{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:34:38Z","timestamp":1760150078864,"version":"build-2065373602"},"reference-count":194,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"V.I. Vernadsky Crimean Federal University","award":["No. FZEG-2021\u20130009","121102900145-0"],"award-info":[{"award-number":["No. FZEG-2021\u20130009","121102900145-0"]}]},{"name":"Development of oligonucleotide constructs for making selective and highly effective preparations for medicine and agriculture","award":["No. FZEG-2021\u20130009","121102900145-0"],"award-info":[{"award-number":["No. FZEG-2021\u20130009","121102900145-0"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Rheumatoid arthritis refers to joint diseases of unclear etiology whose final stages can lead to unbearable pain and complete immobility of the affected joints. As one of the most widely known diseases of the joints, it serves as a study target for a large number of research groups and pharmaceutical companies. Modern treatment with anti-inflammatory drugs, including janus kinase (JAK) inhibitors, monoclonal antibodies, and botanicals (polyphenols, glycosides, alkaloids, etc.) has achieved some success and hope for improving the course of the disease. However, existing drugs against RA have a number of side effects which push researchers to elaborate on more selective and effective drug candidates. The avant-garde of research, which aims to develop treatment of rheumatoid arthritis using antisense oligonucleotides along with nonsteroidal drugs and corticosteroids against inflammation, increases the chances of success and expands the arsenal of drugs. The primary goal in the treatment of this disease is to find therapies that allow patients with rheumatoid arthritis to move their joints without pain. The main purpose of this review is to show the victories and challenges for the treatment of rheumatoid arthritis and the tortuous but promising path of research that aims to help patients experience the joy of freely moving joints without pain.<\/jats:p>","DOI":"10.3390\/medicina59101853","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T10:36:56Z","timestamp":1697625416000},"page":"1853","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Rheumatoid Arthritis Has Won the Battle but Not the War: How Many Joints Will We Save Tomorrow?"],"prefix":"10.3390","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7472-2389","authenticated-orcid":false,"given":"Volodymyr V.","family":"Oberemok","sequence":"first","affiliation":[{"name":"Department of Molecular Genetics and Biotechnologies, Institute of Biochemical Technologies, Ecology and Pharmacy, V.I. Vernadsky Crimean Federal University, Simferopol 295007, Crimea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oksana","family":"Andreeva","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Biotechnologies, Institute of Biochemical Technologies, Ecology and Pharmacy, V.I. Vernadsky Crimean Federal University, Simferopol 295007, Crimea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kateryna","family":"Laikova","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Biotechnologies, Institute of Biochemical Technologies, Ecology and Pharmacy, V.I. Vernadsky Crimean Federal University, Simferopol 295007, Crimea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edie","family":"Alieva","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Biotechnologies, Institute of Biochemical Technologies, Ecology and Pharmacy, V.I. Vernadsky Crimean Federal University, Simferopol 295007, Crimea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zenure","family":"Temirova","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Biotechnologies, Institute of Biochemical Technologies, Ecology and Pharmacy, V.I. Vernadsky Crimean Federal University, Simferopol 295007, Crimea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1056\/NEJMra1004965","article-title":"The pathogenesis of rheumatoid arthritis","volume":"365","author":"McInnes","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_2","first-page":"776","article-title":"Paleopathology in osseous remains from the 16th century. A survey of rheumatic diseases","volume":"25","author":"Medina","year":"1998","journal-title":"J. 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