{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:55:14Z","timestamp":1787028914012,"version":"build-2736575974"},"reference-count":52,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T00:00:00Z","timestamp":1688515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: We aimed to evaluate the oncological and functional outcomes of organ-sparing surgery for testicular germ cell tumors, a procedure that seeks to strike a balance between effective cancer control and organ preservation, in the treatment of testicular tumors. We aimed to discuss the surgical technique and complications, and determine the appropriate candidate selection for this approach. Material and Methods: A comprehensive literature search was conducted to identify relevant studies on organ-sparing surgery for testicular tumors. Various databases, including PubMed, Embase, and Cochrane Library, were used. Studies reporting on surgical techniques, complications, and oncologic and functional outcomes were included for analysis. Results: Current evidence suggests that organ-sparing surgery for testicular germ cell tumors can be considered a safe and efficacious alternative to radical orchiectomy. The procedure is associated with adequate oncological control, as indicated by low recurrence rates and low complication rates. Endocrine testicular function can be preserved in around 80\u201390% of patients and paternity can be achieved in approximately half of the patients. Candidate selection for this surgery is typically based on the following criteria: pre-surgery normal levels of testosterone and luteinizing hormone, synchronous or metachronous bilateral tumors, tumor in a solitary testis, and tumor size less than 50% of the testis. Conclusions: Organ-sparing surgery for testicular germ cell tumors offers a promising approach that balances oncological control and preservation of testicular function. Further research, including large-scale prospective studies and long-term follow-ups, is warranted to validate the effectiveness and durability of organ-sparing surgery and to identify optimal patient selection criteria.<\/jats:p>","DOI":"10.3390\/medicina59071249","type":"journal-article","created":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T00:34:30Z","timestamp":1688603670000},"page":"1249","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Organ-Sparing Surgery for Testicular Germ Cell Tumors: A Current Perspective"],"prefix":"10.3390","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2997-5886","authenticated-orcid":false,"given":"Esther","family":"Garc\u00eda Rojo","sequence":"first","affiliation":[{"name":"Department of Urology, Hospital Universitario HM Sanchinarro, 28050 Madrid, Spain"},{"name":"ROC Clinic Direction, Mart\u00ednez Campos 17, 28010 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6995-246X","authenticated-orcid":false,"given":"Gianluca","family":"Giannarini","sequence":"additional","affiliation":[{"name":"Urology Unit, Santa Maria della Misericordia University Hospital, 33100 Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borja","family":"Garc\u00eda G\u00f3mez","sequence":"additional","affiliation":[{"name":"ROC Clinic Direction, Mart\u00ednez Campos 17, 28010 Madrid, Spain"},{"name":"Department of Urology, Hospital Universitario HM Montepr\u00edncipe, 28660 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier Amalio","family":"Feltes Ochoa","sequence":"additional","affiliation":[{"name":"ROC Clinic Direction, Mart\u00ednez Campos 17, 28010 Madrid, Spain"},{"name":"Department of Urology, Hospital Universitario HM Puerta del Sur, 28938 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0767-3465","authenticated-orcid":false,"given":"F\u00e9lix","family":"Guerrero Ramos","sequence":"additional","affiliation":[{"name":"Department of Urology, Hospital Universitario HM Sanchinarro, 28050 Madrid, Spain"},{"name":"ROC Clinic Direction, Mart\u00ednez Campos 17, 28010 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Alonso Isa","sequence":"additional","affiliation":[{"name":"ROC Clinic Direction, Mart\u00ednez Campos 17, 28010 Madrid, Spain"},{"name":"Department of Urology, Hospital Universitario HM Puerta del Sur, 28938 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Brime Menendez","sequence":"additional","affiliation":[{"name":"Department of Urology, Hospital Universitario HM Sanchinarro, 28050 Madrid, Spain"},{"name":"ROC Clinic Direction, Mart\u00ednez Campos 17, 28010 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Manuel","family":"Saenz Calzada","sequence":"additional","affiliation":[{"name":"ROC Clinic Direction, Mart\u00ednez Campos 17, 28010 Madrid, Spain"},{"name":"Department of Urology, Hospital Universitario HM Puerta del Sur, 28938 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Justo Quintas","sequence":"additional","affiliation":[{"name":"Department of Urology, Hospital Universitario HM Sanchinarro, 28050 Madrid, Spain"},{"name":"ROC Clinic Direction, Mart\u00ednez Campos 17, 28010 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agust\u00edn","family":"Fraile","sequence":"additional","affiliation":[{"name":"ROC Clinic Direction, Mart\u00ednez Campos 17, 28010 Madrid, Spain"},{"name":"Department of Urology, Hospital Universitario HM Rivas, 28521 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9706-8516","authenticated-orcid":false,"given":"Celeste","family":"Manfredi","sequence":"additional","affiliation":[{"name":"Unit of Urology, Department of Woman, Child and General and Specialized Surgery, University of Campania \u201cLuigi Vanvitelli\u201d, 81100 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Romero Otero","sequence":"additional","affiliation":[{"name":"Department of Urology, Hospital Universitario HM Sanchinarro, 28050 Madrid, Spain"},{"name":"ROC Clinic Direction, Mart\u00ednez Campos 17, 28010 Madrid, Spain"},{"name":"Department of Urology, Hospital Universitario HM Montepr\u00edncipe, 28660 Madrid, Spain"},{"name":"Department of Urology, Hospital Universitario HM Puerta del Sur, 28938 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,5]]},"reference":[{"key":"ref_1","unstructured":"(2023, May 02). 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