{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T23:08:16Z","timestamp":1794265696740,"version":"4.9.0"},"reference-count":30,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T00:00:00Z","timestamp":1694736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Aortic stenosis (AS) is a widespread valvular disease in developed countries, primarily among the elderly. Transcatheter aortic valve replacement (TAVR) has become a viable alternative to aortic valve surgery for patients with severe AS who are deemed a high surgical risk or for whom the AS is found to be inoperable. Predicting outcomes after TAVR is essential. The Naples Prognostic Score (NPS) is a new scoring method that evaluates nutritional status and inflammation. Our study is aims to examine the relationship between the NPS and outcomes for patients receiving TAVR. Material and Methods: We conducted a retrospective study of 370 patients who underwent TAVR across three tertiary medical centres from March 2019 to March 2023. The patients were divided into two groups based on their NPS, namely, low (0, 1, and 2) and high (3 and 4). Our study is primarily aimed to determine the one-year mortality rate. Results: Within one year, the mortality rate for the entire group was 8.6%. Nonetheless, the low-NPS group had a rate of 5.0%, whereas the high-NPS group had a rate of 13%. The difference between the two groups was statistically significant, with a p-value of 0.06. Conclusions: Our results show that NPS is an independent predictor of one-year mortality in patients undergoing TAVR.<\/jats:p>","DOI":"10.3390\/medicina59091666","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T03:50:10Z","timestamp":1694749810000},"page":"1666","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A Novel Score to Predict One-Year Mortality after Transcatheter Aortic Valve Replacement, Naples Prognostic Score"],"prefix":"10.3390","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7140-1010","authenticated-orcid":false,"given":"Zehra G\u00fcven","family":"\u00c7etin","sequence":"first","affiliation":[{"name":"Cardiology Department, Ankara Bilkent City Hospital, 06800 Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7723-9912","authenticated-orcid":false,"given":"Ahmet","family":"Balun","sequence":"additional","affiliation":[{"name":"Cardiology Department, Band\u0131rma Onyedi Eylul University, 10200 Bal\u0131kesir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6138-3699","authenticated-orcid":false,"given":"H\u00fclya","family":"\u00c7i\u00e7ek\u00e7io\u011flu","sequence":"additional","affiliation":[{"name":"Cardiology Department, Ankara Bilkent City Hospital, 06800 Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6266-2291","authenticated-orcid":false,"given":"Bekir","family":"Demirta\u015f","sequence":"additional","affiliation":[{"name":"Cardiology Department, Ankara Etlik City Hospital, 06170 Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat Mehmet","family":"Yi\u011fitba\u015f\u0131","sequence":"additional","affiliation":[{"name":"Sar\u0131kam\u0131s State Hospital, 36500 Kars, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerem","family":"\u00d6zbek","sequence":"additional","affiliation":[{"name":"Cardiology Department, Ankara Bilkent City Hospital, 06800 Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"\u00c7etin","sequence":"additional","affiliation":[{"name":"Cardiology Department, Ankara Bilkent City Hospital, 06800 Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1161\/CIRCULATIONAHA.119.041080","article-title":"Contemporary Presentation and Management of Valvular Heart Disease: The EURObservational Research Programme Valvular Heart Disease II Survey","volume":"140","author":"Iung","year":"2019","journal-title":"Circulation"},{"key":"ref_2","first-page":"e72","article-title":"2020 ACC\/AHA Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"143","author":"Otto","year":"2021","journal-title":"Circulation"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/eurheartj\/ehab395","article-title":"2021 ESC\/EACTS Guidelines for the management of valvular heart disease","volume":"43","author":"Vahanian","year":"2022","journal-title":"Eur. Heart J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S0003-4975(97)00017-9","article-title":"The Society of Thoracic Surgeons National Cardiac Surgery Database: Current Risk Assessment","volume":"63","author":"Edwards","year":"1997","journal-title":"Ann. Thorac. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S1010-7940(99)00134-7","article-title":"European system for cardiac operative risk evaluation (EuroSCORE)","volume":"16","author":"Nashef","year":"1999","journal-title":"Eur. J. Cardio-Thorac. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1093\/eurheartj\/ehv756","article-title":"TAVI or No TAVI: Identifying patients unlikely to benefit from transcatheter aortic valve implantation","volume":"37","author":"Puri","year":"2016","journal-title":"Eur. Heart J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1097\/DCR.0000000000000961","article-title":"Naples Prognostic Score, Based on Nutritional and Inflammatory Status, is an Independent Predictor of Long-term Outcome in Patients Undergoing Surgery for Colorectal Cancer","volume":"60","author":"Galizia","year":"2017","journal-title":"Dis. Colon Rectum"},{"key":"ref_8","first-page":"404","article-title":"Inflammatory and nutritional status is a predictor of long-term outcome in patients undergoing surgery for gastric cancer. Validation of the Naples prognostic score","volume":"90","author":"Galizia","year":"2019","journal-title":"Ann. Ital. Chir."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"219","DOI":"10.2217\/bmm-2022-0689","article-title":"Impact of Naples Prognostic Score on midterm all-cause mortality in patients with decompensated heart failure","volume":"17","author":"Erdogan","year":"2023","journal-title":"Biomark. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"61","DOI":"10.18087\/cardio.2023.3.n2328","article-title":"Is the Naples prognostic score useful for predicting heart failure mortality","volume":"63","author":"Suygun","year":"2023","journal-title":"Kardiologiia"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Birdal, O., Pay, L., Aksakal, E., Yumurtas, A.C., Cinier, G., Yucel, E., Tanboga, I.H., Karagoz, A., and Oduncu, V. (2023). Naples Prognostic Score and Prediction of Left Ventricular Ejection Fraction in STEMI Patients. Angiology, 1\u20138.","DOI":"10.1177\/00033197231161903"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Erdogan, A., Genc, O., Ozkan, E., Goksu, M.M., Ibisoglu, E., Bilen, M.N., Guler, A., and Karagoz, A. (2023). Impact of Naples Prognostic Score at Admission on In-Hospital and Follow-Up Outcomes Among Patients with ST-Segment Elevation Myocardial Infarction. Angiology, 1\u201311.","DOI":"10.1177\/00033197231151559"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1016\/j.jacc.2021.02.038","article-title":"Valve Academic Research Consortium 3: Updated Endpoint Definitions for Aortic Valve Clinical Research","volume":"77","author":"Piazza","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1002\/ehf2.12837","article-title":"Inflammatory signatures are associated with increased mortality after transfemoral transcatheter aortic valve implantation","volume":"7","author":"Hoffmann","year":"2020","journal-title":"ESC Heart Fail."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"164","DOI":"10.21037\/cdt.2018.03.01","article-title":"Value of neutrophil to lymphocyte ratio as a predictor of mortality in patients undergoing aortic valve replacement","volume":"8","author":"Habib","year":"2018","journal-title":"Cardiovasc. Diagn. Ther."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"S313","DOI":"10.1016\/j.ihj.2018.08.002","article-title":"Neutrophil-to-lymphocyte ratio predicts heart failure readmissions and outcomes in patients undergoing transcatheter aortic valve replacement","volume":"70","author":"Khalil","year":"2018","journal-title":"Indian Heart J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.ijcard.2016.08.260","article-title":"Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) can risk stratify patients in transcatheter aortic valve replacement (TAVR)","volume":"223","author":"Condado","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e024091","DOI":"10.1161\/JAHA.121.024091","article-title":"Neutrophil-to-Lymphocyte Ratios in Patients Undergoing Aortic Valve Replacement: The PARTNER Trials and Registries","volume":"11","author":"Shahim","year":"2022","journal-title":"J. Am. Heart Assoc."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e026294","DOI":"10.1161\/JAHA.122.026294","article-title":"Prevalence and Prognostic Significance of Malnutrition in Older Japanese Adults at High Surgical Risk Undergoing Transcatheter Aortic Valve Implantation","volume":"11","author":"Ishizu","year":"2022","journal-title":"J. Am. Heart Assoc."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.amjcard.2021.07.016","article-title":"Impact of the Geriatric Nutritional Risk Index in Patients Undergoing Transcatheter Aortic Valve Implantation","volume":"157","author":"Koseki","year":"2021","journal-title":"Am. J. Cardiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"312","DOI":"10.5603\/CJ.a2019.0038","article-title":"Nutritional risk index is a better predictor of early mortality than conventional nutritional markers after transcatheter aortic valve replacement: A prospective cohort study","volume":"28","author":"Papadopoulos","year":"2021","journal-title":"Cardiol. J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/jcsm.12689","article-title":"Frailty in patients undergoing transcatheter aortic valve replacement: Prognostic value of the Geriatric Nutritional Risk Index","volume":"12","author":"Seoudy","year":"2021","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s00392-019-01497-9","article-title":"Nutritional status and risk of all-cause mortality in patients undergoing transcatheter aortic valve replacement assessment using the geriatric nutritional risk index and the controlling nutritional status score","volume":"109","author":"Lee","year":"2020","journal-title":"Clin. Res. Cardiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.amjcard.2016.11.019","article-title":"Prognostic Value of Hypoalbuminemia After Transcatheter Aortic Valve Implantation (from the Japanese Multicenter OCEAN-TAVI Registry)","volume":"119","author":"Yamamoto","year":"2017","journal-title":"Am. J. Cardiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jtcvs.2012.09.002","article-title":"Updated standardized endpoint definitions for transcatheter aortic valve implantation: The Valve Academic Research Consortium-2 consensus document*","volume":"145","author":"Kappetein","year":"2013","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3036","DOI":"10.1111\/jocs.16801","article-title":"Frailty and clinical outcomes following aortic valve replacement","volume":"37","author":"Ram","year":"2022","journal-title":"J. Card. Surg."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Sudo, M., Shamekhi, J., Aksoy, A., Al-Kassou, B., Tanaka, T., Silaschi, M., Weber, M., Nickenig, G., and Zimmer, S. (2023). A simply calculated nutritional index provides clinical implications in patients undergoing transcatheter aortic valve replacement. Clin. Res. Cardiol., 1\u201310.","DOI":"10.1007\/s00392-023-02220-5"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"5095","DOI":"10.1111\/jocs.17212","article-title":"Neutrophil to lymphocyte ratio predicts permanent pacemaker implantation in TAVR patients","volume":"37","author":"Totaro","year":"2022","journal-title":"J. Card. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1016\/j.amjcard.2017.07.061","article-title":"Timing of Susceptibility to Mortality and Heart Failure in Patients With Preexisting Atrial Fibrillation After Transcatheter Aortic Valve Implantation","volume":"120","author":"Hioki","year":"2017","journal-title":"Am. J. Cardiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1016\/j.jacc.2020.09.595","article-title":"STS-ACC TVT Registry of Transcatheter Aortic Valve Replacement","volume":"76","author":"Carroll","year":"2020","journal-title":"J. Am. Coll. Cardiol."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/9\/1666\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:51:30Z","timestamp":1760129490000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/9\/1666"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,15]]},"references-count":30,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["medicina59091666"],"URL":"https:\/\/doi.org\/10.3390\/medicina59091666","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,15]]}}}