{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:48:25Z","timestamp":1790660905164,"version":"4.1.0"},"reference-count":26,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,7,30]],"date-time":"2023-07-30T00:00:00Z","timestamp":1690675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and objectives: The global burden of non-communicable diseases like obesity and cancer, particularly colorectal cancer (CRC), is increasing. The present study aimed to investigate the association between CRC location (proximal vs. distal) and patient demographic factors including age, sex, and BMI, as well as cancer stage at diagnosis. Materials and Methods: In this cross-sectional study, data from 830 patients diagnosed with CRC were analyzed. The variables included age, sex, weight, height, BMI, cancer location, and cancer stage at diagnosis. Patients were stratified into three age groups and three BMI categories, and we analyzed the association between cancer location and these variables using Chi-squared tests and multivariate logistic regression. Results: The rectum and ascending colon were the most common locations of malignant neoplasms. No statistically significant differences in cancer location across age groups were observed. Significant differences were found in the BMI across age groups, particularly in the normal weight and overweight categories. Normal weight and obese patients had a higher proportion of Stage 3 and Stage 4 cancers. Obesity emerged as a significant predictor for rectal cancer in a multivariate logistic regression analysis, with an odds ratio of 1.56. However, no significant associations were found between cancer location and other factors like age, gender, or cancer stage. Conclusions: Our study revealed that normal weight and obese patients had a higher proportion of Stage 3 and Stage 4 cancers, with obesity emerging as a significant predictor for rectal cancer. It is important to note that while obesity was found to be a significant predictor for rectal cancer, the development and location of colorectal cancer is likely influenced by various factors beyond those studied here. Therefore, further research is needed to investigate the roles of other potential risk factors, like loss of SIRT6 and adipose tissue homeostasis. Additionally, inflammation associated with microbiota in the colorectal mucosa, systemic gene expression, and visceral obesity may also play important roles in the development and progression of colorectal cancer. Understanding these intricate relationships is crucial for better screening, disease prognosis, and management strategies.<\/jats:p>","DOI":"10.3390\/medicina59081399","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T01:28:46Z","timestamp":1690766926000},"page":"1399","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Exploring the Influence of Age, Gender and Body Mass Index on Colorectal Cancer Location"],"prefix":"10.3390","volume":"59","author":[{"given":"Dorel","family":"Popovici","sequence":"first","affiliation":[{"name":"Department of Oncology, Faculty of Medicine, Victor Babe\u015f University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Stanisav","sequence":"additional","affiliation":[{"name":"Departments of Radiology, Victor Babe\u015f University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1628-2359","authenticated-orcid":false,"given":"Sorin","family":"Saftescu","sequence":"additional","affiliation":[{"name":"Department of Oncology, Faculty of Medicine, Victor Babe\u015f University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serban","family":"Negru","sequence":"additional","affiliation":[{"name":"Department of Oncology, Faculty of Medicine, Victor Babe\u015f University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radu","family":"Dragomir","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology, Victor Babe\u015f University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Ciurescu","sequence":"additional","affiliation":[{"name":"Departments of Medical and Surgical Specialties, Faculty of Medicine, Transylvania University of Bra\u0219ov, 500019 Brasov, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Razvan","family":"Diaconescu","sequence":"additional","affiliation":[{"name":"Departments of General Surgery, Vasile Goldi\u015f Western University of Arad, 310025 Arad, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,30]]},"reference":[{"key":"ref_1","unstructured":"Ritchie, H., and Roser, M. (2023, April 13). Obesity. Our World in Data, August. Available online: https:\/\/ourworldindata.org\/obesity#note-1."},{"key":"ref_2","unstructured":"World Health Organization (2023, April 13). Cancer Today. Available online: https:\/\/gco.iarc.fr\/today\/home."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e219","DOI":"10.1016\/S2542-5196(23)00021-9","article-title":"Food Processing and Cancer Risk in Europe: Results from the Prospective EPIC Cohort Study","volume":"7","author":"Kliemann","year":"2023","journal-title":"Lancet Planet. Health"},{"key":"ref_4","unstructured":"Kumar, R., and Lewis, C.R. (2023, April 15). Colon Cancer Screening, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK559064."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"8928","DOI":"10.1038\/s41598-023-36111-6","article-title":"The Risk of Colorectal Cancer according to Obesity Status at Four-Year Intervals: A Nationwide Population-Based Cohort Study","volume":"13","author":"Seo","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Safizadeh, F., Mandic, M., Pulte, D., Niedermaier, T., Hoffmeister, M., and Brenner, H. (2023). The Underestimated Impact of Excess Body Weight on Colorectal Cancer Risk: Evidence from the UK Biobank Cohort. Br. J. Cancer, 1\u20139.","DOI":"10.1038\/s41416-023-02351-6"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"612826","DOI":"10.3389\/fimmu.2021.612826","article-title":"Immune System, Microbiota, and Microbial Metabolites: The Unresolved Triad in Colorectal Cancer Microenvironment","volume":"12","author":"Hanus","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1177\/2050640619840451","article-title":"Clinical Stages of Colorectal Cancer Diagnosed in Obese and Overweight Individuals in the Polish Colonoscopy Screening Program","volume":"7","author":"Spychalski","year":"2019","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/s41467-018-08159-w","article-title":"Central Body Fatness Is a Stronger Predictor of Cancer Risk than Overall Body Size","volume":"10","author":"Barberio","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12967-016-0772-5","article-title":"Obesity and Colorectal Cancer: Molecular Features of Adipose Tissue","volume":"14","year":"2016","journal-title":"J. Transl. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/s41416-018-0124-8","article-title":"Adiposity and Risks of Colorectal and Small Intestine Cancer in Chinese Adults: A Prospective Study of 0.5 Million People","volume":"119","author":"Pang","year":"2018","journal-title":"Br. J. Cancer"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e158451","DOI":"10.1172\/JCI158451","article-title":"Metabolic Changes in Aging Humans: Current Evidence and Therapeutic Strategies","volume":"132","author":"Palmer","year":"2022","journal-title":"J. Clin. Investig."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"400","DOI":"10.21037\/atm.2020.02.184","article-title":"The Cellular Pathways of Liver Fibrosis in Non-Alcoholic Steatohepatitis","volume":"8","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.2147\/DMSO.S300250","article-title":"Weight Gain after 20 Years of Age Is Associated with Unfavorable Lifestyle and Increased Prevalence of Metabolic Disorders","volume":"14","author":"Takebe","year":"2021","journal-title":"Diabetes Metab. Syndr. Obes. Targets Ther."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Kasprzak, A. (2021). The Role of Tumor Microenvironment Cells in Colorectal Cancer (CRC) Cachexia. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22041565"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1177\/2050640618803825","article-title":"Association of Obesity with Colonic Findings in Screening Colonoscopy in a Large Population-Based Study","volume":"6","author":"Kobiela","year":"2018","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Soltani, G., Poursheikhani, A., Yassi, M., Hayatbakhsh, A., Kerachian, M., and Kerachian, M.A. (2019). Obesity, Diabetes and the Risk of Colorectal Adenoma and Cancer. BMC Endocr. Disord., 19.","DOI":"10.1186\/s12902-019-0444-6"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1038\/s41467-022-29085-y","article-title":"A Non-Dividing Cell Population with High Pyruvate Dehydrogenase Kinase Activity Regulates Metabolic Heterogeneity and Tumorigenesis in the Intestine","volume":"13","author":"Sebastian","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"164","DOI":"10.4093\/dmj.2022.0270","article-title":"Multiple Roles of Sirtuin 6 in Adipose Tissue Inflammation","volume":"47","author":"Bae","year":"2023","journal-title":"Diabetes Metab. J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"21556","DOI":"10.1038\/s41598-021-01086-9","article-title":"Different Prognostic Impact of Glucose Uptake in Visceral Adipose Tissue according to Sex in Patients with Colorectal Cancer","volume":"11","author":"Lee","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1038\/ijo.2017.80","article-title":"Myeloperoxidase-Positive Cell Infiltration of Normal Colorectal Mucosa Is Related to Body Fatness and Is Predictive of Adenoma Occurrence","volume":"41","author":"Mariani","year":"2017","journal-title":"Int. J. Obes."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"108052","DOI":"10.1016\/j.pharmthera.2021.108052","article-title":"Myeloperoxidase: Growing Importance in Cancer Pathogenesis and Potential Drug Target","volume":"236","author":"Raftopoulou","year":"2022","journal-title":"Pharmacol. Ther."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1038\/s41467-021-23265-y","article-title":"Identification of Microbial Markers across Populations in Early Detection of Colorectal Cancer","volume":"12","author":"Wu","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"4200","DOI":"10.1038\/s41388-022-02395-7","article-title":"Parvimonas Micra Promotes Colorectal Tumorigenesis and Is Associated with Prognosis of Colorectal Cancer Patients","volume":"41","author":"Zhao","year":"2022","journal-title":"Oncogene"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Kneis, B., Wirtz, S., Weber, K., Denz, A., Gittler, M., Geppert, C., Brunner, M., Krautz, C., Siebenh\u00fcner, A.R., and Schierwagen, R. (2023). Colon Cancer Microbiome Landscaping: Differences in Right- and Left-Sided Colon Cancer and a Tumor Microbiome-Ileal Microbiome Association. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24043265"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/s42003-022-03486-7","article-title":"Platelets from Patients with Visceral Obesity Promote Colon Cancer Growth","volume":"5","author":"Cariello","year":"2022","journal-title":"Commun. 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