{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:27:49Z","timestamp":1760149669067,"version":"build-2065373602"},"reference-count":31,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:00:00Z","timestamp":1694044800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>COVID-19-associated coinfections increase the patient\u2019s risk of developing a severe form of the disease and, consequently, the risk of death. The term \u201cflurona\u201d was proposed to describe the coinfection of the influenza virus and SARS-CoV-2. This report is about a case of a 7-month-old female infant who died due to flurona coinfection. A histopathological exam showed activation of microglia (becoming CD45 positive), bronchial inflammation, diffuse alveolar damage in proliferative phase with vasculitis, a peribronchial infiltrate that was predominantly CD20-positive, and a vascular wall infiltrate that was predominantly CD3-positive. The aggressiveness of the two respiratory viruses added up and they caused extensive lung inflammation, which led to respiratory failure, multiple organ failure, and death. Tissues injuries caused by both the influenza virus and SARS-CoV-2 could be observed, without the ability to certify the dominance of the aggression of one of the two viruses.<\/jats:p>","DOI":"10.3390\/medicina59091616","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T09:51:37Z","timestamp":1694080297000},"page":"1616","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Flurona: The First Autopsied Case"],"prefix":"10.3390","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3465-9474","authenticated-orcid":false,"given":"Ionu\u021b Isaia","family":"Jeican","sequence":"first","affiliation":[{"name":"Department of Anatomy and Embryology, Iuliu Hatieganu University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Gheban","sequence":"additional","affiliation":[{"name":"Department of Pathology, Iuliu Hatieganu University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania"},{"name":"Department of Pathology, Emergency Clinical Hospital for Children, 400370 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Mari\u0219","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Emergency Clinical Hospital for Children, 400370 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2858-8470","authenticated-orcid":false,"given":"Silviu","family":"Albu","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery and Otorhinolaryngology, University Clinical Hospital of Railway Company, Iuliu Hatieganu University of Medicine and Pharmacy, 400015 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7051-3758","authenticated-orcid":false,"given":"Maria","family":"Alua\u0219","sequence":"additional","affiliation":[{"name":"Department of Oral Health, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6124-8582","authenticated-orcid":false,"given":"Costel Vasile","family":"Siserman","sequence":"additional","affiliation":[{"name":"Institute of Legal Medicine, 400006 Cluj-Napoca, Romania"},{"name":"Department of Legal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogdan Alexandru","family":"Gheban","sequence":"additional","affiliation":[{"name":"Department of Histology, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania"},{"name":"Department of Pathology, Emergency Clinical County Hospital, 400347 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5310","DOI":"10.1002\/jmv.27102","article-title":"Viral coinfections in COVID-19","volume":"93","author":"Aghbash","year":"2021","journal-title":"J. Med. Virol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.tim.2021.03.018","article-title":"Bacterial Coinfections in Coronavirus Disease 2019","volume":"29","author":"Westblade","year":"2021","journal-title":"Trends Microbiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e0016321","DOI":"10.1128\/Spectrum.00163-21","article-title":"Coinfections with Other Respiratory Pathogens among Patients with COVID-19","volume":"1","author":"Sreenath","year":"2021","journal-title":"Microbiol. Spectr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e2365","DOI":"10.1002\/rmv.2365","article-title":"Respiratory viral co-infections in patients with COVID-19 and associated outcomes: A systematic review and meta-analysis","volume":"1","author":"Krumbein","year":"2023","journal-title":"Rev. Med. Virol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Jeican, I.I., Ini\u0219ca, P., Gheban, D., T\u0103b\u0103ran, F., Alua\u0219, M., Trombitas, V., Cristea, V., Crivii, C., Junie, L.M., and Albu, S. (2021). COVID-19 and Pneumocystis jirovecii Pulmonary Coinfection\u2014The First Case Confirmed through Autopsy. Medicina, 57.","DOI":"10.3390\/medicina57040302"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/irv.12398","article-title":"The frequency of influenza and bacterial coinfection: A systematic review and meta-analysis","volume":"10","author":"Klein","year":"2016","journal-title":"Influenza Respir. Viruses"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/S0140-6736(22)00383-X","article-title":"SARS-CoV-2 co-infection with influenza viruses, respiratory syncytial virus, or adenoviruses","volume":"399","author":"Swets","year":"2022","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1093\/ije\/dyab081","article-title":"Interactions between SARS-CoV-2 and influenza, and the impact of coinfection on disease severity: A test-negative design","volume":"4","author":"Stowe","year":"2021","journal-title":"Int. J. Epidemiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"100036","DOI":"10.1016\/j.jcvp.2021.100036","article-title":"Co-infection of SARS-CoV-2 and influenza viruses: A systematic review and meta-analysis","volume":"1","author":"Dao","year":"2021","journal-title":"J. Clin. Virol. Plus."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s12038-021-00221-y","article-title":"Why are some coronavirus variants more infectious?","volume":"4","author":"Mukherjee","year":"2021","journal-title":"J. Biosci."},{"key":"ref_11","first-page":"e26660","article-title":"COVID-19 Pathogen Viral Evolution Leading to Increased Infectivity","volume":"7","author":"Parag","year":"2022","journal-title":"Cureus"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/irv.12824","article-title":"Influenza and COVID-19: What does co-existence mean?","volume":"15","author":"Chotpitayasunondh","year":"2021","journal-title":"Influenza Respir. Viruses"},{"key":"ref_13","unstructured":"McGeorge, F. (2023, March 25). Explaining \u2018Flurona\u2019: A Simultaneous Flu, COVID-19 Infection. Available online: https:\/\/www.clickondetroit.com\/health\/2022\/01\/12\/explaining-flurona-a-simultaneous-flu-covid-19-infection\/."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"4056","DOI":"10.1002\/jmv.27874","article-title":"Disease of influenza virus and SARS-CoV-2 coinfection: Flurona or Flucovid?","volume":"9","author":"Liu","year":"2022","journal-title":"J. Med. Virol."},{"key":"ref_15","unstructured":"WHO (2023, March 08). Infection Prevention and Control for the Safe Management of a Dead Body in the Context of COVID-19. Available online: https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/331538\/WHO-COVID-19-lPC_DBMgmt-2020.1-eng.pdf."},{"key":"ref_16","unstructured":"Centers for Disease Control and Prevention (2023, March 16). Collection and Submission of Postmortem Specimens from Deceased Persons with Known or Suspected COVID-19, 2020. (Interim Guidance), Available online: https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/hcp\/guidance-postmortem-specimens.html."},{"key":"ref_17","unstructured":"European Centre for Disease Prevention and Control (2023, March 16). Considerations Related to the Safe Handling of Bodies of Deceased Persons with Suspected or Confirmed COVID-11. Available online: https:\/\/www.ecdc.europa.eu\/en\/publications-data\/considerations-related-safe-handling-bodies-deceased-persons-suspected-or."},{"key":"ref_18","unstructured":"(2023, March 01). National Institute for Public Health from Romania. Available online: https:\/\/www.cnscbt.ro\/index.php\/info-medical\/2047-metodologia-de-supraveghere-a-covid-19-actualizare-23-10-2020-1\/file."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/s41422-021-00473-1","article-title":"Coinfection with influenza A virus enhances SARS-CoV-2 infectivity","volume":"31","author":"Bai","year":"2021","journal-title":"Cell Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1056\/NEJMoa2015432","article-title":"Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in COVID-19","volume":"383","author":"Ackermann","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s00251-023-01294-9","article-title":"Role of T cells in severe COVID-19 disease, protection, and long term immunity","volume":"75","author":"Hermens","year":"2023","journal-title":"Immunogenetics"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/s41590-021-01122-w","article-title":"The T cell immune response against SARS-CoV-2","volume":"23","author":"Moss","year":"2022","journal-title":"Nat. Immunol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Gheban-Ro\u0219ca, I.-A., Gheban, B.-A., Pop, B., Mironescu, D.-C., Siserman, V.C., Jianu, E.M., Drugan, T., and Bolboac\u0103, S.D. (2023). Identification of Histopathological Biomarkers in Fatal Cases of Coronavirus Disease: A Study on Lung Tissue. Diagnostics, 13.","DOI":"10.3390\/diagnostics13122039"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Jeican, I.I., Ini\u0219ca, P., Gheban, D., Anton, V., Laz\u0103r, M., Vic\u0103, M.L., Mironescu, D., Rebeleanu, C., Crivii, C.B., and Alua\u0219, M. (2023). Histopathological Lung Findings in COVID-19 B.1.617.2 SARS-CoV-2 Delta Variant. J. Pers. Med., 13.","DOI":"10.3390\/jpm13020279"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1053\/j.semdp.2017.06.005","article-title":"Histopathology of viral infections of the lung","volume":"34","author":"Pritt","year":"2017","journal-title":"Semin. Diagn. Pathol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.3174\/ajnr.A6715","article-title":"Imaging Features of Acute Encephalopathy in Patients with COVID-19: A Case Series","volume":"41","author":"Kihira","year":"2020","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e0109122","DOI":"10.1128\/spectrum.01091-22","article-title":"SARS-CoV-2 Infection of Microglia Elicits Proinflammatory Activation and Apoptotic Cell Death","volume":"10","author":"Jeong","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"135528","DOI":"10.1016\/j.neulet.2020.135528","article-title":"What can we learn from brain autopsies in COVID-19?","volume":"742","author":"Mukerji","year":"2021","journal-title":"Neurosci. Lett."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"908081","DOI":"10.3389\/fneur.2022.908081","article-title":"Young COVID-19 Patients Show a Higher Degree of Microglial Activation When Compared to Controls","volume":"13","author":"Matschke","year":"2022","journal-title":"Front. Neurol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.2353\/ajpath.2006.050875","article-title":"Kupffer cell-dependent hepatitis occurs during influenza infection","volume":"4","author":"Polakos","year":"2006","journal-title":"Am. J. Pathol."},{"key":"ref_31","unstructured":"Zander, D.S., and Carol, F.C. (2018). Pulmonary Pathology, Elsevier."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/9\/1616\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:46:35Z","timestamp":1760129195000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/9\/1616"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,7]]},"references-count":31,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["medicina59091616"],"URL":"https:\/\/doi.org\/10.3390\/medicina59091616","relation":{},"ISSN":["1648-9144"],"issn-type":[{"type":"electronic","value":"1648-9144"}],"subject":[],"published":{"date-parts":[[2023,9,7]]}}}