{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T11:52:14Z","timestamp":1775476334444,"version":"3.50.1"},"reference-count":16,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T00:00:00Z","timestamp":1695772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Endomag Ltd."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>The magnetic technique using superparamagnetic nanoparticles of iron oxide has been well established for sentinel lymph node detection. Its main advantage is in the context of logistics, with the possibility to inject several weeks before surgery and the possibility to give access to sentinel lymph node biopsy for women worldwide in places without nuclear medicine facilities. We have not yet seen the full potential of this technique, and new implications have been developed for breast tumour localisation with paramagnetic clips and axillary staging after neoadjuvant chemotherapy using paramagnetic clips inserted in lymph node metastases before chemotherapy. In this report, we have presented our experience of the magnetic technique starting in 2014, and we have highlighted our current and future research directions.<\/jats:p>","DOI":"10.3390\/medicina59101727","type":"journal-article","created":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T07:38:46Z","timestamp":1695800326000},"page":"1727","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Magnetic Technique\u2014A Novel and Promising Method to Improve Axillary Staging Localisation from a Swedish Perspective"],"prefix":"10.3390","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0130-7296","authenticated-orcid":false,"given":"Fredrik","family":"W\u00e4rnberg","sequence":"first","affiliation":[{"name":"Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 41345 Gothenburg, Sweden"},{"name":"Department of Surgery, Sahlgrenska University Hospital, Region V\u00e4stra G\u00f6taland, 41345 Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Obondo","sequence":"additional","affiliation":[{"name":"Department of Surgery, S\u00f6dersjukhuset, 11883 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1687-8390","authenticated-orcid":false,"given":"Kian","family":"Chin","sequence":"additional","affiliation":[{"name":"Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 41345 Gothenburg, Sweden"},{"name":"Department of Surgery, Sahlgrenska University Hospital, Region V\u00e4stra G\u00f6taland, 41345 Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.2217\/nnm-2017-0137","article-title":"How can nanoparticles be used in sentinel node detection?","volume":"12","author":"Ahmed","year":"2017","journal-title":"Nanomedicine"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"913","DOI":"10.2214\/AJR.17.18345","article-title":"Initial Clinical Experience with an Inducible Magnetic Seed System for Preoperative Breast Lesion Localization","volume":"210","author":"Price","year":"2018","journal-title":"AJR Am. J. Roentgenol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s10549-016-3809-9","article-title":"The Nordic SentiMag trial: A comparison of super paramagnetic iron oxide (SPIO) nanoparticles versus Tc(99) and patent blue in the detection of sentinel node (SN) in patients with breast cancer and a meta-analysis of earlier studies","volume":"157","author":"Karakatsanis","year":"2016","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"37","DOI":"10.21614\/chirurgia.2673","article-title":"Sentimag\u00ae Technique for Sentinel Lymph Node Biopsy in Breast Cancer Patients: Evaluation of Effectiveness, Feasibility and Challenges","volume":"117","author":"Nadeem","year":"2022","journal-title":"Chirurgia"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3510","DOI":"10.1245\/s10434-019-07577-4","article-title":"SentimagIC: A Non-inferiority Trial Comparing Superparamagnetic Iron Oxide Versus Technetium-99 m and Blue Dye in the Detection of Axillary Sentinel Nodes in Patients with Early-Stage Breast Cancer","volume":"26","author":"Alvarado","year":"2019","journal-title":"Ann. Surg. Oncol."},{"key":"ref_6","unstructured":"Hersi, A.-F. (2021, December 01). Superparamagnetic Iron Oxide Nanoparticles, a Novel Tracer in Breast Cancer Surgery. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1778. Uppsala Universitet 2021. Available online: https:\/\/www.avhandlingar.se\/om\/Abdi-fatah+Hersi\/."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Hersi, A.F., Pistiolis, L., Dussan Luberth, C., Vikhe-Patil, E., Nilsson, F., Mohammed, I., Olofsson Bagge, R., W\u00e4rnberg, F., Eriksson, S., and Karakatsanis, A. (2021). Optimizing Dose and Timing in Magnetic Tracer Techniques for Sentinel Lymph Node Detection in Early Breast Cancers: The Prospective Multicenter SentiDose Trial. Cancers, 13.","DOI":"10.3390\/cancers13040693"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"4064","DOI":"10.1245\/s10434-022-13064-0","article-title":"Delayed Sentinel Lymph Node Dissection in Patients with a Preoperative Diagnosis of Ductal Cancer In Situ by Preoperative Injection with Superparamagnetic Iron Oxide (SPIO) Nanoparticles: The SentiNot Study","volume":"30","author":"Karakatsanis","year":"2023","journal-title":"Ann. Surg. Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s41747-021-00257-7","article-title":"Breast MRI in patients after breast conserving surgery with sentinel node procedure using a superparamagnetic tracer","volume":"6","author":"Christenhusz","year":"2022","journal-title":"Eur. Radiol. Exp."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e359","DOI":"10.1093\/bjs\/znab277","article-title":"Accurate axillary staging by superparamagnetic iron oxide-enhanced MRI at 1.5 T with fat-suppression sequence as an alternative to sentinel node biopsy in breast cancer","volume":"108","author":"Motomura","year":"2021","journal-title":"Br. J. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.ejso.2021.12.467","article-title":"Sentinel lymph node localization and staging with a low-dose of superparamagnetic iron oxide (SPIO) enhanced MRI and magnetometer in patients with cutaneous melanoma of the extremity\u2014The MAGMEN feasibility study","volume":"48","author":"Mirzaei","year":"2022","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Banys-Paluchowski, M., K\u00fchn, T., Masannat, Y., Rubio, I., de Boniface, J., Ditsch, N., Karadeniz Cakmak, G., Karakatsanis, A., Dave, R., and Hahn, M. (2023). Localization Techniques for Non-Palpable Breast Lesions: Current Status, Knowledge Gaps, and Rationale for the MELODY Study (EUBREAST-4\/iBRA-NET, NCT 05559411). Cancers, 15.","DOI":"10.3390\/cancers15041173"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"26","DOI":"10.29337\/ijsp.136","article-title":"A Novel Mixed-Methods Platform Study Protocol for Investigating New Surgical Devices, with Embedded Shared Learning: Ibra-net Breast Lesion Localisation Study","volume":"25","author":"Bromley","year":"2021","journal-title":"Int. J. Surg. Protoc."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.ejso.2022.12.019","article-title":"Clinical utility of axillary nodal markers in breast cancer","volume":"49","author":"Barry","year":"2023","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1016\/j.ejso.2022.07.014","article-title":"Results of shared learning of a new magnetic seed localisation device\u2014A UK iBRA-NET breast cancer localisation study","volume":"48","author":"Morgan","year":"2022","journal-title":"Eur. J. Surg. 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