{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T18:25:46Z","timestamp":1780079146288,"version":"3.54.0"},"reference-count":63,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T00:00:00Z","timestamp":1688342400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: This study aimed to assess the clinical-pathological profile of patients with invasive cutaneous melanomas and to identify the parameters with a prognostic role in the lymph nodal spread of this malignant tumor. Materials and Methods: We performed a retrospective study on patients with invasive cutaneous melanomas who underwent surgery in the \u201cPius Br\u00eenzeu\u201d County Clinical Emergency Hospital from Timi\u0219oara, Romania, and were evaluated for the status of loco-regional lymph nodes. We selected and analyzed some parameters searching for their relationship with lymph node metastases. Results: We identified 79 patients with invasive cutaneous melanomas (29 men and 50 women, mean age 59.36 years). A percentage of 58.3% of melanomas had Breslow tumor thickness &gt;2 mm; 69.6% of melanomas showed a Clark level IV\u2013V. Tumor ulceration was present in 59.5% of melanomas. A mitotic rate of \u22655 mitoses\/mm2 was observed in 48.1% of melanomas. Tumor-infiltrating lymphocytes (TILs), non-brisk, were present in 59.5% of cases and 22.8% of patients had satellite\/in-transit metastasis (SINTM). Tumor regression was identified in 44.3% of cases. Lymph nodes metastases were found in 43.1% of patients. Statistical analysis showed that lymph node metastases were more frequent in melanomas with Breslow thickness &gt;2 mm (p = 0.0002), high Clark level (p = 0.0026), mitotic rate &gt;5 mitoses\/mm2 (p = 0.0044), ulceration (p = 0.0107), lymphovascular invasion (p = 0.0182), SINTM (p = 0.0302), and non-brisk TILs (p = 0.0302). Conclusions: The Breslow thickness &gt;2 mm, high Clark level, high mitotic rate and ulceration are the most important prognostic factors for lymph nodal spread in cutaneous melanomas. However, some melanomas without these clinical-pathological features can have an unexpected, aggressive evolution, which entails the necessity of close and prolonged clinical follow-up of patients, including those with lesions considered without risk.<\/jats:p>","DOI":"10.3390\/medicina59071241","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T08:25:24Z","timestamp":1688545524000},"page":"1241","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Invasive Cutaneous Melanoma: Evaluating the Prognostic Significance of Some Parameters Associated with Lymph Node Metastases"],"prefix":"10.3390","volume":"59","author":[{"given":"Octavia","family":"Vi\u021ba","sequence":"first","affiliation":[{"name":"Department of Microscopic Morphology-Morphopatology, ANAPATMOL Research Center, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0898-795X","authenticated-orcid":false,"given":"Aura","family":"Jurescu","sequence":"additional","affiliation":[{"name":"Department of Microscopic Morphology-Morphopatology, ANAPATMOL Research Center, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9261-5309","authenticated-orcid":false,"given":"Adrian","family":"V\u0103duva","sequence":"additional","affiliation":[{"name":"Department of Microscopic Morphology-Morphopatology, ANAPATMOL Research Center, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"Department of Pathology, \u201cPius Br\u00eenzeu\u201d County Clinical Emergency Hospital, 300723 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remus","family":"Cornea","sequence":"additional","affiliation":[{"name":"Department of Microscopic Morphology-Morphopatology, ANAPATMOL Research Center, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"Department of Pathology, \u201cPius Br\u00eenzeu\u201d County Clinical Emergency Hospital, 300723 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marioara","family":"Cornianu","sequence":"additional","affiliation":[{"name":"Department of Microscopic Morphology-Morphopatology, ANAPATMOL Research Center, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"Department of Pathology, \u201cPius Br\u00eenzeu\u201d County Clinical Emergency Hospital, 300723 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorina","family":"T\u0103ban","sequence":"additional","affiliation":[{"name":"Department of Microscopic Morphology-Morphopatology, ANAPATMOL Research Center, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"Department of Pathology, \u201cPius Br\u00eenzeu\u201d County Clinical Emergency Hospital, 300723 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Szilagyi","sequence":"additional","affiliation":[{"name":"Department of Pathology, \u201cPius Br\u00eenzeu\u201d County Clinical Emergency Hospital, 300723 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Mic\u0219escu","sequence":"additional","affiliation":[{"name":"Department of Microscopic Morphology-Morphopatology, ANAPATMOL Research Center, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Natar\u00e2\u0219","sequence":"additional","affiliation":[{"name":"Department of Microscopic Morphology-Morphopatology, ANAPATMOL Research Center, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"Department of Pathology, \u201cPius Br\u00eenzeu\u201d County Clinical Emergency Hospital, 300723 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0767-2718","authenticated-orcid":false,"given":"Alis","family":"Dema","sequence":"additional","affiliation":[{"name":"Department of Microscopic Morphology-Morphopatology, ANAPATMOL Research Center, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"Department of Pathology, \u201cPius Br\u00eenzeu\u201d County Clinical Emergency Hospital, 300723 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,3]]},"reference":[{"key":"ref_1","first-page":"1005","article-title":"Melanoma: Epidemiology, risk factors, pathogenesis, diagnosis and classification","volume":"28","author":"Rastrelli","year":"2014","journal-title":"In Vivo"},{"key":"ref_2","first-page":"591","article-title":"Vital signs: Melanoma incidence and mortality trends and projections\u2014United States, 1982\u20132030","volume":"64","author":"Guy","year":"2015","journal-title":"Morb. 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