{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:28:14Z","timestamp":1792787294456,"version":"4.5.0"},"reference-count":56,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:00:00Z","timestamp":1696464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Orthodontic aligners are changing the practice of orthodontics. This system of orthodontic appliances is becoming the mainstay appliance of choice for orthodontic offices in many countries. Patient preferences and lifestyle needs have made this appliance the primary choice when seeking care. In the early days, appliances lacked the efficiency and effectiveness of traditional bracket-wire systems, but modern systems are now able to handle a more comprehensive orthodontic caseload. Current systems provide newer biomechanical strategies and artificial intelligence-driven tooth movements for better outcomes. These improvements now mean that an orthodontist can be better prepared to manage a larger number of orthodontic malocclusions. This paper aims to discuss some of the evolution of orthodontic aligners and to describe to orthodontists the fundamentals of aligner therapy. In addition, it will provide an evidence-based outcome to the existing treatment outcomes in the current literature.<\/jats:p>","DOI":"10.3390\/medicina59101773","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T09:14:22Z","timestamp":1696497262000},"page":"1773","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Orthodontic Aligners: Current Perspectives for the Modern Orthodontic Office"],"prefix":"10.3390","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4606-9551","authenticated-orcid":false,"given":"Chung How","family":"Kau","sequence":"first","affiliation":[{"name":"Department of Orthodontics, University of Alabama at Birmingham, Birmingham, AL 35233, USA"},{"name":"Department of Surgery, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6548-3590","authenticated-orcid":false,"given":"Jen","family":"Soh","sequence":"additional","affiliation":[{"name":"Private Orthodontic Practice, Braces & Aesthetics Dental Clinic Pte Ltd., Singapore 307506, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teti","family":"Christou","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, University of Alabama at Birmingham, Birmingham, AL 35233, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akanksha","family":"Mangal","sequence":"additional","affiliation":[{"name":"Orthodontic Clinical Fellowship, School of Orthodontics, Jacksonville University, Jacksonville, FL 32211, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.xaor.2022.04.009","article-title":"Emerging insights and new developments in clear aligner therapy: A review of the literature","volume":"2","author":"Hartshorne","year":"2022","journal-title":"AJO-DO Clin. 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