{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:26:16Z","timestamp":1768004776533,"version":"3.49.0"},"reference-count":28,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T00:00:00Z","timestamp":1685664000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Purpose: Cystic echinococcosis (CE) is a common, complex parasitic disease that constitutes a major public health concern. CE demonstrates high endemicity in areas where dogs are used for herding or where animal husbandry practices involve close contact with livestock. It can clinically manifest with a variety of signs and symptoms, such as cholangitis, jaundice, pancreatitis, external biliary fistula, inferior vena cava obstruction, portal hypertension, and superinfection. The latter can notably be related to suppuration, either by rupture or bacteremia. The aim of this study is to report our 76-year-old patient who presented with a primarily infected giant-suppurated hydatid cyst of the liver and its surgical management. Methods: In this case, the diagnosis was based primarily on clinical presentation, computed tomography (CT) scan, and magnetic resonance imaging (MRI) of the patient\u2019s abdomen. The surgical procedure of choice was the partial retaining of the pericystic membrane and drainage of the cystic contents (partial pericystectomy). Results: The surgical management and meticulous long-term follow-up of our patient produced a positive outcome without any post-operative complications.<\/jats:p>","DOI":"10.3390\/medicina59061070","type":"journal-article","created":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T01:33:54Z","timestamp":1685669634000},"page":"1070","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Giant Echinococcosis of the Liver with Suppuration: A Case Report and Review of the Literature"],"prefix":"10.3390","volume":"59","author":[{"given":"Christoforos S.","family":"Kosmidis","sequence":"first","affiliation":[{"name":"European Interbalkan Medical Center, 10 Asklipiou Street, 55535 Pylaia, Greece"},{"name":"3rd Surgical Department, University General Hospital of Thessaloniki \u201cAHEPA\u201d, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 1st St. Kiriakidi Street, 54621 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"3rd Surgical Department, University General Hospital of Thessaloniki \u201cAHEPA\u201d, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 1st St. Kiriakidi Street, 54621 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6674-7500","authenticated-orcid":false,"given":"Chrysi Maria","family":"Mystakidou","sequence":"additional","affiliation":[{"name":"Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9869-7835","authenticated-orcid":false,"given":"Christina","family":"Sevva","sequence":"additional","affiliation":[{"name":"3rd Surgical Department, University General Hospital of Thessaloniki \u201cAHEPA\u201d, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 1st St. Kiriakidi Street, 54621 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charilaos","family":"Koulouris","sequence":"additional","affiliation":[{"name":"European Interbalkan Medical Center, 10 Asklipiou Street, 55535 Pylaia, Greece"},{"name":"3rd Surgical Department, University General Hospital of Thessaloniki \u201cAHEPA\u201d, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 1st St. Kiriakidi Street, 54621 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5849-5515","authenticated-orcid":false,"given":"Nikolaos","family":"Varsamis","sequence":"additional","affiliation":[{"name":"European Interbalkan Medical Center, 10 Asklipiou Street, 55535 Pylaia, Greece"},{"name":"3rd Surgical Department, University General Hospital of Thessaloniki \u201cAHEPA\u201d, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 1st St. Kiriakidi Street, 54621 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stylianos","family":"Mantalovas","sequence":"additional","affiliation":[{"name":"3rd Surgical Department, University General Hospital of Thessaloniki \u201cAHEPA\u201d, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 1st St. Kiriakidi Street, 54621 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2366-3283","authenticated-orcid":false,"given":"Vasileios","family":"Lagopoulos","sequence":"additional","affiliation":[{"name":"3rd Surgical Department, University General Hospital of Thessaloniki \u201cAHEPA\u201d, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 1st St. Kiriakidi Street, 54621 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasiliki","family":"Magra","sequence":"additional","affiliation":[{"name":"3rd Surgical Department, University General Hospital of Thessaloniki \u201cAHEPA\u201d, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 1st St. Kiriakidi Street, 54621 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasiliki","family":"Theodorou","sequence":"additional","affiliation":[{"name":"Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Styliani","family":"Ouzouni","sequence":"additional","affiliation":[{"name":"Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos","family":"Iason Katsios","sequence":"additional","affiliation":[{"name":"Medical School, Faculty of Health Sciences, University of Ioannina, 45110 Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paraskevi","family":"Axi","sequence":"additional","affiliation":[{"name":"3rd Surgical Department, University General Hospital of Thessaloniki \u201cAHEPA\u201d, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 1st St. Kiriakidi Street, 54621 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2050-8392","authenticated-orcid":false,"given":"Konstantinos","family":"Sapalidis","sequence":"additional","affiliation":[{"name":"3rd Surgical Department, University General Hospital of Thessaloniki \u201cAHEPA\u201d, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 1st St. Kiriakidi Street, 54621 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaak","family":"Kesisoglou","sequence":"additional","affiliation":[{"name":"3rd Surgical Department, University General Hospital of Thessaloniki \u201cAHEPA\u201d, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 1st St. Kiriakidi Street, 54621 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,2]]},"reference":[{"key":"ref_1","first-page":"210","article-title":"The liver involvement of the hydatid disease: A systematic review designed for the hepato-gastroenterologist","volume":"76","author":"Touma","year":"2013","journal-title":"Acta Gastro-Enterol. Belg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"524","DOI":"10.4269\/ajtmh.2002.67.524","article-title":"Hepatic hydatid cysts with superinfection in a non-endemic area in Taiwan","volume":"67","author":"Chen","year":"2002","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/s00423-003-0397-z","article-title":"Echinococcus granulosus infection: The challenge of surgical treatment","volume":"388","author":"Buttenschoen","year":"2003","journal-title":"Langenbeck\u2019s Arch. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"376","DOI":"10.4269\/ajtmh.2010.09-0375","article-title":"Primary super-infection of hydatid cyst-clinical setting and microbiology in 37 cases","volume":"82","author":"Tirado","year":"2010","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1080\/13651820701854669","article-title":"Forty-four years\u2019 experience (1963\u20132006) in the management of primarily infected hydatid cyst of the liver","volume":"10","author":"Prousalidis","year":"2008","journal-title":"Int. Hepato Pancreato Biliary Assoc."},{"key":"ref_6","first-page":"92","article-title":"Pelvic and retroperitoneal hydatid cysts superinfected with Brucella sp. and review of infected hydatid cysts","volume":"30","author":"Arslan","year":"2013","journal-title":"Trop. Biomed."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S1473-3099(07)70134-2","article-title":"Prevention and control of cystic echinococcosis","volume":"7","author":"Craig","year":"2007","journal-title":"Lancet Infect. Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s00261-016-0860-2","article-title":"Hepatic hydatid disease complications: Review of imaging findings and clinical implications","volume":"42","author":"Alghofaily","year":"2017","journal-title":"Abdom. Radiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S1995-7645(12)60035-2","article-title":"Human cystic echinococcosis: Epidemiologic, zoonotic, clinical, diagnostic and therapeutic aspects","volume":"5","author":"Mandal","year":"2012","journal-title":"Asian Pac. J. Trop. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.3748\/wjg.v18.i13.1425","article-title":"Worldwide epidemiology of liver hydatidosis including the Mediterranean area","volume":"18","author":"Grosso","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e00075-18","DOI":"10.1128\/CMR.00075-18","article-title":"Echinococcosis: Advances in the 21st Century","volume":"32","author":"Wen","year":"2019","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1128\/JCM.02420-15","article-title":"Cystic Echinococcosis","volume":"54","author":"Brunetti","year":"2016","journal-title":"J. Clin. Microbiol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Otero-Abad, B., and Torgerson, P.R. (2013). A systematic review of the epidemiology of echinococcosis in domestic and wild animals. PLoS Negl. Trop. Dis., 7.","DOI":"10.1371\/journal.pntd.0002249"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.cegh.2019.12.011","article-title":"Epidemiology and clinical features of human cystic echinococcosis in adults from an endemic area (Morocco)","volume":"8","author":"Amahmid","year":"2020","journal-title":"Clin. Epidemiol. Glob. Health"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/S0140-6736(03)14573-4","article-title":"Echinococcosis","volume":"362","author":"McManus","year":"2003","journal-title":"Lancet"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"145","DOI":"10.4103\/RID.RID_46_22","article-title":"Intrabiliary rupture of hepatic echinococcosis","volume":"9","author":"Farooq","year":"2022","journal-title":"Radiol. Infect. Dis."},{"key":"ref_17","first-page":"428205","article-title":"Serological Diagnosis and Follow-Up of Human Cystic Echinococcosis: A New Hope for the Future?","volume":"2015","author":"Casulli","year":"2015","journal-title":"BioMed Res. Int."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ijid.2008.03.037","article-title":"Echinococcosis: A review. International journal of infectious diseases","volume":"13","author":"Moro","year":"2009","journal-title":"Int. Soc. Infect. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.4254\/wjh.v8.i28.1169","article-title":"Current status of diagnosis and treatment of hepatic echinococcosis","volume":"8","author":"Mihmanli","year":"2016","journal-title":"World J. Hepatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13244-019-0805-8","article-title":"Complications of hepatic echinococcosis: Multimodality imaging approach","volume":"10","author":"Greco","year":"2019","journal-title":"Insights Into Imaging."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"447","DOI":"10.4103\/2141-9248.133476","article-title":"Uncommon locations and presentations of hydatid cyst","volume":"4","author":"Sachar","year":"2014","journal-title":"Ann. Med. Health Sci. Res."},{"key":"ref_22","first-page":"180","article-title":"Uncommon localizations of hydatid cyst","volume":"37","author":"Salamone","year":"2016","journal-title":"Rev. Lit. Il G. Di Chir."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"633","DOI":"10.4254\/wjh.v7.i3.633","article-title":"Unusual presentation of severely disseminated and rapidly progressive hydatic cyst: Malignant hydatidosis","volume":"7","author":"Hammami","year":"2015","journal-title":"World J. Hepatol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"103","DOI":"10.32947\/ajps.v13i2.208","article-title":"A Study of Some Biochemical Changes in Hydatid Cyst Patients Before And After Surgical removal of hydatid cyst","volume":"13","author":"Sura","year":"2013","journal-title":"l Mustansiriyah J. Pharm. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.4314\/ahs.v19i3.17","article-title":"Evaluation of clinical, diagnostic and treatment aspects in hydatid disease: Analysis of an 8-year experience","volume":"19","author":"Sen","year":"2019","journal-title":"Afr. Health Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"208","DOI":"10.14701\/ahbps.2018.22.3.208","article-title":"Surgical approaches to hepatic hydatidosis ranging from partial cystectomy to liver transplantation","volume":"22","author":"Goja","year":"2018","journal-title":"Ann. Hepato-Biliary-Pancreat. Surg."},{"key":"ref_27","first-page":"15","article-title":"Postoperative recurrence of cystic hydatidosis. Canadian journal of surgery","volume":"55","author":"Prousalidis","year":"2012","journal-title":"J. Can. De Chir."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s002680020368","article-title":"Evolution of surgery for liver hydatidosis from 1950 to today: Analysis of a personal experience","volume":"25","author":"Cirenei","year":"2001","journal-title":"World J. Surg."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/6\/1070\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:47:33Z","timestamp":1760125653000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/6\/1070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,2]]},"references-count":28,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["medicina59061070"],"URL":"https:\/\/doi.org\/10.3390\/medicina59061070","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,2]]}}}