{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:40:57Z","timestamp":1792644057220,"version":"4.5.0"},"reference-count":62,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T00:00:00Z","timestamp":1696204800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Colorectal cancer (CRC) continues to be an essential public health problem. Our study aimed to evaluate the prognostic significance of classic prognostic factors and some less-studied histopathological parameters in CRC. Materials and Methods: We performed a retrospective study on 71 colorectal carcinoma patients who underwent surgery at the \u201cPius Br\u00eenzeu\u201d County Clinical Emergency Hospital in Timi\u0219oara, Romania. We analyzed the classic parameters but also tumor budding (TB), poorly differentiated clusters (PDCs) of cells, tumor-infiltrating lymphocytes (TILs), and the configuration of the tumor border on hematoxylin\u2013eosin slides. Results: A high degree of malignancy (p = 0.006), deep invasion of the intestinal wall (p = 0.003), an advanced stage of the disease (p &lt; 0.0001), lymphovascular invasion (p &lt; 0.0001), perineural invasion (p &lt; 0.0001), high-grade TB (p &lt; 0.0001), high-grade PDCs (p &lt; 0.0001), infiltrative tumor border configuration (p &lt; 0.0001) showed a positive correlation with lymph node metastases. Conclusions: The analyzed parameters positively correlate with unfavorable prognostic factors in CRC. We highlight the value of classic prognostic factors along with a series of less-known parameters that are more accessible and easier to evaluate using standard staining techniques and that could predict the risk of relapse or aggressive evolution in patients with CRC.<\/jats:p>","DOI":"10.3390\/medicina59101761","type":"journal-article","created":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T11:56:49Z","timestamp":1696247809000},"page":"1761","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Colorectal Carcinomas: Searching for New Histological Parameters Associated with Lymph Node Metastases"],"prefix":"10.3390","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0898-795X","authenticated-orcid":false,"given":"Aura","family":"Jurescu","sequence":"first","affiliation":[{"name":"Department of Microscopic Morphology-Morphopathology, ANAPATMOL Research Center, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9261-5309","authenticated-orcid":false,"given":"Adrian","family":"V\u0103duva","sequence":"additional","affiliation":[{"name":"Department of Microscopic Morphology-Morphopathology, ANAPATMOL Research Center, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"Department of Pathology, \u201cPius Br\u00eenzeu\u201d County Clinical Emergency Hospital, 300723 Timi\u015foara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8259-9437","authenticated-orcid":false,"given":"Octavia","family":"Vi\u021ba","sequence":"additional","affiliation":[{"name":"Department of Microscopic Morphology-Morphopathology, ANAPATMOL Research Center, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelina","family":"Gheju","sequence":"additional","affiliation":[{"name":"Emergency County Hospital Deva, 330032 Deva, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remus","family":"Cornea","sequence":"additional","affiliation":[{"name":"Department of Microscopic Morphology-Morphopathology, ANAPATMOL Research Center, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"Department of Pathology, \u201cPius Br\u00eenzeu\u201d County Clinical Emergency Hospital, 300723 Timi\u015foara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2291-4917","authenticated-orcid":false,"given":"Codru\u021ba","family":"L\u0103zureanu","sequence":"additional","affiliation":[{"name":"Department of Microscopic Morphology-Morphopathology, ANAPATMOL Research Center, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"Department of Pathology, \u201cPius Br\u00eenzeu\u201d County Clinical Emergency Hospital, 300723 Timi\u015foara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca","family":"Mure\u0219an","sequence":"additional","affiliation":[{"name":"Department of Microscopic Morphology-Morphopathology, ANAPATMOL Research Center, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"Department of Pathology, \u201cPius Br\u00eenzeu\u201d County Clinical Emergency Hospital, 300723 Timi\u015foara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marioara","family":"Cornianu","sequence":"additional","affiliation":[{"name":"Department of Microscopic Morphology-Morphopathology, ANAPATMOL Research Center, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"Department of Pathology, \u201cPius Br\u00eenzeu\u201d County Clinical Emergency Hospital, 300723 Timi\u015foara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorina","family":"T\u0103ban","sequence":"additional","affiliation":[{"name":"Department of Microscopic Morphology-Morphopathology, ANAPATMOL Research Center, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"Department of Pathology, \u201cPius Br\u00eenzeu\u201d County Clinical Emergency Hospital, 300723 Timi\u015foara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alis","family":"Dema","sequence":"additional","affiliation":[{"name":"Department of Microscopic Morphology-Morphopathology, ANAPATMOL Research Center, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"Department of Pathology, \u201cPius Br\u00eenzeu\u201d County Clinical Emergency Hospital, 300723 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