{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T08:20:19Z","timestamp":1784535619483,"version":"3.55.0"},"reference-count":43,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,7,9]],"date-time":"2023-07-09T00:00:00Z","timestamp":1688860800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation of Korea (NRF)","award":["2021R1G1A1094093"],"award-info":[{"award-number":["2021R1G1A1094093"]}]},{"name":"Soonchunhyang University Research Fund","award":["2021R1G1A1094093"],"award-info":[{"award-number":["2021R1G1A1094093"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Hyperuricemia is associated with a variety of comorbidities. The objective of this study was to investigate the association between hyperuricemia and hearing impairment in Korean adults. Materials and Methods: Audiometric and laboratory test data from the 2019 to 2020 Korean National Health and Nutrition Examination Survey (KNHANES) were used for analysis. Hearing impairment was defined as a pure-tone average (0.5, 1, 2, 4 kHz) threshold level \u2265 41 decibels. The definition of hyperuricemia was different for males and females: &gt;7 mg\/dL for males vs. &gt;6 mg\/dL for females. Results: A total of 4857 (weight n = 17,990,725) subjects were analyzed. The mean age was 56.8 years old. The weighted prevalence was 12.1% for hyperuricemia and 2.5% for gout. The prevalence of hearing impairment was 13.4%. In the univariable analysis, hyperuricemia was significantly associated with hearing impairment. However, the diagnosis of gout was not associated with hearing impairment. In the multivariable analysis, hyperuricemia (odds ratios (OR): 1.41, 95% confidence interval [CI]: 1.03\u20131.92, p = 0.030) was associated with hearing impairment along with age (OR: 1.12, 95% CI: 1.10\u20131.14, p &lt; 0.001), female sex (OR: 0.43, 95% CI: 0.34\u20130.64, p &lt; 0.001), education (OR: 0.43, 95% CI: 0.30\u20130.63, p = 0.001), and occupational noise exposure (OR: 1.67, 95% CI: 1.25\u20132.22, p = 0.001). In the subgroup analysis, hyperuricemia was associated with hearing impairment in females (OR: 1.59, 95% CI: 1.02\u20132.48, p = 0.041) and the elderly aged 60 years or more (OR: 1.45, 95% CI: 1.05\u20131.99, p = 0.023). Conclusions: Hyperuricemia was independently associated with hearing impairment, especially in females and the elderly aged 60 years or more.<\/jats:p>","DOI":"10.3390\/medicina59071273","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T00:35:21Z","timestamp":1688949321000},"page":"1273","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Association between Hyperuricemia and Hearing Impairment: Results from the Korean National Health and Nutrition Examination Survey"],"prefix":"10.3390","volume":"59","author":[{"given":"Hyemin","family":"Jeong","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology, Soonchunhyang University Bucheon Hospital, Bucheon 14854, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4491-5088","authenticated-orcid":false,"given":"Young-Soo","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Sanggye Paik Hospital, College of Medicine, Inje University, Seoul 01757, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan-Hong","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology, Soonchunhyang University Bucheon Hospital, Bucheon 14854, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1001\/jamaoto.2017.2513","article-title":"Association of age-related hearing loss with cognitive function, cognitive impairment, and dementia: A systematic review and meta-analysis","volume":"144","author":"Loughrey","year":"2018","journal-title":"JAMA Otolaryngol. 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