5761-0617","authenticated-orcid":false,"given":"Anca","family":"Tigora","sequence":"additional","affiliation":[{"name":"General Surgery Department, Carol Davila Nephrology Hospital Bucharest, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin","family":"Georgescu","sequence":"additional","affiliation":[{"name":"General Surgery Department, Carol Davila Nephrology Hospital Bucharest, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5361-053X","authenticated-orcid":false,"given":"Virgiliu","family":"Prunoiu","sequence":"additional","affiliation":[{"name":"Tenth Department of Surgery, University of Medicine and Pharmacy \u201cCarol Davila\u201d Bucharest, 050474 Bucharest, Romania"},{"name":"Oncological Institute \u201cProf. Dr. Alexandru Trestioreanu\u201d, 022328 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costin","family":"Pasnicu","sequence":"additional","affiliation":[{"name":"General Surgery Department, Carol Davila Nephrology Hospital Bucharest, 020021 Bucharest, Romania"},{"name":"Tenth Department of Surgery, University of 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Craiova Emergency Clinical 7 Hospital, 200642 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Strambu","sequence":"additional","affiliation":[{"name":"General Surgery Department, Carol Davila Nephrology Hospital Bucharest, 020021 Bucharest, Romania"},{"name":"Tenth Department of Surgery, University of Medicine and Pharmacy \u201cCarol Davila\u201d Bucharest, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0145-2126(85)90016-5","article-title":"A novel monoclonal antibody BI-3C5 recognises myeloblasts and non-B non-T lymphoblasts in acute leukaemias and CGL blast crises, and reacts with immature cells in normal bone marrow","volume":"9","author":"Tindle","year":"1985","journal-title":"Leuk. 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