{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:13:31Z","timestamp":1789132411774,"version":"build-2803163510"},"reference-count":113,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T00:00:00Z","timestamp":1688601600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>The introduction of the term Persistent Spinal Pain Syndrome (PSPS-T1\/2), replacing the older term Failed Back Surgery Syndrome (FBSS), has significantly influenced our approach to diagnosing and treating post-surgical spinal pain. This comprehensive review discusses this change and its effects on patient care. Various diagnostic methods are employed to elucidate the underlying causes of back pain, and this information is critical in guiding treatment decisions. The management of PSPS-T1\/2 involves both causative treatments, which directly address the root cause of pain, and symptomatic treatments, which focus on managing the symptoms of pain and improving overall function. The importance of a multidisciplinary and holistic approach is emphasized in the treatment of PSPS-T1\/2. This approach is patient-centered and treatment plans are customized to individual patient needs and circumstances. The review concludes with a reflection on the impact of the new PSPS nomenclature on the perception and management of post-surgical spinal pain.<\/jats:p>","DOI":"10.3390\/medicina59071255","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T01:41:36Z","timestamp":1688694096000},"page":"1255","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Failed Back Surgery Syndrome: No Longer a Surgeon\u2019s Defeat\u2014A Narrative Review"],"prefix":"10.3390","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6781-7013","authenticated-orcid":false,"given":"Grzegorz","family":"Mi\u0119kisiak","sequence":"first","affiliation":[{"name":"Institute of Medicine, University of Opole, 45-040 Opole, Poland"},{"name":"Vratislavia Medica Hospital, 51-134 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.21037\/atm.2020.02.175","article-title":"Global Low Back Pain Prevalence and Years Lived with Disability from 1990 to 2017: Estimates from the Global Burden of Disease Study 2017","volume":"8","author":"Wu","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s11916-019-0757-1","article-title":"Low Back Pain, a Comprehensive Review: Pathophysiology, Diagnosis, and Treatment","volume":"23","author":"Urits","year":"2019","journal-title":"Curr. Pain Headache Rep."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1007\/s00586-017-5432-9","article-title":"The Global Spine Care Initiative: A Summary of the Global Burden of Low Back and Neck Pain Studies","volume":"27","author":"Hurwitz","year":"2018","journal-title":"Eur. Spine J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"350","DOI":"10.2519\/jospt.2020.9971","article-title":"International Framework for Red Flags for Potential Serious Spinal Pathologies","volume":"50","author":"Finucane","year":"2020","journal-title":"J. Orthop. Sport. Phys. Ther."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.amjmed.2019.06.005","article-title":"Low Back Pain in the Emergency Department: Prevalence of Serious Spinal Pathologies and Diagnostic Accuracy of Red Flags","volume":"133","author":"Galliker","year":"2020","journal-title":"Am. J. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"4696180","DOI":"10.1155\/2018\/4696180","article-title":"The Impact of Chronic Discogenic Low Back Pain: Costs and Patients\u2019 Burden","volume":"2018","author":"Geurts","year":"2018","journal-title":"Pain Res. Manag."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"423","DOI":"10.2471\/BLT.18.226050","article-title":"Care for Low Back Pain: Can Health Systems Deliver?","volume":"97","author":"Traeger","year":"2019","journal-title":"Bull. World Health Organ."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"102548","DOI":"10.1016\/j.jhealeco.2021.102548","article-title":"Alternative Payment Models and Physician Treatment Decisions: Evidence from Lower Back Pain","volume":"80","author":"Ding","year":"2021","journal-title":"J. Health Econ."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"979","DOI":"10.2147\/JPR.S92776","article-title":"Failed Back Surgery Syndrome: Current Perspectives","volume":"9","author":"Baber","year":"2016","journal-title":"J. Pain Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/j.1526-4637.2011.01089.x","article-title":"Failed Back Surgery Syndrome","volume":"12","author":"Chan","year":"2011","journal-title":"Pain Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1016\/j.neuchi.2014.10.107","article-title":"Failed Back Surgery Syndrome: Who Has Failed?","volume":"61","author":"Pang","year":"2015","journal-title":"Neurochirurgie"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1016\/j.neuchi.2014.12.001","article-title":"Failed Back Surgery Syndrome: What\u2019s in a Name? A Proposal to Replace \u201cFBSS\u201d by \u201cPOPS\u201d\u2026","volume":"61","author":"Rigoard","year":"2015","journal-title":"Neurochirurgie"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/j.pain.0000000000001384","article-title":"Chronic Pain as a Symptom or a Disease: The IASP Classification of Chronic Pain for the International Classification of Diseases (ICD-11)","volume":"160","author":"Treede","year":"2019","journal-title":"Pain"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1093\/pm\/pnab015","article-title":"Persistent Spinal Pain Syndrome: A Proposal for Failed Back Surgery Syndrome and ICD-11","volume":"22","author":"Christelis","year":"2021","journal-title":"Pain Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/j.pain.0000000000001390","article-title":"The IASP Classification of Chronic Pain for ICD-11: Chronic Primary Pain","volume":"160","author":"Nicholas","year":"2019","journal-title":"Pain"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Naiditch, N., Billot, M., Goudman, L., Cornet, P., Roulaud, M., Ounajim, A., Page, P., Lorgeoux, B., Baron, S., and Nivole, K. (2021). Professional Status of Persistent Spinal Pain Syndrome Patients after Spinal Surgery (PSPS-T2): What Really Matters? A Prospective Study Introducing the Concept of \u201cAdapted Professional Activity\u201d Inferred from Clinical, Psychological and Social Influence. J. Clin. Med., 10.","DOI":"10.3390\/jcm10215055"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Naiditch, N., Billot, M., Moens, M., Goudman, L., Cornet, P., le Breton, D., Roulaud, M., Ounajim, A., Page, P., and Lorgeoux, B. (2021). Persistent Spinal Pain Syndrome Type 2 (PSPS-T2), a Social Pain? Advocacy for a Social Gradient of Health Approach to Chronic Pain. J. Clin. Med., 10.","DOI":"10.3390\/jcm10132817"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.2147\/JPR.S320923","article-title":"Persistent Spinal Pain Syndrome: New Terminology for a New Era","volume":"14","author":"Petersen","year":"2021","journal-title":"J. Pain Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"rjac431","DOI":"10.1093\/jscr\/rjac431","article-title":"Spinal Fusion Surgery\u2014The Need to Follow the \u2018BRAN\u2019 Toolkit (Benefits, Risks, Alternatives, Nothing): A Case Report","volume":"2022","author":"Ampat","year":"2022","journal-title":"J. Surg. Case Rep."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jocn.2022.06.027","article-title":"The Incidence of Failed Back Surgery Syndrome Varies between Clinical Setting and Procedure Type","volume":"103","author":"Stanton","year":"2022","journal-title":"J. Clin. Neurosci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/j.biopha.2017.12.001","article-title":"Association of Inflammatory Mediators with Pain Perception","volume":"96","author":"Ronchetti","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3126464","DOI":"10.1155\/2019\/3126464","article-title":"Optimizing the Management and Outcomes of Failed Back Surgery Syndrome: A Consensus Statement on Definition and Outlines for Patient Assessment","volume":"2019","author":"Rigoard","year":"2019","journal-title":"Pain Res. Manag."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Yam, M.F., Loh, Y.C., Tan, C.S., Adam, S.K., Manan, N.A., and Basir, R. (2018). General Pathways of Pain Sensation and the Major Neurotransmitters Involved in Pain Regulation. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19082164"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Malfliet, A., Kregel, J., Meeus, M., Danneels, L., Cagnie, B., Roussel, N., and Nijs, J. (2018). Patients with Chronic Spinal Pain Benefit from Pain Neuroscience Education Regardless the Self-Reported Signs of Central Sensitization: Secondary Analysis of a Randomized Controlled Multicenter Trial. PM&R, 10.","DOI":"10.1016\/j.pmrj.2018.04.010"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.bbi.2019.08.190","article-title":"MiR-200a-3p Modulates Gene Expression in Comorbid Pain and Depression: Molecular Implication for Central Sensitization","volume":"82","author":"Satyanarayanan","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3389\/fpain.2021.646068","article-title":"Satellite Glial Cells in Pain Research: A Targeted Viewpoint of Potential and Future Directions","volume":"2","author":"Gazerani","year":"2021","journal-title":"Front. Pain Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s12974-019-1524-2","article-title":"An Update on Reactive Astrocytes in Chronic Pain","volume":"16","author":"Li","year":"2019","journal-title":"J. Neuroinflamm."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"100469","DOI":"10.1016\/j.mtbio.2022.100469","article-title":"Continuous Release of Mefloquine Featured in Electrospun Fiber Membranes Alleviates Epidural Fibrosis and Aids in Sensory Neurological Function after Lumbar Laminectomy","volume":"17","author":"Yue","year":"2022","journal-title":"Mater. Today Bio"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3482","DOI":"10.3389\/fphar.2021.774316","article-title":"The Preventive Effect of Decorin on Epidural Fibrosis and Epidural Adhesions After Laminectomy","volume":"12","author":"Ding","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Crosio, A., Ronchi, G., Fornasari, B.E., Odella, S., Raimondo, S., and Tos, P. (2021). Experimental Methods to Simulate and Evaluate Postsurgical Peripheral Nerve Scarring. J. Clin. Med., 10.","DOI":"10.3390\/jcm10081613"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e318","DOI":"10.1016\/j.wneu.2018.11.158","article-title":"Risk Factors for Surgical Site Infection After Spinal Surgery: A Systematic Review and Meta-Analysis Based on Twenty-Seven Studies","volume":"123","author":"Peng","year":"2019","journal-title":"World Neurosurg."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Souslian, F.G., and Patel, P.D. (2021). Review and Analysis of Modern Lumbar Spinal Fusion Techniques. Br. J. Neurosurg., 1\u20137.","DOI":"10.1080\/02688697.2021.1881041"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00701-022-05421-5","article-title":"Incidental Dural Tears Associated with Worse Clinical Outcomes in Patients Operated for Lumbar Spinal Stenosis","volume":"165","author":"Alhaug","year":"2023","journal-title":"Acta Neurochir."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Lin, T.Y., Wang, Y.C., Chang, C.W., Wong, C.B., Cheng, Y.H., and Fu, T.S. (2019). Surgical Outcomes for Upper Lumbar Disc Herniation: Decompression Alone versus Fusion Surgery. J. Clin. Med., 8.","DOI":"10.3390\/jcm8091435"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e941","DOI":"10.1016\/j.wneu.2018.01.004","article-title":"Histopathologic Analysis of Tamoxifen on Epidural Fibrosis","volume":"111","author":"Ozturk","year":"2018","journal-title":"World Neurosurg."},{"key":"ref_36","first-page":"e11927","article-title":"Post-Surgical Inflammatory Neuropathy: An Underappreciated but Critical and Treatable Cause of Postoperative Neuropathy","volume":"12","author":"Godlewski","year":"2020","journal-title":"Cureus"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"104S","DOI":"10.1177\/2192568219859314","article-title":"The Use of Intraoperative Neurophysiological Monitoring in Spine Surgery","volume":"10","author":"Charalampidis","year":"2020","journal-title":"Glob. Spine J."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s11420-019-09732-9","article-title":"Surgical Strategies for the Treatment of Lumbar Pseudarthrosis in Degenerative Spine Surgery: A Literature Review and Case Study","volume":"16","author":"Derman","year":"2020","journal-title":"HSS J."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1007\/s00256-019-03181-5","article-title":"The Diagnostic Accuracy of Imaging Modalities to Detect Pseudarthrosis after Spinal Fusion\u2014A Systematic Review and Meta-Analysis of the Literature","volume":"48","author":"Peters","year":"2019","journal-title":"Skelet. Radiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1053\/j.semss.2019.03.002","article-title":"Evaluation and Workup in Revision Spine Surgery","volume":"31","author":"Hills","year":"2019","journal-title":"Semin. Spine Surg."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1097\/BRS.0000000000002460","article-title":"Magnetic Resonance Neurography of the Lumbosacral Plexus in Failed Back Surgery Syndrome","volume":"43","author":"Dessouky","year":"2018","journal-title":"Spine"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1177\/0963689718796072","article-title":"Narcotic Addiction in Failed Back Surgery Syndrome","volume":"28","author":"Chen","year":"2019","journal-title":"Cell Transplant."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s00586-020-06314-w","article-title":"Revision after Spinal Stenosis Surgery","volume":"29","author":"Seresti","year":"2020","journal-title":"Eur. Spine J."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s10103-019-02803-7","article-title":"Laser-Assisted Endoscopic Lumbar Foraminotomy for Failed Back Surgery Syndrome in Elderly Patients","volume":"35","author":"Ahn","year":"2019","journal-title":"Lasers Med. Sci."},{"key":"ref_45","first-page":"282","article-title":"Adjacent Segment Syndrome after Failed Back Surgery: Biomechanics, Diagnosis, and Treatment","volume":"88","year":"2021","journal-title":"Minerva Anestesiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1007\/s00264-018-4246-7","article-title":"Persistent Radiculopathy after Surgical Treatment for Lumbar Disc Herniation: Causes and Treatment Options","volume":"43","author":"Rogerson","year":"2019","journal-title":"Int. Orthop."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1590\/1413-785220202801218823","article-title":"Effect of platelet-rich plasma, fat pad and dural matrix in preventing epidural fibrosis","volume":"28","author":"Guler","year":"2020","journal-title":"Acta Ortop. Bras."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.spinee.2019.10.001","article-title":"Patients\u2019 Expectations of Spine Surgery for Degenerative Conditions: Results from the Canadian Spine Outcomes and Research Network (CSORN)","volume":"20","author":"Canizares","year":"2020","journal-title":"Spine J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.spinee.2018.11.011","article-title":"A Web-Based Platform to Accommodate Symptoms of Anxiety and Depression by Featuring Social Interaction and Animated Information in Patients Undergoing Lumbar Spine Fusion: A Randomized Clinical Trial","volume":"19","author":"Nielsen","year":"2019","journal-title":"Spine J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.spinee.2018.03.017","article-title":"Anxiety and Depression in Spine Surgery\u2014A Systematic Integrative Review","volume":"18","author":"Bjerrum","year":"2018","journal-title":"Spine J."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.spinee.2017.05.028","article-title":"Discriminative Ability of Commonly Used Indices to Predict Adverse Outcomes after Poster Lumbar Fusion: A Comparison of Demographics, ASA, the Modified Charlson Comorbidity Index, and the Modified Frailty Index","volume":"18","author":"Ondeck","year":"2018","journal-title":"Spine J."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.spinee.2018.02.005","article-title":"Risk Factor Analysis of Adjacent Segment Disease Requiring Surgery after Short Lumbar Fusion: The Influence of Rheumatoid Arthritis","volume":"18","author":"Park","year":"2018","journal-title":"Spine J."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.spinee.2020.04.008","article-title":"Multidisciplinary Approaches to Complication Reduction in Complex Spine Surgery: A Systematic Review","volume":"20","author":"Friedman","year":"2020","journal-title":"Spine J."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1007\/s00586-018-5469-4","article-title":"Eurospine 2017 Full Paper Award: Time to Remove Our Rose-Tinted Spectacles: A Candid Appraisal of the Relative Success of Surgery in over 4500 Patients with Degenerative Disorders of the Lumbar Spine, Hip or Knee","volume":"27","author":"Mannion","year":"2018","journal-title":"Eur. Spine J."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"47","DOI":"10.4103\/ais.ais_38_18","article-title":"Management of Failed Back Surgery Syndrome (FBSS)","volume":"8","author":"Abubakar","year":"2018","journal-title":"Arch. Int. Surg."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1037\/rep0000200","article-title":"Yellow Flags as Predictors of Rehabilitation Outcome in Chronic Low Back Pain","volume":"63","author":"Glattacker","year":"2018","journal-title":"Rehabil. Psychol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"167","DOI":"10.4103\/jcvjs.JCVJS_70_19","article-title":"Spinopelvic Parameters in Patients with Lumbar Degenerative Disc Disease, Spondylolisthesis, and Failed Back Syndrome: Comparison Vis-\u00e0-Vis Normal Asymptomatic Population and Treatment Implications","volume":"10","author":"Borkar","year":"2019","journal-title":"J. Craniovertebr. Junction Spine"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e417","DOI":"10.1016\/j.wneu.2019.02.067","article-title":"Characteristics of Spinopelvic Sagittal Alignment in Lumbar Degenerative Disease","volume":"126","year":"2019","journal-title":"World Neurosurg."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"101027","DOI":"10.1016\/j.semss.2023.101027","article-title":"Age-Adjusted Alignment Goals in Adult Spinal Deformity Surgery","volume":"35","author":"Greenberg","year":"2023","journal-title":"Semin. Spine Surg."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.nec.2018.03.003","article-title":"Spinopelvic Parameters: Lumbar Lordosis, Pelvic Incidence, Pelvic Tilt, and Sacral Slope: What Does a Spine Surgeon Need to Know to Plan a Lumbar Deformity Correction?","volume":"29","author":"Celestre","year":"2018","journal-title":"Neurosurg. Clin. N. Am."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1016\/j.spinee.2022.04.003","article-title":"Global Alignment and Proportion (GAP) Score in Asymptomatic Individuals: Is It Universal?","volume":"22","author":"Ma","year":"2022","journal-title":"Spine J."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1097\/BRS.0000000000004464","article-title":"Pelvic Nonresponse Following Treatment of Adult Spinal Deformity: Influence of Realignment Strategies on Occurrence","volume":"48","author":"Passias","year":"2023","journal-title":"Spine"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"E933","DOI":"10.1097\/BRS.0000000000003468","article-title":"Proximal Junctional Kyphosis in Degenerative Sagittal Deformity after Under- and Overcorrection of Lumbar Lordosis: Does Overcorrection of Lumbar Lordosis Instigate PJK?","volume":"45","author":"Im","year":"2020","journal-title":"Spine"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s13244-022-01246-z","article-title":"The Current Role and Future Directions of Imaging in Failed Back Surgery Syndrome Patients: An Educational Review","volume":"13","author":"Witkam","year":"2022","journal-title":"Insights Imaging"},{"key":"ref_65","first-page":"9940001","article-title":"Imaging Assessment of the Postoperative Spine: An Updated Pictorial Review of Selected Complications","volume":"2021","author":"Ternovoy","year":"2021","journal-title":"BioMed Res. Int."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1097\/RLI.0000000000000798","article-title":"Magnetic Resonance Imaging Around Metal at 1.5 Tesla: Techniques from Basic to Advanced and Clinical Impact","volume":"56","author":"Germann","year":"2021","journal-title":"Investig. Radiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"E126","DOI":"10.1148\/rg.2021200092","article-title":"Improving Mr Image Quality in Patients with Metallic Implants","volume":"41","author":"Lee","year":"2021","journal-title":"Radiographics"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/jmri.28296","article-title":"MR Neurography of Lumbosacral Plexus: Incremental Value Over XR, CT, and MRI of L Spine with Improved Outcomes in Patients with Radiculopathy and Failed Back Surgery Syndrome","volume":"57","author":"Chhabra","year":"2023","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s00256-022-04219-x","article-title":"Differences in Time-to-Fusion Based on \u201cAbsence of Peri-Graft Radiolucency\u201d and \u201cTrabecular Bone Bridging\u201d Criteria after Transforaminal Lumbar Interbody Fusion in Patients with Low and Normal Bone Density","volume":"52","author":"Choi","year":"2023","journal-title":"Skelet. Radiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"716","DOI":"10.3171\/2019.11.SPINE19868","article-title":"Computed Tomography Hounsfield Unit-Based Prediction of Pedicle Screw Loosening after Surgery for Degenerative Lumbar Spine Disease","volume":"32","author":"Zou","year":"2020","journal-title":"J. Neurosurg. Spine"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"E10","DOI":"10.3171\/2019.2.FOCUS18617","article-title":"Radiographic Outcomes of Endoscopic Decompression for Lumbar Spinal Stenosis","volume":"46","author":"Khalsa","year":"2019","journal-title":"Neurosurg. Focus"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"e1243","DOI":"10.1016\/j.wneu.2022.06.013","article-title":"SPECT-CT as a Predictor of Pain Generators in Patients Undergoing Intra-Articular Injections for Chronic Neck and Back Pain","volume":"164","author":"Garcia","year":"2022","journal-title":"World Neurosurg."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.spinee.2021.11.016","article-title":"When Does CT Myelography Add Value beyond MRI for Lumbar Degenerative Disease?","volume":"22","author":"Weisenthal","year":"2022","journal-title":"Spine J."},{"key":"ref_74","unstructured":"Hanscom, D., and Grunert, P. (2020). The Resident\u2019s Guide to Spine Surgery, Springer."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1148\/rg.2020190135","article-title":"CT Myelography: Clinical Indications and Imaging Findings","volume":"40","author":"Patel","year":"2020","journal-title":"Radiographics"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.cpet.2018.08.011","article-title":"Clinical Applications of Positron Emission Tomography in the Evaluation of Spine and Joint Disorders","volume":"14","author":"Ayubcha","year":"2019","journal-title":"PET Clin."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.jbspin.2019.01.009","article-title":"Added Value of [18F]Fluorodeoxyglucose Positron Emission Tomography\/Computed Tomography for the Diagnosis of Post-Operative Instrumented Spine Infection","volume":"86","author":"Follenfant","year":"2019","journal-title":"Jt. Bone Spine"},{"key":"ref_78","first-page":"31","article-title":"Epidurography","volume":"13","author":"Khan","year":"2019","journal-title":"Anaesth. Pain Intensive Care"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Funao, H., Yokosuka, K., Ukai, J., Nakanishi, K., Paku, M., Tomita, T., Hoshino, M., Saito, T., Ishii, K., and Sato, K. (2022). Efficacy of Minimally Invasive Trans-Sacral Canal Plasty between Patients with and without Failed Back Surgery Syndrome. Medicina, 58.","DOI":"10.3390\/medicina58020251"},{"key":"ref_80","first-page":"27","article-title":"Algorithm for Performing Cervical Epidural Steroid Injections with Contrast Spread Technique","volume":"15","author":"Perper","year":"2020","journal-title":"J. Orthop. Trauma Surg. Relat. Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/1754-9485.13308","article-title":"Image-Guided Spinal Injection for Pain Management","volume":"66","author":"Wong","year":"2022","journal-title":"J. Med. Imaging Radiat. Oncol."},{"key":"ref_82","unstructured":"Ah. Shin, D. (2019). Endoscopic Procedures on the Spine, Springer."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1093\/pm\/pnz225","article-title":"Contrast Dispersion on Epidurography May Be Associated with Clinical Outcomes After Percutaneous Epidural Neuroplasty Using an Inflatable Balloon Catheter","volume":"21","author":"Kim","year":"2020","journal-title":"Pain Med."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"3","DOI":"10.35353\/ajp.2021.00017","article-title":"Early Clinical Outcome of Comparative Study between Revision Operation and Radiofrequency Treatment for Management of Failed Back Surgery Syndrome","volume":"7","author":"Park","year":"2021","journal-title":"Asian J. Pain"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"8184592","DOI":"10.1155\/2019\/8184592","article-title":"Optimizing the Management and Outcomes of Failed Back Surgery Syndrome: A Proposal of a Standardized Multidisciplinary Team Care Pathway","volume":"2019","author":"Gatzinsky","year":"2019","journal-title":"Pain Res. Manag."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"101261","DOI":"10.1016\/j.ctcp.2020.101261","article-title":"Manipulative and Manual Therapies in the Management of Patients with Prior Lumbar Surgery: A Systematic Review","volume":"42","author":"Daniels","year":"2021","journal-title":"Complement. Ther. Clin. Pract."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.jbmt.2020.08.016","article-title":"Cognitive Functional Therapy (CFT) Compared with Core Training Exercise (CTE) in Patients with Failed Back Surgery Syndrome (FBSS): A Study Protocol for a Randomized Controlled Trial","volume":"26","author":"Avila","year":"2021","journal-title":"J. Bodyw. Mov. Ther."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1001\/jamaneurol.2018.0492","article-title":"Effect of Pain Neuroscience Education Combined with Cognition-Targeted Motor Control Training on Chronic Spinal Pain: A Randomized Clinical Trial","volume":"75","author":"Malfliet","year":"2018","journal-title":"JAMA Neurol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"54070","DOI":"10.1136\/bmjopen-2021-054070","article-title":"Protocol: Clinical Decision-Making for Spinal Manipulation for Persistent Spinal Pain Following Lumbar Surgery: A Protocol for a Systematic Review and Meta-Analysis of Individual Participant Data","volume":"11","author":"Trager","year":"2021","journal-title":"BMJ Open"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1177\/21925682221141385","article-title":"Non-Invasive Treatments for Failed Back Surgery Syndrome: A Systematic Review","volume":"13","author":"Papalia","year":"2023","journal-title":"Glob. Spine J."},{"key":"ref_91","first-page":"100066","article-title":"Role of Simultaneous Bilateral Transforaminal Epidural Steroid Injections in Patients with Prior Lumbar Fusions or Laminectomies: A Retrospective Case Series","volume":"1","author":"Zeng","year":"2022","journal-title":"Interv. Pain Med."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1007\/s00586-019-06011-3","article-title":"Dextrose Injections for Failed Back Surgery Syndrome: A Consecutive Case Series","volume":"28","author":"Solmaz","year":"2019","journal-title":"Eur. Spine J."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1097\/j.pain.0000000000001478","article-title":"Extended-Release Gabapentin for Failed Back Surgery Syndrome: Results from a Randomized Double-Blind Cross-over Study","volume":"160","author":"Gewandter","year":"2019","journal-title":"Pain"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"S57","DOI":"10.1016\/j.neuchi.2015.01.001","article-title":"Medical Management of Failed Back Surgery Syndrome in Europe: Evaluation Modalities and Treatment Proposals","volume":"61","author":"Durand","year":"2015","journal-title":"Neurochirurgie"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Sheldon, B.L., Olmsted, Z.T., Sabourin, S., Heydari, E., Harland, T.A., and Pilitsis, J.G. (2022). Review of the Treatments for Central Neuropathic Pain. Brain Sci., 12.","DOI":"10.3390\/brainsci12121727"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1001\/jamaneurol.2022.4166","article-title":"Long-Term Outcomes in Use of Opioids, Nonpharmacologic Pain Interventions, and Total Costs of Spinal Cord Stimulators Compared with Conventional Medical Therapy for Chronic Pain","volume":"80","author":"Dhruva","year":"2023","journal-title":"JAMA Neurol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1055\/s-0038-1673680","article-title":"Radicular Pain Syndromes: Cervical, Lumbar, and Spinal Stenosis","volume":"38","author":"Patel","year":"2018","journal-title":"Semin. Neurol."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Hershkovich, O., Mor, Y., and Lotan, R. (2022). Intravenous Corticosteroid Therapy for Acute Lumbar Radicular Pain. J. Clin. Med., 11.","DOI":"10.3390\/jcm11175127"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1093\/rheumatology\/ker151","article-title":"Efficacy and Tolerance of Systemic Steroids in Sciatica: A Systematic Review and Meta-Analysis","volume":"50","author":"Roncoroni","year":"2011","journal-title":"Rheumatology"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/ner.12737","article-title":"Intrathecal Trialing of Continuous Infusion Combination Therapy with Hydromorphone and Bupivacaine in Failed Back Surgery Patients","volume":"21","author":"Galica","year":"2018","journal-title":"Neuromodul. Technol. Neural Interface"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1097\/BRS.0000000000002217","article-title":"Treatment Options for Failed Back Surgery Syndrome Patients with Refractory Chronic Pain: An Evidence Based Approach","volume":"42","author":"Amirdelfan","year":"2017","journal-title":"Spine"},{"key":"ref_102","first-page":"31","article-title":"Gabapentin versus Naproxen in the Management of Failed Back Surgery Syndrome; a Randomized Controlled Trial","volume":"65","author":"Khosravi","year":"2014","journal-title":"Acta Anaesthesiol. Belg."},{"key":"ref_103","first-page":"344","article-title":"Preventive Analgesia with Pregabalin in Neuropathic Pain from \u201cFailed Back Surgery Syndrome\u201d: Assessment of Sleep Quality and Disability","volume":"17","author":"Canos","year":"2016","journal-title":"Pain Med."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.31616\/asj.2018.0237","article-title":"Antidepressants in Spine Surgery: A Systematic Review to Determine Benefits and Risks","volume":"13","author":"Bayoumi","year":"2019","journal-title":"Asian Spine J."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"E29","DOI":"10.36076\/ppj.2017.1.E29","article-title":"Treatment Outcomes for Patients with Failed Surgery","volume":"1","author":"Cho","year":"2017","journal-title":"Pain Physician"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"66S","DOI":"10.1177\/2192568220970163","article-title":"A Systematic Review of the Cost-Utility of Spinal Cord Stimulation for Persistent Low Back Pain in Patients with Failed Back Surgery Syndrome","volume":"11","author":"McClure","year":"2021","journal-title":"Glob. Spine J."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/ner.12204","article-title":"The Appropriate Use of Neurostimulation: New and Evolving Neurostimulation Therapies and Applicable Treatment for Chronic Pain and Selected Disease States. Neuromodulation Appropriateness Consensus Committee","volume":"17","author":"Deer","year":"2014","journal-title":"Neuromodulation"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"17","DOI":"10.36076\/pmcr.2022.6.17","article-title":"Spinal Cord Stimulation Therapy for Failed Back Surgery Syndrome in a Patient with Mild Dementia Case Report","volume":"6","author":"Lopez","year":"2022","journal-title":"Pain Med. Case Rep."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1590\/s1808-185120181703193251","article-title":"Spinal Cord Stimulation for Fail Back Surgery Syndrome: Literature Review and Clinical Study","volume":"17","author":"Kashcheev","year":"2018","journal-title":"Coluna\/Columna"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"642","DOI":"10.4184\/asj.2017.11.4.642","article-title":"Neuropathic Pain after Spinal Surgery","volume":"11","author":"Cho","year":"2017","journal-title":"Asian Spine J."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1007\/s00586-022-07334-4","article-title":"Onset of Mental Disorders in Patients Who Developed Failed Back Surgery Syndrome","volume":"31","author":"Stanton","year":"2022","journal-title":"Eur. Spine J."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"E78","DOI":"10.1097\/BSD.0000000000000730","article-title":"Depression Increases the Rates of Neurological Complications and Failed Back Surgery Syndrome in Patients Undergoing Lumbar Spine Surgery","volume":"32","author":"Schoell","year":"2019","journal-title":"Clin. Spine Surg."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1093\/ptj\/pzy022","article-title":"Cognitive Functional Therapy: An Integrated Behavioral Approach for the Targeted Management of Disabling Low Back Pain","volume":"98","author":"Caneiro","year":"2018","journal-title":"Phys Ther."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/7\/1255\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:07:05Z","timestamp":1760126825000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/7\/1255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,6]]},"references-count":113,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,7]]}},"alternative-id":["medicina59071255"],"URL":"https:\/\/doi.org\/10.3390\/medicina59071255","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,6]]}}}