{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T04:14:30Z","timestamp":1789186470531,"version":"build-2803163510"},"reference-count":56,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Atherosclerosis is a multifactorial process in which inflammatory markers have both therapeutic and prognostic roles. Recent studies bring into question the importance of assessing new inflammatory markers in relation to the severity of peripheral artery disease (PAD), such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and lymphocyte-to-C-reactive protein ratio (LCR). Materials and Methods: We conducted a retrospective and descriptive study including 652 patients with PAD, who were divided into two groups according to the severity of the ankle\u2013brachial index value: mild and moderate obstruction (257 patients) and severe obstruction (395 patients). We evaluated demographics, anthropometric data and clinical and paraclinical parameters in relation to the novel inflammatory biomarkers mentioned above. Results: Weight (p = 0.048), smoking (p = 0.033), the number of cardiovascular risk factors (p = 0.041), NLR (p = 0.037), LCR (p = 0.041) and PLR (p = 0.019), the presence of gangrene (p = 0.001) and the number of lesions detected via peripheral angiography (p &lt; 0.001) were statistically significant parameters in our study. For the group of patients with severe obstruction, all three inflammatory biomarkers were statistically significantly correlated with a serum low-density lipoprotein\u2013cholesterol level, the number of cardiovascular risk factors, rest pain, gangrene and a risk of amputation. In addition, directly proportional relationships were found between NLR, PLR and the number of stenotic lesions (p = 0.018, p = 0.016). Also, NLR (area under the curve &lt;AUC&gt; = 0.682, p = 0.010) and PLR (AUC = 0.692, p = 0.006) were predictors associated with a high risk of amputation in patients with an ABI &lt; 0.5. Conclusions: in our study, we demonstrated the importance of assessing inflammatory markers in relation to the presence of cardiovascular risk factors through the therapeutic and prognostic value demonstrated in PAD.<\/jats:p>","DOI":"10.3390\/medicina59091557","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T01:56:57Z","timestamp":1693187817000},"page":"1557","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The Role Played by Novel Inflammatory Markers in Assessment of Peripheral Artery Disease"],"prefix":"10.3390","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2762-0918","authenticated-orcid":false,"given":"Viviana","family":"Onofrei","sequence":"first","affiliation":[{"name":"Department of Medical Specialties I and III, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, University Street No. 16, 700115 Iasi, Romania"},{"name":"\u201cSt. Spiridon\u201d Clinical Emergency Hospital, Independence Boulevard No. 1, 700111 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9827-6133","authenticated-orcid":false,"given":"Adrian","family":"Cri\u0219an","sequence":"additional","affiliation":[{"name":"\u201cSt. Spiridon\u201d Clinical Emergency Hospital, Independence Boulevard No. 1, 700111 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7313-3320","authenticated-orcid":false,"given":"Cristina Andreea","family":"Adam","sequence":"additional","affiliation":[{"name":"Department of Medical Specialties I and III, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, University Street No. 16, 700115 Iasi, Romania"},{"name":"Clinical Rehabilitation Hospital, Cardiovascular Rehabilitation Clinic, Pantelimon Halipa Street No. 14, 700661 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2334-9953","authenticated-orcid":false,"given":"Dragos Traian Marius","family":"Marcu","sequence":"additional","affiliation":[{"name":"Department of Medical Specialties I and III, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, University Street No. 16, 700115 Iasi, Romania"},{"name":"Clinical Hospital of Pneumophthisiology Ia\u0219i, Doctor Iosif Cihac Street no 30, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai \u0218tefan Cristian","family":"Haba","sequence":"additional","affiliation":[{"name":"Department of Medical Specialties I and III, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, University Street No. 16, 700115 Iasi, Romania"},{"name":"\u201cSt. Spiridon\u201d Clinical Emergency Hospital, Independence Boulevard No. 1, 700111 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Carina","family":"Tribus","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Dentistry, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Internal Medicine, Ilfov County Emergency Hospital, 022104 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0043-9051","authenticated-orcid":false,"given":"Alexandr","family":"Ceasovschih","sequence":"additional","affiliation":[{"name":"Department of Medical Specialties I and III, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, University Street No. 16, 700115 Iasi, Romania"},{"name":"\u201cSt. Spiridon\u201d Clinical Emergency Hospital, Independence Boulevard No. 1, 700111 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5148-8769","authenticated-orcid":false,"given":"Irina Mihaela","family":"E\u0219anu","sequence":"additional","affiliation":[{"name":"Department of Medical Specialties I and III, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, University Street No. 16, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1239-8058","authenticated-orcid":false,"given":"Antoneta Dacia","family":"Petroaie","sequence":"additional","affiliation":[{"name":"Department of Medical Specialties I and III, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, University Street No. 16, 700115 Iasi, Romania"},{"name":"Department of Family Medicine, Preventive Medicine and Interdisciplinary, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, University Street No. 16, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3732-0350","authenticated-orcid":false,"given":"Radu","family":"Cri\u0219an-Dabija","sequence":"additional","affiliation":[{"name":"Department of Medical Specialties I and III, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, University Street No. 16, 700115 Iasi, Romania"},{"name":"Clinical Hospital of Pneumophthisiology Ia\u0219i, Doctor Iosif Cihac Street no 30, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Magdalena","family":"Leon-Constantin","sequence":"additional","affiliation":[{"name":"Department of Medical Specialties I and III, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, University Street No. 16, 700115 Iasi, Romania"},{"name":"Clinical Rehabilitation Hospital, Cardiovascular Rehabilitation Clinic, Pantelimon Halipa Street No. 14, 700661 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2564-537X","authenticated-orcid":false,"given":"Carmen","family":"Cump\u0103t","sequence":"additional","affiliation":[{"name":"Department of Medical Specialties I and III, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, University Street No. 16, 700115 Iasi, Romania"},{"name":"Clinical Rehabilitation Hospital, Cardiovascular Rehabilitation Clinic, Pantelimon Halipa Street No. 14, 700661 Iasi, Romania"},{"name":"Department of Management, \u201cAlexandru Ioan Cuza\u201d University, Blv. Carol I, 700506 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1801-9327","authenticated-orcid":false,"given":"Florin","family":"Mitu","sequence":"additional","affiliation":[{"name":"Department of Medical Specialties I and III, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, University Street No. 16, 700115 Iasi, Romania"},{"name":"Clinical Rehabilitation Hospital, Cardiovascular Rehabilitation Clinic, Pantelimon Halipa Street No. 14, 700661 Iasi, Romania"},{"name":"Academy of Medical Sciences, 030167 Bucharest, Romania"},{"name":"Academy of Romanian Scientists, 700050 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"101082","DOI":"10.1016\/j.cpcardiol.2021.101082","article-title":"Peripheral Artery Disease: A Comprehensive Updated Review","volume":"47","author":"Shamaki","year":"2022","journal-title":"Curr. Probl. 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