{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:10:47Z","timestamp":1760130647372,"version":"build-2065373602"},"reference-count":11,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T00:00:00Z","timestamp":1693267200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Basic Science Research Program through the National Research Foundation of Korea (NRF)","award":["NRF-2017R1D1A3B03036299"],"award-info":[{"award-number":["NRF-2017R1D1A3B03036299"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background: Aside from primary pseudotumor cerebri syndrome (PTCS) with an unknown etiology (i.e., idiopathic intracranial hypertension), which typically occurs in association with obesity, several conditions including cerebral venous abnormalities, drug use, and hormonal imbalance may be a secondary cause of PTCS. However, a focal space-occupying lesion outside of the brain as a cause of PTCS has rarely been reported. Case Presentation: A previously healthy 34-year-old man presented with blurred vision for three weeks. The patient had a three-month preceding history of worsening headache. On admission, he was hypertensive (160\/90 mmHg) and underweight with a body mass index of 18.4 kg\/m2. Fundus examination documented papilledema in both eyes. Neurological examination was unremarkable except for mild nuchal rigidity, and results of routine serologic testing were normal. Gadolinium-enhanced brain magnetic resonance imaging revealed bilateral posterior scleral flattening, suggesting intracranial hypertension. There was no other abnormal brain parenchymal lesion or meningeal enhancement. Cerebrospinal fluid (CSF) assay showed a markedly increased opening pressure (30.0 cmH2O) with normal CSF composition. A tentative diagnosis of PTCS was made based on ophthalmological, neuroradiological, and laboratory findings. During differential diagnosis, abdomen computed tomography demonstrated a huge benign cystic lesion (14.7 \u00d7 10.6 \u00d7 16.4 cm) in the right retroperitoneal space, which originated from the mesentery and resulted in hydronephrosis and renovascular hypertension due to external compression of the right kidney. Other evaluations were unremarkable. After successful surgical removal of the cyst, clinical symptoms such as headache, blurred vision, and papilledema on fundus examination were markedly improved, and blood pressure was normalized during the three-month follow-up period. Conclusions: A large retroperitoneal cyst that can increase intra-abdominal pressure could be a rare cause of PTCS. Therefore, meticulous evaluation is warranted for patients with PTCS, especially those without known risk factors.<\/jats:p>","DOI":"10.3390\/medicina59091573","type":"journal-article","created":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T09:48:15Z","timestamp":1693388895000},"page":"1573","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Case Report of Pseudotumor Cerebri Syndrome with a Huge Retroperitoneal Cyst"],"prefix":"10.3390","volume":"59","author":[{"given":"Jae-Myung","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Neurology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju 61469, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyunsoo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju 61469, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung Wook","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju 61469, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong-Min","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju 61469, Republic of Korea"},{"name":"National Research Center for Dementia, Gwangju 61469, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0637-5394","authenticated-orcid":false,"given":"Man-Seok","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju 61469, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1212\/WNL.0b013e3182a55f17","article-title":"Revised diagnostic criteria for the pseudotumor cerebri syndrome in adults and children","volume":"81","author":"Friedman","year":"2013","journal-title":"Neurology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1186\/1752-1947-7-261","article-title":"The CARE (CAse REport) guidelines and the standardization of case reports","volume":"7","author":"Rison","year":"2013","journal-title":"J. Med. Case Rep."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S1474-4422(15)00298-7","article-title":"Understanding idiopathic intracranial hypertension: Mechanisms, management, and future directions","volume":"15","author":"Markey","year":"2016","journal-title":"Lancet Neurol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1111\/j.1468-1331.2008.02207.x","article-title":"Obesity may not be a risk factor for idiopathic intracranial hypertension in Asians","volume":"15","author":"Kim","year":"2008","journal-title":"Eur. J. Neurol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/IIO.0b013e3182aabf11","article-title":"Epidemiology and risk factors for idiopathic intracranial hypertension","volume":"54","author":"Chen","year":"2014","journal-title":"Int. Ophthalmol. Clin."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/ajh.20388","article-title":"Myelofibrosis-associated massive splenomegaly: A cause of increased intra-abdominal pressure, pulmonary hypertension, and positional dyspnea","volume":"80","author":"Ziakas","year":"2005","journal-title":"Am. J. Hematol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/0887-8994(86)90055-X","article-title":"Pseudotumor cerebri associated with obstructive nephropathy","volume":"2","author":"Noetzel","year":"1986","journal-title":"Pediatr. Neurol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ccm.2008.09.003","article-title":"Intra-abdominal hypertension: Evolving concepts","volume":"30","author":"Malbrain","year":"2009","journal-title":"Clin. Chest Med."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Mu\u00f1oz-Durango, N., Fuentes, C.A., Castillo, A.E., Gonz\u00e1lez-G\u00f3mez, L.M., Vecchiola, A., Fardella, C.E., and Kalergis, A. (2016). Role of the Renin-Angiotensin-Aldosterone System beyond Blood Pressure Regulation: Molecular and Cellular Mechanisms Involved in End-Organ Damage during Arterial Hypertension. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17070797"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Hu, W., Wang, C., Wu, Q., Chen, Y., Gao, W., Ying, G., Zhu, Y., and Yan, W. (2020). Intracranial hypertension due to spinal cord tumor misdiagnosed as pseudotumor cerebri syndrome: Case report. BMC Neurol., 20.","DOI":"10.1186\/s12883-020-02000-y"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"118069","DOI":"10.1016\/j.jns.2021.118069","article-title":"Sonographic and ophthalmic assessment of optic nerve in patients with idiopathic intracranial hypertension: A longitudinal study","volume":"430","author":"Knodel","year":"2021","journal-title":"J. Neurol. 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