{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:28:17Z","timestamp":1793381297403,"version":"4.5.0"},"reference-count":67,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T00:00:00Z","timestamp":1687564800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Hypermagnesemia is a relatively uncommon but potentially life-threatening electrolyte disturbance characterized by elevated magnesium concentrations in the blood. Magnesium is a crucial mineral involved in various physiological functions, such as neuromuscular conduction, cardiac excitability, vasomotor tone, insulin metabolism, and muscular contraction. Hypomagnesemia is a prevalent electrolyte disturbance that can lead to several neuromuscular, cardiac, or nervous system disorders. Hypermagnesemia has been associated with adverse clinical outcomes, particularly in hospitalized patients. Prompt identification and management of hypermagnesemia are crucial to prevent complications, such as respiratory and cardiovascular negative outcomes, neuromuscular dysfunction, and coma. Preventing hypermagnesemia is crucial, particularly in high-risk populations, such as patients with impaired renal function or those receiving magnesium-containing medications or supplements. Clinical management of hypermagnesemia involves discontinuing magnesium-containing therapies, intravenous fluid therapy, or dialysis in severe cases. Furthermore, healthcare providers should monitor serum magnesium concentration in patients at risk of hypermagnesemia and promptly intervene if the concentration exceeds the normal range.<\/jats:p>","DOI":"10.3390\/medicina59071190","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T02:05:02Z","timestamp":1687745102000},"page":"1190","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Hypermagnesemia in Clinical Practice"],"prefix":"10.3390","volume":"59","author":[{"given":"Aya Hasan","family":"Aal-Hamad","sequence":"first","affiliation":[{"name":"Department of Emergency, Sultan Qaboos University Hospital, P.O. Box 141, Muscat 123, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2077-7186","authenticated-orcid":false,"given":"Abdullah M.","family":"Al-Alawi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Sultan Qaboos University Hospital, P.O. Box 141, Muscat 123, Oman"},{"name":"Internal Medicine Residency Training Program, Oman Medical Specialty Board, P.O. Box 1422, Al-Khoudh 132, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4103-8174","authenticated-orcid":false,"given":"Masoud Salim","family":"Kashoub","sequence":"additional","affiliation":[{"name":"Department of Medicine, Sultan Qaboos University Hospital, P.O. Box 141, Muscat 123, Oman"},{"name":"Internal Medicine Residency Training Program, Oman Medical Specialty Board, P.O. Box 1422, Al-Khoudh 132, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5622-6987","authenticated-orcid":false,"given":"Henrik","family":"Falhammar","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, QB85, Karolinska University Hospital, 17176 Stockholm, Sweden"},{"name":"Department of Molecular Medicine and Surgery, Karolinska Institute, 17177 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,24]]},"reference":[{"key":"ref_1","first-page":"9041694","article-title":"Magnesium and Human Health: Perspectives and Research Directions","volume":"2018","author":"Majoni","year":"2018","journal-title":"Int. J. Endocrinol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"8199","DOI":"10.3390\/nu7095388","article-title":"Magnesium in Prevention and Therapy","volume":"7","author":"Schmidt","year":"2015","journal-title":"Nutrients"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1111\/imj.15442","article-title":"Characteristics and health outcomes of patients hospitalised with hypomagnesaemia: A retrospective study from a single centre in the Northern Territory of Australia","volume":"52","author":"Berhane","year":"2022","journal-title":"Intern. Med. J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.mayocp.2015.04.023","article-title":"Dysmagnesemia in Hospitalized Patients: Prevalence and Prognostic Importance","volume":"90","author":"Cheungpasitporn","year":"2015","journal-title":"Mayo Clin. Proc."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.abb.2006.05.005","article-title":"Role of magnesium in hypertension","volume":"458","author":"Sontia","year":"2007","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1085\/jgp.20028740","article-title":"TRPM7 provides an ion channel mechanism for cellular entry of trace metal ions","volume":"121","author":"Hermosura","year":"2003","journal-title":"J. Gen. Physiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1113\/jphysiol.2004.080200","article-title":"A critical role of TRPM channel-kinase for human magnesium transport","volume":"566","author":"Schlingmann","year":"2005","journal-title":"J. Physiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.abb.2011.05.010","article-title":"Cellular magnesium homeostasis","volume":"512","author":"Romani","year":"2011","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"R2001","DOI":"10.1152\/ajpregu.00153.2007","article-title":"Relationship between low magnesium status and TRPM6 expression in the kidney and large intestine","volume":"294","author":"Rondon","year":"2008","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1161\/01.RES.66.2.355","article-title":"Antagonistic modulatory roles of magnesium and calcium on release of endothelium-derived relaxing factor and smooth muscle tone","volume":"66","author":"Gold","year":"1990","journal-title":"Circ. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"260","DOI":"10.2174\/1573401313666170427162740","article-title":"Intestinal Absorption and Factors Influencing Bioavailability of Magnesium-An Update","volume":"13","author":"Schuchardt","year":"2017","journal-title":"Curr. Nutr. Food Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1172\/JCI105781","article-title":"The mechanisms of sodium absorption in the human small intestine","volume":"47","author":"Fordtran","year":"1968","journal-title":"J. Clin. Investig."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"219","DOI":"10.2147\/IJNRD.S42054","article-title":"Hypomagnesemia: A clinical perspective","volume":"7","author":"Pham","year":"2014","journal-title":"Int. J. Nephrol. Renovasc Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/ng889","article-title":"Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family","volume":"31","author":"Schlingmann","year":"2002","journal-title":"Nat. Genet."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"i15","DOI":"10.1093\/ndtplus\/sfr164","article-title":"Regulation of magnesium balance: Lessons learned from human genetic disease","volume":"5","author":"Hoenderop","year":"2012","journal-title":"Clin. Kidney J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"4641","DOI":"10.1210\/jc.2002-021404","article-title":"Normocalcemic primary hyperparathyroidism: Evidence for a generalized target-tissue resistance to parathyroid hormone","volume":"88","author":"Maruani","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_17","first-page":"157","article-title":"Transepithelial Ca2+ and Mg2+ transport in the cortical thick ascending limb of Henle\u2019s loop of the mouse is a voltage-dependent process","volume":"16","author":"Roinel","year":"1993","journal-title":"Ren. Physiol. Biochem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1517\/14740338.2011.606213","article-title":"Risk of anti-EGFR monoclonal antibody-related hypomagnesemia: Systematic review and pooled analysis of randomized studies","volume":"11","author":"Petrelli","year":"2012","journal-title":"Expert. Opin. Drug. Saf."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/81543","article-title":"Dominant isolated renal magnesium loss is caused by misrouting of the Na(+),K(+)-ATPase gamma-subunit","volume":"26","author":"Meij","year":"2000","journal-title":"Nat. Genet."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1042\/cs0700277","article-title":"Effects of acid-base disturbances on renal handling of magnesium in the dog","volume":"70","author":"Wong","year":"1986","journal-title":"Clin. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.00012.2014","article-title":"Magnesium in man: Implications for health and disease","volume":"95","author":"Hoenderop","year":"2015","journal-title":"Physiol. Rev."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Ahmed, F., and Mohammed, A. (2019). Magnesium: The Forgotten Electrolyte-A Review on Hypomagnesemia. Med. Sci., 7.","DOI":"10.3390\/medsci7040056"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Workinger, J.L., Doyle, R.P., and Bortz, J. (2018). Challenges in the Diagnosis of Magnesium Status. Nutrients, 10.","DOI":"10.3390\/nu10091202"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1093\/clinchem\/41.4.615","article-title":"Los Angeles County-University of Southern California Medical Center clinical pathology case conference: Extreme hypermagnesemia in a neonate","volume":"41","author":"Huey","year":"1995","journal-title":"Clin. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1159\/000184491","article-title":"Extreme hypermagnesemia due to ingestion of Dead Sea water","volume":"47","author":"Oren","year":"1987","journal-title":"Nephron"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3109\/03014460.2010.500472","article-title":"Prevalence of hypo- and hypermagnesemia in an Iranian urban population","volume":"38","author":"Syedmoradi","year":"2011","journal-title":"Ann. Hum. Biol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Smith, J.M., Lowe, R.F., Fullerton, J., Currie, S.M., Harris, L., and Felker-Kantor, E. (2013). An integrative review of the side effects related to the use of magnesium sulfate for pre-eclampsia and eclampsia management. BMC Pregnancy Childbirth, 13.","DOI":"10.1186\/1471-2393-13-34"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1016\/S0140-6736(02)08778-0","article-title":"Magpie Trial Collaboration Group. Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: A randomised placebo-controlled trial","volume":"359","author":"Altman","year":"2002","journal-title":"Lancet"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1001\/jama.1990.03440220087036","article-title":"Frequency of hypomagnesemia and hypermagnesemia. Requested vs routine","volume":"263","author":"Whang","year":"1990","journal-title":"JAMA"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/sdi.12411","article-title":"Pathophysiology of Calcium, Phosphorus, and Magnesium Dysregulation in Chronic Kidney Disease","volume":"28","author":"Felsenfeld","year":"2015","journal-title":"Semin. Dial."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1080\/21548331.2020.1724723","article-title":"Impact of admission serum magnesium levels on long-term mortality in hospitalized patients","volume":"48","author":"Cheungpasitporn","year":"2020","journal-title":"Hosp. Pract."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.ejim.2015.05.013","article-title":"Hypermagnesemia is a strong independent risk factor for mortality in critically ill patients: Results from a cross-sectional study","volume":"26","author":"Haider","year":"2015","journal-title":"Eur. J. Intern. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"625133","DOI":"10.3389\/fcvm.2021.625133","article-title":"High-Normal Serum Magnesium and Hypermagnesemia Are Associated With Increased 30-Day In-Hospital Mortality: A Retrospective Cohort Study","volume":"8","author":"Tan","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Li, J., Imtiaz, M.S., Beard, N.A., Dulhunty, A.F., Thorne, R., vanHelden, D.F., and Laver, D.R. (2013). \u00df-Adrenergic stimulation increases RyR2 activity via intracellular Ca2+ and Mg2+ regulation. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0058334"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1097\/00003246-198808000-00004","article-title":"Muscle and serum magnesium in pulmonary intensive care unit patients","volume":"16","author":"Fiaccadori","year":"1988","journal-title":"Crit. Care Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1136\/jim-2021-001948","article-title":"Serum magnesium levels in hospitalized patients with SARS-CoV-2","volume":"70","author":"Sharma","year":"2022","journal-title":"J. Investig. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"i3","DOI":"10.1093\/ndtplus\/sfr163","article-title":"Magnesium basics","volume":"5","author":"Ketteler","year":"2012","journal-title":"Clin. Kidney J."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Bouillon-Minois, J.B., Khaled, L., Vitte, F., Miraillet, L., Eschalier, R., Jabaudon, M., Sapin, V., Derault, L., Kahouadji, S., and Brailova, M. (2023). Ionized Magnesium: Interpretation and Interest in Atrial Fibrillation. Nutrients, 15.","DOI":"10.3390\/nu15010236"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"86","DOI":"10.5049\/EBP.2008.6.2.86","article-title":"Magnesium metabolism","volume":"6","author":"Seo","year":"2008","journal-title":"Electrolyte Blood Press."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/ams2.334","article-title":"The characteristics of patients with hypermagnesemia who underwent emergency hemodialysis","volume":"5","author":"Nishikawa","year":"2018","journal-title":"Acute Med. Surg."},{"key":"ref_41","unstructured":"Cascella, M., and Vaqar, S. (2023). Hypermagnesemia, StatPearls Publishing."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"F485","DOI":"10.1152\/ajprenal.00608.2009","article-title":"Physiology and pathophysiology of the calcium-sensing receptor in the kidney","volume":"298","author":"Riccardi","year":"2010","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s11154-016-9395-7","article-title":"Thyroid dysfunction and kidney disease: An update","volume":"18","author":"Iglesias","year":"2017","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1258\/acb.2008.007248","article-title":"The relationship between estimated glomerular filtration rate and thyroid function: An observational study","volume":"45","author":"Woodward","year":"2008","journal-title":"Ann. Clin. Biochem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1056\/NEJM199409293311306","article-title":"The molecular basis of thyroid hormone action","volume":"331","author":"Brent","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1043-2760(00)00263-0","article-title":"Gene regulation by thyroid hormone","volume":"11","author":"Wu","year":"2000","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1152\/physrev.2001.81.3.1097","article-title":"Physiological and molecular basis of thyroid hormone action","volume":"81","author":"Yen","year":"2001","journal-title":"Physiol. Rev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s13730-018-0359-5","article-title":"Severe hypermagnesemia induced by magnesium oxide ingestion: A case series","volume":"8","author":"Yamaguchi","year":"2019","journal-title":"CEN Case Rep."},{"key":"ref_49","first-page":"413","article-title":"Fatal Hypermagnesemia: An acute ingestion of Epsom Salt in a patient with normal renal function","volume":"9","author":"Zahid","year":"2018","journal-title":"Caspian J. Intern. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3164\/jcbn.18-117","article-title":"Clinical features of hypermagnesemia in patients with functional constipation taking daily magnesium oxide","volume":"65","author":"Mori","year":"2019","journal-title":"J. Clin. Biochem. Nutr."},{"key":"ref_51","first-page":"287","article-title":"Base changes in the alkalosis produced by the treatment of gastric ulcer with alkalies","volume":"2","author":"Cope","year":"1936","journal-title":"Clin. Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"261","DOI":"10.4065\/84.3.261","article-title":"Milk-alkali syndrome","volume":"84","author":"Medarov","year":"2009","journal-title":"Mayo Clin. Proc."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"E106","DOI":"10.1111\/hdi.12763","article-title":"Inadvertently high dialysate magnesium causing weakness and nausea in hemodialysis patients","volume":"23","author":"Chakurkar","year":"2019","journal-title":"Hemodial. Int."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/S0022-5347(17)49851-X","article-title":"Hypermagnesemia associated with hemiacidrin irrigation","volume":"132","author":"Thompson","year":"1984","journal-title":"J. Urol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/bs.afnr.2021.01.001","article-title":"Magnesium: The recent research and developments","volume":"96","author":"Falhammar","year":"2021","journal-title":"Adv. Food Nutr. Res."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Razzaque, M.S. (2018). Magnesium: Are We Consuming Enough?. Nutrients, 10.","DOI":"10.3390\/nu10121863"},{"key":"ref_57","first-page":"2435","article-title":"Tumor lysis syndrome. A life-threatening complication during cytostatic treatment of chemosensitive types of cancer","volume":"111","author":"Wibe","year":"1991","journal-title":"Tidsskr. Nor. Laegeforen"},{"key":"ref_58","first-page":"47","article-title":"Magnesium metabolism and its disorders","volume":"24","author":"Swaminathan","year":"2003","journal-title":"Clin. Biochem. Rev."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0009-8981(99)00258-2","article-title":"Magnesium. An update on physiological, clinical and analytical aspects","volume":"294","author":"Saris","year":"2000","journal-title":"Clin. Chim. Acta."},{"key":"ref_60","unstructured":"Caballero, B., Allen, L., and Prentice, A. (2005). Encyclopedia of Human Nutrition, Elsevier Science."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.emc.2013.12.006","article-title":"Calcium, magnesium, and phosphate abnormalities in the emergency department","volume":"32","author":"Chang","year":"2014","journal-title":"Emerg. Med. Clin. N. Am."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2169\/internalmedicine.45.1482","article-title":"Cathartic-induced fatal hypermagnesemia in the elderly","volume":"45","author":"Onishi","year":"2006","journal-title":"Intern. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1292\/jvms.20-0720","article-title":"High-magnesium exposure to bullfrog heart causes ST segment elevation","volume":"83","author":"Kazama","year":"2021","journal-title":"J. Vet. Med. Sci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3345\/kjp.2013.56.7.308","article-title":"Severe hypermagnesemia presenting with abnormal electrocardiographic findings similar to those of hyperkalemia in a child undergoing peritoneal dialysis","volume":"56","author":"Jhang","year":"2013","journal-title":"Korean J. Pediatr."},{"key":"ref_65","unstructured":"Gupta, A.S.L.Y.A. (2023). Hypermagnesemia: Causes, Symptoms, and Treatment, UpToDate."},{"key":"ref_66","unstructured":"DynaMed (2023, May 01). Hypermagnesemia-Approach to the Patient. Available online: https:\/\/www.dynamed.com\/approach-to\/hypermagnesemia-approach-to-the-patient#GUID-90892592-B90F-48C6-ACF1-D53C3D5648E4."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.pop.2008.01.007","article-title":"Disorders involving calcium, phosphorus, and magnesium","volume":"35","author":"Moe","year":"2008","journal-title":"Prim. Care"}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/7\/1190\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:59:35Z","timestamp":1760126375000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/7\/1190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,24]]},"references-count":67,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,7]]}},"alternative-id":["medicina59071190"],"URL":"https:\/\/doi.org\/10.3390\/medicina59071190","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,24]]}}}