{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:23:49Z","timestamp":1760149429195,"version":"build-2065373602"},"reference-count":20,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T00:00:00Z","timestamp":1691107200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Health, Czech Republic\u2014conceptual development of research organization","award":["00064165"],"award-info":[{"award-number":["00064165"]}]},{"name":"Cooperatio Program","award":["00064165"],"award-info":[{"award-number":["00064165"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Insulinoma is a rare tumor of the Langerhans islets of the pancreas. It produces insulin and causes severe hypoglycemia with neuroglycopenic symptoms. The incidence is low, at about 1\u20132 per 1 million inhabitants per year. The diagnosis is based on the presence of Whipple\u2019s triad and the result of a fasting test. Surgery is the treatment of choice. Objectives: A retrospective observational study of patients operated on for insulinoma in our hospital focused on the diagnosis, the type of surgery, and complications. Materials and Methods: We retrospectively reviewed patients operated on due to insulinoma. There were 116 surgeries between 2000 and 2022. There were 79 females and 37 males in this group. A fasting test and a CT examination were performed on all the patients. Results: The average duration of the fasting test was 18 h. Insulinoma was found in the body and tail of the pancreas in more than half of the patients. Enucleation was the most frequent type of surgery. Complications that were Clavien Dindo grade III or more occurred in 18% of the patients. The most frequent complications were abscesses and pancreatic fistula. Five patients had malignant insulinoma. Conclusions: Surgery is the treatment of choice in the case of insulinomas. The enucleation of the tumor is a sufficient treatment for benign insulinomas, which are not in contact with the main pancreatic duct. Due to the low incidence of the condition, the centralization of patients is recommended.<\/jats:p>","DOI":"10.3390\/medicina59081423","type":"journal-article","created":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T09:27:48Z","timestamp":1691141268000},"page":"1423","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Diagnosis and Surgical Management of Insulinomas\u2014A 23-Year Single-Center Experience"],"prefix":"10.3390","volume":"59","author":[{"given":"David","family":"Hoskovec","sequence":"first","affiliation":[{"name":"1st Department of Surgery, General University Hospital, U nemocnice 2, 12000 Prague, Czech Republic"},{"name":"1st Medical Faculty, Charles University, Katerinska 32, 12000 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zden\u011bk","family":"Kr\u0161ka","sequence":"additional","affiliation":[{"name":"1st Department of Surgery, General University Hospital, U nemocnice 2, 12000 Prague, Czech Republic"},{"name":"1st Medical Faculty, Charles University, Katerinska 32, 12000 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"\u0160krha","sequence":"additional","affiliation":[{"name":"1st Medical Faculty, Charles University, Katerinska 32, 12000 Prague, Czech Republic"},{"name":"3rd Department of Inner Medicine, General University Hospital, U nemocnice 2, 12000 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavol","family":"Klobu\u0161ick\u00fd","sequence":"additional","affiliation":[{"name":"1st Medical Faculty, Charles University, Katerinska 32, 12000 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petr","family":"Dytrych","sequence":"additional","affiliation":[{"name":"1st Department of Surgery, General University Hospital, U nemocnice 2, 12000 Prague, Czech Republic"},{"name":"1st Medical Faculty, Charles University, Katerinska 32, 12000 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s40618-019-01091-w","article-title":"The functioning side of the pancreas: A review on insulinomas","volume":"43","author":"Maggio","year":"2020","journal-title":"J. Endocrinol. Investig."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2059481","DOI":"10.1155\/2018\/2059481","article-title":"Characteristics and Outcomes of 79 Patients with an Insulinoma: A Nationwide Retrospective Study in Finland","volume":"2018","author":"Peltola","year":"2018","journal-title":"Int. J. Endocrinol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1007\/s00423-016-1496-y","article-title":"Diagnosis and surgical management of insulinomas in 33 consecutive patients at a single institution","volume":"401","author":"Wei","year":"2016","journal-title":"Langenbeck\u2019s Arch. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"771","DOI":"10.4103\/ijmr.IJMR_1477_14","article-title":"Evolving management of insulinoma: Experience at a tertiary care centre","volume":"144","author":"Jyotsna","year":"2016","journal-title":"Indian J. Med. Res."},{"key":"ref_5","first-page":"505","article-title":"Insulinoma\u2014rare, but important clinical problem. Analysis of a Series of 530 Patients Who Underwent Surgical Treatment for the Pancreatic Tumor","volume":"86","author":"Hogendorf","year":"2015","journal-title":"Pol. J. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"515","DOI":"10.5114\/aoms.2016.60311","article-title":"Management of the hormonal syndrome of neuroendocrine tumors","volume":"13","author":"Gut","year":"2017","journal-title":"Arch. Med. Sci."},{"key":"ref_7","first-page":"389","article-title":"Diagnostics and treatment of organic hyperinsulinism--experience in 105 cases","volume":"148","author":"Skrha","year":"2009","journal-title":"Cas. Lek. Cesk."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"858","DOI":"10.4103\/2230-8210.141385","article-title":"Insulinoma case series: Experience of a tertiary care center","volume":"18","author":"Kalra","year":"2014","journal-title":"Indian J. Endocrinol. Metab."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1159\/000357779","article-title":"Enucleation and Limited Pancreatic Resection Provide Long-Term Cure for Insulinoma in Multiple Endocrine Neoplasia Type","volume":"98","author":"Bartsch","year":"2013","journal-title":"Neuroendocrinology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"5843","DOI":"10.1210\/jc.2018-02754","article-title":"68Ga-Exendin-4 PET\/CT Detects Insulinomas in Patients with Endogenous Hyperinsulinemic Hypoglycemia in MEN-1","volume":"104","author":"Antwi","year":"2019","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/jhbp.642","article-title":"Importance of localization of insulinomas: A systematic analysis","volume":"26","author":"Burghardt","year":"2019","journal-title":"J. Hepato-Biliary-Pancreatic Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1002\/jhbp.224","article-title":"Determinants of surgical resection for pancreatic neuroendocrine tumors","volume":"22","author":"Doi","year":"2015","journal-title":"J. Hepato-Biliary-Pancreatic Sci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ijscr.2019.09.024","article-title":"Near infrared light examination as part of the management of sporadic pancreatic head insulinoma: Case report","volume":"64","author":"Constantinescu","year":"2019","journal-title":"Int. J. Surg. Case Rep."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1159\/000456630","article-title":"Surgical Therapy of Sporadic Pancreatic Neuroendocrine Neoplasias G1\/G2","volume":"33","author":"Fendrich","year":"2017","journal-title":"Visc. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1001\/archsurg.2011.1843","article-title":"Surgical management of insulinomas: Short- and long-term outcomes after enucleations and pancreatic resections","volume":"147","author":"Crippa","year":"2012","journal-title":"Arch. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1097\/MPA.0000000000000110","article-title":"A Systematic Review of Localization, Surgical Treatment Options, and Outcome of Insulinoma","volume":"43","author":"Mehrabi","year":"2014","journal-title":"Pancreas"},{"key":"ref_17","unstructured":"(2023, July 18). Available online: https:\/\/www.enets.org\/guidelines.html."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1007\/s00423-011-0801-z","article-title":"Enucleation in pancreatic surgery: Indications, technique, and outcome compared to standard pancreatic resections","volume":"396","author":"Hackert","year":"2011","journal-title":"Langenbeck\u2019s Arch. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.pan.2018.01.009","article-title":"Insulinoma: A retrospective study analyzing the differences between benign and malignant tumors","volume":"18","author":"Toyoshima","year":"2018","journal-title":"Pancreatology"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Yu, J., Ping, F., Zhang, H., Li, W., Yuan, T., Fu, Y., Feng, K., Xia, W., Xu, L., and Li, Y. (2018). Clinical Management of Malignant Insulinoma: A single Institution\u2019s experience over three decades. BMC Endocr. Disord., 18.","DOI":"10.1186\/s12902-018-0321-8"}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/8\/1423\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:25:49Z","timestamp":1760127949000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/8\/1423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,4]]},"references-count":20,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2023,8]]}},"alternative-id":["medicina59081423"],"URL":"https:\/\/doi.org\/10.3390\/medicina59081423","relation":{},"ISSN":["1648-9144"],"issn-type":[{"type":"electronic","value":"1648-9144"}],"subject":[],"published":{"date-parts":[[2023,8,4]]}}}