{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T10:23:36Z","timestamp":1771669416408,"version":"3.50.1"},"reference-count":25,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T00:00:00Z","timestamp":1692316800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Vulvovaginal infections pose significant health challenges for women, necessitating effective treatment approaches. This retrospective observational study aimed at investigating the efficacy of collagen-based vaginal ovules therapy, specifically Plurigin Ovules, in restoring cervical epithelialization and reducing inflammation in mycotic, viral, and bacterial cervico-vaginitis. Materials and Methods: A total of 398 women with cervico-vaginitis were included in the study, categorized into three groups: bacterial cervico-vaginitis (Group A), viral cervico-vaginitis (Group B), and fungal cervico-vaginitis (Group C). Participants received vaginal therapy with Plurigin Ovules for three months. Vaginal health parameters were assessed at baseline (T0) and after six months (T1) using various diagnostic tests and analyzed with appropriate statistical tests. Results: Significant improvement in cervico-vaginitis was observed in all three groups. At T1, 87.7% patients of Group A, 66.7% of Group B, and 71.5% of Group C achieved infection resolution (all p &lt; 0.05). Positive colposcopy results decreased across all groups (p &lt; 0.001). Positive vaginal swabs and altered vaginal pH decreased in group A and C (p &lt; 0.001). Positive HPV tests decreased in Group B (p &lt; 0.001). Positive Pap tests and clinical examinations decreased significantly across all groups (p &lt; 0.001). The odds ratios were calculated to reveal the significant associations between these diagnostic outcomes. The therapy was well-tolerated, and no major adverse events were reported. Conclusion: Plurigin Ovules exhibited promising therapeutic outcomes in the three cervico-vaginitis conditions studied. Bacterial cervico-vaginitis showed the most significant improvement, followed by fungal and viral cervico-vaginitis. These findings emphasize the potential of Plurigin Ovules as an effective therapeutic option for cervico-vaginal inflammation and infection, highlighting its role in promoting re-epithelialization and reducing inflammatory processes in the cervix and vagina.<\/jats:p>","DOI":"10.3390\/medicina59081490","type":"journal-article","created":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T10:28:48Z","timestamp":1692354528000},"page":"1490","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Collagen-Based Ovule Therapy Reduces Inflammation and Improve Cervical Epithelialization in Patients with Fungal, Viral, and Bacterial Cervico-Vaginitis"],"prefix":"10.3390","volume":"59","author":[{"given":"Nicoletta","family":"De Rosa","sequence":"first","affiliation":[{"name":"Ginecology and Obstetric Department, Pio XI Hospital, 20832 Monza-Brianza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizia","family":"Santangelo","sequence":"additional","affiliation":[{"name":"Hospital of National Relevance \u201cA. Cardarelli\u201d, 80113 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celestino","family":"Todisco","sequence":"additional","affiliation":[{"name":"ASL Napoli 3 Sud, 80059 Torre del Greco, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana","family":"Dequerquis","sequence":"additional","affiliation":[{"name":"Hospital of National Relevance \u201cA. Cardarelli\u201d, 80113 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Santangelo","sequence":"additional","affiliation":[{"name":"Hospital of National Relevance \u201cA. Cardarelli\u201d, 80113 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"963752","DOI":"10.3389\/frph.2022.963752","article-title":"The female reproductive tract microbiotas, inflammation, and gynecological conditions","volume":"4","author":"Gholiof","year":"2022","journal-title":"Front. Reprod. Health"},{"key":"ref_2","first-page":"196","article-title":"Non-sexually transmitted bacterial infections of the vulva","volume":"4","author":"Chaitanya","year":"2022","journal-title":"J. Ski. Sex. Transm. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"631972","DOI":"10.3389\/fcimb.2021.631972","article-title":"The Female Vaginal Microbiome in Health and Bacterial Vaginosis","volume":"11","author":"Chen","year":"2021","journal-title":"Front. Cell. Infect. 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