{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T22:09:08Z","timestamp":1792534148614,"version":"4.5.0"},"reference-count":42,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T00:00:00Z","timestamp":1688688000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Because most individuals with chronic back pain (CLBP) have no specific cause, it is usually described as central sensitization. Pain neuroscience education (PNE) in top-down pain control may be effective against carryover effects; however, this remains unclear. In this study, the carryover effect was qualitatively and quantitatively synthesized and analyzed. Materials and Methods: Randomized controlled trials (RCTs) on PNE in individuals with CLBP were conducted using international databases until January 2023. Using RevMan5.4 provided by Cochrane, qualitative and quantitative analyses were performed with a risk of bias and meta-analysis, respectively. Results: Nine RCTs involving 1038 individuals with CLBP were included in the analysis. Four main results were identified: First, PNE had a short-term carryover effect on pain intensity (SMD = \u22121.55, 95% confidence interval [CI] = \u22122.59 to \u22120.50); second, PNE had a short-term carryover effect on pain catastrophizing (SMD = \u22122.47, 95% CI = \u22123.44 to \u22121.50); third, PNE had short- and long-term carryover effects on kinesiophobia (SMD = \u22123.51, 95% CI = \u22124.83 to \u22122.19); fourth, the appropriate therapeutic intensity of PNE for the pain intensity of individuals (SMD = \u22120.83, 95% CI = \u22121.60 to \u22120.07). Conclusions: PNE has a short-term carryover effect on pain intensity and pain cognition in individuals with CLBP and a long-term carryover effect on kinesiophobia.<\/jats:p>","DOI":"10.3390\/medicina59071268","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T00:35:21Z","timestamp":1688949321000},"page":"1268","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Carryover Effects of Pain Neuroscience Education on Patients with Chronic Lower Back Pain: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1271-788X","authenticated-orcid":false,"given":"Seungwoo","family":"Shin","sequence":"first","affiliation":[{"name":"Gwangju Sang Moo Hospital, 181-7, Sangmujayu-ro, Gwangju 61948, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6538-3872","authenticated-orcid":false,"given":"Hyunjoong","family":"Kim","sequence":"additional","affiliation":[{"name":"Neuromusculoskeletal Science Laboratory, 306 Jangsin-ro, Gwangju 62287, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1007\/s00586-010-1502-y","article-title":"An updated overview of clinical guidelines for the management of non-specific low back pain in primary care","volume":"19","author":"Koes","year":"2010","journal-title":"Eur. 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