{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:42:29Z","timestamp":1776386549278,"version":"3.51.2"},"reference-count":48,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:00:00Z","timestamp":1697414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"General Program for Clinical Research at Peking University Shenzhen Hospital","award":["LCYJ2021004"],"award-info":[{"award-number":["LCYJ2021004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Peritoneal dialysis-associated peritonitis (PDAP) poses significant challenges in peritoneal dialysis (PD) patient management and outcomes. Total bilirubin has gained attention due to its antioxidant and immunomodulatory properties. However, its relationship with PDAP prognosis remains underexplored. Materials and Methods: We conducted a retrospective single-center study involving 243 PDAP patients stratified into tertile-based groups according to total bilirubin levels. The association between total bilirubin levels and treatment failure risk was investigated through statistical analyses and restricted cubic spline curve analysis. Results: Our analysis revealed a non-linear correlation between total bilirubin levels and PDAP treatment failure risk. At total bilirubin levels below 8.24 \u00b5mol\/L, a protective effect was observed, while levels exceeding this threshold heightened the risk of treatment failure. Conclusions: This study unveils a dual role of total bilirubin in PDAP prognosis. Below a certain threshold, it confers protection, while higher levels exacerbate the risk of treatment failure. These findings emphasize the need for further investigation in larger, multicenter prospective studies to validate and elucidate the mechanisms behind bilirubin\u2019s impact on PDAP, potentially guiding the development of targeted therapeutic strategies.<\/jats:p>","DOI":"10.3390\/medicina59101837","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T05:43:49Z","timestamp":1697435029000},"page":"1837","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association of Different Total Bilirubin Levels with Prognosis of Peritoneal Dialysis-Associated Peritonitis"],"prefix":"10.3390","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2962-1199","authenticated-orcid":false,"given":"Yujian","family":"He","sequence":"first","affiliation":[{"name":"Renal Division, Peking University Shenzhen Hospital, Lianhua Road 1120, Shenzhen 518036, China"},{"name":"PKU-Shenzhen Clinical Institute of Shantou University Medical College, Lianhua Road 1120, Shenzhen 518036, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Renal Division, Peking University Shenzhen Hospital, Lianhua Road 1120, Shenzhen 518036, China"},{"name":"PKU-Shenzhen Clinical Institute of Shenzhen University Medical College, Lianhua Road 1120, Shenzhen 518036, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Xiao","sequence":"additional","affiliation":[{"name":"Renal Division, Peking University Shenzhen Hospital, Lianhua Road 1120, Shenzhen 518036, China"},{"name":"PKU-Shenzhen Clinical Institute of Shantou University Medical College, Lianhua Road 1120, Shenzhen 518036, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5942-4962","authenticated-orcid":false,"given":"Qingyun","family":"Luo","sequence":"additional","affiliation":[{"name":"Renal Division, Peking University Shenzhen Hospital, Lianhua Road 1120, Shenzhen 518036, China"},{"name":"PKU-Shenzhen Clinical Institute of Shenzhen University Medical College, Lianhua Road 1120, Shenzhen 518036, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengpeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Renal Division, Peking University Shenzhen Hospital, Lianhua Road 1120, Shenzhen 518036, China"},{"name":"PKU-Shenzhen Clinical Institute of Shenzhen University Medical College, Lianhua Road 1120, Shenzhen 518036, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7076-5817","authenticated-orcid":false,"given":"Xu","family":"Wang","sequence":"additional","affiliation":[{"name":"Renal Division, Peking University Shenzhen Hospital, Lianhua Road 1120, Shenzhen 518036, China"},{"name":"PKU-Shenzhen Clinical Institute of Shenzhen University Medical College, Lianhua Road 1120, Shenzhen 518036, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"He","sequence":"additional","affiliation":[{"name":"Renal Division, Peking University Shenzhen Hospital, Lianhua Road 1120, Shenzhen 518036, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zibo","family":"Xiong","sequence":"additional","affiliation":[{"name":"Renal Division, Peking University Shenzhen Hospital, Lianhua Road 1120, Shenzhen 518036, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3747\/pdi.2018.00180","article-title":"The Association of Cognitive Impairment with Peritoneal Dialysis-Related Peritonitis","volume":"39","author":"Liao","year":"2019","journal-title":"Perit. 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