{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T19:21:33Z","timestamp":1779909693947,"version":"3.53.1"},"reference-count":30,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T00:00:00Z","timestamp":1697155200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"King Saud University, Riyadh, Saudi Arabia","award":["RSP2023R119"],"award-info":[{"award-number":["RSP2023R119"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: HIV disease is recognized to cause inconsistencies in coagulation via various pathways during infection. Some studies have indicated that HIV-infected patients are prone to developing thrombocytopenia, thrombosis, or autoantibodies that may cause difficulties in diagnosis. This study is intended to measure the trend of coagulation parameters in Sudanese patients with HIV. Materials and Methods: A cross-sectional study was carried out in patients with HIV admitted to the Sudan National AIDS Program (SNAP) from January 2018 to December 2019. Prothrombin time (PT), partial thromboplastin time (PTT), thrombin time (TT), D-dimer (DD), hemoglobin (HB), total lymphocyte count (TLC), platelet count (PLT), and a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13 (ADAMTS13), were evaluated among HIV Sudanese patients. Results: Out of the 44 HIV patients included, 6 (13.6%) were found to have thrombotic thrombocytopenic purpura-like events and 12 (27.2%) had antiphospholipid antibodies, of whom 8 (66.6%) showed anticardiolipin antibody (1gG (75%) and IgM (25%)) and 4 showed lupus anticoagulants. The HB, TLC, and PLT values were found to be significantly lower in HIV patients than in control (p = 0.000, 0.000, and 0.050, respectively). The PT and ADAMTS13 values showed no significant difference between HIV patients and control (p = 0.613 and 0.266, respectively). The PTT, TT, and DD values were found to be augmented in HIV patients versus the control (p = 0.000). Conclusions: Thrombotic thrombocytopenic purpura-like events among HIV Sudanese patients were explored. In addition, antiphospholipid antibodies were strikingly seen in these patients. Additional research is anticipated to confirm these diagnoses.<\/jats:p>","DOI":"10.3390\/medicina59101826","type":"journal-article","created":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T06:07:26Z","timestamp":1697177246000},"page":"1826","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Trends of Coagulation Parameters in Human Immunodeficiency Virus Patients"],"prefix":"10.3390","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5089-9531","authenticated-orcid":false,"given":"Bashir Abdrhman","family":"Bashir","sequence":"first","affiliation":[{"name":"Department of Hematology, Faculty of Medical Laboratory Sciences, Port Sudan Ahlia College, Port Sudan 33312, Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1544-7932","authenticated-orcid":false,"given":"Mohamed Hassan","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Hematology, Faculty of Medical Laboratory Science, National University, Khartoum 11111, Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1487-2005","authenticated-orcid":false,"given":"Mohamed A.","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Microbiology, Faculty of Pharmacy, International University of Africa, Khartoum 11111, Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wadah","family":"Osman","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, University of Khartoum, Al-Qasr Ave., Khartoum 11111, Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4220-7854","authenticated-orcid":false,"given":"Ramzi A.","family":"Mothana","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2543-748X","authenticated-orcid":false,"given":"Sidgi","family":"Hasson","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool L3 3AF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,13]]},"reference":[{"key":"ref_1","first-page":"121","article-title":"Abnormal coagulation profile in people living with HIV-AIDS on combined Antiretroviral Therapy: Findings from a case-control study in the Ho municipality, Ghana","volume":"29","author":"Ephraim","year":"2018","journal-title":"Pan Afr. Med J."},{"key":"ref_2","first-page":"1","article-title":"Anti-Human Immunodeficiency Virus (HIV) Agents","volume":"12","author":"Okolie","year":"2003","journal-title":"J. Med. Lab. Sci."},{"key":"ref_3","first-page":"437","article-title":"Correlation of CD4 count with platelet count, prothrombin time and activated partial thromboplastin time among HIV patients in Benin City, Nigeria","volume":"58","author":"Omoregie","year":"2009","journal-title":"West Indian Med. J."},{"key":"ref_4","first-page":"9","article-title":"A study of hematological manifestations of HIV infection","volume":"27","author":"Kasthuri","year":"2006","journal-title":"Indian J. Sex. Transm. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Dikshit, B., Wanchu, A., Sachdeva, R.K., Sharma, A., and Das, R. (2009). Profile of hematological abnormalities of Indian HIV infected individuals. BMC Blood Disord., 9.","DOI":"10.1186\/1471-2326-9-5"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"89","DOI":"10.17925\/EOH.2012.08.02.89","article-title":"HIV-associated Thrombotic Thrombocytopenic Purpura\u2014What We Know So Far","volume":"8","author":"Meiring","year":"2012","journal-title":"Eur. Oncol. Haematol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.hoc.2017.08.010","article-title":"Thrombotic Microangiopathies (TTP, HUS, HELLP)","volume":"31","author":"Kappler","year":"2017","journal-title":"Hematol. Oncol. Clin N. Am."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Becker, A.C., Libhaber, E., Sliwa, K., Singh, S., Stewart, S., and Tikly, M. (2011). Antiphospholipid antibodies in black South Africans with hiv and acute coronary syndromes: Prevalence and clinical correlates. BMC Res. Notes, 4.","DOI":"10.1186\/1756-0500-4-379"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1111\/j.1365-3156.2011.02870.x","article-title":"Total Lymphocyte count is a good marker for HIV-related mortality and can be used as a tool for starting HIV treatment in a resource-limited setting","volume":"16","author":"Oudenhoven","year":"2011","journal-title":"Trop. Med. Int. Health"},{"key":"ref_10","first-page":"2","article-title":"Determination of hematological and immunological parameters among HIV positive patients taking highly active antiretroviral treatment and treatment na\u00efve in the antiretroviral therapy clinic of Gondar University Hospital, Gondar, Northwest Ethiopia: A comparative cross-sectional study","volume":"14","author":"Bamlaku","year":"2014","journal-title":"BMC Hematol."},{"key":"ref_11","first-page":"484","article-title":"Hematologic Manifestations of HIV\/AIDS","volume":"9","author":"Mehta","year":"2011","journal-title":"Med. Update"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"94","DOI":"10.9790\/0853-139294101","article-title":"The Correlation of Values of CD4 Count, Platelet, Pt, Aptt, Fibrinogen and Factor VIII Concentrations among HIV Positive Patients in FMC Owerri","volume":"13","author":"Okoroiwu","year":"2014","journal-title":"IOSR J. Dent. Med. Sci."},{"key":"ref_13","first-page":"45","article-title":"Effect of CD4 Counts on Coagulation Parameters among HIV Positive Patients in Federal Medical Centre, Owerri, Nigeria","volume":"2","author":"Obeagu","year":"2015","journal-title":"Int. J. Curr. Res. Biosci. Plant Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"374","DOI":"10.4103\/0972-5229.183903","article-title":"Thrombotic microangiopathy as an initial manifestation in HIV patients","volume":"20","author":"Dineshkumar","year":"2016","journal-title":"Indian J. Crit. Care Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1086\/344778","article-title":"Thrombotic microangiopathy in patients with acquired immunodeficiency syndrome before and during the era of introduction of highly active antiretroviral therapy","volume":"35","author":"Gervasoni","year":"2002","journal-title":"Clin. Infect. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Alfano, G., Cappelli, G., Fontana, F., Di Lullo, L., Di Iorio, B., Bellasi, A., and Guaraldi, G. (2019). Kidney Disease in HIV Infection. J. Clin. Med., 8.","DOI":"10.3390\/jcm8081254"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"8378947","DOI":"10.1155\/2020\/8378947","article-title":"Renal Dysfunction among HIV-Infected Patients on Antiretroviral Therapy in Dar es Salaam, Tanzania: A Cross-Sectional Study","volume":"2020","author":"Mwemezi","year":"2020","journal-title":"Int. J. Nephrol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Ifeanyichukwu, M.O., Ibekilo Sylvester, N., John Aja O\u2019 Brien, C., and Co, O. (2016). Activated Partial Thromplastin Time, Prothrombin Time, Thrombin Time and Platelet Count Study in HIV Seropositive Subjects at Nnamdi Azikiwe Teaching Hospital Nnewi. Transl. Biomed., 7.","DOI":"10.21767\/2172-0479.100063"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.3851\/IMP2297","article-title":"Elevated D-Dimer Is independently Associated with Endothelial Dysfunction: A Cross-Sectional Study in HIV-Infected Adults on Antiretroviral Therapy","volume":"17","author":"Hileman","year":"2012","journal-title":"Antivir. Ther."},{"key":"ref_20","first-page":"1","article-title":"Estimation and Assessment of Plasma D-Dimer Levels in HIV Patients","volume":"4","author":"Himmat","year":"2016","journal-title":"J. Biosci. Med."},{"key":"ref_21","first-page":"6782595","article-title":"Coagulation Parameters in Human Immunodeficiency Virus Infected Patients: A Systematic Review and Meta-Analysis","volume":"2022","author":"Getawa","year":"2022","journal-title":"AIDS Res. Treat."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12959-018-0189-x","article-title":"Thrombotic thrombocytopenic purpura (TTP)-like syndrome in the HIV era","volume":"16","author":"Louw","year":"2018","journal-title":"Thromb. J."},{"key":"ref_23","first-page":"127","article-title":"HIV Infection Increases the Risk of Thrombotic Thrombocytopenic Purpura","volume":"4","author":"Dobson","year":"2018","journal-title":"J. Thromb. Circ."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/hiv.12310","article-title":"Immune activation in the course of HIV-1 infection: Causes, phenotypes and persistence under therapy","volume":"17","author":"Younas","year":"2016","journal-title":"HIV Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.hoc.2013.02.006","article-title":"Thrombotic thrombocytopenic purpura and the atypical hemolytic uremic syndrome","volume":"27","author":"Tsai","year":"2013","journal-title":"Hematol. Oncol. Clin. N. Am."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1182\/asheducation-2013.1.292","article-title":"Thrombotic thrombocytopenic purpura: Basic pathophysiology and therapeutic strategies","volume":"2013","author":"Crawley","year":"2013","journal-title":"Hematol. Am. Soc. Hematol. Educ. Program"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"121","DOI":"10.4103\/0253-7184.102127","article-title":"Recurrent thrombosis in an HIV-1 infected child","volume":"33","author":"Shah","year":"2012","journal-title":"Indian J. Sex Transm. Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/jcla.10093","article-title":"Prevalnce of antiphospholipid and antiplatelet antibodies in Human Immunodeficiency virus (HIV)-infected Chilean Patients","volume":"17","author":"Palomo","year":"2003","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"362","DOI":"10.3389\/fped.2018.00362","article-title":"The differences between childhood and adult-onset antiphospholipid syndrome","volume":"6","author":"Wincup","year":"2018","journal-title":"Front. Pediatr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"47","DOI":"10.4103\/0377-4929.59182","article-title":"Lupus anticoagulant, in human immunodeficiency virus-infected patients on highly active antiretroviral therapy","volume":"53","author":"Awodu","year":"2010","journal-title":"Indian J. Pathol. Microbiol."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/10\/1826\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:06:23Z","timestamp":1760130383000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/59\/10\/1826"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,13]]},"references-count":30,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["medicina59101826"],"URL":"https:\/\/doi.org\/10.3390\/medicina59101826","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,13]]}}}