{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:10:23Z","timestamp":1760148623250,"version":"build-2065373602"},"reference-count":34,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T00:00:00Z","timestamp":1684195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Acquired von Willebrand factor deficiency has been described in patients with aortic valve stenosis due to high shear forces developed during passage through the narrowed valve orifice, which determines structural changes in this molecule. Similar flow conditions are present in patients with an aortic prosthesis that presents a patient-prosthesis mismatch. Patient-prosthesis mismatch is described by the smaller effective orifice area of the prosthesis than the native valve, which would probably determine similar changes in the molecules of the von Willebrand factor, leading to acquiring von Willebrand deficiency.<\/jats:p>","DOI":"10.3390\/medicina59050954","type":"journal-article","created":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T02:37:51Z","timestamp":1684204671000},"page":"954","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Acquired Von Willebrand Factor Deficiency at Patient-Prosthesis Mismatch after AVR Procedure\u2014A Narrative Review"],"prefix":"10.3390","volume":"59","author":[{"given":"Andrei Emanuel","family":"Grigorescu","sequence":"first","affiliation":[{"name":"Department of Cardiology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"},{"name":"Research Center of the Institute of Cardiovascular and Heart Disease of Timisoara, 300310 Timisoara, Romania"},{"name":"Division of Cardiovascular Surgery, Institute for Cardiovascular Diseases, 300391 Timisoara, Romania"},{"name":"Doctoral School Medicine\u2014Pharmacy, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei","family":"Anghel","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darius Gheorghe","family":"Buriman","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery, Institute for Cardiovascular Diseases, 300391 Timisoara, Romania"},{"name":"Doctoral School Medicine\u2014Pharmacy, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"},{"name":"Center for Translational Research and Systems Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4870-8249","authenticated-orcid":false,"given":"Horea","family":"Feier","sequence":"additional","affiliation":[{"name":"Department of Cardiology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"},{"name":"Research Center of the Institute of Cardiovascular and Heart Disease of Timisoara, 300310 Timisoara, Romania"},{"name":"Division of Cardiovascular Surgery, Institute for Cardiovascular Diseases, 300391 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,16]]},"reference":[{"key":"ref_1","unstructured":"Baumgartner, H., Camm, A.J., L\u00fcscher, T.F., Maurer, G., and Serruys, P.W. 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