{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:53:51Z","timestamp":1791644031544,"version":"4.3.4"},"reference-count":38,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T00:00:00Z","timestamp":1687737600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Coagulation disorders during COVID-19 infection are associated with a poorer prognosis and higher disease severity because thrombosis and inflammation are two processes that interfere with each other. A very important issue for clinicians is timely and adequate hemostasis and inflammation monitoring to prevent and treat potentially lethal consequences. The aim of this study was to identify specific hemostatic parameters that are associated with a higher risk of intrahospital mortality. Materials and Methods: This study was approved by the Ethics Committee of the Clinical Center Nis in Serbia. One hundred and forty-two patients presented with COVID-19 ARDS and were admitted to the ICU in the Clinic for Anesthesiology at the Clinical Center Nis from 14 April 2020 to 25 May 2020. Upon admission, blood was collected for biochemical and coagulation testing. The data obtained were analyzed using the Statistical Package for Social Sciences (SPSS v. 25, Chicago, IL, USA). Results: Among all the parameters assessed, older age; increased levels of fibrinogen, INR, D-dimer, and presepsin; and higher results in the platelet aggregation tests (aggregation induced by adenosine diphosphate based on the ADP test (AU\/min), aggregation induced by arachidonic acid based on the ASPI test (AU\/min), and aggregation induced by thrombin based on the TRAP test (AU\/min)) and some assays of the viscoelastic test (clot amplitude after 5 min in the extrinsic coagulation pathway based on the A5 EX-test (mm), clot amplitude after 10 min in the extrinsic coagulation pathway based on the A10 EX-test (mm), clot amplitude after 5 min regarding functional fibrinogen based on the A5 FIB-test (mm), clot amplitude after 10 min regarding functional fibrinogen based on the A10 FIB-test (mm), and maximum clot firmness based on the MCF FIB-test (mm)); and lower values of viscoelastic clotting time in the extrinsic coagulation pathway based on the CT EX-test (s) were significantly correlated with mortality. In the multivariate analysis, D-dimer levels above 860 ng\/mL, higher TRAP test value bins, and values above the normal reference range of the A10 FIB test were found to be independent predictors of mortality. Conclusions: Sophisticated hemostasis parameters can contribute to early risk assessment, which has initially been performed only on the basis of patients\u2019 clinical status. Hypercoagulability is the main coagulation disorder in COVID-19 infection.<\/jats:p>","DOI":"10.3390\/medicina59071202","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T01:42:02Z","timestamp":1687830122000},"page":"1202","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Monitoring the Coagulation Profile of COVID-19 Patients Using Standard and ClotPro\u00ae Hemostasis Tests"],"prefix":"10.3390","volume":"59","author":[{"given":"Dragan","family":"Mili\u0107","sequence":"first","affiliation":[{"name":"Medical School of Nis, University of Nis, 18000 Nis, Serbia"},{"name":"Clinic of Cardiovascular Surgery, University Clinical Center Nis, 18000 Nis, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8898-948X","authenticated-orcid":false,"given":"Milan","family":"Lazarevi\u0107","sequence":"additional","affiliation":[{"name":"Medical School of Nis, University of Nis, 18000 Nis, Serbia"},{"name":"Clinic of Cardiovascular Surgery, University Clinical Center Nis, 18000 Nis, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6875-4253","authenticated-orcid":false,"given":"Natalija","family":"Vukovi\u0107","sequence":"additional","affiliation":[{"name":"Clinic for Anesthesiology and Intensive Therapy, University Clinical Center Nis, 18000 Nis, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandar","family":"Kamenov","sequence":"additional","affiliation":[{"name":"Medical School of Nis, University of Nis, 18000 Nis, Serbia"},{"name":"Clinic of Cardiovascular Surgery, University Clinical Center Nis, 18000 Nis, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Velimir","family":"Peri\u0107","sequence":"additional","affiliation":[{"name":"Medical School of Nis, University of Nis, 18000 Nis, Serbia"},{"name":"Clinic of Cardiovascular Surgery, University Clinical Center Nis, 18000 Nis, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mla\u0111an","family":"Golubovi\u0107","sequence":"additional","affiliation":[{"name":"Medical School of Nis, University of Nis, 18000 Nis, Serbia"},{"name":"Clinic of Cardiovascular Surgery, University Clinical Center Nis, 18000 Nis, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marija","family":"Sto\u0161i\u0107","sequence":"additional","affiliation":[{"name":"Medical School of Nis, University of Nis, 18000 Nis, Serbia"},{"name":"Clinic of Cardiovascular Surgery, University Clinical Center Nis, 18000 Nis, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrije","family":"Spasi\u0107","sequence":"additional","affiliation":[{"name":"Clinic of Cardiovascular Surgery, University Clinical Center Nis, 18000 Nis, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Stojiljkovi\u0107","sequence":"additional","affiliation":[{"name":"Medical School of Nis, University of Nis, 18000 Nis, Serbia"},{"name":"Clinic of Cardiovascular Surgery, University Clinical Center Nis, 18000 Nis, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragana","family":"Stokanovi\u0107","sequence":"additional","affiliation":[{"name":"Medical School of Nis, University of Nis, 18000 Nis, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S2213-2600(20)30079-5","article-title":"Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: A single-centered, retrospective, observational study","volume":"8","author":"Yang","year":"2020","journal-title":"Lancet Respir. 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