{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:18:39Z","timestamp":1785417519153,"version":"3.56.0"},"reference-count":14,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,7,23]],"date-time":"2023-07-23T00:00:00Z","timestamp":1690070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>The current paper presents a case of a 33-year-old female with an uncommon localization of a leiomyoma in the oral cavity\u2014the anterior palatal fibromucosa and the incisive papilla. The patient referred to the Oro-Maxillo-Facial Surgery Clinic of Emergency City Hospital Timisoara, Romania, complaining of a slight discomfort in the act of mastication and the occurrence and persistence of a diastema between the upper central incisors, due to the presence of a nodule located in the anterior palatal mucosa, between the upper central incisors, without any changes of the subjacent bone structure in the anterior hard palate visible on a cone beam computed tomography image (CBCT). The lesion was removed using a surgical excisional biopsy and a histopathological examination was performed using morphological Hematoxylin\u2013Eosin (HE) staining and additional immunohistochemical (IHC) reactions, in order to confirm the diagnosis. On microscopic examination, bundles of spindle cells were found with eosinophilic cytoplasm and vesicular nuclei, with finely granular chromatin. The immunohistochemical reactions were positive for smooth muscle actin (SMA) and desmin and negative for vimentin. The treatment of choice for leiomyoma of the oral cavity is surgical excision with clear margins, followed by periodical clinical monitoring.<\/jats:p>","DOI":"10.3390\/medicina59071346","type":"journal-article","created":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T00:57:30Z","timestamp":1690160250000},"page":"1346","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Leiomyoma with Uncommon Localization\u2014Incisive Papilla and Palatal Fibromucosa: A Case Report"],"prefix":"10.3390","volume":"59","author":[{"given":"Marina","family":"Rakitovan","sequence":"first","affiliation":[{"name":"Department of Microscopic Morphology, University of Medicine and Pharmacy \u201cVictor Babes\u201d, 300041 Timisoara, Romania"},{"name":"Oro-Maxillo-Facial Surgery Clinic of the Emergency City Hospital, 300062 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Nicoara","sequence":"additional","affiliation":[{"name":"Oro-Maxillo-Facial Surgery Clinic of the Emergency City Hospital, 300062 Timisoara, Romania"},{"name":"Discipline of Dentoalveolar Surgery, University of Medicine and Pharmacy \u201cVictor Babes\u201d, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raluca","family":"Closca","sequence":"additional","affiliation":[{"name":"Department of Microscopic Morphology, University of Medicine and Pharmacy \u201cVictor Babes\u201d, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7755-4608","authenticated-orcid":false,"given":"Nicolae","family":"Balica","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, University of Medicine and Pharmacy \u201cVictor Babes\u201d, 300041 Timisoara, Romania"},{"name":"Otorhinolaryngology Clinic, Emergency City Hospital, 300054 Timisoara, Romania"},{"name":"OftalmoSensory-Tumor Research Center-ORL (EYE-ENT), University of Medicine and Pharmacy \u201cVictor Babes\u201d, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6669-7715","authenticated-orcid":false,"given":"Eugen","family":"Stefanescu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, University of Medicine and Pharmacy \u201cVictor Babes\u201d, 300041 Timisoara, Romania"},{"name":"Otorhinolaryngology Clinic, Emergency City Hospital, 300054 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5755-179X","authenticated-orcid":false,"given":"Flavia","family":"Baderca","sequence":"additional","affiliation":[{"name":"Department of Microscopic Morphology, University of Medicine and Pharmacy \u201cVictor Babes\u201d, 300041 Timisoara, Romania"},{"name":"Service of Pathology, Emergency City Hospital, 300254 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,23]]},"reference":[{"key":"ref_1","first-page":"9","article-title":"Leiomyoma of oral cavity: Case report and literature review","volume":"2","author":"Gianluca","year":"2011","journal-title":"Ann. Stomatol. (Roma)"},{"key":"ref_2","first-page":"294","article-title":"Leiomyoma and Leiomyosarcoma (Primary and Metastatic) of the Oral and Maxillofacial Region: A Clinicopathological and Immunohistochemical Study of 27 Cases","volume":"16","author":"Costa","year":"2022","journal-title":"Head. Neck Pathol."},{"key":"ref_3","first-page":"53","article-title":"Oral leiomyoma in retromolartrigone. A case report","volume":"12","year":"2007","journal-title":"Med. Oral. Patol. Oral. Cir. Bucal"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"520","DOI":"10.2174\/1874210601711010520","article-title":"Oral Leiomyoma in an Adult Male: A Case Report","volume":"11","author":"Nguyen","year":"2017","journal-title":"Open Dent. J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"361","DOI":"10.4103\/0973-029X.86727","article-title":"Oral leiomyoma","volume":"15","author":"Kaur","year":"2011","journal-title":"J. Oral. Maxillofac. 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Ed.)"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1067\/moe.2002.125276","article-title":"Clinicopathologic characterization of oral angioleiomyomas","volume":"94","author":"Brooks","year":"2002","journal-title":"Oral. Surg. Oral. Med. Oral. Pathol. Oral. Radiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1259\/dmfr\/22632903","article-title":"Intraosseous oral leiomyoma: Systematic review and report of one case","volume":"32","author":"Liang","year":"2003","journal-title":"Dentomaxillofac. 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