{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T00:18:48Z","timestamp":1771028328169,"version":"3.50.1"},"reference-count":25,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T00:00:00Z","timestamp":1692230400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objective: To examine the effects of the lockdown on diet adherence and stress levels in patients with laryngopharyngeal reflux (LPR). Materials and Methods: Patients with a positive LPR diagnosis at the hypopharyngeal-esophageal impedance-pH monitoring were treated from a pre- to lockdown period with a 3-month high-protein, low-fat, alkaline, plant-based diet, with behavioral changes, and an association of pantoprazole (20 MG\/d) and alginate (Gaviscon 3\/d). The following patient-reported outcomes questionnaire and findings instrument were used: Reflux Symptom Score-12 (RSS-12) and Reflux Sign Assessment (RSA). At the posttreatment time, patients were invited to evaluate the impact of lockdown on diet adherence and stress management with a predefined grid of foods and beverages and the perceived stress scale (PSS), respectively. Results: Thirty-two patients completed the evaluations. RSS-12 and RSA significantly improved from baseline to 3-month posttreatment. Most patients experienced mild-to-severe stress levels at the end of the lockdown. The level of stress substantially increased in 11 patients (34%) due to the lockdown, while it did not change in 11 patients (44%). In 11 cases (34%), patients reported that the adherence to the anti-reflux diet was better than initially presumed thanks to the lockdown period, while 44% (N = 14) reported that the lockdown did not impact the adherence to a diet. PSS and RSS-12 were significantly correlated at the end of the pandemic (rs = 0.681; p &lt; 0.001). The increase in stress level was positively associated with the lack of adherence to diet (rs = 0.367; p = 0.039). Conclusions: During the lockdown, the diet habits of LPR patients were improved in one-third and unchanged in 44% of cases. The stress level was increased in one-third of patients, which was associated with an increase in symptom scores.<\/jats:p>","DOI":"10.3390\/medicina59081475","type":"journal-article","created":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T10:15:48Z","timestamp":1692267348000},"page":"1475","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Laryngopharyngeal Reflux Patient Changes during the COVID-19 Quarantine"],"prefix":"10.3390","volume":"59","author":[{"given":"Alexandra","family":"Rodriguez","sequence":"first","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, CHU Saint-Pierre, 1000 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Younes","family":"Steffens","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, CHU Saint-Pierre, 1000 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Calvo-Henriquez","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Hospital Complex of Santiago de Compostela, 15706 Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1829-6597","authenticated-orcid":false,"given":"Miguel","family":"Mayo-Y\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology-Head and Neck Surgery Department, Complexo Hospitalario Universitario A Coru\u00f1a (CHUAC), 15006 A Coru\u00f1a, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihaela","family":"Horoi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, CHU Saint-Pierre, 1000 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0845-0845","authenticated-orcid":false,"given":"Jerome R.","family":"Lechien","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, CHU Saint-Pierre, 1000 Brussels, Belgium"},{"name":"Department of Otolaryngology, Elsan Hospital, 86000 Paris, France"},{"name":"Department of Otolaryngology-Head and Neck Surgery, Foch Hospital, School of Medicine, University Paris Saclay, 75000 Paris, France"},{"name":"Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), 7000 Mons, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1177\/0194599819827488","article-title":"Evaluation and Management of Laryngopharyngeal Reflux Disease: State of the Art Review","volume":"160","author":"Lechien","year":"2019","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1007\/s00405-019-05482-w","article-title":"Association between laryngopharyngeal reflux disease and autonomic nerve dysfunction","volume":"276","author":"Wang","year":"2019","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_3","first-page":"e2021440","article-title":"Adherence to the Mediterranean Diet during the COVID-19 national lockdowns: A systematic review of observational studies","volume":"92","author":"Mosconi","year":"2021","journal-title":"Acta Biomed."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"105743","DOI":"10.1016\/j.appet.2021.105743","article-title":"Changes in home cooking and culinary practices among the French population during the COVID-19 lockdown","volume":"168","author":"Sarda","year":"2021","journal-title":"Appetite"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1177\/01945998211029831","article-title":"Normative Ambulatory Reflux Monitoring Metrics for Laryngopharyngeal Reflux: A Systematic Review of 720 Healthy Individuals","volume":"166","author":"Lechien","year":"2021","journal-title":"Otolaryngol. Neck Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s00405-019-05711-2","article-title":"Patients with acid, high-fat and low-protein diet have higher laryngopharyngeal reflux episodes at the impedance-pH monitoring","volume":"277","author":"Lechien","year":"2020","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1177\/0194599820941003","article-title":"Development and Validation of the Short Version of the Reflux Symptom Score: Reflux Symptom Score\u201312","volume":"164","author":"Lechien","year":"2020","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1177\/0003489419888947","article-title":"Validity and Reliability of the Reflux Sign Assessment","volume":"129","author":"Lechien","year":"2020","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1177\/1359105313508346","article-title":"New, normative, English-sample data for the Short Form Perceived Stress Scale (PSS-4)","volume":"18","author":"Warttig","year":"2013","journal-title":"J. Health Psychol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1007\/s00405-019-05631-1","article-title":"Development of scores assessing the refluxogenic potential of diet of patients with laryngopharyngeal reflux","volume":"276","author":"Lechien","year":"2019","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.1002\/jmv.26731","article-title":"Epidemiology and precision of SARS-CoV-2 detection following lockdown and relaxation measures","volume":"93","author":"Leuzinger","year":"2021","journal-title":"J. Med. Virol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1002\/jmv.26659","article-title":"SARS-CoV-2 in Argentina: Lockdown, mobility, and contagion","volume":"93","author":"Larrosa","year":"2021","journal-title":"J. Med. Virol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/jmv.26253","article-title":"Effects of COVID-19 lockdown on epidemic diseases of childhood","volume":"93","author":"Belingheri","year":"2021","journal-title":"J. Med. Virol."},{"key":"ref_14","first-page":"909","article-title":"Prevalence of laryngopharyngeal reflux disease in Fuzhou region of China","volume":"51","author":"Chen","year":"2016","journal-title":"Zhonghua er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1007\/s00405-012-2028-1","article-title":"The prevalence of laryngopharyngeal reflux in the English population","volume":"269","author":"Kamani","year":"2012","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"\u00c1lvarez-G\u00f3mez, C., De La Higuera, M., Rivas-Garc\u00eda, L., Diaz-Castro, J., Moreno-Fernandez, J., and Lopez-Frias, M. (2021). Has COVID-19 Changed the Lifestyle and Dietary Habits in the Spanish Population after Confinement?. Foods, 10.","DOI":"10.3390\/foods10102443"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1002\/jmv.27549","article-title":"A large-scale meta-analytic atlas of mental health problems prevalence during the COVID-19 early pandemic","volume":"94","author":"Dragioti","year":"2022","journal-title":"J. Med. Virol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/jmv.27272","article-title":"Impact of COVID-19 on the mental health in a cohort of Italian rehabilitation healthcare workers","volume":"94","author":"Giorgio","year":"2022","journal-title":"J. Med. Virol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1177\/0194599813482103","article-title":"Evaluating the autonomic nervous system in patients with laryngopharyngeal reflux","volume":"148","author":"Huang","year":"2013","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e00408","DOI":"10.14309\/ctg.0000000000000408","article-title":"Impaired Proximal Esophageal Contractility Predicts Pharyngeal Reflux in Patients with Laryngopharyngeal Reflux Symptoms","volume":"12","author":"Sikavi","year":"2021","journal-title":"Clin. Transl. Gastroenterol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1002\/jmv.25998","article-title":"The impact of laryngopharyngeal reflux disease on 95 hospitalized patients with COVID-19 in Wuhan, China: A retrospective study","volume":"92","author":"Jiang","year":"2020","journal-title":"J. Med. Virol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"103950","DOI":"10.1016\/j.amjoto.2023.103950","article-title":"COVID-related dysphonia and persistent long-COVID voice sequelae: A systematic review and meta-analysis","volume":"44","author":"Lin","year":"2023","journal-title":"Am. J. Otolaryngol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1113\/EP090802","article-title":"Long COVID: Mechanisms, risk factors and recovery","volume":"108","author":"Astin","year":"2023","journal-title":"Exp. Physiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1225698","DOI":"10.3389\/fpsyg.2023.1225698","article-title":"Emotional control and factors differentiating it in the adult population of Poland during the COVID-19 pandemic","volume":"14","year":"2023","journal-title":"Front. Psychol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Liozidou, A., Varela, V., Vlastos, D.D., Giogkaraki, E., Alzueta, E., Perrin, P.B., Ramos-Usuga, D., and Arango-Lasprilla, J.C. (2023). Forced social isolation and lockdown during the COVID-19 pandemic: Depression, anxiety, trauma-distress and coping mechanisms of a Greek sample. Z. Gesundh. 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