{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:30:20Z","timestamp":1789173020945,"version":"build-2803163510"},"reference-count":37,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T00:00:00Z","timestamp":1694131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Technological Development, Montenegro"},{"name":"Ministry of Education, Science and Technological Development, Republic of Serbia"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: There are no studies regarding comparative analysis of hematological parameters in patients with psoriasis (PsO) and atopic dermatitis (AD), whereas studies examining serum biomarkers of immunity and inflammation in these entities are scarce and contradictory. We aimed to compare such parameters in patients with PsO and AD. Materials and Methods: Patients with PsO (n = 40) and AD (n = 40) were consecutively included in this cross-sectional study. Hematological parameters and biomarkers of immunity and inflammation (interferon-gamma (IFN-\u03b3), interleukine (IL)-22 and C-reactive protein (CRP)) were determined. Results: While the mean corpuscular volume (MCV) was higher in the PsO group vs. the AD group (p &lt; 0.05), there was no difference in the other examined parameters between groups. A higher neutrophil-to-lymphocyte ratio (NLR) was found in patients with AD &gt; 50 years vs. patients with PsO of similar age (p &lt; 0.05). Higher IL-22 levels were found in patients with AD &lt; 50 years vs. patients with PsO of similar age (p &lt; 0.05). Lower IL-22 levels were found in patients with AD &gt; 50 years vs. patients with AD &lt; 50 years (p &lt; 0.05). Patients with PsO and with comorbidities had lower platelets (PLT), plateletcrit (PCT) and platelet-to-lymphocyte ratio (PLR), whereas lymphocytes, red cell distribution width-to-PLT ratio (RPR) and mean platelet volume\/PLT ratio (MPR) were higher vs. PsO patients without comorbidities. Patients with AD and with comorbidities had lower PCT and PLR, whereas RPR was higher vs. AD patients without comorbidities. Conclusions: A higher pro-inflammatory state (i.e., higher NLR and IL-22) was found in AD vs. PsO in age-specific groups. A higher pro-inflammatory state (i.e., as reflected by platelet indexes) was found in both diseases with comorbidities.<\/jats:p>","DOI":"10.3390\/medicina59091622","type":"journal-article","created":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T07:52:11Z","timestamp":1694159531000},"page":"1622","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Comparative Study of Hematological Parameters and Biomarkers of Immunity and Inflammation in Patients with Psoriasis and Atopic Dermatitis"],"prefix":"10.3390","volume":"59","author":[{"given":"Mirjana","family":"Bakic","sequence":"first","affiliation":[{"name":"Clinic for Dermatovenerology, Clinical Center of Montenegro, 81000 Podgorica, Montenegro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7870-0996","authenticated-orcid":false,"given":"Aleksandra","family":"Klisic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Montenegro, 81000 Podgorica, Montenegro"},{"name":"Center for Laboratory Diagnostics, Primary Health Care Center, 81000 Podgorica, Montenegro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesna","family":"Karanikolic","sequence":"additional","affiliation":[{"name":"Clinic for Skin Diseases of the Clinical Center Nis, School of Medicine, University of Nis, 18000 Nis, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1092668","DOI":"10.3389\/fimmu.2023.1092668","article-title":"Therapeutic effects of mesenchymal stem cells and their derivatives in common skin inflammatory diseases: Atopic dermatitis and psoriasis","volume":"14","author":"Yang","year":"2023","journal-title":"Front. Immunol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1111\/j.1538-7836.2004.00836.x","article-title":"Platelet activation in type 2 diabetes mellitus","volume":"2","author":"Ferroni","year":"2004","journal-title":"J. Thromb. Haemost"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1080\/09537100802082249","article-title":"Platelet function in cutaneous diseases","volume":"19","author":"Brzoza","year":"2008","journal-title":"Platelets"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Sugimoto, E., Matsuda, H., Shibata, S., Mizuno, Y., Koyama, A., Li, L., Taira, H., Ito, Y., Awaji, K., and Yamashita, T. (2023). Impact of Pretreatment Systemic Inflammatory Markers on Treatment Persistence with Biologics and Conventional Systemic Therapy: A Retrospective Study of Patients with Psoriasis Vulgaris and Psoriatic Arthritis. J. Clin. Med., 12.","DOI":"10.3390\/jcm12083046"},{"key":"ref_5","first-page":"3038","article-title":"Total leukocyte count, leukocyte subsets and their indexes in relation to cardiovascular risk in adolescent population","volume":"25","author":"Klisic","year":"2021","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_6","first-page":"2775","article-title":"Novel leukocyte and thrombocyte indexes in patients with prediabetes and type 2 diabetes mellitus","volume":"26","author":"Klisic","year":"2022","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"8915253","DOI":"10.1155\/2021\/8915253","article-title":"New Markers of Platelet Activation and Reactivity and Oxidative Stress Parameters in Patients Undergoing Coronary Artery Bypass Grafting","volume":"2021","author":"Vukicevic","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1043380","DOI":"10.3389\/fimmu.2023.1043380","article-title":"Exploring the association and causal effect between white blood cells and psoriasis using large-scale population data","volume":"14","author":"Zhou","year":"2023","journal-title":"Front. Immunol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s10238-022-00820-5","article-title":"The association between platelet indices and presence and severity of psoriasis: A systematic review and meta-analysis","volume":"23","author":"Liu","year":"2023","journal-title":"Clin. Exp. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"688","DOI":"10.4103\/ijd.ijd_689_22","article-title":"Do Platelet Count and mean Platelet Volume have a Predictive Role as a Marker in Children with Atopic Dermatitis?","volume":"67","author":"Akcal","year":"2022","journal-title":"Indian. J. Dermatol."},{"key":"ref_11","first-page":"1","article-title":"Oxidative stress and metabolic biomarkers in patients with psoriasis","volume":"42","author":"Bakic","year":"2023","journal-title":"J. Med. Biochem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1182\/blood.2019000200","article-title":"TNF-\u03b1-driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging","volume":"134","author":"McMahon","year":"2019","journal-title":"Blood"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Yi, P., Jiang, J., Wang, Z., Wang, X., Zhao, M., Wu, H., and Ding, Y. (2022). Comparison of mean platelet volume (MPV) and red blood cell distribution width (RDW) between psoriasis patients and controls: A systematic review and meta-analysis. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0264504"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"199","DOI":"10.5937\/jomb0-27237","article-title":"Increased red blood cell distribution width in patients with plaque psoriasis","volume":"40","author":"Gisondi","year":"2021","journal-title":"J. Med. Biochem."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Conic, R.R., Damiani, G., Schrom, K.P., Ramser, A.E., Zheng, C., Xu, R., McCormick, T.S., and Cooper, K.D. (2020). Psoriasis and Psoriatic Arthritis Cardiovascular Disease Endotypes Identified by Red Blood Cell Distribution Width and Mean Platelet Volume. J. Clin. Med., 9.","DOI":"10.3390\/jcm9010186"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"143","DOI":"10.15586\/aei.v50i4.557","article-title":"Immunological differences between atopic dermatitis, psoriasis, and their combination in adult patients","volume":"50","author":"Bozek","year":"2022","journal-title":"Allergol. Immunopathol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"7527859","DOI":"10.1155\/2020\/7527859","article-title":"Atopic Dermatitis and Psoriasis as Overlapping Syndromes","volume":"2020","author":"Bozek","year":"2020","journal-title":"Mediat. Inflamm."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jaci.2019.01.015","article-title":"Age-specific changes in the molecular phenotype of patients with moderate-to-severe atopic dermatitis","volume":"144","author":"Zhou","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1182\/blood-2004-07-2599","article-title":"The origins of age-related proinflammatory state","volume":"105","author":"Ferrucci","year":"2005","journal-title":"Blood"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12948-017-0077-0","article-title":"Immunosenescence in aging: Between immune cells depletion and cytokines up-regulation","volume":"15","author":"Ventura","year":"2017","journal-title":"Clin. Mol. Allergy"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.jaad.2017.05.017","article-title":"Skin-infiltrating, interleukin-22-producing T cells differentiate pediatric psoriasis from adult psoriasis","volume":"77","author":"Cordoro","year":"2017","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s10753-013-9715-y","article-title":"Targeting interleukin-22 in psoriasis","volume":"37","author":"Hao","year":"2014","journal-title":"Inflammation"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"317","DOI":"10.7888\/juoeh.32.317","article-title":"Psoriasis and other Th17-mediated skin diseases","volume":"32","author":"Tokura","year":"2010","journal-title":"J. UOEH"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Guttman-Yassky, E., Irvine, A.D., Brunner, P.M., Kim, B.S., Boguniewicz, M., Parmentier, J., Platt, A.M., and Kabashima, K. (J. Allergy Clin. Immunol., 2023). The Role of Janus Kinase Signaling in the Pathology of Atopic Dermatitis, J. Allergy Clin. Immunol., in press.","DOI":"10.1016\/j.jaci.2023.07.010"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.jaad.2018.01.016","article-title":"Efficacy and safety of fezakinumab (an IL-22 monoclonal antibody) in adults with moderate-to-severe atopic dermatitis inadequately controlled by conventional treatments: A randomized, double-blind, phase 2a trial","volume":"78","author":"Brunner","year":"2018","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/cia2.12049","article-title":"Immune mediators and therapies for pruritus in atopic dermatitis and psoriasis","volume":"2","author":"Yu","year":"2019","journal-title":"J. Cutan. Immunol. Allergy"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s40535-014-0003-1","article-title":"The immunological and genetic aspects in psoriasis","volume":"1","author":"Sun","year":"2014","journal-title":"Appl. Inform."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1159\/000339866","article-title":"Comparative study of systemic inflammatory responses in psoriasis vulgaris and mild to moderate allergic contact dermatitis","volume":"225","author":"Kaur","year":"2012","journal-title":"Dermatology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"410","DOI":"10.5455\/medarh.2018.72.410-413","article-title":"Serum Concentrations of Interferon Gamma (IFN-\u03b3) in Patients with Psoriasis: Correlation with Clinical Type and Severity of the Disease","volume":"72","author":"Kurtovic","year":"2018","journal-title":"Med. Arch."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1155\/MI.2005.273","article-title":"Serum levels of TNF-alpha, IFN-gamma, IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severity","volume":"2005","author":"Arican","year":"2005","journal-title":"Mediat. Inflamm."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/j.1365-2230.2009.03704.x","article-title":"Serum cytokines and growth factor levels in Japanese patients with psoriasis","volume":"35","author":"Takahashi","year":"2010","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00005-018-0527-5","article-title":"Interleukin-22 and Its Correlation with Disease Activity in Plaque Psoriasis","volume":"67","author":"Wawrzycki","year":"2019","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s00403-011-1159-3","article-title":"Kinetics of circulating Th17 cytokines and adipokines in psoriasis patients","volume":"303","author":"Nakajima","year":"2011","journal-title":"Arch. Dermatol. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jdermsci.2010.03.018","article-title":"Serum IL-22 correlates with psoriatic severity and serum IL-6 correlates with susceptibility to phototherapy","volume":"58","author":"Lo","year":"2010","journal-title":"J. Dermatol. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1684\/ejd.2011.1335","article-title":"Effect of methotrexate on serum levels of IL-22 in patients with psoriasis","volume":"21","author":"Meephansan","year":"2011","journal-title":"Eur. J. Dermatol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1080\/14712598.2022.2113872","article-title":"New frontiers in personalized medicine in psoriasis","volume":"22","author":"Camela","year":"2022","journal-title":"Expert Opin. Biol. Ther."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41573-021-00266-6","article-title":"Atopic dermatitis: An expanding therapeutic pipeline for a complex disease","volume":"21","author":"Bieber","year":"2022","journal-title":"Nat. Rev. Drug Discov."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/9\/1622\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:47:10Z","timestamp":1760129230000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/9\/1622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,8]]},"references-count":37,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["medicina59091622"],"URL":"https:\/\/doi.org\/10.3390\/medicina59091622","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,8]]}}}