{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T06:20:03Z","timestamp":1770704403726,"version":"3.49.0"},"reference-count":66,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:00:00Z","timestamp":1694649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Primary Sj\u00f6gren\u2019s syndrome (pSS) is a heterogeneous chronic autoimmune disorder with multiple clinical manifestations that can develop into non-Hodgkin\u2019s lymphoma in mucosa-associated lymphoid tissue. The pathogenesis of Sj\u00f6gren\u2019s syndrome (SS) is not completely understood, but it is assumed that pathogenesis of SS is multifactorial. The microbiota plays a notable role in the development of autoimmune disorders, including Sj\u00f6gren\u2019s syndrome. Molecular mimicry, metabolite changes and epithelial tolerance breakdown are pathways that might help to clarify the potential contribution of the microbiota to SS pathogenesis. This review aims to provide an overview of recent studies describing microbiota changes and microbiota mechanisms associated with Sj\u00f6gren\u2019s syndrome. Data on the microbiota in SS from PubMed, Web of Science, Scopus and the Cochrane Library databases are summarized. Overall, the microbiota makes a major contribution to the development of Sj\u00f6gren\u2019s syndrome and progression. Future microbiota studies should improve the management of this heterogeneous autoimmune disease.<\/jats:p>","DOI":"10.3390\/medicina59091661","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T02:54:13Z","timestamp":1694746453000},"page":"1661","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Insights into Microbiota in Sj\u00f6gren\u2019s Syndrome"],"prefix":"10.3390","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8412-5227","authenticated-orcid":false,"given":"Diana","family":"Mieliauskait\u0117","sequence":"first","affiliation":[{"name":"State Research Institute Center for Innovative Medicine, Department of Experimental, Preventive and Clinical Medicine, Santariski\u0173 St. 5, LT-08405 Vilnius, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vilius","family":"Kontenis","sequence":"additional","affiliation":[{"name":"State Research Institute Center for Innovative Medicine, Department of Experimental, Preventive and Clinical Medicine, Santariski\u0173 St. 5, LT-08405 Vilnius, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,14]]},"reference":[{"key":"ref_1","first-page":"2211","article-title":"Sj\u00f6gren\u2019s syndrome: One year in review 2022","volume":"40","author":"Chatzis","year":"2022","journal-title":"Clin. 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