{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:47:48Z","timestamp":1791229668548,"version":"4.1.0"},"reference-count":94,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,5,14]],"date-time":"2023-05-14T00:00:00Z","timestamp":1684022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Both cutaneous melanoma (CM) and uveal melanoma (UM) represent important causes of morbidity and mortality. In this review, we evaluate the available knowledge on the differences and similarities between cutaneous melanoma and uveal melanoma, focusing on the epidemiological aspects and risk factors. Uveal melanoma is a rare condition but is the most prevalent primary intra-ocular malignant tumor in adults. Cutaneous melanoma, on the other hand, is significantly more common. While the frequency of cutaneous melanoma has increased in the last decades worldwide, the incidence of uveal melanoma has remained stable. Although both tumors arise from melanocytes, they are very distinct entities biologically, with complex and varied etiologies. Both conditions are encountered more frequently by individuals with a fair phenotype. ultraviolet-radiation is an important, well-documented risk factor for the development of CM, but has shown not to be of specific risk in UM. Although cutaneous and ocular melanomas seem to be inherited independently, there are reported cases of concomitant primary tumors in the same patient.<\/jats:p>","DOI":"10.3390\/medicina59050943","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T02:56:57Z","timestamp":1684119417000},"page":"943","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Differences and Similarities in Epidemiology and Risk Factors for Cutaneous and Uveal Melanoma"],"prefix":"10.3390","volume":"59","author":[{"given":"Daciana Elena","family":"Br\u0103ni\u0219teanu","sequence":"first","affiliation":[{"name":"Dermatology Department, \u2018Grigore T. Popa\u2019 University of Medicine and Pharmacy, 700115 Iasi, Romania"},{"name":"Railway Clinical Hospital, 700506 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2859-2066","authenticated-orcid":false,"given":"Elena","family":"Porumb-Andrese","sequence":"additional","affiliation":[{"name":"Dermatology Department, \u2018Grigore T. Popa\u2019 University of Medicine and Pharmacy, 700115 Iasi, Romania"},{"name":"Railway Clinical Hospital, 700506 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"St\u0103ric\u0103","sequence":"additional","affiliation":[{"name":"Dermatology Department, \u2018Grigore T. Popa\u2019 University of Medicine and Pharmacy, 700115 Iasi, Romania"},{"name":"Railway Clinical Hospital, 700506 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca Catalina","family":"Munteanu","sequence":"additional","affiliation":[{"name":"Dermatology Department, \u2018Grigore T. Popa\u2019 University of Medicine and Pharmacy, 700115 Iasi, Romania"},{"name":"Railway Clinical Hospital, 700506 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9838-836X","authenticated-orcid":false,"given":"Mihaela Paula","family":"Toader","sequence":"additional","affiliation":[{"name":"Railway Clinical Hospital, 700506 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihail","family":"Zemba","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, \u2018Carol Davila\u2019 University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0891-4857","authenticated-orcid":false,"given":"Vlad","family":"Porumb","sequence":"additional","affiliation":[{"name":"Department Surgery, \u2018Grigore T. 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Cell Melanoma Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1093\/oxfordjournals.bmb.a072986","article-title":"Pathology of ocular melanomas","volume":"51","author":"McCartney","year":"1995","journal-title":"Br. Med. Bull."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1056\/NEJM199107183250306","article-title":"Cutaneous melanoma","volume":"325","author":"Koh","year":"1991","journal-title":"N. Engl. J. Med."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"van der Kooij, M.K., Speetjens, F.M., van der Burg, S.H., and Kapiteijn, E. (2019). Uveal Versus Cutaneous Melanoma; Same Origin, Very Distinct Tumor Types. Cancers, 11.","DOI":"10.3390\/cancers11060845"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/j.1751-1097.2007.00226.x","article-title":"The protective role of melanin against UV damage in human skin","volume":"84","author":"Brenner","year":"2008","journal-title":"Photochem. Photobiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/1011-1344(92)85027-R","article-title":"Properties and function of the ocular melanin\u2014A photobiophysical view","volume":"12","author":"Sarna","year":"1992","journal-title":"J. Photochem. Photobiol. B"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1001\/archopht.124.1.54","article-title":"The association between host susceptibility factors and uveal melanoma\u2014A meta-analysis","volume":"124","author":"Weis","year":"2006","journal-title":"Arch. Ophthalmol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1001\/archderm.139.8.1067","article-title":"Ocular melanoma: A review and the relationship to cutaneous melanoma","volume":"139","author":"Hurst","year":"2003","journal-title":"Arch. Dermatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.3892\/etm.2021.10863","article-title":"Uveal melanoma diagnosis and current treatment options (Review)","volume":"22","author":"Branisteanu","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"ref_12","first-page":"45","article-title":"Cancer Incidence in Five Continents. Comparability and quality of data","volume":"120","author":"Parkin","year":"1992","journal-title":"IARC Sci. Publ."},{"key":"ref_13","first-page":"149","article-title":"Recent data on the epidemiology of malignant melanoma","volume":"2","author":"Elwood","year":"1975","journal-title":"Semin. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1093\/oxfordjournals.aje.a113706","article-title":"Mathematical modelling of malignant melanoma trends in Norway, 1953\u20131978","volume":"118","author":"Boyle","year":"1983","journal-title":"Am. J. Epidemio."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ejcsup.2013.07.012","article-title":"Melanoma epidemiology, biology and prognosis","volume":"11","author":"Ali","year":"2013","journal-title":"EJC Suppl."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1016\/j.ophtha.2011.01.040","article-title":"Uveal melanoma: Trends in incidence, treatment, and survival","volume":"118","author":"Singh","year":"2011","journal-title":"Ophthalmology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/eye.2016.275","article-title":"Uveal melanoma: Relatively rare but deadly cancer","volume":"31","author":"Kaliki","year":"2017","journal-title":"Eye"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1016\/j.ophtha.2007.01.032","article-title":"EUROCARE Working Group: Incidence of uveal melanoma in Europe","volume":"114","author":"Virgili","year":"2007","journal-title":"Ophthalmology"},{"key":"ref_19","unstructured":"Kyrgidis, A. (2017). Cutaneous Melanoma, Academic Press."},{"key":"ref_20","unstructured":"National Cancer Institute (2010). SEER Cancer Statistics Factsheets: Melanoma of the Skin."},{"key":"ref_21","unstructured":"CLARA (2011). EUCAN Cancer Factsheets, Canc\u00e9rop\u00f4le Lyon, Auvergne, Rhone-Alps (CLARA)."},{"key":"ref_22","unstructured":"ECIS-European Cancer Information System (2022, May 01). Measuring Cancer Burden and Its Time Trends across EUROPE. Available online: https:\/\/ecis.jrc.ec.europa.eu."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e2020033","DOI":"10.5826\/dpc.1003a33","article-title":"Melanoma epidemiology and early detection in Europe: Diversity and disparities","volume":"10","author":"Forsea","year":"2020","journal-title":"Dermatol. Pract. Concept."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"423","DOI":"10.2147\/CCID.S87645","article-title":"Melanoma risk perception and prevention behavior among African-Americans: The minority melanoma paradox","volume":"8","author":"Goldenberg","year":"2015","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.ajo.2005.05.034","article-title":"Population based incidence of uveal melanoma in various races and ethnic groups","volume":"140","author":"Hu","year":"2005","journal-title":"Am. J. Ophthalmol."},{"key":"ref_26","first-page":"1005","article-title":"Melanoma: Epidemiology, risk factors, pathogenesis, diagnosis and classification","volume":"28","author":"Rastrelli","year":"2014","journal-title":"In Vivo"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/s41598-020-73534-x","article-title":"Clinical features and survival outcomes of ocular melanoma in a multi ethnic Asian cohort","volume":"10","author":"Tan","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_28","first-page":"1071","article-title":"Cutaneous melanoma: From pathogenesis to therapy (Review)","volume":"52","author":"Leonardi","year":"2018","journal-title":"Int. J. Oncol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1034\/j.1600-0749.2003.00047.x","article-title":"Acquired melanocytic nevi as risk factor for melanoma development. A comprehensive review of epidemiological data","volume":"16","author":"Bauer","year":"2003","journal-title":"Pigment. Cell Res."},{"key":"ref_30","first-page":"1481","article-title":"Melanoma: Molecular pathogenesis and emerging target therapies (Review)","volume":"34","author":"Russo","year":"2009","journal-title":"Int. J. Oncol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1053\/j.seminoncol.2016.08.003","article-title":"Genetic predisposition to melanoma","volume":"43","author":"Hawkes","year":"2016","journal-title":"Semin. Oncol."},{"key":"ref_32","unstructured":"Fitzpatrick, T.B., Eisen, A.Z., Wolff, K., Freedberg, I.M., and Austen, K.F. (1993). Neoplasms: Malignant melanoma. Dermatology in General Medicine, McGraw-Hill. [4th ed.]."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"500","DOI":"10.4065\/81.4.500","article-title":"Cutaneous malignant melanoma","volume":"81","author":"Cummins","year":"2006","journal-title":"Mayo Clin. Proc."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1111\/j.1751-1097.2011.00970.x","article-title":"Melanocortin 1 receptor variants: Functional role and pigmentary associations","volume":"87","author":"Dessinioti","year":"2011","journal-title":"Photochem. Photobiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/oxfordjournals.aje.a117359","article-title":"Cutaneous melanoma in women, I: Exposure to sunlight, ability to tan, and other risk factors related to ultraviolet light","volume":"141","author":"Holly","year":"1995","journal-title":"Am. J. Epidemiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1093\/oxfordjournals.aje.a117360","article-title":"Cutaneous melanoma in women, II: Phenotypic characteristics and other host-related factors","volume":"141","author":"Holly","year":"1995","journal-title":"Am. J. Epidemiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1365-2133.1990.tb08238.x","article-title":"Malignant melanoma: Aetiological importance of individual pigmentation and sun exposure","volume":"122","author":"Beitner","year":"1990","journal-title":"Br. J. Dermatol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Porumb-Andrese, E., Scutariu, M.M., Luchian, I., Schreiner, T.G., M\u00e2r\u0163u, I., Porumb, V., Popa, C.G., Sandu, D., and Ursu, R.G. (2021). Molecular Profile of Skin Cancer. Appl. Sci., 11.","DOI":"10.3390\/app11199142"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/978-3-642-82641-2_3","article-title":"The causes of malignant melanoma: Results from the West Australian Lions Melanoma Research Project","volume":"102","author":"Holman","year":"1986","journal-title":"Recent Results Cancer Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1136\/bmj.288.6411.99","article-title":"Pigmentation and skin reaction to sun as risk factors for cutaneous melanoma: Western Canada Melanoma Study","volume":"288","author":"Elwood","year":"1984","journal-title":"BMJ"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/978-3-642-82641-2_5","article-title":"Epidemiology of malignant melanoma: Pigmentary traits, ultraviolet radiation, and the identification of high-risk populations","volume":"102","author":"Dubin","year":"1986","journal-title":"Recent Results Cancer Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1076\/0928-6586(200009)731-VFT159","article-title":"Ultraviolet light exposure as a risk factor for ocular melanoma in Queensland, Australia","volume":"7","author":"Pane","year":"2000","journal-title":"Ophthalmic Epidemiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1023\/A:1011271420974","article-title":"Occupational risk factors, ultraviolet radiation, and ocular melanoma: A case-control study in France","volume":"12","author":"Guenel","year":"2001","journal-title":"Cancer Causes Control."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1097\/00001648-200109000-00015","article-title":"Occupational sunlight exposure and cancer incidence among Swedish construction workers","volume":"12","author":"Hakansson","year":"2001","journal-title":"Epidemiology"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1002\/ijc.1281","article-title":"Eye color and cutaneous nevi predict risk of ocular melanoma in Australia","volume":"92","author":"Vajdic","year":"2001","journal-title":"Int. J. Cancer"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/ijc.10579","article-title":"Sun exposure predicts risk of ocular melanoma in Australia","volume":"101","author":"Vajdic","year":"2002","journal-title":"Int. J. Cancer"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"270","DOI":"10.5271\/sjweh.675","article-title":"Occupation as a risk factor for uveal melanoma in Germany","volume":"28","author":"Stang","year":"2002","journal-title":"Scand. J. Work Environ. Health"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1089\/jop.1992.8.35","article-title":"Quantitative determination of the melanin contents in ocular tissues from human blue and brown eyes","volume":"8","author":"Menon","year":"1992","journal-title":"J. Ocul. Pharmacol."},{"key":"ref_49","unstructured":"Shields, J.A., and Shields, C.L. (1992). Intraocular Tumors: A Text and Atlas, WB Saunders Co., Ltd."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1001\/archderm.139.3.282","article-title":"The transformation rate of moles (melanocytic nevi) into cutaneous melanoma: A population-based estimate","volume":"139","author":"Tsao","year":"2003","journal-title":"Arch. Dermatol."},{"key":"ref_51","first-page":"1230","article-title":"Ocular melanoma: An overview of the current status","volume":"6","author":"Jovanovic","year":"2013","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_52","unstructured":"Yanoff, M., and Fine, B.S. (2022). Ocular Pathology, Mosby. [5th ed.]."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/jid.1989.86","article-title":"Human melanocyte neoplasms and their etiologic relationship with sunlight","volume":"92","author":"Elder","year":"1989","journal-title":"J. Invest. Dermatol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1001\/archderm.139.12.1620","article-title":"Cutaneous melanomas associated with nevi","volume":"139","author":"Bevona","year":"2003","journal-title":"Arch. Dermatol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"458","DOI":"10.7326\/0003-4819-102-4-458","article-title":"High risk of malignant melanoma in melanoma prone families with dysplastic nevi","volume":"102","author":"Greene","year":"1985","journal-title":"Ann. Intern. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"518","DOI":"10.2340\/0001555571518524","article-title":"Common and dysplastic naevi as risk factors for cutaneous malignant melanoma in a Swedish population","volume":"71","author":"Augustsson","year":"1991","journal-title":"Acta Derm. Venereol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/1097-0142(19900715)66:2<387::AID-CNCR2820660232>3.0.CO;2-J","article-title":"Count of benign melanocytic nevi as a major indicator of risk for nonfamilial nodular and superficial spreading melanoma","volume":"66","author":"Grob","year":"1990","journal-title":"Cancer"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0190-9622(87)70230-8","article-title":"Number of melanocytic nevi as a major risk factor for malignant melanoma","volume":"17","author":"Holly","year":"1987","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/978-3-642-82641-2_14","article-title":"Epidemiology of intraocular melanoma","volume":"102","author":"Tucker","year":"1986","journal-title":"Recent Results Cancer Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1001\/jamaophthalmol.2013.129","article-title":"Association of ocular and oculodermal melanocytosis with the rate of uveal melanoma metastasis: Analysis of 7872 consecutive eyes","volume":"131","author":"Shields","year":"2013","journal-title":"JAMA Ophthalmol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1177\/1120672120906999","article-title":"Neurofibromatosis type 1 and melanoma of the iris arising from a dysplastic nevus: A rare yet casual association?","volume":"31","author":"Alessio","year":"2021","journal-title":"Eur. J. Ophthalmol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3390\/dermatopathology10010013","article-title":"Histopathological Diagnosis of Malignant Melanoma at the Dawn of 2023: Knowledge Gained and New Challenges","volume":"10","author":"Cazzato","year":"2023","journal-title":"Dermatopathology"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3390\/dermatopathology8030033","article-title":"Animal-Type Melanoma\/Pigmented Epithelioid Melanocytoma: History and Features of a Controversial Entity","volume":"8","author":"Cazzato","year":"2021","journal-title":"Dermatopathology"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"360136","DOI":"10.1155\/2010\/360136","article-title":"Genetics of uveal melanoma and cutaneous melanoma: Two of a kind?","volume":"2010","author":"Paridaens","year":"2010","journal-title":"Dermatol. Res. Pract."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"4467","DOI":"10.3892\/mmr.2016.5791","article-title":"Occupational exposure to carcinogens: Benzene, pesticides and fibers (Review)","volume":"14","author":"Falzone","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1289\/ehp.93101252","article-title":"Effect of intermittent exposure to sunlight on melanoma risk among indoor workers and sun-sensitive individuals","volume":"101","author":"Nelemans","year":"1993","journal-title":"Environ. Health Perspect."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/(SICI)1097-0215(19971009)73:2<198::AID-IJC6>3.0.CO;2-R","article-title":"Melanoma and sun exposure: An overview of published studies","volume":"73","author":"Elwood","year":"1997","journal-title":"Int. J. Cancer"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1023\/A:1018440801577","article-title":"Sunlight and cancer","volume":"8","author":"English","year":"1997","journal-title":"Cancer Causes Control."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1056\/NEJM199904293401707","article-title":"Mechanisms of disease: The pathogenesis of melanoma induced by ultraviolet radiation","volume":"340","author":"Gilchrest","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_70","first-page":"291","article-title":"Association of surface ultraviolet B radiation levels with melanoma and nonmelanoma skin cancer in United States blacks","volume":"9","author":"Pennello","year":"2000","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.3892\/or.2014.2977","article-title":"Analysis of the B-RafV600E mutation in cutaneous melanoma patients with occupational sun exposure","volume":"31","author":"Candido","year":"2014","journal-title":"Oncol. Rep."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ejca.2004.10.016","article-title":"Meta-analysis of risk factors for cutaneous melanoma: II. Sun exposure","volume":"41","author":"Gandini","year":"2005","journal-title":"Eur. J. Cancer"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0039-6257(88)90173-7","article-title":"Epidemiologic aspects of uveal melanoma","volume":"32","author":"Egan","year":"1988","journal-title":"Surv. Ophthalmol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/00008390-200506000-00012","article-title":"Cutaneous, ocular and visceral melanoma in African Americans and Caucasians","volume":"15","author":"Tsai","year":"2005","journal-title":"Melanoma Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.ophtha.2008.09.040","article-title":"Positive interaction between light iris color and ultraviolet radiation in relation to the risk of uveal melanoma: A case-control study","volume":"116","author":"Bornfeld","year":"2009","journal-title":"Ophthalmology"},{"key":"ref_76","unstructured":"Shields, J.A., and Shields, S.C. (2007). Intraocular Tumors: An Atlas and Textbook, Lippincott Williams & Wilkins. [2nd ed.]."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"De Lange, M.J., Razzaq, L., Versluis, M., Verlinde, S., Dogrus\u00f6z, M., B\u00f6hringer, S., Marinkovic, M., Luyten, G.P., De Keizer, R.J., and De Gruijl, F.R. (2015). Distribution of GNAQ and GNA11 mutation signatures in uveal melanoma points to a light dependent mutation mechanism. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0138002"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/j.ophtha.2005.04.020","article-title":"Intermittent and chronic ultraviolet light exposure and uveal melanoma: A meta analysis","volume":"112","author":"Shah","year":"2005","journal-title":"Ophthalmology"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/nature11624","article-title":"An ultravioletradiation-independent pathway to melanoma arcinogenesis in the red hair\/fair skin background","volume":"491","author":"Mitra","year":"2012","journal-title":"Nature"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0002-9394(14)77792-X","article-title":"The familial occurrence of cutaneous melanoma, intraocular melanoma, and the dysplastic nevus syndrome","volume":"96","author":"Greene","year":"1983","journal-title":"Am. J. Ophthalmol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1001\/archderm.1988.01670080019010","article-title":"The dysplastic nevus syndrome","volume":"124","author":"Clark","year":"1988","journal-title":"Arch. Dermatol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0190-9622(90)70010-F","article-title":"Dysplastic melanocytic nevi and cutaneous melanoma: Markers of increased melanoma risk for affected persons and blood relatives","volume":"22","author":"Albert","year":"1990","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1469-1809.1986.tb01046.x","article-title":"Clinical and genetic studies in six Dutch kindreds with the dysplastic naevus syndrome","volume":"50","author":"Bergman","year":"1986","journal-title":"Ann. Hum. Genet."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1001\/archderm.1978.01640170032006","article-title":"Origin of familial malignant melanomas from heritable melanocytic lesions: The B-K mole syndrome","volume":"114","author":"Clark","year":"1978","journal-title":"Arch. Dermatol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1001\/archderm.1991.01680080082006","article-title":"Dysplastic nevi: Occurrence in first- and second-degree relatives of patients with sporadic dysplastic nevus syndrome","volume":"127","author":"Crijns","year":"1991","journal-title":"Arch. Dermatol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/1097-0142(196801)21:1<119::AID-CNCR2820210118>3.0.CO;2-W","article-title":"Heredity and intraocular malignant melanoma. Study of two families and review of forty-five cases","volume":"21","author":"Lynch","year":"1968","journal-title":"Cancer"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/bjc.1981.225","article-title":"Tumor spectrum in the FAMMM syndrome","volume":"44","author":"Lynch","year":"1981","journal-title":"Br. J. Cancer"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1006\/scbi.2000.0149","article-title":"Hereditary cutaneous melanoma","volume":"10","author":"Platz","year":"2000","journal-title":"Semin. Cancer Biol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.ophtha.2006.08.041","article-title":"Genetic study of familial uveal melanoma: Association of uveal and cutaneous melanoma with cutaneous and ocular nevi","volume":"114","author":"Smith","year":"2007","journal-title":"Ophthalmology"},{"key":"ref_90","unstructured":"American Society of Clinical Oncology (2023, March 01). Eye Melanoma\u2014Statistics. Available online: https:\/\/www.cancer.net\/cancer-types\/eye-melanoma\/statistics."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"3000605221106706","DOI":"10.1177\/03000605221106706","article-title":"Cutaneous melanoma incidence, mortality, and survival in Manizales, Colombia: A population-based study","volume":"50","year":"2022","journal-title":"J. Int. Med. Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1002\/cam4.1152","article-title":"Survival of cutaneous melanoma based on sex, age, and stage in the United States, 1992\u20132011","volume":"6","author":"Enninga","year":"2017","journal-title":"Cancer Med."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Dika, E., Patrizi, A., Lambertini, M., Manuelpillai, N., Fiorentino, M., Altimari, A., Ferracin, M., Lauriola, M., Fabbri, E., and Campione, E. (2019). Estrogen Receptors and Melanoma: A Review. Cells, 8.","DOI":"10.3390\/cells8111463"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"6700","DOI":"10.1002\/cam4.5458","article-title":"Sex-based differences in early and late uveal melanoma-related mortality","volume":"12","year":"2023","journal-title":"Cancer Med."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/5\/943\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:34:37Z","timestamp":1760124877000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/5\/943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,14]]},"references-count":94,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["medicina59050943"],"URL":"https:\/\/doi.org\/10.3390\/medicina59050943","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,14]]}}}